ABSTRACT
Since its initial detection in Africa, the West Nile virus has disseminated widely across all continents, becoming endemic in numerous countries, including the Russian Federation. A substantial expansion of the West Nile virus range was observed in the European part of the Russian territory in 1999. In light of this epidemiological trend, research endeavours focusing on monitoring West Nile virus circulation activity in endemic regions of the country have gained paramount significance. A substantial dataset has been accrued from 2007 onwards regarding genomic variability and dissemination dynamics across the country throughout the entire monitoring period for the West Nile fever pathogen. The objective of this study was to characterise West Nile virus isolates that have been circulating in the Russian Federation and identify their molecular and genetic characteristics. A phylogenetic analysis of 55 complete genome sequences revealed that the West Nile virus population within the Russian Federation is genetically heterogeneous and is represented by four major clades. One of these clades is currently exhibiting extensive spread into new regions of the country.
Subject(s)
Genetic Variation , Phylogeny , West Nile Fever , West Nile virus , West Nile virus/genetics , West Nile virus/classification , West Nile virus/isolation & purification , Russia/epidemiology , West Nile Fever/virology , West Nile Fever/epidemiology , Humans , Genome, Viral/genetics , AnimalsABSTRACT
Results of use of UroBeam laser diode in 72 patients with benign prostatic hyperplasia (BPH) were analyzed. Average prostate volume was 67.29 +/- 26.72 cm3, the duration of vaporization--69.2 +/- 23.7 min. Blood loss was minimal. In the period from 2 weeks to 4 months after surgery, 9 patients have developed acute urinary retention. In the early postoperative period, acute prostatitis was diagnosed in 7 patients and was jugulated using drug treatment. The laser vaporization of BPH led to a three-fold reduction in the severity of urinary disorders and increase the urinary flow rate. The combination of laser vaporization of the prostate with transurethral resection of the prostate allow to improve the recovery of urination after surgery.
Subject(s)
Laser Therapy/methods , Prostatic Hyperplasia/surgery , Aged , Aged, 80 and over , Humans , Kallikreins/blood , Laser Therapy/adverse effects , Laser Therapy/instrumentation , Lasers, Semiconductor , Male , Middle Aged , Prostate-Specific Antigen/blood , Prostatic Hyperplasia/diagnosis , Transurethral Resection of Prostate/methods , Treatment Outcome , Urinary Retention/etiologyABSTRACT
In 20 acute experiments on 40 mongrel dogs ranging in weight from 15 to 20 kg, a heterotopic heart transplant was implanted into the chest of the recipient with experimentally induced right ventricular failure. A detailed description is presented of the operative technique in acute and chronic experiments. Haemodynamic findings attest to the efficacy of the work of the transplant, the right ventricle of which is able to take over most of the work of the right ventricle of the recipient.
