An oral cancer screening program in Brazil: Analysis of seven years of outcome after its implementation in the suburban cities of São Paulo.

OBJECTIVE: To describe the implementation of an oral cancer screening program at the Barretos Cancer Hospital (BCH) and present the outcome based on data obtained from 2014 to 2020. MATERIALS AND METHODS: The residents of the Regional Health District of Barretos (DRS-V) were personally invited by community health agents or nurses, and among 13,973 people, 15,222 oral examinations were carried out over the years in 18 of its municipalities. Oral examinations were performed at the Mobile Dental Unit and at the Prevention Department of the BCH. Inclusion criteria were being 35 years of age or older, having a personal history of tobacco or alcohol consumption, or having a lesion in the oral cavity found by community health agent or self-reported, regardless of age or risk factors. RESULTS AND CONCLUSION: The main result of our study was the stages of oral cancer among screen detected cases were smaller compared to cases in the hospital registry, in the state and in Brazil. Oral cancer detection rate per 1,000 oral examinations was 10.7.The early stages of oral cancer found by screening in primary care facilities or using mobile units suggest that, when organized, screening may improve the prognosis of oral cancer.

Acid-base potentiometric titration using a stainless steel electrode without oxidative treatment.

An AISI 304 stainless steel laminar electrode without oxidative treatment was investigated for the potentiometric titration of hydrochloric acid with sodium hydroxide. The proposed electrode was obtained from metalworking cuttings. Scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray fluorescence spectroscopy and X-ray diffraction were used to study the surface morphology and chemical composition of the electrode. The electrode showed a sensitivity of 59.18 ± 0.37 mV/pH, which was reproducible under intermediate conditions. Potentiometric titration showed a curve with deviations from pH 9.5 with respect to the glass electrode. However, this did not affect the quantification as the jumps of the curves coincided. The endpoint was 9.25 mL for both electrodes and the hydrochloric acid concentration was 0.0845 mol/L, with a deviation of 0.0004 mol/L from the standard concentration of 0.0841 mol/L. The nonartificially oxidised electrode did not show any crystalline oxide phases, whereas after oxidation it showed semicrystalline phases of iron and chromium oxides and increased the crystallinity of the steel. Despite the low content of surface oxides, stainless steel electrodes can give a Nernstian response to pH, depending on the surface characteristics of the material. This leads to the need to calibrate any electrode prior to oxidative treatment to rule out a Nernstian response without surface modification.

Structural relaxation, dynamical arrest, and aging in soft-sphere liquids.

We investigate the structural relaxation of a soft-sphere liquid quenched isochorically (ϕ = 0.7) and instantaneously to different temperatures Tf above and below the glass transition. For this, we combine extensive Brownian dynamics simulations and theoretical calculations based on the non-equilibrium self-consistent generalized Langevin equation (NE-SCGLE) theory. The response of the liquid to a quench generally consists of a sub-linear increase of the α-relaxation time with system's age. Approaching the ideal glass-transition temperature from above (Tf > Ta), sub-aging appears as a transient process describing a broad equilibration crossover for quenches to nearly arrested states. This allows us to empirically determine an equilibration timescale teq(Tf) that becomes increasingly longer as Tf approaches Ta. For quenches inside the glass (Tf ≤ Ta), the growth rate of the structural relaxation time becomes progressively larger as Tf decreases and, unlike the equilibration scenario, τα remains evolving within the whole observation time-window. These features are consistently found in theory and simulations with remarkable semi-quantitative agreement and coincide with those revealed in a previous and complementary study [P. Mendoza-Méndez et al., Phys. Rev. 96, 022608 (2017)] that considered a sequence of quenches with fixed final temperature Tf = 0 but increasing ϕ toward the hard-sphere dynamical arrest volume fraction ϕHS a=0.582. The NE-SCGLE analysis, however, unveils various fundamental aspects of the glass transition, involving the abrupt passage from the ordinary equilibration scenario to the persistent aging effects that are characteristic of glass-forming liquids. The theory also explains that, within the time window of any experimental observation, this can only be observed as a continuous crossover.

Kinetics and mathematical model of killer/sensitive interaction under different physicochemical conditions of must/wine: a study from a biological point of view.

Fermentation of grape must to wine is carried out by a complex microbial mixture, which also involves spoilage yeasts of wine. The latter yeasts produce organoleptic changes that cause significant economic losses to the wine industry. SO2 is traditionally used to control this spoilage populations, but because of its harmful effects on human health, biocontrol has emerged as an alternative treatment. Although studies have been carried out to select biocontroller yeasts and examine their underlying mechanisms of action, reports on their application have not been published yet. To better understand the interaction and the successful application of biocontrol, the use of mathematical models, among other methods, is important, as they facilitate the prediction of success or failure of the antagonist. The objective of the present study was to use an existing mathematical model to obtain information about the yeast's interaction assayed and to validate its predictive use under different physicochemical conditions during the wine fermentation, and eventually predict biocontrol kinetics. The mathematical model was applied to the fermentation conditions and provided information on the kinetic parameters of the biocontrol interaction and allowed interpretations about other parameters. The model was applied in the different physicochemical conditions for the biocontrol and did not fit correctly to experimental data, and therefore an improvement was proposed which was successful and presented new hypotheses.

External waveguide magnetic resonance imaging for lower limbs at 3 T.

PURPOSE: We report a method based on the traveling-wave MRI approach, in order to acquire images of human lower limbs with an external waveguide at 3 T. METHODS: We use a parallel-plate waveguide and an RF surface coil for reception, while a whole-body birdcage is used for transmission. The waveguide and the surface coil are located right outside the magnet, in the magnetic resonance (MR) conditional devices zone. We ran numerical simulations to investigate the B 1 field generated by the surface coil located at one of the waveguides, as well as a saline-solution phantom positioned on the opposite side (150 cm away) inside the magnet. RESULTS: We obtained phantom images by varying the distance between the coil and the phantom, in order to investigate the signal-to-noise ratio and to validate our numerical simulations. Lower limb images of a healthy volunteer were also acquired, demonstrating the viability of this approach. Standard pulse sequences were used and no physical modifications were made to the MR imager. CONCLUSIONS: These numerical and experimental results show that traveling-wave MRI can produce high-quality images with only a simple waveguide and an RF coil located outside the magnet. This can be particularly favorable when acquiring images of lower limbs requiring a larger field of view.

Triple Leidenfrost Effect: Preventing Coalescence of Drops on a Hot Plate.

We report on the collision-coalescence dynamics of drops in Leidenfrost state using liquids with different physicochemical properties. Drops of the same liquid deposited on a hot concave surface coalesce practically at contact, but when drops of different liquids collide, they can bounce several times before finally coalescing when the one that evaporates faster reaches a size similar to its capillary length. The bouncing dynamics is produced because the drops are not only in Leidenfrost state with the substrate, they also experience Leidenfrost effect between them at the moment of collision. This happens due to their different boiling temperatures, and therefore, the hotter drop works as a hot surface for the drop with lower boiling point, producing three contact zones of Leidenfrost state simultaneously. We called this scenario the triple Leidenfrost effect.

Health risk assessment in children living in an urban area with hydrofluorosis: San Luis Potosí Mexico case study.

BACKGROUND: Fluoride is an inorganic element, which can be found in high concentrations in groundwater. Its consumption and exposure have consequences on human health. The objective of this study was to evaluate fluoride exposure and develop a health risk assessment in children from an urban area with hydrofluorosis in Mexico. METHODS: Water fluoride levels in active wells were provided by the Water State Agency and divided into three zones: agriculture zone (Zone A), metallurgical zone (Zone B), and industrial zone (Zone C). Urinary fluoride levels were determined by potentiometric method using an ion-selective electrode. Health risk assessment was performed through Monte Carlo model analysis and hazard quotient was calculated. RESULTS: According to fluoride well concentration, all zones have high concentration especially Zone B (2.55 ± 0.98 mg/L). Urinary fluoride concentrations were highest in children in Zone B (1.42 ± 0.8 mg/L). The estimated median daily intake dose of fluoride was 0.084 mg/Kg-day for the children living in zone B. The highest mean HQ value was to Zone B (1.400 ± 0.980), followed by Zone C (0.626 ± 0.443). CONCLUSION: The levels of fluoride exposure registered are a potential risk to generate adverse health effects in children in the San Luis Potosi metropolitan area.

Remote RF excitation for small-bore MR imager at 15.2 T.

We report a method for remote excitation of the RF signal for preclinical-equivalent ultra high field Magnetic Resonance Imaging (MRI). A parallel-plate waveguide together with a bio-inspired surface coil were used to perform remote excitation experiments to acquire images with a small-bore MR imager at 15.2 T. The imager bore size limits the RF coil transmitter dimensions, so the Gielis super-formula was used to design an RF coil with small dimensions. Electromagnetic simulations of the principal mode were run to study the waveguide filled with air and loaded with a saline solution-filled tube. Radiation patterns were also computed in a semi-anechoic chamber for the same scenarios as above. A saline solution-filled spherical phantom and a formaldehyde-fixed mouse phantom were used to acquire images. Radiation patterns showed an omnidirectional distribution with no side lobes, and a very smooth behaviour with almost no loss of information in the saline solution-filled tube and without. The theoretical wave impedance was calculated and compared with simulated results showing an excellent correspondence. Spherical phantom image data and simulation results of B1 were contrasted and showed an important correlation. Ex vivo mouse images were of high quality and exhibited clear delineation of anatomical structures. These imaging results are in very good agreement with the simulations. Numerical, theoretical and experimental results validate this approach, using a bio-inspired surface coil with a simple waveguide for preclinical small-bore MRI at ultra high field.

[Applications of tranexamic acid in Orthopaedics and Traumatology]. / Aplicaciones del ácido tranexámico en cirugía Ortopédica y Traumatología.

INTRODUCTION: Tranexamic acid is an antifibrinolytic drug which has been used in many disciplines of Medicine, as well as in Orthopaedics and Traumatology, with the objective of diminishing and preventing blood loss and the necessity of allogenic blood transfusion. This study has the objective to demonstrate the uses, indications and contraindications of tranexamic acid in the different subspecialties of Orthopaedics and Traumatology. MATERIAL AND METHODS: A through search was performed looking at the most recent evidence regarding the use of tranexamic acid in the different subspecialties of Orthopaedics and Traumatology, as well as its indications, contraindications and adverse effects. RESULTS: Tranexamic acid has a great amount of applications in Orthopaedics and Traumatology, especially in primary and revision knee and hip arthroplasties, spine surgery and trauma. It has been observed that tranexamic acid is effective in diminishing perioperative bleeding, less necessity of blood transfusion, among other benefits. Tranexamic acid is a safe drug, which does not increase the risk of developing thrombotic events in healthy patients. There are a number of administration routes of tranexamic acid as well as many dosage regimens, all being efficient. Therefore, no standardization regarding the best administration route and most effective dose has been established. CONCLUSIONS: Tranexamic acid is a safe and effective drug for diminishing perioperative bleeding and to avoid the necessity of blood transfusion, with many applications in Orthopaedics and Traumatology.

INTRODUCCIÓN: El ácido tranexámico (ATX) es un medicamento antifibrinolítico que se ha utilizado en diversas disciplinas de la medicina, entre ellas en la Ortopedia y Traumatología con el objetivo de prevenir y disminuir el sangrado y evitar la necesidad de transfusiones. El presente trabajo tiene el objetivo de revisar los usos, indicaciones y contraindicaciones del ATX en Ortopedia y Traumatología. MATERIAL Y MÉTODOS: Se realizó una búsqueda de la evidencia más importante y reciente acerca del uso del ATX en Ortopedia y Traumatología, así como sus indicaciones, contraindicaciones y efectos adversos. RESULTADOS: El ATX tiene una gran cantidad de aplicaciones dentro de las que destacan las artroplastías de rodilla, cadera (primarias y de revisión), la cirugía de columna y el trauma, observándose con su uso una disminución en el sangrado perioperatorio y en la necesidad de transfusiones. El ATX es seguro, no aumenta el riesgo de desarrollar efectos trombóticos en pacientes sanos. Existen múltiples vías de administración, así como múltiples regímenes de dosis, todas siendo eficaces, por lo que aún no se ha estandarizado la mejor vía de administración ni la dosis más eficaz. CONCLUSIONES: El ATX es un medicamento seguro y eficaz para la disminución del sangrado perioperatorio.

Prediction of Egg Weight from External Egg Traits of Guinea Fowl Using Multiple Linear Regression and Regression Tree Methods

The study was done to predict egg weight from the external traits of the Guinea fowl egg using the statistical methods of multiple linear regression (MLR) and regression tree analysis (RTA). A total of 110 eggs from a flock of 23-week-old Guinea fowl were evaluated. Egg weight (EW) and external traits: eggshell weight (ESW), egg polar diameter (EPD), egg equatorial diameter (EED), egg shape index (ESI), and egg surface area (ESA) were measured. Descriptive statistics, Pearson correlation coefficients, and regression equations using the MLR were obtained; additionally, a RTA was done using the CHAID algorithm with the SPSS software (IBM ver. 22). EW presented positive correlations (p 59.03 cm2 and a polar diameter > 5.10 cm. The proposed statistical methods can be used to reliably predict the egg weight of Guinea fowl.

Prediction of Egg Weight from External Egg Traits of Guinea Fowl Using Multiple Linear Regression and Regression Tree Methods

The study was done to predict egg weight from the external traits of the Guinea fowl egg using the statistical methods of multiple linear regression (MLR) and regression tree analysis (RTA). A total of 110 eggs from a flock of 23-week-old Guinea fowl were evaluated. Egg weight (EW) and external traits: eggshell weight (ESW), egg polar diameter (EPD), egg equatorial diameter (EED), egg shape index (ESI), and egg surface area (ESA) were measured. Descriptive statistics, Pearson correlation coefficients, and regression equations using the MLR were obtained; additionally, a RTA was done using the CHAID algorithm with the SPSS software (IBM ver. 22). EW presented positive correlations (p<0.0001) with ESA (r = 0.72), EPD (r = 0.65), and EED (r = 0.49). EW can be predicted through MLR using ESA as a predictor variable (R2 = 72%). Predictive accuracy improves when adding EPD and EED traits to the model (R2 = 75%). The RTA built a diagram using ESA, EED, and EPD as significant independent variables; of these, the most important variable was ESA (F = 50,295, df1 = 4, and df2 = 105; Adj. p<0.000) and the variation explained for EW was 74%. Likewise, the RTA showed that the highest egg weight (41.818 g) is obtained from eggs with a surface area > 59.03 cm2 and a polar diameter > 5.10 cm. The proposed statistical methods can be used to reliably predict the egg weight of Guinea fowl.(AU)

Air entrainment and granular bubbles generated by a jet of grains entering water.

HYPOTHESIS: A water jet penetrating into a water pool produces air entrainment and bubbles that rise to the surface and disintegrate. A similar scenario can be expected when a granular jet enters into water. This phenomenon is common in natural and industrial processes but remains so far unexplored. EXPERIMENTS: A collimated jet of monodisperse silica beads was poured into water and the process was filmed with a high-speed camera. The grain size, jet impact velocity, and the liquid physical properties were systematically varied. FINDINGS: For grains of ~50-300µm in diameter, the granular jet deforms the air-water interface, penetrates the pool and produces air entrainment. Most of the entrained air is contained in the interstitial space of the jet, and its volume is linearly proportional to the volume of grains. The bubbles formed in this process are covered by a layer of grains attached to the bubble air-water interface due to capillary-induced cohesion. These "granular bubbles" are stable over time because the granular shell prevents coalescence and keeps the air encapsulated, either if the bubbles rise to the surface or sink to the bottom of the pool, which is determined by the competition of the buoyancy and the weight of the assembly.

Ray Systems and Craters Generated by the Impact of Nonspherical Projectiles.

The impact of a spherical projectile on an evened-out granular bed generates a uniform ejecta of material and a crater with a raised circular rim. Recently, Sabuwala et al. [Phys. Rev. Lett. 120, 264501 (2018)PRLTAO0031-900710.1103/PhysRevLett.120.264501] found that the uniform blanket of ejecta changes to a set of radial streaks when a spherical body impacts on an undulated granular surface, being a plausible explanation to the enigmatic ray systems on planetary bodies. Here, we show that ray systems can also be generated by the impact of nonspherical projectiles on a flat granular surface. This is a reasonable explanation considering that meteorites are rarely spherical. Moreover, by impacting bodies of different geometries, we show that the crater size follows the same power-law scaling with the impact energy found for spherical projectiles, and the crater rim becomes circular as the impact energy is increased regardless of the projectile shape, which helps to understand why most impact craters in nature are rounded.

Vigilancia intensificada de eventos de salud pública en comunidades desplazadas por inundaciones en Paraguay, 2015-2016 / Intensified surveillance of public health events in communities displaced by floods in Paraguay, 2015-2016

Introducción: La vigilancia epidemiológica de la morbilidad y la mortalidad relacionadas a los desastres, es fundamental para organizar y gestionar los recursos, equipos y personal necesarios para responder efectivamente a las situaciones de emergencia. Se describe la implementación del sistema de vigilancia intensificada en poblaciones desplazadas por inundaciones en Paraguay, período 2015/2016. Materiales y métodos: Estudio descriptivo de corte trasversal, entre el 28/12/2015 y 12/07/2016, en todo el territorio nacional. Como fuentes de datos se utilizaron la planilla de notificación diaria de enfermedades, el consolidado de situación de albergues. Se diseñó un sistema de carga de datos por la web. Para el análisis de datos se utilizó el programa informático Epi Info 7.1.5, con medidas estadísticas de tendencia central como medias, medianas, proporciones. Resultados: Se registraron 68.699 personas afectadas. De las cuales, 32,4% eran menores de 5 años. Un 48,0 % se alojaron en refugios formales y 36,7% en campamentos informales, en ambos se identificó déficit de condiciones sanitarias básicas. Se registraron 23.877 consultas. Las enfermedades más frecuentes: Infección respiratoria aguda no neumonía (33%), hipertensión arterial (19%), enfermedad tipo influenza (14%), lesiones de la piel (6%) y diarreas (6%). Un 3% correspondió al síndrome febril agudo, dos casos confirmados de leptospirosis. No se registraron brotes de enfermedades infecciosas. Conclusión: La aplicación de la vigilancia intensificada durante el evento de inundación permitió la identificación de grupos de riesgo y sus problemas de salud más frecuentes. Esto fue fundamental en la orientación de los esfuerzos de prevención y control durante del desastre. Palabras claves: Desastres naturales, inundaciones, vigilancia en salud pública, epidemiología, Paraguay.

Introduction: The importance of epidemiological surveillance of morbidity and mortality related to disasters is that it is essential to organize and manage resources, equipment and personnel necessary to respond effectively to emergencies. The implementation of an intensified surveillance system in populations displaced by flooding in the affected regions of Paraguay during the 2015/2016 period is described. Materials and methods: Descriptive study of cross section, between 12/28/2015 and 7/12/2016, throughout the national territory. As data sources, the planning of the daily notifications of diseases is used, the consolidation of the situation of the shelters. A web data loading system was designed. For the analysis of the data, it is the Epi Info 7.1.5 computer program, with measures of central tendency such as means, medians, and proportions. Results: 68,699 affected people were registered. Of which, 32.4% were under 5 years old; 48.0% were housed in formal shelters and 36.7% in informal camps, both of which identified a deficit of basic sanitary conditions. There were 23,877 queries. The most frequent diseases: Acute respiratory infection, pneumonia (33%), hypertension (19%), influenza-like illness (14%), skin lesions (6%) and diarrhea (6%). 3% corresponded to the acute febrile syndrome, two confirmed cases of leptospirosis. There were no outbreaks of infectious diseases. Conclusion: The implementation of intensified surveillance during the flooding event allowed a better understanding of the general situation of the displaced population, as well as the identification of risk groups and their most frequent health problems. This was instrumental in guiding the prevention and control efforts during the disaster. Keywords: Natural disasters, floods, public health surveillance, epidemiology, Paraguay.

Sex difference in counts of α4 and α7 nicotinic acetylcholine receptors in the nasal polyps of adults with or without exposure to tobacco smoke.

OBJECTIVE: To assess counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults with or without long-term exposure to cigarette tobacco smoke. METHODS: Twenty-two patients with and 22 patients without exposure to cigarette tobacco smoke participated in the study. After endoscopic polypectomy, the fragments of the nasal polyps were analysed by immunohistochemistry. RESULTS: Compared to patients with no exposure, patients with exposure showed higher counts of α4 and α7 nicotinic acetylcholine receptors (t-test, p 0.05). CONCLUSION: Exposure to cigarette tobacco smoke may induce increased counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults, with lower counts in males than females without exposure to tobacco smoke.

Evaluation of behaviour of Lachancea thermotolerans biocontrol agents on grape fermentations.

Previous researches have showed that Lachancea thermotolerans strains RCKT4 and RCKT5 inhibited the growth of Aspergillus. However, currently, there are no data on their nutritional preferences, as a possible substrate competitor against Saccharomyces cerevisiae, and their effects on fermentation. In this work, we observed that the biocontrol yeasts and S. cerevisiae BSc203, based on the utilization of 16 carbonate sources, revealed significant differences in the nutritional profile (biocontrol yeasts NS:0·25, BSc203 NS:0·56). Lachancea thermotolerans strains did not occupy the same niche as that of BSc203 (NOI:0·44). The biocontrol agents and BSc203 presented similar competitive attitude in terms of the sugar, ethanol and sulphite tolerances. During fermentation, the biocontrol yeasts were found to tolerate up to 12% v/v ethanol, 250 mg ml-1 of total SO2 and 30° Brix sugar. In mixed cultures, L. thermotolerans strains did not negatively affect the growth of BSc203 and the wine quality, except when RCKT4 was initially inoculated at a high proportion in the mixed culture 1MSK4 (1%BSc203/99%RCKT4), resulting in a lower production of CO2 and ethanol, in comparison with pure BSc203. RCKT5, at a high proportion, in 1MSK5 (1%BSc203/99%RCKT5) presented promising oenological properties. This fermentation showed lower acetic acid contents and higher total acidity than pure BSc203. SIGNIFICANCE AND IMPACT OF THE STUDY: Generally it is not evaluated if the biofungicide yeasts sprayed on vegetables alter the quality of the fermented products. This work focused on the importance of assessing the possible effects of yeast-based fungicides used in vineyards on grape fermentation, especially on Saccharomyces cerevisiae growth. In this context, the competition between biofungicide yeasts and S. cerevisiae under winemaking conditions is investigated.

Re-emergence of rabies virus maintained by canid populations in Paraguay.

Paraguay has registered no human cases of rabies since 2004, and the last case in dogs, reported in 2009, was due to a variant maintained in the common vampire bat "Desmodus rotundus". In 2014, a dog was diagnosed as positive for rabies with aggression towards a boy and all required measures of control were successfully adopted. Epidemiological investigation revealed that the dog was not vaccinated and had been attacked by a crab-eating fox, "zorro" (Cerdocyon thous). The sample was diagnosed by the Official Veterinary Service of the Country and sent to the Center on Rabies Research from the University of São Paulo, Brazil, for antigenic and genetic characterization. A second sample from a dog positive for rabies in the same region in 2015 and 11 samples from a rabies outbreak from Asuncion in 1996 were also characterized. The antigenic profile of the samples, AgV2, was compatible with one of the variants maintained by dogs in Latin America. In genetic characterization, the samples segregated in the canine (domestic and wild species)-related group in an independent subgroup that also included samples from Argentina. These results and the epidemiology of the case indicate that even with the control of rabies in domestic animals, the virus can still circulate in wildlife and may be transmitted to domestic animals and humans, demonstrating the importance of continuous and improved surveillance and control of rabies, including in wild species, to prevent outbreaks in controlled areas.

The performance of mobile screening units in a breast cancer screening program in Brazil.

PURPOSE: In Brazil, access to breast cancer screening outside of urban centers is limited. This study aims to describe the coverage and performance of a breast cancer screening program implemented with Mobile Screening Units (MSU) in northern São Paulo state. METHODS: This is a retrospective cohort study of a population-based mammography program targeting women ages 40-69 in 108 municipalities from 12/2010 to 07/2015. Screening coverage rates were estimated using the Brazil 2010 census data. We calculated performance measures for the number of exams, recalls, and detected cases of cancer. Screen-detected cases were compared to clinically detected cases using hospital cancer registry data and a propensity-score matching method. The down-staging of screen-detected cases relative to clinically detected cases was assessed using logistic regression to calculate risk ratios (RRs) with 95% confidence intervals. RESULTS: 122,634 women were screened through the MSU program, representing a cumulative coverage rate of 54.8% in the target population. For initial and subsequent rounds, recall rates were 12.25 and 6.10% and cancer detection rates were 3.63 (95% CI 3.23-4.10) and 1.94 (95% CI 1.59-2.41), respectively. 92.51% of referrals were successful. Screen-detected cases had more favorable prognoses than clinically detected cases, including smaller tumor size and a decreased risk of late-stage detection (RR 0.14 95% CI 0.074-0.25). CONCLUSIONS: MSUs are a feasible method for the delivery of mammography services in this setting. Patients who had breast cancer detected on an MSU had favorable prognostic factors when compared with clinically detected cases arising from the same target population.

Surface depression with double-angle geometry during the discharge of grains from a silo.

When rough grains in loose packing conditions are discharged from a silo, a conical depression with a single slope is formed at the surface. We observed that the increase of volume fraction generates a more complex depression, characterized by two angles of discharge: one at the bottom similar to the angle of repose and a considerably larger upper angle. The change in slope appears at the boundary between a dense stagnant region at the periphery and the central flowing channel formed over the aperture. Since the material in the latter zone is always fluidized, the flow rate is unaffected by the initial packing of the bed. On the other hand, the contrast between both angles is markedly smaller when smooth particles of the same size and density are used, which reveals that high packing fraction and friction must combine to produce the observed geometry. Our results show that the surface profile helps to identify by simple visual inspection the packing conditions of a granular bed, being useful to prevent undesirable collapses during silo discharge in industry.