Probing the content of affective semantic memory following caregiving-related early adversity.

Cognitive science has demonstrated that we construct knowledge about the world by abstracting patterns from routinely encountered experiences and storing them as semantic memories. This preregistered study tested the hypothesis that caregiving-related early adversities (crEAs) shape affective semantic memories to reflect the content of those adverse interpersonal-affective experiences. We also tested the hypothesis that because affective semantic memories may continue to evolve in response to later-occurring positive experiences, child-perceived attachment security will inform their content. The sample comprised 160 children (ages 6-12 at Visit 1; 87F/73 M), 66% of whom experienced crEAs (n = 105). At Visit 1, crEA exposure prior to study enrollment was operationalized as parental-reports endorsing a history of crEAs (abuse/neglect, permanent/significant parent-child separation); while child-reports assessed concurrent attachment security. A false memory task was administered online ∼2.5 years later (Visit 2) to probe the content of affective semantic memories-specifically attachment schemas. Results showed that crEA exposure (vs. no exposure) was associated with a higher likelihood of falsely endorsing insecure (vs. secure) schema scenes. Attachment security moderated the association between crEA exposure and insecure schema-based false recognition. Findings suggest that interpersonal-affective semantic schemas include representations of parent-child interactions that may capture the quality of one's own attachment experiences and that these representations shape how children remember attachment-relevant narrative events. Findings are also consistent with the hypothesis that these affective semantic memories can be modified by later experiences. Moving forward, the approach taken in this study provides a means of operationalizing Bowlby's notion of internal working models within a cognitive neuroscience framework. RESEARCH HIGHLIGHTS: Affective semantic memories representing insecure schema knowledge (child needs + needs-not-met) may be more salient, elaborated, and persistent among youths exposed to early caregiving adversity. All youths, irrespective of early caregiving adversity exposure, may possess affective semantic memories that represent knowledge of secure schemas (child needs + needs-met). Establishing secure relationships with parents following early-occurring caregiving adversity may attenuate the expression of insecure semantic memories, suggesting potential malleability. Affective semantic memories include schema representations of parent-child interactions that may capture the quality of one's own attachment experiences and shape how youths remember attachment-relevant events.

The effects of parental presence on amygdala and mPFC activation during fear conditioning: An exploratory study.

Learning safe versus dangerous cues is crucial for survival. During development, parents can influence fear learning by buffering their children's stress response and increasing exploration of potentially aversive stimuli. Rodent findings suggest that these behavioral effects are mediated through parental presence modulation of the amygdala and medial prefrontal cortex (mPFC). Here, we investigated whether similar parental modulation of amygdala and mPFC during fear learning occurs in humans. Using a within-subjects design, behavioral (final N = 48, 6-17 years, mean = 11.61, SD = 2.84, 60% females/40% males) and neuroimaging data (final N = 39, 6-17 years, mean = 12.03, SD = 2.98, 59% females/41% males) were acquired during a classical fear conditioning task, which included a CS+ followed by an aversive noise (US; 75% reinforcement rate) and a CS-. Conditioning occurred once in physical contact with the participant's parent and once alone (order counterbalanced). Region of interest analyses examined the unconditioned stress response by BOLD activation to the US (vs. implicit baseline) and learning by activation to the CS+ (vs. CS-). Results showed that during US presentation, parental presence reduced the centromedial amygdala activity, suggesting buffering of the unconditioned stress response. In response to learned stimuli, parental presence reduced mPFC activity to the CS+ (relative to the CS-), although this result did not survive multiple comparisons' correction. These preliminary findings indicate that parents modulate amygdala and mPFC activity during exposure to unconditioned and conditioned fear stimuli, potentially providing insight into the neural mechanisms by which parents act as a social buffer during fear learning. RESEARCH HIGHLIGHTS: (1)This study used a within-participant experimental design to investigate how parental presence (vs. absence) affects youth's neural responses in a classical fear conditioning task. (2)Parental presence reduced the youth's centromedial amygdala activation to the unconditioned stimulus (US), suggesting parental buffering of the neural unconditioned response (UR). (3)Parental presence reduced the youth's mPFC activation to a conditioned threat cue (CS+) compared to a safety cue (CS-), suggesting possible parental modulation of fear learning.

Telomere Erosion and Depressive Symptoms Across Development Following Institutional Care.

OBJECTIVE: A large literature has identified exposure to early caregiving adversities as a potent risk for developing affective psychopathology, with depression, in particular, increasing across childhood into adolescence. Evidence suggests telomere erosion, a marker of biological aging, may underlie associations between adverse early-life experiences and later depressive behavior; yet, little is understood about this association during development. METHOD: The current accelerated longitudinal study examined concurrent telomere length and depressive symptoms concurrently, 2 and 4 years later, from the preschool period through adolescence among children exposed (n =116) and not exposed (n = 242) to early previous institutional (PI) care. RESULTS: PI care was associated with shorter telomeres on average and with quadratic age-related growth in depressive symptoms, indicating a steeper association between PI care and depressive symptoms in younger age groups that leveled off in adolescence. Contrary to studies in adult samples, telomere length was not associated with depressive symptoms, and it did not predict future symptoms. CONCLUSION: These findings indicate that early caregiving disruptions increase the risk for both accelerated biological aging and depressive symptoms, although these variables did not correlate with each other during this age range.

The Added Value of Crosstalk Between Developmental Circuit Neuroscience and Clinical Practice to Inform the Treatment of Adolescent Anxiety.

Significant advances have been made in recent years regarding the developmental trajectories of brain circuits and networks, revealing links between brain structure and function. Emerging evidence highlights the importance of developmental trajectories in determining early psychiatric outcomes. However, efforts to encourage crosstalk between basic developmental neuroscience and clinical practice are limited. Here, we focus on the potential advantage of considering features of neural circuit development when optimizing treatments for adolescent patient populations. Drawing on characteristics of adolescent neurodevelopment, we highlight two examples, safety cues and incentives, that leverage insights from neural circuit development and may have great promise for augmenting existing behavioral treatments for anxiety disorders during adolescence. This commentary seeks to serve as a framework to maximize the translational potential of basic research in developmental populations for strengthening psychiatric treatments. In turn, input from clinical practice including the identification of age-specific clinically relevant phenotypes will continue to guide future basic research in the same neural circuits to better reflect clinical practices. Encouraging reciprocal communication to bridge the gap between basic developmental neuroscience research and clinical implementation is an important step toward advancing both research and practice in this domain.

Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.

It has been established that early-life adversity impacts brain development, but the role of development itself has largely been ignored. We take a developmentally-sensitive approach to examine the neurodevelopmental sequelae of early adversity in a preregistered meta-analysis of 27,234 youth (birth to 18-years-old), providing the largest group of adversity-exposed youth to date. Findings demonstrate that early-life adversity does not have an ontogenetically uniform impact on brain volumes, but instead exhibits age-, experience-, and region-specific associations. Relative to non-exposed comparisons, interpersonal early adversity (e.g., family-based maltreatment) was associated with initially larger volumes in frontolimbic regions until ∼10-years-old, after which these exposures were linked to increasingly smaller volumes. By contrast, socioeconomic disadvantage (e.g., poverty) was associated with smaller volumes in temporal-limbic regions in childhood, which were attenuated at older ages. These findings advance ongoing debates regarding why, when, and how early-life adversity shapes later neural outcomes.

Characterizing the dimensional structure of early-life adversity in the Adolescent Brain Cognitive Development (ABCD) Study.

Early-life adversity has profound consequences for youth neurodevelopment and adjustment; however, experiences of adversity are heterogeneous and interrelated in complex ways that can be difficult to operationalize and organize in developmental research. We sought to characterize the underlying dimensional structure of co-occurring adverse experiences among a subset of youth (ages 9-10) from the Adolescent Brain Cognitive Development (ABCD) Study (N = 7115), a community sample of youth in the United States. We identified 60 environmental and experiential variables that reflect adverse experiences. Exploratory factor analysis identified 10 robust dimensions of early-life adversity co-occurrence, corresponding to conceptual domains such as caregiver substance use and biological caregiver separation, caregiver psychopathology, caregiver lack of support, and socioeconomic disadvantage / neighborhood lack of safety. These dimensions demonstrated distinct associations with internalizing problems, externalizing problems, cognitive flexibility, and inhibitory control. Non-metric multidimensional scaling characterized qualitative similarity among the 10 identified dimensions. Results supported a nonlinear three-dimensional structure representing early-life adversity, including continuous gradients of "perspective", "environmental uncertainty", and "acts of omission/commission". Our findings suggest that there are distinct dimensions of early-life adversity co-occurrence in the ABCD sample at baseline, and the resulting dimensions may have unique implications for neurodevelopment and youth behavior.

Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis.

It has been established that early-life adversity impacts brain development, but the role of development itself has largely been ignored. We take a developmentally-sensitive approach to examine the neurodevelopmental sequelae of early adversity in a preregistered meta-analysis of 27,234 youth (birth to 18-years-old), providing the largest group of adversity-exposed youth to date. Findings demonstrate that early-life adversity does not have an ontogenetically uniform impact on brain volumes, but instead exhibits age-, experience-, and region-specific associations. Relative to non-exposed comparisons, interpersonal early adversity (e.g., family-based maltreatment) was associated with initially larger volumes in frontolimbic regions until ~10-years-old, after which these exposures were linked to increasingly smaller volumes. By contrast, socioeconomic disadvantage (e.g., poverty) was associated with smaller volumes in temporal-limbic regions in childhood, which were attenuated at older ages. These findings advance ongoing debates regarding why, when, and how early-life adversity shapes later neural outcomes.

Within-person Changes in Co-rumination and Rumination in Adolescence: Examining Heterogeneity and the Moderating Roles of Gender and Time.

Although previous work has consistently identified positive associations between co-rumination and rumination during adolescence, little to no research has examined how this relationship operates on the person-specific level. The current study aimed to extend current developmental theories of co-rumination and rumination by examining within-person associations between these constructs. Survey data was collected from 1502 adolescents (Mage = 13.20; 52% girls; 52% non-Hispanic White) every six-months across the span of 3.5 years. The results showed that at time-points when adolescents reported co-ruminating more than their usual level, they reported concurrent increases in rumination. This association was stronger for boys and strengthened over time. Despite substantial between-person heterogeneity, 97% of adolescents showed positive associations between co-rumination and rumination. This research has important implications for mental health professionals, school systems, and parents who may look to teach adolescents about effective emotion-regulation.

Parent problem drinking trajectory classes predict anxiety in adolescence and emerging adulthood.

BACKGROUND: This study identified latent trajectory classes for maternal problem drinking and paternal problem drinking and examined the associations between these trajectory classes and offspring anxiety symptoms during adolescence and emerging adulthood. METHODS: Participants (n = 870; 54% female; 59% non-Hispanic White; Mage = 16.10, SD = 0.71) were administered surveys during the spring of 2007, 2008, and 2009, and 2014. RESULTS: Fit indices from parallel process growth mixture models suggested three dual trajectory classes: (1) Low initial levels of maternal problem drinking and paternal problem drinking that increased over time (Low-Both); (2) Low initial levels of maternal problem drinking that increased over time and high initial levels of paternal problem drinking that increased slightly over time (Low-Mom/High-Dad); (3) High initial levels of maternal problem drinking that increased slightly over time and low initial levels of paternal problem drinking that remained relatively stable over time (High-Mom/Low-Dad). Girls were more likely than boys to be classified in the Low-Mom/High-Dad and High-Mom/Low-Dad classes, relative to the Low-Both trajectory class. In addition, adolescents in the High-Mom/Low-Dad trajectory class reported the most anxiety symptoms during adolescence and emerging adulthood. LIMITATIONS: Limitations include the reliance on one informant (the adolescent/emerging adult) and the geographically limited sample (northeastern United States). CONCLUSIONS: Prevention and intervention programs aimed at reducing anxiety should consider changes in alcohol use in both the father and the mother over time. Moreover, special attention should be paid to maternal problem drinking given that it appears to be a salient risk factor for anxiety during adolescence and emerging adulthood.

Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes.

Early psychosocial adversities exist at many levels, including caregiving-related, extrafamilial, and sociodemographic, which despite their high interrelatedness may have unique impacts on development. In this paper, we focus on caregiving-related early adversities (crEAs) and parse the heterogeneity of crEAs via data reduction techniques that identify experiential cooccurrences. Using network science, we characterized crEA cooccurrences to represent the comorbidity of crEA experiences across a sample of school-age children (n = 258; 6-12 years old) with a history of crEAs. crEA dimensions (variable level) and crEA subtypes (subject level) were identified using parallel factor analysis/principal component analysis and graph-based Louvain community detection. Bagging enhancement with cross-validation provided estimates of robustness. These data-driven dimensions/subtypes showed evidence of stability, transcended traditional sociolegally defined groups, were more homogenous than sociolegally defined groups, and reduced statistical correlations with sociodemographic factors. Finally, random forests showed both unique and common predictive importance of the crEA dimensions/subtypes for childhood mental health symptoms and academic skills. These data-driven outcomes provide additional tools and recommendations for crEA data reduction to inform precision medicine efforts in this area.

Modeling heterogeneity in the simultaneous emotional costs and social benefits of co-rumination.

Co-rumination is the act of perseverating on problems or negative emotions with another person. Past research has shown that co-rumination has tradeoffs, as it is related to more anxiety and depressive symptoms, yet also heightened feelings of closeness and better relationship quality. However, there has been little repeated measures work, leaving unknown the influence of within-person changes in co-rumination on individuals' functioning. Using data from 1,504 adolescents collected as part of a seven-wave study over 4 years, we hypothesized that at times when adolescents coruminated above their own average level of co-rumination, they would report more anxiety and depressive symptoms, as well as increased closeness with friends at concurrent timepoints. Moreover, we investigated heterogeneity in these effects, exploring whether there was variability in whether adolescents experienced simultaneous costs and benefits of increased co-rumination. The results reveal that the average adolescent reported associated increases in anxiety symptoms, depressive symptoms, and closeness with friends at times when they reported coruminating at higher-than-typical levels. Yet, there was significant heterogeneity in these effects, as some adolescents solely experienced costs of co-rumination and others experienced just benefits. Moreover, adolescents who experienced stronger-than-average effects of co-rumination on anxiety and depressive symptoms reported less of an increase in closeness with friends. These findings offer important insight into how co-rumination is associated with social-emotional functioning and have implications for recommending best practices for seeking support and discussing problems with close others. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Appearance-related teasing and substance use during early adolescence.

Appearance-related teasing is a pervasive form of bullying during adolescence. Yet, the impact of appearance-related teasing on risk for alcohol and marijuana use is unknown. This study, therefore, examined the relationship between appearance-related teasing and the use of alcohol and marijuana in a sample of 1,344 students (52% female; 51% non-Hispanic White; ages 11-14 years, M = 13.20, SD = 0.65) from 5 public middle schools. Participants completed a survey that assessed demographic characteristics, weight status, depressive symptoms, general peer victimization, experiences of appearance-related teasing perpetrated by family and peers, and substance use in the fall of 2016 (Time 1 [T1]) and spring of 2017 (T2). Findings at baseline (T1) indicated that more frequent appearance-related teasing was associated with higher concurrent levels of total alcohol consumption, binge drinking, and marijuana use (ps < .001). Longitudinally, more frequent appearance-related teasing at T1 predicted greater increases in total alcohol consumption (p < .01) and binge drinking frequency (p < .05) by T2 but was unrelated to changes in marijuana use (p > .05), adjusting for age, gender, race and ethnicity, perceived socioeconomic status, body mass index z scores, depressive symptoms, general peer victimization frequency, and substance use at T1. Moderation analyses generally suggested that the positive associations between appearance-related teasing and alcohol use measures were stronger among adolescents who were girls (vs. boys) and who were overweight or obese (vs. nonoverweight). These findings suggest that appearance-related teasing may play a role in the origins of alcohol use during early adolescence and emphasize the need to mitigate the effects of appearance-related teasing and prevent early substance use. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Social media use and risky behaviors in adolescents: A meta-analysis.

INTRODUCTION: This systematic review and meta-analysis examined the associations between social media use and risky behaviors during adolescence, and evaluated study characteristics (e.g., sample age, type of social media platform assessed) that may moderate these relationships. METHODS: A comprehensive search strategy identified relevant studies from PsycInfo, PubMed, Google Scholar, and Proquest Dissertations and Theses Global. RESULTS: The final sample included 27 independent cross-sectional studies with a total of 67,407 adolescents (Mage = 15.5, range: 12.6-18.0 years; 51.7% girls; 57.2% White). Results from random effects models indicated that there were positive, small-to-medium correlations between social media use and engagement in risky behaviors generally (r = 0.21, 95% CI = 0.16-0.25), substance use (r = 0.19, 95% CI = 0.12-0.26), and risky sexual behaviors (r = 0.21, 95% CI = 0.15-0.28). There were an insufficient number of independent samples available to conduct a random effect models for violence-related behaviors (k = 3). Moderator analyses suggested that studies assessing solely early social media platforms (e.g., Facebook/MySpace only) in relation to substance use had smaller effect sizes than substance use studies assessing a broader range of contemporary social media platforms. In addition, younger samples had larger effect sizes for studies focused on social media use and risky sexual behaviors. CONCLUSIONS: The positive links identified between social media and risky behaviors during adolescence in this meta-analysis suggest that developmental theories of risk taking would benefit from incorporating the social media context. Longitudinal studies are needed to clarify directionality and make more specific practice and policy recommendations so that social media is a safe place in which adolescents can thrive.

Adolescent Psychological Functioning and Membership in Latent Adolescent-Parent Communication Dual Trajectory Classes.

The primary goal of this study was to examine the relationship between adolescents' psychological functioning (as indicated by depressive symptoms) and substance use (alcohol and drug use) and membership in adolescent-parent communication trajectory subgroups in a large, diverse community sample of adolescents from the United States (n = 1,057; 53% female; 51% Caucasian; Age: M = 16.15, SD = .75). Adolescents completed questionnaires at three annual assessments. Fit indices from parallel process growth mixture models suggested three dual trajectory classes: (1) Average communication with both parents (Average-Both); (2) Good adolescent-mother and poor adolescent-father communication (Good-Mom/Poor-Dad); and (3) Poor adolescent-mother and good adolescent-father communication (Poor-Mom/Good-Dad). The trajectory classes differed by gender. In addition, psychological functioning and substance use were differentially related to the trajectory classes.

Social Media Use Subgroups Differentially Predict Psychosocial Well-Being During Early Adolescence.

Despite the salience of the social media context to psychosocial development, little is known about social media use patterns and how they relate to psychological and social functioning over time during early adolescence. This longitudinal study, therefore, identified subgroups of early adolescents based on their social media use and examined whether these subgroups predicted psychosocial functioning. Adolescents (N = 1205; 11-14 years; 51% female; 51% white) completed surveys at baseline and a six-month follow-up. There were three social media use subgroups at baseline: high overall social media use (8%); high Instagram/Snapchat use (53%); and low overall social media use (39%). The high social media use subgroup predicted higher depressive symptoms, panic disorder symptoms, delinquent behaviors, family conflict, as well as lower family and friend support, than the High-Instagram/Snapchat and low social media use subgroups. The high Instagram/Snapchat use subgroup predicted higher delinquent behaviors and school avoidance than the low social media use subgroup, but also higher close friendship competence and friend support as compared to both the high social media use and low social media use subgroups. Social media use patterns appear to differentially predict psychosocial adjustment during early adolescence, with high social media use being the most problematic and patterns of high Instagram/Snapchat use and low social media use having distinct developmental tradeoffs.

Self-Competence and Depressive Symptoms in Middle-Late Adolescence: Disentangling the Direction of Effect.

This study examined the temporal relation between self-competence (academic, social, athletic, physical appearance, and close friend) and depressive symptoms in a large, diverse community sample of 636 adolescents. Surveys were administered to all 10th- and 11th-grade students at participating high schools at baseline (mean age = 16.10, SD = .71) and 1 year later. Girls reported higher levels of self-competence in close friendships and more depressive symptoms, whereas boys reported higher levels of self-competence in athletics and physical appearance. However, there were no gender differences in the associations between self-competence and depressive symptoms. Results from autoregressive, cross-lagged path analyses indicated that depressive symptoms predicted self-competence more consistently than self-competence predicted depressive symptoms during middle-late adolescence. Implications for prevention are discussed.

Protective Factors Associated with Daily Affective Reactivity and Instability During Adolescence.

The daily emotional experiences of adolescents are dynamic, vary significantly across individuals, and are crucial to their psychological adjustment, warranting a need to identify factors that promote adaptive affective responses to stressors and attenuated affective instability. The objective of this study, therefore, was to examine protective factors linked to individual differences in daily affective reactivity and instability utilizing a daily diary design in a national sample of 100 U.S. adolescents (13-17 years; 40% girls; 79% White). Adolescents completed a baseline survey and then 14 daily online surveys. Better mother-adolescent communication predicted lower negative affect reactivity, whereas greater use of problem-focused coping strategies predicted higher positive affect reactivity. Greater trait resilience and instrumental support seeking predicted lower negative affect instability. Conversely, more emotional support seeking predicted higher negative affect instability. No factors were associated with positive affect instability, and father-adolescent communication was unrelated to daily affective reactivity and instability. The findings implicate specific protective factors associated with distinct aspects of affective reactivity and instability.

Age-varying associations between coping and depressive symptoms throughout adolescence and emerging adulthood.

The objective of the current study was to apply the novel technique of time-varying effect modeling to examine age-varying associations between specific coping strategies and depressive symptoms across adolescence and emerging adulthood (ages 14-24). The participants were drawn from a community sample and followed across 4 years of high school and once 5 years postgraduation (N = 1,251, 53% female, 58% non-Hispanic White). Coping and depressive symptom questionnaires were administered across all data collection time points. Time-varying effect modeling used all available data (N = 5,651 measurement occasions) and adjusted for gender. Venting emotions and denial were associated with more depressive symptoms at a similar magnitude across adolescence and emerging adulthood. A positive association between problem solving oriented strategies (planning, active coping) and depressive symptoms was not observed until age 17.5, after which the magnitude of the association strengthened. More frequent instrumental and emotional support seeking were linked to fewer depressive symptoms between ages 18.8 and 23.6. More frequent use of humor was associated with greater depressive symptoms from ages 14.0 to 14.6, but with fewer depressive symptoms from ages 16.8 to 18.8. The findings illuminate when and how associations between specific coping strategies and depressive symptoms may emerge and change across developmental age, generating both theoretical and clinical implications.

Associations between friend conflict and affective states in the daily lives of adolescents.

This study examined the associations between friend conflict, defined as arguments with friends, and affective states using a daily diary design in a community sample of adolescents. Participants were 100 U.S. adolescents (13-17 years; 40% girls; 79% white). Adolescents completed an online survey on 14 consecutive evenings. Adolescents reported significantly higher anger/hostility, confusion, and tension/anxiety and less friendliness on days during which they experienced friend conflict relative to no-conflict days. However, no same-day associations for depressed affect, fatigue, or vigor were found. Adolescents experiencing friend conflict reported increased next-day anger/hostility, depressed affect, and tension/anxiety, but not other affective states. Higher levels of anger/hostility and depressed affect predicted an increased likelihood of next-day friend conflict. Conversely, higher levels of friendliness and vigor predicted a decreased likelihood of next-day friend conflict. These findings suggest that directional relationships between adolescents' friend conflicts and their affective states vary by affective domain.