Doppler Velocimetry of the Ophthalmic Artery Behavior in Twin Pregnancy.

Our main objective was to evaluate the ophthalmic artery Doppler behavior in twin pregnancies and compare with singleton pregnancies. We studied 64 healthy twin pregnant women between 12 to 38 weeks of gestation. Resistance index (RI), pulsatility index (PI), and peak ratio (PR) were determined. The control group consisted of 289 singletons. Linear regression analysis was performed to evaluate the association between gestational age and the ophthalmic indexes. Student t test was used to compare the means and standard deviation of the Doppler indexes. There was a decrease in RI and PI and an increase in PR with advancing gestational age (ρ < 0.0001, 0.0052, and 0.0033). The means ± SDs for RI, PI, and PR were 0.77 ± 0.07, 1.79 ± 0.46, and 0.53 ± 0.12, in women with twin pregnancies and 0.75 ± 0.05, 1.88 ± 0.43, and 0.52 ± 0.10 in singletons. No significant difference was found between the PI and PR values, but significant difference was found in the RI values between the groups (P = 0.0332). We concluded that there are no significant differences in ophthalmic artery behavior in twins and the same reference values established in singleton pregnancies can be applied for PI and PR indexes in the evaluation of twin pregnancies. These indexes were the best to evaluate twin pregnancies.

Ultrasonographic Evaluation of Uterine Involution in the Early Puerperium.

Purpose Our aim was to describe the changes observed by ultrasonography in uterine dimensions during the early puerperium among women who experienced an uncomplicated puerperium. Additionally, the influence of parity, mode of delivery, breastfeeding and birth weight on uterine involution was evaluated. Methods Ninety-one patients underwent an ultrasound examination on days 1 (D1), 2 (D2) and 7 (D7) of the postpartum period. The longitudinal, anteroposterior and transverse uterine diameters were measured, and the uterine volume was calculated by the formula: longitudinal diameter (LD) X anteroposterior diameter (APD) X transverse diameter (TD) X 0.45. The thickness and length of the uterine cavity were also measured. Results The uterine volume and the LD, APD and TD decreased by 44.8%, 20.9%, 11.8% and 20.0% respectively. The uterine cavity thickness was reduced by 23%, and the length of the cavity was reduced by 27.2% on D7. Uterine involution was correlated inversely with parity when the day of the postpartum period was not taken into account (p = 0.01). However, when the uterine involution was correlated to parity separately, with D1, D2 or D3, no correlations were found. A significant difference occurred at D2, when it was found that the uterus had a smaller volume following cesarean section compared with vaginal delivery (p = 0.04). The high birth weight and breastfeeding were significantly related to uterine involution (p ≤ 0.01 and p = 0.04). Conclusion The sonographic evaluation of the uterus in the early puerperium should consider birth weight, breastfeeding and parity, as well as the delivery route on D2, to identify abnormalities related to uterine involution.

Ultrasonographic Evaluation of Uterine Involution in the Early Puerperium / Avaliação ultrassonográfica da involução uterina no puerpério precoce

Abstract Purpose Our aim was to describe the changes observed by ultrasonography in uterine dimensions during the early puerperium among women who experienced an uncomplicated puerperium. Additionally, the influence of parity, mode of delivery, breastfeeding and birth weight on uterine involution was evaluated. Methods Ninety-one patients underwent an ultrasound examination on days 1 (D1), 2 (D2) and 7 (D7) of the postpartum period. The longitudinal, anteroposterior and transverse uterine diameters were measured, and the uterine volume was calculated by the formula: longitudinal diameter (LD) X anteroposterior diameter (APD) X transverse diameter (TD) X 0.45. The thickness and length of the uterine cavity were also measured. Results The uterine volume and the LD, APD and TD decreased by 44.8%, 20.9%, 11.8% and 20.0% respectively. The uterine cavity thickness was reduced by 23%, and the length of the cavity was reduced by 27.2% on D7. Uterine involution was correlated inversely with parity when the day of the postpartum period was not taken into account (p= 0.01). However, when the uterine involution was correlated to parity separately, with D1, D2 or D3, no correlations were found. A significant difference occurred at D2, when it was found that the uterus had a smaller volume following cesarean section compared with vaginal delivery (p= 0.04). The high birth weight and breastfeeding were significantly related to uterine involution (p ≤ 0.01 and p= 0.04). Conclusion The sonographic evaluation of the uterus in the early puerperium should consider birth weight, breastfeeding and parity, as well as the delivery route on D2, to identify abnormalities related to uterine involution.

Resumo Objetivo Descrever as alterações observadas pela ultrassonografia nas dimensões uterinas durante o puerpério precoce em mulheres com evolução puerperal não complicada, considerando a influência da paridade, tipo de parto, amamentação e peso ao nascer sobre a involução uterina. Métodos Noventa e uma pacientes foram submetidas a exame ultrassonográfico nos dias 1 (D1), 2 (D2) e 7 (D7) do puerpério. Os diâmetros uterinos longitudinal, anteroposterior e transversal foram medidos, e o volume uterino foi calculado pela fórmula: diâmetro longitudinal (DL) X diâmetro anteroposterior (DAP) X diâmetro transverso (DT) X 0,45. A espessura e comprimento da cavidade uterina também foram medidos. Resultados O volume uterino e o DL, DAP e DT diminuíram 44,8%, 20,9%, 11.8% e 20,0% respectivamente no D7. A espessura da cavidade uterina reduziu em 23%, e o comprimento da cavidade foi reduzido em 27,2% no D7. A involução uterina se correlacionou inversamente com a paridade quando o dia do puerpério não foi levado em conta (p= 0,01). Uma diferença significativa foi encontrada em D2, quando se verificou que o útero tinha um volume menor no grupo submetido a cesariana em comparação com o parto vaginal (p= 0,04). O peso ao nascer elevado e amamentação apresentaram relação estatisticamente significativa com a involução uterina (p ≤ 0,01 e p= 0,04). Conclusão A avaliação ultrassonográfica do útero no puerpério precoce deve considerar o peso ao nascer, a amamentação e a paridade, assim como a via de parto no D2, para a identificação de anormalidades relacionadas à involução uterina.

Entendendo a pesquisa clínica VI: formatando a pergunta do estudo / Understanding the clinical research VI: formatting the research question

O primeiro passo na concepção de qualquer pesquisa clínica é ter uma "ideia" para o estudo. A ideia para um estudo geralmente vem da experiência e da percepção de que há uma necessidade de se obter uma resposta clara a uma pergunta de pesquisa bem definida. Uma vez que a pergunta do estudo tenha sido identificada, o próximo passo é uma avaliação crítica da literatura existente para descobrir o que exatamente se sabe sobre o assunto, certificando-se de que a pergunta ainda não foi respondida. As perguntas primárias e secundárias do estudo devem ser elaboradas de formas clara e concisa, permitindo a identificação da exposição e dos desfechos de interesse, assim como a magnitude do efeito previsto.(AU)

The first step in designing any clinical research is to have an "idea" for the study. The idea for a study usually comes from experience and the perception that there is a need to obtain a clear answer to a well defined question. Once the research question has been identified, the next step is a critical review of the literature to find out what exactly is known about it and to make sure that the question has not been answered. The primary and secondary questions of the research should be drafted clearly and concisely, allowing the identification of exposure and outcomes of interest, as well as the magnitude of the expected effect.(AU)

Entendendo a pesquisa clínica IV: estudos de caso controle / Understanding the clinical research IV: case-control studies

O desenho de um estudo pode ser definido como a forma em que se incluem e comparam os sujeitos da pesquisa com determinadas características. Os estudos são divididos habitualmente em experimentais e não experimentais (observacionais), onde a diferença está na possibilidade do investigador ter ou não controle sobre a exposição de um fator (agente etiológico ou terapêutico). Nos concentraremos aqui no estudo de caso-controle. Um estudo caso-controle é um estudo observacional para determinar se uma exposição está associada com um desfecho. De maneira simplificada, identificar um grupo conhecido por ter o desfecho (casos) e um grupo conhecido por não tê-lo (controles), olhando para trás no tempo para saber quais indivíduos em cada grupo tiveram a exposição e comparar a frequência da exposição no grupo caso com o grupo controle.(AU)

The study design can be defined as the way in which they include and compare the subjects participant with certain characteristics. The studies are usually classified as experimental and non-experimental (observational), whose difference is the possibility of the researcher to control the exposure of a factor (etiological or therapeutic agent). We will focus here on the case-control study. The cohort study is an observational study designed to help determine if an exposure is associated with an outcome. In short words, the case-control study identify a group known to have the outcome (cases) and a group known to be free of the outcome (controls). It looks back in time to learn which subjects in each group had the exposure and compare the frequency of the exposure in the case group to the control group.(AU)

Entendendo a pesquisa clínica III: estudos de coorte / Understanding the clinical research III: cohort studies

O desenho de um estudo pode ser definido como a forma em que se incluem e comparam os sujeitos da pesquisa com determinadas características. Os estudos são divididos habitualmente em experimentais e não experimentais (observacionais), cuja diferença está na possibilidade de o investigador ter ou não controle sobre a exposição de um fator (agente etiológico ou terapêutico). Nos concentraremos aqui no estudo de coorte. O estudo de coorte é um estudo observacional no qual os indivíduos são classificados (ou selecionados) segundo o status de exposição (expostos e não expostos), sendo seguidos para avaliar a incidência da doença em determinado período de tempo.(AU)

The study design can be defined as the way in which the participant subjects with certain characteristics are included and compared. The studies are usually classified as experimental and non-experimental (observational), whose difference is the possibility of the researcher to control the exposure of a factor (etiological or therapeutic agent). We will focus here on the cohort study .The cohort study is an observational study in which subjects are classified (or selected) according to the exposure status (exposed and unexposed ), being followed to assess the incidence of the disease in a period of time.(AU)

Effects of electroacupuncture on stress-related symptoms in medical students: a randomised placebo-controlled study.

OBJECTIVE: To assess the effects of electroacupuncture (EA) on relieving stress-related symptoms-sleep disorders, anxiety, depression and burnout-in medical students. METHODS: Eighty-two students were randomised into an EA treatment group (n=30), a sham TENS group (n=18) and an untreated control group (n=34). EA was applied at a continuous frequency of 2 Hz to the limbs, face, ears and scalp for 20 min once a week, over 6-8 weeks. Sham transcutaneous electrical nerve stimulation (TENS) was performed on similar sites for the same number of times in each session and for the same length of time. Outcome measurements included a comparison of the indices obtained by different self-applied questionnaires before and after treatment. The surveys used were the Mini-Sleep Questionnaire (MSQ), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), the Beck Depression and Anxiety Inventories (BDI and BAI) and the Maslach Burnout Inventory-Student Survey (MBI-SS), in addition to the Quality of Life Questionnaire-abbreviated version (WHOQOL-bref). RESULTS: EA significantly improved scores on the MSQ, PSQI, BDI and the cynicism and academic efficacy (AE) dimensions of the MBI-SS in relation to the control. Sleep quality (MSQ) improved from 36.9 (SD 7.6) to 25.0 (5.7) with EA, 37.6 (6.0) to 32.1 (6.9) with sham TENS, and 36.5 (5.9) to 33.6 (6.7) in the controls (p=0.0000). Compared with the sham TENS group, EA significantly reduced scores on the PSQI. Score improvements in the sham TENS group in relation to control group were significant in the MSQ, BDI and AE. In the EA group, the number of students with better scores after intervention was significantly higher for the MSQ, PSQI, ESS and BAI. This only occurred for the MSQ in the sham TENS group and for the MSQ and ESS in the control group. CONCLUSIONS: EA significantly reduced stress-related mental symptoms. The improvement obtained by sham TENS compared with the control group confirmed the presence of a placebo effect resulting from the treatment ritual.

The impact of non- and genetically modified soybean diets in aorta wall remodeling.

The aim of this study was to evaluate the influence of nongenetically modified soybean (non-GMS) and genetically modified soybean (GMS) meal on growth and cardiometabolic parameters in rats. Thirty male Wistar rats were divided into 3 groups (n= 10): non-GMS, GMS, and control group (CG). All animals received water and an isocaloric diet ad libitum for 455 d. Blood was drawn by cardiac puncture, and serum was separated for subsequent biochemical analyses (total cholesterol, triacylglycerols, insulin, glucose, and testosterone). The aorta was quickly harvested and fixed; the body fat mass was removed and weighed. Non-GMS and GMS had a growth index (GI) similar to CG but with a lower body weight (P < 0.05) and a lower amount of body fat mass (P < 0.05). Total cholesterol, triacylglycerol, glucose concentrations, and aortic tunics were reduced (P < 0.05) in non-GMS and GMS compared to CG. Non-GMS and GMS are able to reduced serum cholesterol, triacylglycerols, glucose, and aortic remodeling in aged rats. No differences were observed between non-GMS and GMS in all parameters.