1.
Angew Chem Int Ed Engl
; 44(19): 2903-7, 2005 May 06.
Article
in English
| MEDLINE
| ID: mdl-15827972
Subject(s)
Antineoplastic Agents/chemical synthesis , Integrin alpha4beta1/antagonists & inhibitors , Liver Neoplasms , Melanoma , Animals , Antineoplastic Agents/therapeutic use , Crystallography, X-Ray , Cyclization , Drug Design , Liver Neoplasms/drug therapy , Male , Melanoma/drug therapy , Melanoma/secondary , Mice , Mice, Inbred C57BL , Molecular Structure , Stereoisomerism
2.
Mol Divers
; 7(2-4): 175-80, 2003.
Article
in English
| MEDLINE
| ID: mdl-14870848
ABSTRACT
Microwave irradiation induces the 1,3-dipolar cycloaddition of imines derived from alpha-aminoesters with beta-nitrostyrenes in the absence of solvent within 10-15 min. The reaction proceeds to give yields in the range 81-86% and three isomeric pyrrolidines are obtained in the cycloaddition. Consequently, the use of three imines and two beta-nitrostyrenes gives rise to a library of 18 nitroproline esters. The use of classical heating with longer reaction times (24 h) gives lower yields of products (below 50%) and only two stereoisomers can be detected in each reaction.