3D angle-independent Doppler and speckle tracking for the myocardium and blood flow

A technology based on velocity ratio indices is described for application in the myocardium. Angle-independent Doppler indices, such as the pulsatility index, which employ velocity ratios, can be measured even if the ultrasound beam vector at the moving target and the motion vector are not in a known plane. The unknown plane situation is often encountered when an ultrasound beam interrogates sites in the myocardium. The velocities employed in an index calculation must be close to the same or opposite directions. The Doppler velocity ratio indices are independent of angle in 3D space as are ratio indices based on 1D strain and 1D speckle tracking. Angle-independent results with spectral Doppler methods are discussed. Possible future imaging techniques based on velocity ratios are presented. By using indices that involve ratios, several other sources of error cancel in addition to that of angular dependence for example errors due to less than optimum gain settings and beam distortion. This makes the indices reliable as research or clinical tools. Ratio techniques can be readily implemented with current commercial blood flow pulsed wave duplex Doppler equipment or with pulsed wave tissue Doppler equipment. In 70 patients where the quality of the real-time B-mode looked suitable for the Doppler velocity ratio technique, there was only one case where clear spectra could not be obtained for both the LV wall and the septum. A reproducibility study of spectra from the septum of the heart shows a 12% difference in velocity ratios in the repeat measurements.

Airborne radiometric survey of a Chernobyl-contaminated mountain area in Norway - using ground-level measurements for validation.

An airborne radiometric survey can be an efficient way to investigate contamination of large areas after nuclear accidents. In the current study, a helicopter borne gamma ray spectrometry survey was carried out in a vast mountainous area in Norway, where the contamination from the 1986 Chernobyl accident still affects animal husbandry more than 30 years after the fallout occurred. The 137Cs activity densities provided by the aerial survey was validated using various independent ground-based measurements - including soil samples and in situ measurements (at 1 m above ground). Despite considerable small-scale heterogeneity, demonstrated by the ground-based measurements, strong correlations were obtained between the results from the aerial survey - after introducing more detailed instrument calibration and spectre analysis - and the ground-level data. Adjusted R2 values were around 0.9, and linear correlation coefficients close to unity.

The use of mapped geology as a predictor of radon potential in Norway.

Radon exposure is considered to cause several hundred fatalities from lung-cancer each year in Norway. A national map identifying areas which are likely to be exposed to elevated radon concentrations would be a useful tool for decision-making authorities, and would be particularly important in areas where only few indoor radon measurements exist. An earlier Norwegian study (Smethurst et al. 2008) produced radon hazard maps by examining the relationship between airborne gamma-ray spectrometry, bedrock and drift geology, and indoor radon. The study was limited to the Oslo region where substantial indoor radon and airborne equivalent uranium datasets were available, and did not attempt to test the statistical significance of relationships, or to quantify the confidence of its predictions. While it can be anticipated that airborne measurements may have useful predictive power for indoor radon, airborne measurement coverage in Norway is at present sparse; to provide national coverage of radon hazard estimates, a good understanding of the relationship between geology and indoor radon is therefore important. In this work we use a new enlarged (n = 34,563) form of the indoor radon dataset with national coverage, and we use it to examine the relationship between geology and indoor radon concentrations. We use this relationship to characterise geological classes by their radon potential, and we produce a national radon hazard map which includes confidence limits on the likelihood of areas having elevated radon concentrations, and which covers the whole of mainland Norway, even areas where little or no indoor radon data are available. We find that bedrock and drift geology classes can account for around 40% of the total observed variation in radon potential. We test geology-based predictions of RP (radon potential) against locally-derived estimates of RP, and produce classification matrices with kappa values in the range 0.37-0.56. Our classifier has high predictive value but suffers from low sensitivities for radon affected areas. We investigate an alternative classification method based on a Naïve Bayes classifier which results in similar overall performance. The work forms part of an ongoing study which will eventually incorporate airborne equivalent uranium data, as and when new airborne data become available.

Classification of arterial plaque by spectral analysis in remodelled human atherosclerotic coronary arteries.

We aimed to characterise and to identify the predominant plaque type in vivo using unprocessed radiofrequency (RF) intravascular ultrasound (US) backscatter, in remodelled segments of human atherosclerotic coronary arteries. A total of 16 remodelled segments were identified using a 30-MHz intravascular ultrasound (IVUS) scanner in vivo. Of these, 9 segments were classified as positively remodelled (>1.05 of the total vessel area in comparison with the proximal and distal reference segments) and 7 as negatively remodelled (<0.95 of reference segment area). Spectral parameters (maximum power, mean power, minimum power and power at 30 MHz) were determined and plaque type was defined as mixed fibrous, calcified or lipid-rich. Positively remodelled segments had a larger total vessel area (16.5 +/- 1.1 mm2 vs. 8.7 +/- 0.9 mm2, p<0.01) and plaque area (7.3 +/- 1.1 mm2 vs. 4.4 +/- 0.8 mm2, p=0.05) than negatively remodelled segments. Both positively and negatively remodelled segments had a greater percentage of fibrous plaque (p<0.01) than calcified or lipid-rich plaque. Comparing positively and negatively remodelled segments, there was no significant difference between the proportion of fibrous, calcified or lipid-rich plaque. We have been able to characterise and to identify plaque composition in vivo in human atherosclerotic coronary arteries. Our data suggest that remodelled segments are predominantly composed of fibrous plaque, as identified by RF analysis, although plaque composition is similar, irrespective of the remodelling type.