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1.
Lang Speech Hear Serv Sch ; 55(1): 105-129, 2024 Jan 11.
Article in English | MEDLINE | ID: mdl-37934883

ABSTRACT

PURPOSE: This study explores limitations in communication in daily life of children with developmental language disorder (DLD) from their parents' perspective as well as communicative abilities and social functioning in the classroom from their teacher's perspective. Furthermore, differences between children with mixed receptive-expressive disorder and children with expressive-only disorder in communication in daily life and social functioning are studied. METHOD: Data were collected through questionnaires completed by parents and teachers of children (5-6 years old) who attended schools for special education for DLD. Language test scores were retrieved from school records. Parents of 60 children answered open-ended questions about situations and circumstances in which their child was most troubled by language difficulties. Teachers of 83 children rated communicative abilities, social competence, and student-teacher relationship. RESULTS: Parents reported communication with strangers as most troublesome and mentioned the influence of the mental state of their child. Parents considered limitations in expressing oneself and being understood and not being intelligible as core difficulties. Teachers rated the children's communicative abilities in the school context as inadequate, but their scores concerning social competence and the quality of teacher-child relationships fell within the normal range. Children with receptive-expressive disorder experienced limitations in communication in almost all situations, whereas those with expressive disorder faced limitations in specific situations. Children with receptive-expressive disorder were also significantly more limited in their communicative abilities and social competence at school than children with expressive disorder. No differences were found between the two groups in the quality of the teacher-child relationship. CONCLUSIONS: The results confirm that children with DLD face significant challenges in a variety of communicative situations. We found indications that children with receptive-expressive disorder experience more severe limitations than children with expressive disorder. The involvement of parents and teachers in evaluating a child's communicative ability provides valuable and clinically relevant information.


Subject(s)
Communication , Language Development Disorders , Humans , Child, Preschool , Child , Parents , Language , Schools
2.
Neurosci Biobehav Rev ; 154: 105398, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37741516

ABSTRACT

Language is a complex multidimensional cognitive system that is connected to many neurocognitive capacities. The development of language is therefore strongly intertwined with the development of these capacities and their neurobiological substrates. Consequently, language problems, for example those of children with Developmental Language Disorder (DLD), are explained by a variety of etiological pathways and each of these pathways will be associated with specific risk factors. In this review, we attempt to link previously described factors that may interfere with language development to putative underlying neurobiological mechanisms of language development, hoping to uncover openings for future therapeutical approaches or interventions that can help children to optimally develop their language skills.


Subject(s)
Language Development Disorders , Child , Humans , Language Development Disorders/etiology , Language Development Disorders/psychology , Language Development , Risk Factors
3.
J Speech Lang Hear Res ; 66(10): 3954-3973, 2023 Oct 04.
Article in English | MEDLINE | ID: mdl-37713541

ABSTRACT

PURPOSE: Developmental language disorder (DLD) is characterized by persistent and unexplained difficulties in language development. Accumulating evidence shows that children with DLD also present with deficits in other cognitive domains, such as executive functioning (EF). There is an ongoing debate on whether exclusively verbal EF abilities are impaired in children with DLD or whether nonverbal EF is also impaired, and whether these EF impairments are related to their language difficulties. The aims of this study were to (a) compare nonverbal performance of preschoolers with DLD and typically developing (TD) peers, (b) examine how nonverbal EF and language abilities are related, and (c) investigate whether a diagnosis of DLD moderates the relationship between EF and language abilities. METHOD: A total of 143 children (nDLD = 65, nTD = 78) participated. All children were between 3 and 6.5 years old and were monolingual Dutch. We assessed nonverbal EF with a visual selective attention task, a visuospatial short-term and working memory task, and a task gauging broad EF abilities. Vocabulary and morphosyntax were each measured with two standardized language tests. We created latent variables for EF, vocabulary, and morphosyntax. RESULTS: Analyses showed that children with DLD were outperformed by their TD peers on all nonverbal EF tasks. Nonverbal EF abilities were related to morphosyntactic abilities in both groups, whereas a relationship between vocabulary and EF skills was found in the TD group only. These relationships were not significantly moderated by a diagnosis of DLD. CONCLUSIONS: We found evidence for nonverbal EF impairments in preschool children with DLD. Moreover, nonverbal EF and morphosyntactic abilities were significantly related in these children. These findings may have implications for intervention and support the improvement of prognostic accuracy. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.24121287.

4.
Autism Dev Lang Impair ; 8: 23969415231179844, 2023.
Article in English | MEDLINE | ID: mdl-37362238

ABSTRACT

Background and Aim: Children with Developmental Language Disorder (DLD) are at an increased risk to develop behaviors associated with Autism Spectrum Disorder (ASD). The relationship between early language difficulties and the occurrence of ASD-related behaviors in DLD is poorly understood. One factor that may hinder progress in understanding this relationship is the etiological heterogeneity of DLD. We therefore study this relationship in an etiologically homogeneous group of children, who share phenotypic characteristics with children with DLD: children with the 22q11.2 Deletion Syndrome (22q11DS). We compare children with 22q11DS, to children with DLD and age-matched typically developing children (TD). Method: 44 children with 22q11DS, 65 children with DLD and 81 TD children, between 3.0-6.5 years old, participated in a longitudinal cohort study that included a baseline measure and a follow-up measure with a 1-year interval. A parental questionnaire (SRS-2) was used to measure the incidence of behaviors in two key behavioral domains associated with ASD: Social Communication and Interaction and Restricted Repetitive Behaviors and Interests. At baseline, we assessed children's expressive and receptive language abilities as well as their intellectual functioning with standardized tests. We compared the distribution of ASD-related behaviors between the three groups. We used regression analyses to investigate whether language abilities at baseline predict ASD-related behavior at follow-up, accounting for ASD-related behavior at baseline, demographic variables and intellectual functioning. Results: Both the children with 22q11DS and the children with DLD displayed significantly more ASD-related behaviors than the TD children. Over 30% of children in both clinical groups had scores exceeding the subclinical threshold for ASD in both behavioral domains. Both in 22q11DS and DLD, baseline receptive language scores were negatively correlated with ASD-related behaviors 1 year later, when controlling for baseline SRS-scores. However, this association was statistically significant only in children with 22q11DS, even when controlled for IQ-scores, and it was significantly stronger as than in the TD group. The strength of the association did not differ significantly between 22q11DS and DLD. Conclusion: Both children with 22q11DS and children with DLD present with elevated rates of ASD-related behaviors at a preschool-age. Only in children with 22q11DS we observed that weaker receptive language skills were related to increased behavioral problems in the domain of social communication and interaction one year later. Implications: Our findings indicate that relations between early language impairment and other behavioral phenotypes may be more feasible to detect in a subgroup of children with a homogeneous etiology, than in a group of children with a heterogeneous etiology (such as children with DLD). Our results in 22q11DS reveal that receptive language is especially important in predicting the occurrence of ASD-related behaviors. Future research is needed to determine to what extent receptive language predicts the occurrence of ASD-related behaviors in children with DLD, especially among those children with DLD with the weakest receptive language. Clinically, screening for ASD-related behaviors in children with developmental language difficulties is recommended from a young age, especially among children with receptive language difficulties.

5.
J Neurodev Disord ; 15(1): 15, 2023 05 13.
Article in English | MEDLINE | ID: mdl-37173621

ABSTRACT

BACKGROUND: Executive functioning (EF) is an umbrella term for various cognitive functions that play a role in monitoring and planning to effectuate goal-directed behavior. The 22q11.2 deletion syndrome (22q11DS), the most common microdeletion syndrome, is associated with a multitude of both somatic and cognitive symptoms, including EF impairments in school-age and adolescence. However, results vary across different EF domains and studies with preschool children are scarce. As EF is critically associated with later psychopathology and adaptive functioning, our first aim was to study EF in preschool children with 22q11DS. Our second aim was to explore the effect of a congenital heart defects (CHD) on EF abilities, as CHD are common in 22q11DS and have been implicated in EF impairment in individuals with CHD without a syndromic origin. METHODS: All children with 22q11DS (n = 44) and typically developing (TD) children (n = 81) were 3.0 to 6.5 years old and participated in a larger prospective study. We administered tasks measuring visual selective attention, visual working memory, and a task gauging broad EF abilities. The presence of CHD was determined by a pediatric cardiologist based on medical records. RESULTS: Analyses showed that children with 22q11DS were outperformed by TD peers on the selective attention task and the working memory task. As many children were unable to complete the broad EF task, we did not run statistical analyses, but provide a qualitative description of the results. There were no differences in EF abilities between children with 22q11DS with and without CHDs. CONCLUSION: To our knowledge, this is the first study measuring EF in a relatively large sample of young children with 22q11DS. Our results show that EF impairments are already present in early childhood in children with 22q11DS. In line with previous studies with older children with 22q11DS, CHDs do not appear to have an effect on EF performance. These findings might have important implications for early intervention and support the improvement of prognostic accuracy.


Subject(s)
DiGeorge Syndrome , Adolescent , Humans , Child, Preschool , Child , DiGeorge Syndrome/complications , Prospective Studies , Executive Function , Cognition , Attention
6.
Schizophr Bull ; 49(Suppl_2): S86-S92, 2023 03 22.
Article in English | MEDLINE | ID: mdl-36946526

ABSTRACT

This workshop summary on natural language processing (NLP) markers for psychosis and other psychiatric disorders presents some of the clinical and research issues that NLP markers might address and some of the activities needed to move in that direction. We propose that the optimal development of NLP markers would occur in the context of research efforts to map out the underlying mechanisms of psychosis and other disorders. In this workshop, we identified some of the challenges to be addressed in developing and implementing NLP markers-based Clinical Decision Support Systems (CDSSs) in psychiatric practice, especially with respect to psychosis. Of note, a CDSS is meant to enhance decision-making by clinicians by providing additional relevant information primarily through software (although CDSSs are not without risks). In psychiatry, a field that relies on subjective clinical ratings that condense rich temporal behavioral information, the inclusion of computational quantitative NLP markers can plausibly lead to operationalized decision models in place of idiosyncratic ones, although ethical issues must always be paramount.


Subject(s)
Decision Support Systems, Clinical , Mental Disorders , Psychotic Disorders , Humans , Natural Language Processing , Linguistics , Psychotic Disorders/diagnosis
7.
Dev Sci ; 26(6): e13377, 2023 Nov.
Article in English | MEDLINE | ID: mdl-36851852

ABSTRACT

We present an exact replication of Experiment 2 from Kovács and Mehler's 2009 study, which showed that 7-month-old infants who are raised bilingually exhibit a cognitive advantage. In the experiment, a sound cue, following an AAB or ABB pattern, predicted the appearance of a visual stimulus on the screen. The stimulus appeared on one side of the screen for nine trials and then switched to the other side. In the original experiment, both mono- and bilingual infants anticipated where the visual stimulus would appear during pre-switch trials. However, during post-switch trials, only bilingual children anticipated that the stimulus would appear on the other side of the screen. The authors took this as evidence of a cognitive advantage. Using the exact same materials in combination with novel analysis techniques (Bayesian analyses, mixed effects modeling and cluster based permutation analyses), we assessed the robustness of these findings in four babylabs (N = 98). Our results did not replicate the original findings: although anticipatory looks increased slightly during post-switch trials for both groups, bilingual infants were not better switchers than monolingual infants. After the original experiment, we presented additional trials to examine whether infants associated sound patterns with cued locations, for which we did not find any evidence either. The results highlight the importance of multicenter replications and more fine-grained statistical analyses to better understand child development. HIGHLIGHTS: We carried out an exact replication across four baby labs of the high-impact study by Kovács and Mehler (2009). We did not replicate the findings of the original study, calling into question the robustness of the claim that bilingual infants have enhanced cognitive abilities. After the original experiment, we presented additional trials to examine whether infants correctly associated sound patterns with cued locations, for which we did not find any evidence. The use of novel analysis techniques (Bayesian analyses, mixed effects modeling and cluster based permutation analyses) allowed us to draw better-informed conclusions.

8.
Dev Sci ; 26(1): e13244, 2023 01.
Article in English | MEDLINE | ID: mdl-35172393

ABSTRACT

We conducted a close replication of the seminal work by Marcus and colleagues from 1999, which showed that after a brief auditory exposure phase, 7-month-old infants were able to learn and generalize a rule to novel syllables not previously present in the exposure phase. This work became the foundation for the theoretical framework by which we assume that infants are able to learn abstract representations and generalize linguistic rules. While some extensions on the original work have shown evidence of rule learning, the outcomes are mixed, and an exact replication of Marcus et al.'s study has thus far not been reported. A recent meta-analysis by Rabagliati and colleagues brings to light that the rule-learning effect depends on stimulus type (e.g., meaningfulness, speech vs. nonspeech) and is not as robust as often assumed. In light of the theoretical importance of the issue at stake, it is appropriate and necessary to assess the replicability and robustness of Marcus et al.'s findings. Here we have undertaken a replication across four labs with a large sample of 7-month-old infants (N = 96), using the same exposure patterns (ABA and ABB), methodology (Headturn Preference Paradigm), and original stimuli. As in the original study, we tested the hypothesis that infants are able to learn abstract "algebraic" rules and apply them to novel input. Our results did not replicate the original findings: infants showed no difference in looking time between test patterns consistent or inconsistent with the familiarization pattern they were exposed to.


Subject(s)
Learning , Speech , Infant , Humans
9.
Am J Speech Lang Pathol ; 32(1): 128-144, 2023 01 11.
Article in English | MEDLINE | ID: mdl-36512754

ABSTRACT

PURPOSE: Young children with 22q11.2 deletion syndrome (22q11DS) often have impaired language development and poor speech intelligibility. Here, we report a comprehensive overview of standardized language assessment in a relatively large sample of preschool-aged children with 22q11DS. We furthermore explored whether speech ability explained variability in language skills. METHOD: Forty-four monolingual Dutch preschoolers (3-6 years) with a confirmed genetic 22q11DS diagnosis participated in this prospective cohort study. Standardized tests (Clinical Evaluation of Language Fundamentals Preschool-2-NL and Peabody Picture Vocabulary Test-III-NL) were administered. Speech intelligibility was rated by two expert speech and language therapists using a standardized procedure. RESULTS: Most children had impaired language skills across all tested domains. The composite score for expressive language was significantly lower than that for receptive language, but the two were strongly correlated. Only small differences between the mean scores on the various subtests were observed, with the lowest scores for expressive morphosyntactic skills. Language scores showed a moderate positive relation with speech intelligibility, but language abilities varied greatly among the children with intelligible speech. CONCLUSIONS: We show that the majority of preschool children with 22q11DS have a broad range of language problems. Other than the relatively larger impairment in expressive than in receptive language skills, our results do not show a clearly delineated language profile. As many of the children with intelligible speech still had below-average language scores, we highlight that language problems require a broad assessment and care in all young children with 22q11DS. Future research using spontaneous language and detailed speech analysis is recommended, to provide more in-depth understanding of children's language profile and the relationship between speech and language in 22q11DS.


Subject(s)
Communication Disorders , DiGeorge Syndrome , Humans , Child, Preschool , Speech Intelligibility , Prospective Studies , Speech Disorders/diagnosis
10.
Int J Lang Commun Disord ; 58(3): 765-785, 2023 05.
Article in English | MEDLINE | ID: mdl-36478026

ABSTRACT

BACKGROUND: Early and effective treatment for children with developmental language disorder (DLD) is important. Although a growing body of research shows the effects of interventions at the group level, clinicians observe large individual differences in language growth, and differences in outcomes across language domains. A systematic understanding of how child characteristics contribute to changes in language skills is still lacking. AIMS: To assess changes in the language domains: expressive morphosyntax; receptive and expressive vocabulary; and comprehension, in children in special needs education for DLD. To explore if differences in language gains between children are related to child characteristics: language profile; severity of the disorder; being raised mono- or multilingually; and cognitive ability. METHODS & PROCEDURES: We extracted data from school records of 154 children (4-6 years old) in special needs education offering a language and communication-stimulating educational environment, including speech and language therapy. Changes in language were measured by comparing the scores on standardized language tests at the beginning and the end of a school year. Next, we related language change to language profile (receptive-expressive versus expressive-only disorders), severity (initial scores), growing up mono- and multilingually, and children's reported non-verbal IQ scores. OUTCOMES & RESULTS: Overall, the children showed significant improvements in expressive morphosyntax, expressive vocabulary and language comprehension. Baseline scores and gains were lowest for expressive morphosyntax. Differences in language gains between children with receptive-expressive disorders and expressive-only disorders were not significant. There was more improvement in children with lower initial scores. There were no differences between mono- and multilingual children, except for expressive vocabulary. There was no evidence of a relation between non-verbal IQ scores and language growth. CONCLUSIONS & IMPLICATIONS: Children with DLD in special needs education showed gains in language performance during one school year. There was, however, little change in morphosyntactic scores, which supports previous studies concluding that poor morphosyntax is a persistent characteristic of DLD. Our results indicate that it is important to include all children with DLD in intervention: children with receptive-expressive and expressive disorders; mono- and multilingual children, and children with high, average and low non-verbal IQ scores. We did not find negative relations between these child factors and changes in language skills. WHAT THIS PAPER ADDS: What is already known on the subject Intervention studies indicate that intervention can be effective, but not for all children with DLD, and not in all language domains. Longitudinal studies on language development show stable growth patterns in children with DLD at the group level. A systematic understanding of how child characteristics contribute to changes in language skills is still lacking. What this paper adds to existing knowledge In this study, we report on the language gains of a cohort of 154 children with DLD (4-6 years old), in a special education setting for children with language disorders. Our sample includes children with receptive-expressive disorders and expressive-only disorders, and monolingual as well as multilingual children. Our results show that children's language skills improved. The co-normed tests we used revealed that the children had much lower growth in morphosyntax than in the other language domains. Language gains between children with receptive-expressive and expressive-only language disorders did not differ, children with lower initial test scores showed more improvement than children with higher initial scores, multilingual children showed more gains in expressive vocabulary than monolingual children, and there was no effect of non-verbal IQ on change in language scores. What are the potential or actual clinical implications of this work? The results suggest that catching up on language is possible for children with DLD. It is important to include all children with DLD in intervention: mono- and multilingual children; children with receptive-expressive and expressive disorders; and children with high, average and low non-verbal IQ scores. We did not find negative relations between these child factors and changes in language skills. The limited growth in morphosyntax compared with other linguistic areas warrants the attention of both practitioners and researchers, with a particular focus on the implementation of research findings in clinical practice.


Subject(s)
Intellectual Disability , Language Development Disorders , Multilingualism , Humans , Child , Child, Preschool , Language Development , Speech Therapy/methods , Cognition , Language Tests , Language Development Disorders/diagnosis , Language Development Disorders/therapy , Language Development Disorders/psychology
11.
J Speech Lang Hear Res ; 65(11): 4250-4267, 2022 11 17.
Article in English | MEDLINE | ID: mdl-36327540

ABSTRACT

PURPOSE: Children with a developmental language disorder (DLD) are often delayed in their grammatical development. This is suggested to be the most important characteristic and clinical marker of DLD. However, it is unknown if this assumption is valid for young children, in the earliest stages of grammatical development. For this reason, this study investigates the complexity, diversity, and accuracy of the grammatical repertoires of 3- to 6-year-old Dutch children with DLD, in comparison to that of typically developing (TD) children matched on grammatical level. METHOD: Language samples of 59 children (29 children with DLD and 30 TD children) were analyzed using multiple measures of grammatical complexity, diversity, and accuracy. The TD children and children with DLD were language-matched on their grammatical development using the levels of the Dutch version of the Language Assessment, Remediation, and Screening Procedure, the Taal Analyse Remediëring en Screening Procedure (TARSP; Schlichting, 2017). Thus, the children with DLD were significantly older than the TD children (respectively DLD age range: 2;7-5;4 [years;months], M age = 4;1; and TD age range: 2;0-3;9, M age = 2;9). RESULTS: The results show that children with DLD are comparable to language-matched TD children in their grammatical accuracy and diversity, but that they produce less complex utterances. CONCLUSIONS: The results indicate that children with DLD lag behind in their grammatical complexity as compared to language-matched TD children. The results also suggest that grammatical TARSP level is not sufficiently informative for selecting treatment goals. Instead, the results underline the importance of conducting language sample analyses, with special reference to the complexity of the utterances of a child with DLD.


Subject(s)
Language Development Disorders , Child , Humans , Child, Preschool , Infant , Language Development Disorders/diagnosis , Linguistics , Language , Ethnicity , Language Tests
12.
J Psychopathol Clin Sci ; 131(2): 172-181, 2022 Feb.
Article in English | MEDLINE | ID: mdl-35230859

ABSTRACT

Schizophrenia-spectrum disorders (SSD) are highly heterogeneous in risk factors, symptom characteristics, and disease course outcome. Although speech anomalies have long been recognized as a core symptom of SSD, speech markers are an unexplored source of symptom heterogeneity that may be informative in recognizing relevant subtypes. This study investigated speech heterogeneity and its relation to clinical characteristics in a large sample of patients with SSD and healthy controls. Speech samples were obtained from 142 patients with SSD and 147 healthy controls by means of open-ended interviews. Speech was analyzed using standardized open-source acoustic speech software. Hierarchical clustering was conducted using acoustic speech markers. Symptom severity was rated with the Positive and Negative Syndrome Scale, and cognition was assessed with the Brief Assessment of Cognition for Schizophrenia. Three speech clusters could be distinguished in the patient group that differed regarding speech properties, independent of medication use. One cluster was characterized by mild speech disturbances, while two severely impaired clusters were recognized (fragmented speakers and prolonged pausers). Both clusters with severely impaired speech had more severe cognitive dysfunction than the mildly impaired speakers. Prolonged pausers specifically had difficulties with memory-related tasks. Prolonged pausing, as opposed to fragmented speaking, related to chronic active psychosis and refractory psychotic symptoms. Based on speech clustering, subtypes of patients emerged with distinct disease trajectories, symptomatology, and cognitive functioning. The identification of clinically relevant subgroups within SSD may help to characterize distinct profiles and benefit the tailoring of early intervention and improvement of long-term functional outcome. (PsycInfo Database Record (c) 2022 APA, all rights reserved).


Subject(s)
Cognition Disorders , Psychotic Disorders , Schizophrenia , Cognition , Cognition Disorders/diagnosis , Humans , Psychotic Disorders/diagnosis , Schizophrenia/diagnosis , Speech
13.
Front Psychol ; 12: 661785, 2021.
Article in English | MEDLINE | ID: mdl-34858245

ABSTRACT

The language abilities of young and adult learners range from memorizing specific items to finding statistical regularities between them (item-bound generalization) and generalizing rules to novel instances (category-based generalization). Both external factors, such as input variability, and internal factors, such as cognitive limitations, have been shown to drive these abilities. However, the exact dynamics between these factors and circumstances under which rule induction emerges remain largely underspecified. Here, we extend our information-theoretic model (Radulescu et al., 2019), based on Shannon's noisy-channel coding theory, which adds into the "formula" for rule induction the crucial dimension of time: the rate of encoding information by a time-sensitive mechanism. The goal of this study is to test the channel capacity-based hypothesis of our model: if the input entropy per second is higher than the maximum rate of information transmission (bits/second), which is determined by the channel capacity, the encoding method moves gradually from item-bound generalization to a more efficient category-based generalization, so as to avoid exceeding the channel capacity. We ran two artificial grammar experiments with adults, in which we sped up the bit rate of information transmission, crucially not by an arbitrary amount but by a factor calculated using the channel capacity formula on previous data. We found that increased bit rate of information transmission in a repetition-based XXY grammar drove the tendency of learners toward category-based generalization, as predicted by our model. Conversely, we found that increased bit rate of information transmission in complex non-adjacent dependency aXb grammar impeded the item-bound generalization of the specific a_b frames, and led to poorer learning, at least judging by our accuracy assessment method. This finding could show that, since increasing the bit rate of information precipitates a change from item-bound to category-based generalization, it impedes the item-bound generalization of the specific a_b frames, and that it facilitates category-based generalization both for the intervening Xs and possibly for a/b categories. Thus, sped up bit rate does not mean that an unrestrainedly increasing bit rate drives rule induction in any context, or grammar. Rather, it is the specific dynamics between the input entropy and the maximum rate of information transmission.

14.
Res Dev Disabil ; 119: 104109, 2021 Dec.
Article in English | MEDLINE | ID: mdl-34655956

ABSTRACT

BACKGROUND: The 22q11.2 Deletion Syndrome (22q11DS) is associated with language deficits and weak intellectual functioning. In other clinical groups, linguistic and cognitive difficulties have been associated with impaired acquisition of narrative abilities. However, little is known about the narrative abilities of children with 22q11DS. AIMS: To describe the ability of children with 22q11DS to produce and comprehend narrative macrostructure. Additionally, to examine the role of intellectual functioning in explaining their narrative difficulties. METHODS AND PROCEDURES: Narrative skills of 14 school-aged children with 22q11DS were compared to those of younger typically developing (TD) children matched on mental age and same-aged peers with Developmental Language Disorder (DLD). OUTCOMES AND RESULTS: Children with 22q11DS had significantly lower scores on narrative comprehension than younger TD children. No significant differences emerged on narrative production. Children with 22q11DS and children with DLD did not differ significantly on any of the narrative measures. CONCLUSIONS AND IMPLICATIONS: Narrative comprehension in children with 22q11DS seems more affected than production. Narrative comprehension difficulties cannot be entirely explained by a low level of intellectual functioning. Narrative comprehension and production abilities in 22q11DS require further consideration.


Subject(s)
Comprehension , DiGeorge Syndrome , Language Development Disorders , Child , DiGeorge Syndrome/complications , Humans , Intelligence , Linguistics , Narration
15.
Neuropsychologia ; 158: 107907, 2021 07 30.
Article in English | MEDLINE | ID: mdl-34058175

ABSTRACT

Language difficulties of children with Developmental Language Disorder (DLD) have been associated with multiple underlying factors and are still poorly understood. One way of investigating the mechanisms of DLD language problems is to compare language-related brain activation patterns of children with DLD to those of a population with similar language difficulties and a uniform etiology. Children with 22q11.2 deletion syndrome (22q11DS) constitute such a population. Here, we conducted an fMRI study, in which children (6-10yo) with DLD and 22q11DS listened to speech alternated with reversed speech. We compared language laterality and language-related brain activation levels with those of typically developing (TD) children who performed the same task. The data revealed no significant differences between groups in language lateralization, but task-related activation levels were lower in children with language impairment than in TD children in several nodes of the language network. We conclude that language impairment in children with DLD and in children with 22q11DS may involve (partially) overlapping cortical areas.


Subject(s)
DiGeorge Syndrome , Language Development Disorders , Brain/diagnostic imaging , Child , Child Language , DiGeorge Syndrome/complications , DiGeorge Syndrome/diagnostic imaging , Humans , Language Development Disorders/etiology , Speech
16.
J Exp Child Psychol ; 206: 105066, 2021 06.
Article in English | MEDLINE | ID: mdl-33571710

ABSTRACT

Deficiencies in discriminating and identifying speech sounds have been widely attested in individuals with dyslexia as well as in young children at family risk (FR) of dyslexia. A speech perception deficit has been hypothesized to be causally related to reading and spelling difficulties. So far, however, early speech perception of FR infants has not been assessed at different ages within a single experimental design. Furthermore, a combination of group- and individual-based analyses has not been made. In this cross-sectional study, vowel discrimination of 6-, 8-, and 10-month-old Dutch FR infants and their nonrisk (no-FR) peers was assessed. Infants (N = 196) were tested on a native English /aː/-/eː/ and non-native English /ɛ/-/æ/ contrast using a hybrid visual habituation paradigm. Frequentist analyses were used to interpret group differences. Bayesian hierarchical modeling was used to classify individuals as speech sound discriminators. FR and no-FR infants discriminated the native contrast at all ages. However, individual classification of the no-FR infants suggests improved discrimination with age, but not for the FR infants. No-FR infants discriminated the non-native contrast at 6 and 10 months, but not at 8 months. FR infants did not show evidence of discriminating the contrast at any of the ages, with 0% being classified as discriminators. The group- and individual-based data are complementary and together point toward speech perception differences between the groups. The findings also indicate that conducting individual analyses on hybrid visual habituation outcomes is possible. These outcomes form a fruitful avenue for gaining more understanding of development, group differences, and prospective relationships.


Subject(s)
Dyslexia , Speech Perception , Bayes Theorem , Child , Child, Preschool , Cross-Sectional Studies , Dyslexia/diagnosis , Humans , Infant , Phonetics , Prospective Studies
17.
Dyslexia ; 27(2): 168-186, 2021 May.
Article in English | MEDLINE | ID: mdl-33631835

ABSTRACT

Using an individual differences approach in children with and without dyslexia, this study investigated the hypothesized relationship between statistical learning ability and literacy (reading and spelling) skills. We examined the clinical relevance of statistical learning (serial reaction time and visual statistical learning tasks) by controlling for potential confounds at the participant level (e.g., non-verbal reasoning, attention and phonological skills including rapid automatized naming and phonological short-term memory). A 100 Dutch-speaking 8- to 11-year-old children with and without dyslexia participated (50 per group), see also van Witteloostuijn et al. (2019) for a study with the same participants. No evidence of a relationship between statistical learning and literacy skills is found above and beyond participant-level variables. Suggestions from the literature that the link between statistical learning and literacy attainment, and therefore its clinical relevance, might be small and strongly influenced by methodological differences between studies are not contradicted by our findings.


Subject(s)
Dyslexia/physiopathology , Individuality , Language Tests , Learning , Phonetics , Attention , Child , Female , Humans , Language , Literacy , Male , Memory, Short-Term , Netherlands , Reaction Time , Reading
18.
Front Psychol ; 11: 1832, 2020.
Article in English | MEDLINE | ID: mdl-32793084

ABSTRACT

Previous research has shown that bilingual children outperform monolinguals on tasks testing cognitive control. Bilinguals' enhanced cognitive control is thought to be caused by the necessity to exert more language control in bilingual compared to monolingual settings. Surprisingly, between-group research of cognitive effects of bilingualism is hardly ever combined with within-group research that investigates relationships between language control and cognitive control. The present study compared 27 monolingual Dutch and 27 bilingual Turkish-Dutch children matched on age and fluid intelligence on their performance in a nonverbal switching task. Within the group of bilinguals, the relationship between nonverbal switching and language switching was examined. The results revealed no between-group differences on nonverbal switching. Within the bilingual sample, response times in the language switching and nonverbal switching tasks were related, although no relationships were found between accuracy, switching cost and mixing cost on both tasks. The results support the hypothesis that children utilize domain-general cognitive control in language switching, but this relationship does not entail that bilinguals have better cognitive control than monolinguals.

19.
Top Cogn Sci ; 12(3): 843-858, 2020 07.
Article in English | MEDLINE | ID: mdl-32729673

ABSTRACT

Learning and processing natural language requires the ability to track syntactic relationships between words and phrases in a sentence, which are often separated by intervening material. These nonadjacent dependencies can be studied using artificial grammar learning paradigms and structured sequence processing tasks. These approaches have been used to demonstrate that human adults, infants and some nonhuman animals are able to detect and learn dependencies between nonadjacent elements within a sequence. However, learning nonadjacent dependencies appears to be more cognitively demanding than detecting dependencies between adjacent elements, and only occurs in certain circumstances. In this review, we discuss different types of nonadjacent dependencies in language and in artificial grammar learning experiments, and how these differences might impact learning. We summarize different types of perceptual cues that facilitate learning, by highlighting the relationship between dependent elements bringing them closer together either physically, attentionally, or perceptually. Finally, we review artificial grammar learning experiments in human adults, infants, and nonhuman animals, and discuss how similarities and differences observed across these groups can provide insights into how language is learned across development and how these language-related abilities might have evolved.


Subject(s)
Biological Evolution , Human Development , Language , Learning , Linguistics , Adult , Animals , Human Development/physiology , Humans , Infant , Learning/physiology
20.
Dev Neurorehabil ; 23(6): 402-406, 2020 Aug.
Article in English | MEDLINE | ID: mdl-32419557

ABSTRACT

The phenotype of triple X syndrome comprises a variety of physical, psychiatric, and cognitive features. Recent evidence suggests that patients are prone to severe language impairments. However, it remains unclear whether verbal impairments are pervasive at all levels of language, or whether one domain is relatively more spared than others. Here we document the language profile of one patient with triple X, using standardized language tests and reports. Results concur in showing that impairments are noticeable both in expressive and receptive language skills, and in vocabulary as well as in structural components of language. Although receptive ability in some tests appears relatively spared, even here A's performance is clearly below average. This single case study further underscores that language and communication at all levels can be severely compromised in patients with triple X. Practitioners should be aware of the limited language abilities that possibly exist in patients with triple X.


Subject(s)
Language Development Disorders/diagnosis , Language Tests/standards , Sex Chromosome Disorders of Sex Development/diagnosis , Trisomy/diagnosis , Child , Chromosomes, Human, X , Female , Humans , Language Development Disorders/etiology , Male , Sex Chromosome Aberrations , Sex Chromosome Disorders of Sex Development/complications , Vocabulary
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