[Lessons learnt from COVID-19: technology for organizing a forced self-isolation regime].

The lessons of COVID-19 have confirmed the effectiveness of measures aimed at strict self-isolation and quarantine. In the People's Republic of China, where any violation of the regime requirements was qualified as a criminal offense, the virus was neutralized when the pandemic was only gaining momentum in Europe and America. However, without proper organization of a restrictive regime, self-isolation can lead to negative consequences in terms of deterioration of health and standard of living. The pandemic has undoubtedly significantly complicated our lives, has taken millions of lives, caused disability, deterioration of material status, rupture of marital ties. One of the reasons for this development of events was the unsatisfactory organization of leisure during self-isolation. The inability to calmly wait out, endure COVID-associated adversities in most countries caused mass popular unrest, gave rise to panic moods. Only those who managed to curb the negative consequences and direct them in the right direction managed to come out of the pandemic with dignity. The authors have developed an organizational technology of the forced self-isolation regime based on the complex of measures and proposed this technology for introduction to daily life of the population during the period of restrictive regimes. The authors are sure that it is especially important to organize leisure and create the most comfortable conditions of the isolated living for the elderly, who are the most sensitive to changes in life stereotypes. The authors propose a set of measures to efficiently organize leisure during self-isolation with physical therapy, cognitive training, as well as measures to fit the body and develop psychological relief, making it possible to reverse the threat of the pandemic in higher health potential and better family relations.

[Cognitive impairment and tactics of using the drug Cerebrolysin. Resolution of the International Council of Experts (May 12, 2023)]. / Kognitivnye narusheniya i taktika primeneniya preparata Tserebrolizin. Rezolyutsiya mezhdunarodnogo soveta ekspertov (12 maya 2023 g.).

The aging of the population and the associated increase in the share of cognitive impairments in the structure of a wide range of diseases are a serious challenge for modern healthcare. Difficulties in the treatment of cognitive disorders are determined by many factors, including the age of patients, comorbidity, forced polypragmasia and the adequacy of the dosage of drugs that restore cognitive activity. The experts discussed information about the therapeutic potential of the drug Cerebrolysin in the treatment of cognitive disorders of various origins, stated significant experience of its effective and safe use in many clinical studies in mild and moderate forms of dementia. At the same time, there was a lack of consistent and systematic data on the dosage regimen, frequency, and duration of use of the drug in different forms of cognitive impairment and the degree of their severity. The aim of the international council of experts was to determine the optimal dosage regimens of the drug Cerebrolysin in patients with various etiologies and severity of cognitive impairment. The result of the work was the approval of a unified scheme for the use of the drug Cerebrolysin, considering the severity of the disease and its duration.

[The cognitive status and aspects of life quality of the Russian researchers].

The publications analysis confirms necessity of studying both status of cognitive capacities of researchers and factors associated with cognitive aging. THE PURPOSE OF THE STUDY: To assess cognitive functions and quality of life of researchers of state institutions. MATERIALS AND METHODS: The single-stage section of state institutions was applied to arrange sampling of 53 researchers (28 females and 25 males) aged from 22 to 73 years. The respondents filled questionnaires "Cognitive screening", "Age is not a drawback", "Depression Geriatric Scale", "Russian validated version of QOL questionnaire SF-36". RESULTS: As in general population, among researchers certain decrease in quality of life with age was established. The respondents aged from 50 to 59 years demonstrated lower indices on scales of physical functioning (p = 0.04), body pain (p = 0.03) and role functioning due to physical condition (p = 0.006). At that, indices of vital activity and social functioning tended to improvement with age. The cognitive impairments were absent in 96.23% of researchers aged from 22 to 73 years and they were present in 1.89% of respondents. In 47.17% of respondents aged from 22 to 67 years, no senile asthenia syndrome was observed. The preasthenia was registered in 39.62% of respondents aged from 24 to 69 years. The syndrome of senile asthenia was established in 11.32% of respondents aged 25-73 years. The depression was absent in 83.02% of respondents aged from 22 to 69 years and it was probably present in 7.55% of respondents aged from 25 to 33 and 49 years. CONCLUSION: According to data of complex screening self-testing, it is established that current state of researchers is characterized by availability of complex of problems related to health disorders, decreased cognitive functions, development of premature aging syndrome and presence of significant number of risk factors of health disorders due to high frequency and combination of these factors. The relationship between cognitive functions and quality of life of researchers is established, in particular, according to scales "Physical functioning", "General health", "Vitality", "Social functioning", "Mental health".

[The medical social technology of health preservation of elderly population in conditions of self-isolation].

In Moscow (as of January 1, 2020), the number of population made up to 12,678,079, and out of them the elderly population made up to 2.8 million. Up to the end of 2020, the number of the elderly will reach 3.3 million requiring implementation of corresponding preventive measures due to mass prevalence of coronavirus infection. The COVID-19 pandemic demonstrated that despite restructuring of functioning of industry, social security and health care, quarantine and self-isolation occurred to be exactly the effective measures. The self-isolation regimen also revealed aggravation of harmful effects of stress factors, hypodynamia, hypooxygenation and decreasing of immunological resistance. It is especially important to organize leisure activities and to create the most comfortable conditions for isolated living of the elderly as most susceptible to infection. The experience demonstrated that properly chosen set of activities during self-isolation regimen both disciplines and permits to apply surplus of free time to intensify health potential and to consolidate family relationships.

[TREATMENT STRATEGY FOR PATIENTS OF OLDER AGE GROUPS IN VIEW OF AGE POLYMORBIDITY].

The probability of side effects and complications of drug therapy of patients of older age increases several times. Therefore, during the working out the standards of care for diseases associated with old age, the geriatric expertise of medicine is important. Russian Association of Gerontology and Geriatrics developed a methodology determining the prognostic impact of the aggregate of drugs and other medical factors to the body of an old person. An expert committee to prepare a draft of geriatric standards was set up.

Analysis of anabolic steroids in body fluids by capillary gas chromatography with a two-channel detection system and a computer.

A method is described for analysis of multi-component mixtures of steroid metabolites in biological fluids by means of capillary gas chromatography with glass and fused-silica columns and simultaneous detection of methoxylamine-trimethylsilyl derivatives with universal flame-ionization and selective nitrogen alkali flameionization detectors. A data system was applied to the on-line treatment of the results. Computer programs were designed for precise calculation of Kováts retention indices from the known values for selected natural urinary steroids. The programs allow the selection of nitrogen-containing components, normalized chromatogram plotting for both detection channels and qualitative and quantitative analysis. Results are presented on the detection of metabolites of methandrostenolone, 17 alpha-methyltestosterone, 19-nortestosterone and fluoxymesterone.