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Short-term safety assessment in the use of intravenous zoledronic acid in children.

Högler, Wolfgang; Yap, Fabian; Little, David; Ambler, Geoffrey; McQuade, Mary; Cowell, Christopher T.

J Pediatr ; 145(5): 701-4, 2004 Nov.

Article in English | MEDLINE | ID: mdl-15520785

ABSTRACT

The clinical side effects of the potent new bisphosphonate zoledronic acid in children are unknown. In this study of 34 children with various bone disorders, the frequency of postinfusion flu-like illness, hypocalcemia, and hypophosphatemia was 85%, 74%, and 82%, respectively. No renal side effects were detected after up to 3 consecutive infusions.

Subject(s)

Bone Resorption/metabolism , Diphosphonates/adverse effects , Imidazoles/adverse effects , Adolescent , Bone Resorption/prevention & control , Calcium/blood , Child , Child, Preschool , Creatinine/blood , Diphosphonates/administration & dosage , Female , Fever/chemically induced , Follow-Up Studies , Humans , Imidazoles/administration & dosage , Infusions, Intravenous , Male , Nausea/chemically induced , Pain/chemically induced , Phosphorus/blood , Retrospective Studies , Time Factors , Urea/blood , Vomiting/chemically induced , Zoledronic Acid

ABSTRACT

Subject(s)

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