ABSTRACT
The sinoatrial block is a new side effect of meglumine antimoniate. Prompt interruption of the drug results in the normalization of electrographic changes and prevents sudden cardiac arrest.
ABSTRACT
Verrucous carcinoma (VC) of the nail bed is a rare variant of squamous cell carcinoma that is often misdiagnosed as a benign condition. The clinical presentation of this tumor is very similar to that of warts or onychomycosis hence the delayed appropriate treatment. Its association with human papillomavirus (HPV) infection has rarely been reported. The treatment of VC of the nail unit depends on the extent of the lesion and the presence or the absence of bone. We here report an unusual case of VC of the nail bed of the left big toe in a man associated with HPV53 infection that had been mistaken for a wart for 1 year. The condition was treated by ray amputation.
Subject(s)
Condylomata Acuminata/complications , Human papillomavirus 6/isolation & purification , Penile Neoplasms/etiology , Urethral Diseases/complications , Adult , Condylomata Acuminata/pathology , Condylomata Acuminata/virology , Humans , Male , Penile Neoplasms/pathology , Urethral Diseases/pathology , Urethral Diseases/virologyABSTRACT
Onychomatricoma (OM) is a rare benign tumour of the nail matrix characterized by specific clinical and histologic features. The main clinical signs are thickening of the nail plate, xanthonychia, overcurvature of the nail plate, and multiple splinter haemorrhages. The diagnosis is based on clinical, radiological and histopathological findings. Histologically, the tumour is characterized by filiform epithelial projections. The objective of this study is to present the first reported Tunisian case of OM, focusing on the contribution of magnetic resonance imaging to the diagnosis of OM. A review on the subject is also presented.
ABSTRACT
BACKGROUND: Psoriasis may be considered as falling within the category of psychosomatic disorders. The aim of this study was to investigate the temperament profile in psoriasis patients in Tunisia. METHOD: We performed a prospective and comparative study investigating affective temperament in Tunisian psoriasis patients. Sixty five psoriasis patients and 67 age and sex matched healthy controls were enrolled, aged from 18 to 60 years. The diagnosis was made clinically; if necessary, lesional biopsy was obtained for histopathological examination. Temperament Evaluation of Memphis, Paris and San Diego Auto-questionnaire (TEMPS-A) in its 110-items version was used. Both statistical and descriptive analyses were performed. RESULTS: We found significant gender differences, with women scoring higher in depressive and anxious temperaments. There was no significant difference between temperament scores in psoriasis patients and healthy controls. Irritable temperament scores tend to decrease with disease duration. Stressful event was more frequently associated with anxious and depressive temperaments in women. LIMITATION: This survey has a single-time cross-sectional design. CONCLUSIONS: This study broadens our understanding of the relationship between temperament and psoriasis. Some aggravating factors of the disease seem to be associated with particular temperament traits. Understanding the temperaments would be essential in establishing a cooperative relationship between patients and doctors during the management of this chronic skin disorder.
Subject(s)
Psoriasis/psychology , Temperament , Adolescent , Adult , Affect , Case-Control Studies , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Prospective Studies , Surveys and Questionnaires , Tunisia , Young AdultSubject(s)
Carcinoma, Basal Cell/diagnosis , Carcinoma, Hepatocellular/diagnosis , Facial Neoplasms/diagnosis , Liver Neoplasms/diagnosis , Melanoma/diagnosis , Neoplasms, Multiple Primary/diagnosis , Skin Neoplasms/diagnosis , Aged , Amputation, Surgical , Carcinoma, Basal Cell/surgery , Carcinoma, Hepatocellular/therapy , Embolization, Therapeutic , Facial Neoplasms/surgery , Fingers/pathology , Fingers/surgery , Humans , Liver Neoplasms/surgery , Male , Melanoma/surgery , Nail Diseases/pathology , Nail Diseases/surgery , Neoplasms, Multiple Primary/surgery , Skin Neoplasms/surgeryABSTRACT
Necrobiosis lipoidica is an idiopathic dermatological condition that is strongly associated with diabetes mellitus. It is more commonly seen in women than men. The average age of onset is 30-40 years. Necrobiosis Lipoidica diabeticorum is an extremely rare finding in childhood diabetes. We describe the case of a 13-year-old girl who has had type 1 diabetes mellitus since she was 8 years old. The patient presented with 2 well-defined, persistent plaques with a depressed central area and elevated purple peripheral ring, one on the right thigh and the other over the lateral left leg. Histopathologic evaluation of the patient's biopsy confirmed the diagnosis of necrobiosis lipoidica with transfollicular elimination. Our patient is the second pediatric case described with perforating necrobiosis lipoidica. We review the literature and discuss clinical features, several complications, and the most recent treatment options for necrobiosis lipoidica in diabetic children.
Subject(s)
Diabetes Mellitus, Type 1/complications , Necrobiosis Lipoidica/etiology , Necrobiosis Lipoidica/pathology , Adolescent , Biopsy, Needle , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 1/drug therapy , Drug Therapy, Combination , Female , Follow-Up Studies , Humans , Immunohistochemistry , Insulin/therapeutic use , Lower Extremity , Necrobiosis Lipoidica/drug therapy , Risk Assessment , Severity of Illness IndexABSTRACT
Buschke-Löwenstein tumor (BLT), or giant condyloma acuminatum, is a rare sexually transmitted disease. The virus responsible for condyloma is human papillomavirus, usually serotype 6 or 11. A BLT is always preceded by condyloma acuminatum and may occur at any age after puberty. It is characterized by invasive growth and recurrence after treatment, and malignant transformation is possible. We report the case of a 44-year-old male patient with a 2-year history of a penoscrotal Buschke-Löwenstein tumor.
Subject(s)
Condylomata Acuminata/pathology , Genital Neoplasms, Male/pathology , Skin Neoplasms/pathology , Adult , Humans , MaleABSTRACT
INTRODUCTION: A confidential, free and specialised consultation of sexually transmitted diseases (STD) was initiated since 1993 in the department of Dermatology of hospital Charles Nicolle. We present the epidemiological and clinical features of this consultation. PATIENTS AND METHODS: It is a retrospective study including patients consulting during a period of 7 years (1993-1999). 546 patients were included. The mean age of our patients was 29 years and the sex-ratio 9. The diagnosis of urethritis was done for 242 patients. This diagnosis was clinic in the most cases. Urethral swabs was done for 71 patients. Neisseria gonorrhoeae was isolated in 56 cases and Chlamydia trachomatis in 15 cases. 41 patients were directed to our consultation for a positive syphilis serology. Condyloma were diagnosed in 23 cases and scabies in 12 cases. HIV serology was positive in 10 cases. In 3 cases, the diagnosis of HIV infection was done in this consultation. DISCUSSION: The epidemiologic profile showed a frequency of young men, bachelors and having multiple sexual partners. Clinically, urethritis was the principal STD observed.
