Tunable High-Sensitivity Four-Frequency Refractive Index Sensor Based on Graphene Metamaterial.

As graphene-related technology advances, the benefits of graphene metamaterials become more apparent. In this study, a surface-isolated exciton-based absorber is built by running relevant simulations on graphene, which can achieve more than 98% perfect absorption at multiple frequencies in the MWIR (MediumWavelength Infra-Red (MWIR) band as compared to the typical absorber. The absorber consists of three layers: the bottom layer is gold, the middle layer is dielectric, and the top layer is patterned with graphene. Tunability was achieved by electrically altering graphene's Fermi energy, hence the position of the absorption peak. The influence of graphene's relaxation time on the sensor is discussed. Due to the symmetry of its structure, different angles of light source incidence have little effect on the absorption rate, leading to polarization insensitivity, especially for TE waves, and this absorber has polarization insensitivity at ultra-wide-angle degrees. The sensor is characterized by its tunability, polarisation insensitivity, and high sensitivity, with a sensitivity of up to 21.60 THz/refractive index unit (RIU). This paper demonstrates the feasibility of the multi-frequency sensor and provides a theoretical basis for the realization of the multi-frequency sensor. This makes it possible to apply it to high-sensitivity sensors.

Highly homogeneous and stable single-walled carbon nanotubes dispersion modified by polyvinylpyrrolidone and alkanolamine in water.

A novel noncovalent surface modification of commercial single-walled carbon nanotubes (SWCNTs) was successfully carried out by using ball grinding technology between SWCNTs and mixed dispersants (polyvinylpyrrolidone (PVP) and alkanolamine), affording a highly homogeneous and stable PA-SWCNTs dispersion in water. The homogeneous dispersibility and long storage stability were systematically investigated by transmittance spectroscopy, absorption spectroscopy, zeta potential analyzer, sedimentation photo and transmittance electron microscopy. Under the optimized conditions, the PA-SWCNTs dispersion modified with 0.7 wt% PVP and 0.25 wt% alkanolamine under the condition of total 6 h ball grinding time using paint shaker can be easily well-dispersed in water and has good storage stability, and no sedimentation is observed more than one month. From an industrial perspective, this method is green and easy to operate in industry.

Mesencephalic astrocyte-derived neurotrophic factor ameliorates inflammatory response in polycystic ovary syndrome via inhibiting TLR4-NF-κB-NLRP3 pathway.

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder in women of reproductive age, which often leads to female infertility. Chronic inflammation is a significant factor in the development of PCOS. Our study aimed to explore the impact of mesencephalic astrocyte-derived neurotrophic factor (MANF), a scientifically validated anti-inflammatory factor, on 99 diagnosed PCOS patients. We also investigated its effects on PCOS mice induced with dehydroepiandrosterone (DHEA) and KGN cells induced with dihydrotestosterone (DHT). Our findings revealed a decrease in serum MANF levels in PCOS patients, which were negatively associated with serum tumor necrosis factor-α (TNF-α) and interleukin-1ß (IL-1ß) levels. The administration of recombinant human MANF (rhMANF) in PCOS mice demonstrated a decrease in pro-inflammatory cytokines and monocytes/macrophages in both peripheral blood and ovarian tissues. Furthermore, the inclusion of rhMANF notably ameliorated DHEA-induced ovarian dysfunction and fibrosis by negatively regulating the toll-like receptor 4 (TLR4)-nuclear factor kappa B (NF-κB)-NLR family, pyrin domain containing protein 3 (NLRP3) pathway. Additionally, in vitro experiments showed that the up-regulation of MANF offset DHT-induced inhibition of viability and apoptosis in KGN cells. Collectively, this study highlights the anti-inflammatory properties of MANF in PCOS and suggests its potential as a therapeutic approach for the management of PCOS.

Insights into enhanced immobilization of uranyl carbonate from seawater by Fe-doped MXene.

Extracting uranium from seawater not only reduces radioactive contamination in seawater but also provides a source of uranium energy. However, due to the low concentration of uranium in seawater and the high salinity of seawater, extraction of uranium from seawater is challenging. In this work, we demonstrated a simple strategy to synthesize Fe-doped MXene (Fe@Ti3C2Tx) via a hydrothermal method and applied for uranium enrichment in seawater. The Fe@Ti3C2Tx exhibited excellent adsorption performance in high salinity environments. The removal capacity of Fe@Ti3C2Tx was determined to be 526.6 mg/g for UO2(CO3)22- at 328 K with quick reaction equilibrium (∼ 30 min). Kinetic and thermodynamic analyses of UO2(CO3)22- elimination process on Fe@Ti3C2Tx surface revealed it to be a spontaneous and endothermic single-phase elimination process. FT-IR and XPS analyses further indicated that the removal mechanism of UO2(CO3)22- by Fe@Ti3C2Tx was surface complexation. Our study suggests that Fe@Ti3C2Tx can provide a feasible solution for uranium enrichment in seawater.

Rational design of MOF@COF composites with multi-site functional groups for enhanced elimination of U(VI) from aqueous solution.

Both environment and human beings were menaced by the widespread application of radioactive uranium, high-performance and effective elimination of uranium from wastewater is of important meaning for development of environmental sustainability in the future. In this study, the water-stable MOF material and the highly crystalline COF were compounded by a mild hydrothermal strategy, which achieved efficient removal of U(VI) through the synergistic effect. The composites showed the characteristics of both COFs and MOFs, which will possess higher stability, larger surface area and faster adsorption efficiency that cannot be carried out by a single component. Batch experiments and characterizations (SEM, TEM, XRD, FT-IR, BET, XPS, etc.) indicated that UiO-66-NH2@LZU1 had more stable and multi-layer pore structure and rich active functional groups. The Langmuir model and the pseudo-second-order kinetics fitting was more suitable for the U(VI) elimination process. The greatest uranium adsorbing capacity of UiO-66-NH2@LZU1 (180.4 mg g-1) was observed to exceed the UiO-66-NH2 (108.8 mg g-1) and COF-LZU1 (65.8 mg g-1), which reached the excellent hybrid effects. Furthermore, FT-IR and XPS analyses confirmed that the most nitrogen-containing group from COF-LZU1 and oxygen-containing group of UiO-66-NH2 could be combined with U(VI). In addition, electrostatic interaction was also a mechanism during the removal process. This work displayed that UiO-66-NH2@LZU1 was a prospective hybrid material for radioactive waste remediation. The compound method and application mentioned in this work had provided a theoretical basis for designing and developing multi-functional composite adsorbents, which contributed to the development of new materials for radioactive wastewater treatment technologies.

Two-Dimensional Microstructure-Based Model for Evaluating the Permeability Coefficient of Heterogeneous Construction Materials.

The permeability coefficient of construction materials plays a crucial role in engineering quality and durability. In this study, a microstructure model based on real aggregate shape and digital image technology is proposed to predict the permeability coefficient of concrete. A two-dimensional, three-component finite element model of cement concrete was established considering the interfacial transition zone (ITZ) between aggregate and mortar. The permeability coefficient prediction model was developed by the finite element method. The accuracy of the model was verified by experimental data, and the influence of the water-cement ratio on the permeability coefficient of concrete was analyzed. The results show that this method has good prediction accuracy with a relative error of 1.73%. According to the verified model, the influences of aggregate content, aggregate characteristics, aggregate location, ITZ thickness, and other factors on the permeability of concrete were explored. The higher the water-cement ratio, the higher the permeability coefficient. With the increase in aggregate content, the permeability coefficient decreases. Aggregate permeability has a significant influence on the effective permeability coefficient of concrete within a certain range. The greater the roundness of aggregate, the greater the permeability of concrete. On the contrary, the larger aggregate size causes lower permeability. The permeability coefficient of concrete with segregation is lower than that with uniform distribution. At the same time, the permeability increases with the increase of ITZ thickness.

Efficient decontamination of organic pollutants from wastewater by covalent organic framework-based materials.

Covalent organic frameworks (COFs), assembling through covalent bonds, are a rising class of porous materials. Nowadays, various COFs are widely applied in organic pollutants decontamination due to the outstanding capabilities of large surface area, multiple functional groups, porous structure, excellent absorptivity, flexible design and so on. This review concentrates on the applications of COFs in different decontamination technologies such as solid-phase extraction, membrane filtration and sieving, adsorption, and catalysis reaction. The factors influencing water chemistry, such as pH, temperature, salt concentration and natural organic matter, are summarized in terms of their impact on decontamination performance and the extraction mechanisms for the diverse analytes. The interaction mechanisms between COFs and organic pollutants were hydrogen bonding, π-π stacking, hydrophilic, hydrophobic, and electrostatic interactions. Furthermore, a perspective on current obstacles and upcoming developments of COFs for organic pollutant removal has been provided. Due to their adaptable and versatile design as well as elaborate and diverse functionalization, COFs possess significant possibility in ameliorating environmental pollution.

Influence of humic acid on U(VI) elimination by ZIF-8: Synergistic chemical effect.

ZIF-8, a sort of zeolitic imidazolate frameworks (ZIFs), had showed superior adsorptive property of typical radionuclide U(VI), but it reminded uncertain how the performance of ZIF-8 would be affected by adding humic acid (HA). HA could significantly change the surface charge of ZIFs and the transport of U(VI) in natural settings, which affected the eradication of U(VI) in aquatic ecology. Thus the impact of HA for the U(VI) removal by ZIF-8 as well as its mechanism had been analyzed by batch experiments and spectral analyses. It was demonstrated that the addition of HA increased the maximum removal capacity towards U(VI) from 781.2 mg g-1 to 1398.5 mg g-1. Moreover, removal property in acidic solution was improved, and the influence of background ions on ZIF-8 was reduced. The detailed mechanism was further explored by microscopic spectral analysis. The zeta potential showed that HA enhanced the electronegativity of ZIF-8 thus enhancing the electrostatic interaction with positive ions. Moreover, FT-IR and XPS further indicated that HA enhanced the removal capacity by affecting the surface complexation phenomena and strong chemical interactions between U(VI) and ZIF-8. Also, investigations indicated that the incorporation of HA improved the removal efficiency for U(VI), which had far-reaching significance for the application of ZIF-8 in practical environment.

A nomogram based on metabolic profiling to discriminate lung cancer among patients with lung nodules.

OBJECTIVE: To develop a nomogram that discriminates lung cancer from benign lung nodules through metabolic profiling. METHODS: This was a retrospective cohort study that recruited 848 participants who were randomized into training and validation sets at a 7:3 ratio. Clinical characteristics and metabolic profiles were retrieved. Variables in the training set with statistically significant differences were selected for further least absolute shrinkage and selection operator (LASSO) regression. The nomogram was built from 13 variables identified by stepwise regression analysis. Receiver operating characteristic, calibration curve, and decision curve analyses were conducted to evaluate the performance of the nomogram by internal validation. RESULTS: Thirteen variables were selected through LASSO regression to build the nomogram: age, sex, ornithine, tyrosine, glutamine, valine, serine, asparagine, arginine, methylmalonylcarnitine, tetradecenoylcarnitine, 3-hydroxyisovaleryl carnitine/2-methyl-3-hydroxybutyrylcarnitine, and hydroxybutyrylcarnitine. The nomogram had good discrimination for the training set, with an area under the curve of 0.836 (95% confidence interval: 0.830-0.890). Moreover, the calibration curve with 1000 bootstrap resamples showed that the predicted value coincided well with the actual value. Decision curve analysis described a net benefit superior to baseline within the threshold probability range of 15% to 93%. CONCLUSIONS: The nomogram constructed from metabolic profiling accurately predicted risk of lung cancer.

Low temperature plasma protects against inflammatory agents-mediated dysfunction of theca cells via enhancing MANF expression.

BACKGROUND: Low temperature plasma (LTP) exerts a protective effect in inflammation via enhancing MANF expression. Hyperactivation and dysfunction of theca cells induced by inflammatory agents is accompanied by polycystic ovary syndrome (PCOS), which is a common reproductive and endocrine disorder. However, the effect of LTP on theca cells is still unknown. METHODS AND RESULTS: Theca cells were stimulated with IL-1ß or TNF-α for 12 h, then treated with LTP for 100 s. After 8 h, medium supernatant and theca cells were collected. Production of androgen from theca cells were detected by ELISA. The PCNA and Annexin V levels in theca cells were detected by using immunofluorescent staining. The levels of PCNA, BCL-2 and BAX were evaluated by western blot and qPCR. MTT assay was used to detect the viability of theca cells. The proportions of apoptosis of theca cells were detected by Flow cytometry. The mRNA levels of androgenic genes were detected by qPCR. The MANF levels in medium supernatant and cell lysate were detected by using ELISA, western and qPCR. BIP and CHOP expressions were detected by using western blot and qPCR. We found that LTP irradiation decreased inflammatory agents-induced upregulation of androgen and androgenic genes in theca cells. And LTP irradiation relieves IL-1ß or TNF-α-induced pathological proliferation and apoptosis in theca cells. In terms of mechanism, LTP irradiation increased MANF level in theca cells to inhibit BIP and CHOP expression. CONCLUSION: These evidences suggest the protective effect of LTP on theca cells in inflammatory microenvironment, and LTP has the potential clinical application of PCOS.

Highly efficient extraction of uranium from seawater by polyamide and amidoxime co-functionalized MXene.

Uranium mainly exists in the form of uranyl carbonate in seawater. [UO2(CO3)3]4- has strong stability, which increases the difficulty of uranium extraction from seawater. Meanwhile, the complex marine environment, a large number of coexisting competing ions and biological pollution are all non-negligible disturbing factors. Herein, we introduced amidoxime (AO) groups into the surface of Ti3C2 and grafted polyamides (PA) by a simple one-step hydrothermal method to produce an efficient seawater uranium extraction adsorbent Ti3C2-AO-PA. Owing to the amidoxime groups, the material was highly selective for uranium. And the large number of amino groups in the polyamides gave it ideal resistance to biofouling. The possibility of Ti3C2-AO-PA as an adsorbent for uranium extraction from seawater was confirmed by various characterization techniques, numerous adsorption batch experiments, simulated seawater experiments and antibacterial performance tests. It was demonstrated that the uptake of [UO2(CO3)3]4- by Ti3C2-AO-PA showed fast reaction kinetics (about 120 min), brilliant absorption capacity (81.1 mg·g-1 at pH 8.3), significant high selectivity (32.8 mg-U/g-Ads) and outstanding anti-biological contamination performance (92.9% antibacterial rate). XPS and DFT further indicated that the high extraction ability of Ti3C2-AO-PA for uranium was mainly attributed to the strong complexation of AO and -NH2 with [UO2(CO3)3]4-. These conclusions showed that Ti3C2-AO-PA not only had an ideal application prospect for uranium extraction from seawater, but also provided an available strategy for rapid and selective uranium adsorption from real seawater.

Crotonylation versus acetylation in petunia corollas with reduced acetyl-CoA due to PaACL silencing.

Protein acetylation and crotonylation are important posttranslational modifications of lysine. In animal cells, the correlation of acetylation and crotonylation has been well characterized and the lysines of some proteins are acetylated or crotonylated depending on the relative concentrations of acetyl-CoA and crotonyl-CoA. However, in plants, the correlation of acetylation and crotonylation and the effects of the relative intracellular concentrations of crotonyl-CoA and acetyl-CoA on protein crotonylation and acetylation are not well known. In our previous study, PaACL silencing changed the content of acetyl-CoA in petunia (Petunia hybrida) corollas, and the effect of PaACL silencing on the global acetylation proteome in petunia was analyzed. In the present study, we found that PaACL silencing did not significantly alter the content of crotonyl-CoA. We performed a global crotonylation proteome analysis of the corollas of PaACL-silenced and control petunia plants; we found that protein crotonylation was closely related to protein acetylation and that proteins with more crotonylation sites often had more acetylation sites. Crotonylated proteins and acetylated proteins were enriched in many common Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. However, PaACL silencing resulted in different KEGG pathway enrichments of proteins with different levels of crotonylation sites and acetylation sites. PaACLB1-B2 silencing did not led to changes in the opposite direction in crotonylation and acetylation levels at the same lysine site in cytoplasmic proteins, which indicated that cytoplasmic lysine acetylation and crotonylation might not depend on the relative concentrations of acetyl-CoA and crotonyl-CoA. Moreover, the global crotonylome and acetylome were weakly positively correlated in the corollas of PaACL-silenced and control plants.

Risk factors for contralateral hip refractures in patients aged over 80 years with intertrochanteric femoral fractures.

Purpose: The purpose of this study was to identify which of the risk factors would contribute to the contralateral fracture in very elderly patients after intramedullary nail fixation. Methods: Clinical data of 227 intertrochanteric fracture patients aged 80 years or older were retrospectively reviewed. Intramedullary nails (IMNs) were used on all of the patients. Potential risk factors for contralateral hip refractures were determined using univariate and logistic regression analyses. Results: Contralateral hip refractures occurred in 11 patients (4.84%). Univariate analysis revealed that age, gender, body mass index, fracture classification, hematocrit, D-dimer, and CRP level were not associated with contralateral fractures (P > 0.05). However, neurological diseases, cardiovascular disease, and visual impairments were significantly associated with contralateral fractures (P < 0.05). Multivariate analysis further revealed that neurological diseases (OR 4.25, P = 0.044) and visual impairments (OR 5.42, P = 0.015) were independent risk factors associated with contralateral refractures. Conclusion: To prevent contralateral refractures, more attention should be paid to elderly intertrochanteric fracture patients with underlying neurological disease and visual impairments.

Cold Plasma Irradiation Attenuates Atopic Dermatitis via Enhancing HIF-1α-Induced MANF Transcription Expression.

Cold atmospheric plasma has been widely applied in medical treatment clinically, especially skin diseases. However, the mechanism of cold atmospheric plasma on the treatment of skin diseases is still undefined. In this study, dinitrofluorobenzene-induced atopic dermatitis mice model was constructed. Cold atmospheric plasma was able to decrease skin cells apoptosis, relieve skin inflammation, ER stress and oxidative stress caused by dinitrofluorobenzene stimulation, which was mediated by cold atmospheric plasma-induced MANF expression. In terms of mechanism, hypoxia-inducible factor-1α expression was increased intracellularly after cold atmospheric plasma treatment, which further bound to the promoter region of manf gene and enhanced MANF transcriptional expression. This study reveals that cold atmospheric plasma has a positive effect on atopic dermatitis treatment, also demonstrates the regulatory mechanism of cold atmospheric plasma on MANF expression via HIF-1α, which indicates the potential medical application of cold atmospheric plasma for atopic dermatitis treatment.

An integrative approach to uncover the components, mechanisms, and functions of traditional Chinese medicine prescriptions on male infertility.

Male infertility is a major and growing health problem with an estimated global prevalence of 4.2%. The current therapy is limited by the unknown etiology of MI, emphasizing the critical requirement forward to a more efficient method or medication. Through thousands of years, Traditional Chinese Medicine (TCM) has been shown to be effective in treating MI effectively. However, the components, mechanisms and functions of TCM prescriptions on MI are still obscure, severely limiting its clinical application. In order to discover the molecular mechanism of TCM against MI, our study presents a comprehensive approach integrated data mining, network pharmacology, molecular docking, UHPLC-Q-Orbitrap HRMS, and experimental validation. Here, we begin to acquire 289 clinical TCM prescriptions for MI from a TCM hospital's outpatient department. Then, Core Chinese Materia Medica (CCMM) was then retrieved from the TCM Inheritance Support System (TCMISS), which was utilized to discover the underlying rules and connections in clinical prescriptions. After that, 98 CCMM components and 816 MI targets were obtained from ten distinct databases. Additionally, the network pharmacology methods, including network construction, GO and KEGG pathway enrichment, PPI analysis, were utilized to reveal that kaempferol, quercetin, isorhamnetin, and beta-sitosterol are the core components of CCMM in treating MI. The mechanisms and functions of CCMM against MI are hormone regulation, anti-apoptosis, anti-oxidant stress, and anti-inflammatory. Furthermore, the strong connections between four core components and six key targets were verified using a molecular docking method. Following that, the core components of the CCMM extract were identified using UHPLC-Q-Orbitrap HRMS analysis. Finally, in vivo experiments demonstrated that CCMM and four core components could improve the density, motility, viability of sperm, lecithin corpuscle density, decrease the rate of sperm malformation and testis tissue damage, and regulate the protein expressions of AKT1, MAPK3/1, EGFR, and TNF-α in a mouse model of MI. UHPLC-Q-Orbitrap HRMS analysis and in vivo experiments further validated the results of data mining, network pharmacology, and molecular docking. Our study could uncover the components, mechanisms, and functions of TCM prescriptions against MI and develop a new integrative approach to demonstrate TCM's multi-component, multi-target, and multi-pathway approach to disease treatment.

Cold Plasma Irradiation Regulates Inflammation and Oxidative Stress in Human Bronchial Epithelial Cells and Human Non-Small Cell Lung Carcinoma.

Atmospheric pressure cold plasma has shown multiple biological effects of anti-bacteria and anti-cancer. In this study, the effect of atmospheric pressure cold plasma on respiratory inflammation and oxidant stress is explored. Tunicamycin was used to stimulate human bronchial epithelial cells (HBECs) and A549 cells for inflammatory response and oxidative stress, followed by atmospheric pressure cold plasma treatment. For HBECs and A549 cells, atmospheric pressure cold plasma was able to alleviate tunicamycin-induced cell proliferation inhibition, inflammation and oxidant stress, and enhance nuclear factor-erythroid-2-related factor 2 (NRF2) pathway activation. Moreover, NRF2/ARE (anti-oxidant response elements) pathway was involved in the regulation of atmospheric pressure cold plasma on tunicamycin-induced oxidative stress. These results suggest the positive effect of atmospheric pressure cold plasma on inflammation and oxidant stress of respiratory system, indicating the therapeutic potential of atmospheric pressure cold plasma for respiratory diseases.

MXenes as emerging nanomaterials in water purification and environmental remediation.

Environmental pollution has accelerated and intensified because of the acceleration of industrialization, therefore fabricating excellent materials to remove hazardous pollutants has become inevitable. MXenes as emerging transition metal nitrides, carbides or carbonitrides with high conductivity, hydrophilicity, excellent structural stability, and versatile surface chemistry, become ideal candidates for water purification and environmental remediation. Particularly, MXenes reveal excellent sorption capability and efficient reduction performance for various contaminants of wastewater. In this regard, a comprehensive understanding of the removal behaviors of MXene-based nanomaterials is necessary to explain how they remove various pollutants in water. The eliminate process of MXene-based nanomaterials is collectively influenced by the physicochemical properties of the materials themselves and the chemical properties of different contaminants. Therefore, in this review paper, the synthesis strategies and properties of MXene-based nanomaterials are briefly introduced. Then, the chemical properties, removal behaviors and interaction mechanisms of heavy metal ions, radionuclides, and organic pollutants by MXene-based nanomaterials are highlighted. The overview also emphasizes associated toxicity, secondary contamination, the challenges, and prospects of the MXene-based nanomaterials in the applications of water treatment. This review can supply valuable ideas for fabricating versatile MXene nanomaterials in eliminating water pollution.

Effect of Shewanella oneidensis MR-1 on U(VI) sequestration by montmorillonite.

Bacteria may change the physicochemical properties of montmorillonite and further effect the disposal of high-level radioactive waste. Therefore, we explored the influence of Shewanella oneidensis MR-1 on the elimination of representative radionuclide U(VI) by montmorillonite (MMT). The batch experiments showed that MR-1 significantly enhanced the removal efficiency of U(VI), the adsorption capacity of MMT improved from 8.4 to 16.1 mg/g after addition of MR-1, and the adsorption type changed from Langmuir to Freundlich. FTIR and XPS analysis revealed that hydroxyl, phosphate, carbonyl and amine in MMT + MR-1 were primary actors in the elimination of U(VI). The U 4f high-resolution XPS spectrum of MMT + MR-1 showed U(VI) and U(IV) peaks at the same time, indicating that the adsorption process was accompanied by the reduction reaction, which may be due to the extracellular respiration of MR-1. These investigations are significant to insight the potential significance of microbial processes for the transport and elimination of U(VI) in repositories, which in return will contribute to their safe disposal.

Applications of water-stable metal-organic frameworks in the removal of water pollutants: A review.

Because the pollutants produced by human activities have destroyed the ecological balance of natural water environment, and caused severe impact on human life safety and environmental security. Hence the task of water environment restoration is imminent. Metal-organic frameworks (MOFs), structured from organic ligands and inorganic metal ions, are notable for their outstanding crystallinity, diverse structures, large surface areas, adsorption performance, and excellent component tunability. The water stability of MOFs is a key requisite for their possible actual applications in separation, catalysis, adsorption, and other water environment remediation areas because it is necessary to safeguard the integrity of the material structure during utilization. In this article, we comprehensively review state-of-the-art research progress on the promising potential of MOFs as excellent nanomaterials to remove contaminants from the water environment. Firstly, the fundamental characteristics and preparation methods of several typical water-stable MOFs include UiO, MIL, and ZIF are introduced. Then, the removal property and mechanism of heavy metal ions, radionuclide contaminants, drugs, and organic dyes by different MOFs were compared. Finally, the application prospect of MOFs in pollutant remediation prospected. In this review, the synthesis methods and application in water pollutant removal are explored, which provide ways toward the effective use of water-stable MOFs in materials design and environmental remediation.