ABSTRACT
The antiarrhythmic action of diltiazem in the model of barium arrhythmia was studied in rats non-dependent and dependent on ethanol. The results of our studies showed that single intragastric administration of ethanol jointly with diltiazem did not significantly attenuate the antiarrhythmic effect of diltiazem. Ethanol administered repeatedly and jointly with diltiazem influenced the antiarrhythmic action of diltiazem in different ways, depending on the used dose of diltiazem. After repeated joint administration of ethanol and diltiazem in a lower dose, attenuation of the antiarrhythmic effect of diltiazem was not observed. Repeated joint administration of ethanol and diltiazem in a higher dose attenuated the antiarrhythmic effect of diltiazem. Those experiments also showed that single administration of diltiazem did not significantly influence the ethanol level in the blood; however, when administered repeatedly, diltiazem reduced the concentration of ethanol in blood.
Subject(s)
Arrhythmias, Cardiac/drug therapy , Barium Compounds , Chlorides , Diltiazem/therapeutic use , Ethanol/toxicity , Alcoholism/complications , Animals , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/complications , Barium , Diltiazem/pharmacology , Disease Models, Animal , Dose-Response Relationship, Drug , Drug Interactions , Electrocardiography/drug effects , Ethanol/blood , Male , RatsABSTRACT
The aim of this work was to determine the influence of ethanol on the antiarrhythmic activity of verapamil in the model of calcium arrhythmia in rats non-dependent and dependent on ethanol. The results of the experiment show that a combined, single administration of ethanol and verapamil attenuates in a statistically significant manner the antiarrhythmic effect of verapamil. Ethanol administered repeatedly together with verapamil does not diminish the antiarrhythmic activity of verapamil.
Subject(s)
Arrhythmias, Cardiac/drug therapy , Ethanol/toxicity , Verapamil/pharmacology , Alcoholism/complications , Animals , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/complications , Calcium Chloride , Disease Models, Animal , Drug Interactions , Ethanol/blood , Male , Rats , Verapamil/therapeutic useABSTRACT
Esters of N,N-diethylaminoacetic acid and hydroxyamines, obtained from structurally different natural monoterpenes, were pharmacologically examined. It was proved that salts of the obtained compounds had local anesthetic properties in infiltration anesthesia, compounds 9, 6 and 8 having been more potent than lidocaine. Compounds 7-9 slightly increased the arrhythmogenic dose, and compound 12 - the lethal dose of strophanthin. All the examined compounds transiently decreased the arterial blood pressure and displayed a cardiopressive activity.
Subject(s)
Anesthetics, Local/chemical synthesis , Cardiovascular Agents/chemical synthesis , Hydroxylamines/chemical synthesis , Terpenes/chemical synthesis , Anesthetics, Local/pharmacology , Anesthetics, Local/toxicity , Animals , Anti-Arrhythmia Agents/chemical synthesis , Anti-Arrhythmia Agents/pharmacology , Anti-Arrhythmia Agents/toxicity , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/prevention & control , Blood Pressure/drug effects , Cardiovascular Agents/pharmacology , Cardiovascular Agents/toxicity , Chromatography, Gas , Chromatography, Thin Layer , Guinea Pigs , Heart/drug effects , Hydroxylamines/pharmacology , Hydroxylamines/toxicity , In Vitro Techniques , Lethal Dose 50 , Male , Mice , Rats , Rats, Wistar , Terpenes/pharmacology , Terpenes/toxicityABSTRACT
The effect of ethyl alcohol on the antiarrhythmic action of atenolol in the adrenaline-induced arrhythmia model was studied in rats non-dependent and dependent on ethanol. Atenolol administered jointly with ethanol, in a single dose or repeatedly produced a weaker antiarrhythmic effect than when it was given alone. Moreover, a rise in animal mortality was observed, in particular after atenolol administration in the period of intoxication. No significant effect of atenolol on ethanol blood concentration was found.
Subject(s)
Anti-Arrhythmia Agents , Atenolol/pharmacology , Ethanol/pharmacology , Administration, Oral , Alcoholism/physiopathology , Animals , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/physiopathology , Drug Interactions , Epinephrine , Ethanol/blood , Male , Rats , Rats, Inbred StrainsABSTRACT
Novel 7,8-disubstituted theophyllines 1-6a, with chiral or achiral moiety of 1,2-aminoalcohol in position 8, were obtained as the compounds with expected activity on circulation. Preliminary evaluation of their antiarrhythmic activity and the effect on the cardiovascular system was carried out. The antiarrhythmic activity similar to that of quinidine (with ca. 20 times lower toxicity) was found only for racemic 7-beta-hydroxyethyl-8-(1'-hydroxybut-2'-yl) aminotheophylline 1 and its enantiomers 2, 3 which did not differ markedly in their efficacy. The compounds with the hydroxyethyl moiety in position 7 of theophylline (1-3, 5) showed the hypotensive effect.
