Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters











Language
Publication year range
1.
Clin Transl Oncol ; 8(6): 435-43, 2006 Jun.
Article in English | MEDLINE | ID: mdl-16790397

ABSTRACT

BACKGROUND: Medullary thyroid carcinoma (MTC) is a rare development of thyroid cancer with a no negligible mortality rate. Our aim was to determine factors that predict outcome in patients with MTC. METHODS: We reviewed the records of all patients with MTC (n=56) who underwent treatment at our institution between January 1990 and December 2000. Univariate and multivariate analysis of clinicopathologic predictors of MTC outcome were performed to identify subsets of patients with different probabilities in terms of overall survival, local recurrence, and distant metastases. RESULTS: Multivariate analysis demonstrated that a statistically significant decrease in overall survival is associated with T4b tumours (p=0.06), the presence of distant metastases at the time of presentation (p=0.033), lymphatic invasion (p=0.099), and postoperative treatment (p=0.045). CONCLUSIONS: The analysis of survival curves of patients with MTC shows that the occurrence of locoregional and distant metastases occurs preferentially within the first 5 years, which identifies this as a crucial period for follow-up. In this series of patients with MTC, the tumours classified as T4b, metastases at presentation, the presence of lymphovascular invasion, and postoperative treatment were the most important prognostic features. At present, there is no available beneficial adjuvant therapy. However, as the development of molecular therapy progresses, it should be tested in clinical trials with the purpose of achievement of novel targeted therapies for selected MTC patients with risk factors.


Subject(s)
Carcinoma, Medullary/mortality , Thyroid Neoplasms/mortality , Adult , Aged , Aged, 80 and over , Biomarkers, Tumor/blood , Calcitonin/blood , Carcinoma, Medullary/blood , Female , Follow-Up Studies , Humans , Lymph Node Excision/methods , Lymphatic Metastasis , Male , Middle Aged , Multiple Endocrine Neoplasia Type 2a/mortality , Multivariate Analysis , Neck Dissection , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplasm Recurrence, Local , Portugal/epidemiology , Prognosis , Survival Analysis , Thyroid Neoplasms/blood , Thyroidectomy , Time Factors
2.
Rev. chil. anat ; 19(3): 331-334, 2001. ilus
Article in English | LILACS | ID: lil-310245

ABSTRACT

Los paragangliomas de la glándula tiroides son tumores poco frecuentes. Se presenta un caso clínico de una mujer de 32 años de edad, con una masa en el lóbulo derecho de la glándula tiroides, sin otros síntomas. El diagnóstico inicial, al que se llegó por citopunción, fue de carcinoma medular de tiroides. La opción terapéutica fue de hemitiroidectomía. Los estudios anatomopatológicos de la pieza operatoria y la histoquímica fueron compatibles con un paraganglioma. Se pone de manifiesto las dificultades del diagnóstico y la importancia de la


Subject(s)
Humans , Female , Adult , Paraganglioma , Thyroid Neoplasms , Carcinoma, Medullary , Immunohistochemistry , Thyroidectomy
SELECTION OF CITATIONS
SEARCH DETAIL