Lung Ultrasound and Pleural Artifacts: A Pictorial Review.

Lung ultrasound is a well-established diagnostic approach used in detecting pathological changes near the pleura of the lung. At the acoustic boundary of the lung surface, it is necessary to differentiate between the primary visualization of pleural parenchymal pathologies and the appearance of secondary artifacts when sound waves enter the lung or are reflected at the visceral pleura. The aims of this pictorial essay are to demonstrate the sonographic patterns of various pleural interface artifacts and to illustrate the limitations and pitfalls of the use of ultrasound findings in diagnosing any underlying pathology.

B-line Elastography Measurement of Lung Parenchymal Elasticity.

This paper proposes a method to determine the elasticity of the lung parenchyma from the B-line Doppler signal observed using continuous shear wave elastography, which uses a small vibrator placed on the tissue surface to propagate continuous shear waves with a vibration frequency of approximately 100 Hz. Since the B-line is generated by multiple reflections in fluid-storing alveoli near the lung surface, the ultrasonic multiple-reflection signal from the B-line is affected by the Doppler shift due to shear waves propagating in the lung parenchyma. When multiple B-lines are observed, the propagation velocity can be estimated by measuring the difference in propagation time between the B-lines. Therefore, continuous shear wave elastography can be used to determine the elasticity of the lung parenchyma by measuring the phase difference of shear wave between the B-lines. In this study, three elastic sponges (soft, medium, and hard) with embedded glass beads were used to simulate fluid-storing alveoli. Shear wave velocity measured using the proposed method was compared with that calculated using Young's modulus obtained from compression measurement. Using the proposed method, the measured shear wave velocities (mean ± S.D.) were 3.78 ± 0.23, 4.24 ± 0.12, and 5.06 ± 0.05 m/s for soft, medium, and hard sponges, respectively, which deviated by a maximum of 5.37% from the values calculated using the measured Young's moduli. The shear wave velocities of the sponge phantom were in a velocity range similar to the mean shear wave velocities of healthy and diseased lungs reported by magnetic resonance elastography (3.25 and 4.54 m/s, respectively). B-line elastography may enable emergency diagnoses of acute lung disease using portable ultrasonic echo devices.

Point-of-Care Ultrasound-A New Option for Early Quantitative Assessment of Pulmonary Edema.

The aim of the work described here was to investigate the value of point-of-care ultrasound (POCUS) in the early assessment of the severity of pulmonary edema in rabbits. A rabbit oleic acid (OA)-induced pulmonary edema model was used. Thirty-two New Zealand rabbits were randomly divided into four groups: a control group and three pulmonary edema groups (mild, moderate and severe). Features of transthoracic B-line artifacts (BLA), blood pH, PaO2 and PaCO2, serum inflammatory factors, lung coefficient (LC), lung wet-to-dry weight ratio (W/D) and lung histopathology were assessed. BLA features and severity of pulmonary edema were semiquantitatively scored. Correlations between the number of BLA and PaO2, PaCO2, serum inflammatory factors, LC and W/D were analyzed. An additional 8 rabbits with severe pulmonary edema were used as the verified group, in which the lung was divided into ex vivo BLA (BLA-ev)-free (BLA-ev-free) and BLA-ev-clustered subregions depending on the features of BLA-ev recorded by ex vivo lung ultrasound. Lung specimens from each subregion were collected for histopathological examination. Relationships between features of BLA-ev and lung histopathological abnormalities were analyzed. With increasing doses of OA, number of BLA, W/D and levels of serum inflammatory factors decreased. Meanwhile, lung pathologic abnormalities were aggravated. In addition, time of appearance of BLA, blood pH and PaO2, and PaCO2 decreased dose dependently on OA (p < 0.05). Number of BLA was linear positively correlated with severity of pulmonary edema (r = 0.953, p < 0.05). Consistently, the features of BLA-ev reflected the severity of lung histopathological abnormalities (r = 0.936, p < 0.05). Thus, POCUS is useful in the early quantitative assessment of the severity of pulmonary edema.