Percutaneous Vocal Fold Lateralization in children - a case series of a Brazilian tertiary pediatric hospital (pediatric vocal fold lateralization cases in a Brazilian hospital).

OBJECTIVES: Percutaneous Vocal Fold Lateralization (PVFL) consists of external fixation with non-absorbable percutaneous suture of the vocal fold in a lateral position, under direct glottic visualization. The objective of this study is to determine the effectiveness of PVFL in a university pediatric hospital, as well as to describe the potential risks and complications of the surgery. METHODS: Retrospective cohort study, with data collected from electronic medical records. The study was approved by the Research Ethics Committee of the institution. Surgeries were performed with the modified Lichentenberg technique and data, and outcomes were analyzed. RESULTS: Six patients with Bilateral Vocal Fold Paralysis who underwent Percutaneous Vocal Fold Lateralization were evaluated. Three patients were male. The age at diagnosis ranged from 2 to 132 days (mean 10.5 days). The reason for investigating the upper airway was the presence of increased work of breathing and stridor. Five patients had a favorable clinical evolution, with spontaneous ventilation in room air and absence of stridor or ventilatory effort, without the need for tracheostomy. Surgical results in this series corroborate the findings of other similar cohorts, which showed Percutaneous Vocal Fold Lateralization as a safe and effective procedure in avoiding tracheostomy or allowing decannulation in children with Bilateral Vocal Fold Paralysis. CONCLUSIONS: PVFL seems to be a safe and effective procedure, but it has morbidity, due to immediate, and probably late, non-serious complications. Studies with a larger number of patients, with longer follow-up and using a controlled and randomized clinical design are needed to establish the role of PVFL in the treatment of BVFP in newborns and infants. LEVELS OF EVIDENCE: Level 4 (step 4).

Reproducibility (reliability and agreement) of ventilatory threshold and peak responses during cardiopulmonary exercise test in people with stroke.

BACKGROUND: A cardiopulmonary exercise test (CPET) is used to determine the ventilatory thresholds and to directly assess cardiorespiratory capacity. However, its reproducibility should be tested in people with stroke as sequelae imposed by the stroke may induce important variations among and within each subject, affecting the reproducibility of the physiological responses to CPET. PURPOSE: This cross-sectional repeated measures study design aims to determine the reproducibility of anaerobic threshold (AT), respiratory compensation point (RCP), and maximal cardiorespiratory capacity assessed during a CPET in people with stroke. METHODS: Twenty-eight subjects with hemiparesis after stroke aging 60 ± 13 years were submitted to two treadmill CPETs with identical protocols. DATA ANALYSIS: The reproducibility of heart rate (HR) and oxygen consumption (VO2) obtained at AT, RCP, and peak effort was evaluated by systematic error (paired t-test); reliability (ICC and 95% confidence interval); and agreement (typical error and coefficient of variation). RESULTS: There were no systematic errors for HR and VO2assessed at AT, RCP, and peak effort (p > 0,05). Reliability was high for these variables during CPET (ICCs > 0.93). Agreement was good for all variables. Typical errors for HR and VO2 assessed at AT, RCP, and peak effort were, respectively, 7, 7, and 8 bpm, and 1.51, 1.44, and 1.57 ml.kg-1.min-1. Coefficients of variation assessed at AT, RCP, and peak effort were, respectively, 5.7, 5.1, and 6.0% for HR and 8.7, 7.3, and 7.5% for VO2. CONCLUSIONS: HR and VO2 measured at AT, RCP, and peak effort during a treadmill CPET present good reproducibility in people with stroke, showing high reliability and good agreement.

[Syphilis: uncommon presentation forms]. / Sífilis: formas de presentación poco frecuentes.

Uncommon forms of syphilis exist, among which neurosyphilis, otosyphilis, and ocular syphilis are included. Neurosyphilis is the infection of the central nervous system caused by Treponema pallidum. The clinical manifestations of neurosyphilis are diverse and include early, late, and atypical forms. Syphilis can affect virtually any ocular structure and can occur at any stage of the disease, as well as otosyphilis. The diagnosis of these conditions is often challenging. However, it is important to consider them as a differential diagnosis, as most of these clinical manifestations are reversible with appropriate antibiotic treatment. A case series study of patients diagnosed with neurosyphilis, otosyphilis, and ocular syphilis, who were admitted to a tertiary-level hospital, is here presented: syphilitic meningitis with cranial nerve involvement, and seizures (case 1), ocular syphilis (case 2), general paresis (case 3), and tabes dorsalis (case 4). Half of the patients presented bilateral sensorineural hearing loss; and also half of the patients had reactive VDRL in cerebrospinal fluid. All were treated with aqueous penicillin G, and in two of these cases, ceftriaxone was chosen to complete ambulatory treatment. One patient had an unfavorable outcome and died (case 1); another was lost in follow-up (case 4); one completely resolved his symptoms (case 2); and another one experienced symptom relapse six months after treatment (case 3).

Existen formas de presentación poco frecuentes de sífilis, dentro de las cuales se incluyen la neurosífilis, otosífilis y sífilis ocular. La neurosífilis es la infección del sistema nervioso central por Treponema pallidum. Las manifestaciones clínicas de neurosífilis son variadas e incluyen formas tempranas, tardías y atípicas. Además, la sífilis puede comprometer prácticamente cualquier estructura ocular, en cualquier etapa de la enfermedad, como así también la otosífilis. El diagnóstico de estas entidades suele ser dificultoso. Sin embargo, resulta importante considerarlas como diagnósticos diferenciales, ya que la mayoría de estas manifestaciones son reversibles con tratamiento antibiótico adecuado. Se presenta una serie de casos de pacientes con diagnóstico de neurosífilis, otosífilis y sífilis ocular, que cursaron internación en un hospital de tercer nivel: meningitis sifilítica con compromiso de pares craneales y convulsiones (caso 1), sífilis ocular (caso 2), paresis general (caso 3) y tabes dorsalis (caso 4). La mitad de los pacientes presentó hipoacusia neurosensorial bilateral. El 50% presentó VDRL reactiva en líquido cefalorraquídeo. Todos fueron tratados con penicilina G sódica y en el 50% se optó por el uso de ceftriaxona como modalidad para finalizar el tratamiento en internación domiciliaria. Respecto a la evolución de los pacientes, uno de ellos falleció como consecuencia del cuadro de neurosífilis (caso 1), otro se perdió en el seguimiento (caso 4) mientras que, de los dos restantes, el caso 3 presentó recaída de su enfermedad a los 6 meses del tratamiento y el caso 2 resolvió ad integrum su sintomatología.

Sífilis: formas de presentación poco frecuentes / Syphilis: uncommon presentation forms

Resumen Existen formas de presentación poco frecuentes de sífilis, dentro de las cuales se incluyen la neurosífilis, otosífilis y sífilis ocular. La neurosífilis es la infección del sistema nervioso central por Treponema pallidum. Las manifestaciones clínicas de neurosífilis son variadas e incluyen formas tempranas, tardías y atípicas. Además, la sífilis puede comprometer prácticamente cualquier estructura ocular, en cualquier etapa de la enfermedad, como así también la otosífilis. El diagnóstico de estas en tidades suele ser dificultoso. Sin embargo, resulta impor tante considerarlas como diagnósticos diferenciales, ya que la mayoría de estas manifestaciones son reversibles con tratamiento antibiótico adecuado. Se presenta una serie de casos de pacientes con diagnóstico de neurosí filis, otosífilis y sífilis ocular, que cursaron internación en un hospital de tercer nivel: meningitis sifilítica con compromiso de pares craneales y convulsiones (caso 1), sífilis ocular (caso 2), paresis general (caso 3) y tabes dorsalis (caso 4). La mitad de los pacientes presentó hipoacusia neurosensorial bilateral. El 50% presentó VDRL reactiva en líquido cefalorraquídeo. Todos fueron tratados con penicilina G sódica y en el 50% se optó por el uso de ceftriaxona como modalidad para finalizar el tratamiento en internación domiciliaria. Respecto a la evolución de los pacientes, uno de ellos falleció como consecuencia del cuadro de neurosífilis (caso 1), otro se perdió en el seguimiento (caso 4) mientras que, de los dos restantes, el caso 3 presentó recaída de su enferme dad a los 6 meses del tratamiento y el caso 2 resolvió ad integrum su sintomatología.

Abstract Uncommon forms of syphilis exist, among which neurosyphilis, otosyphilis, and ocular syphilis are included. Neurosyphilis is the infection of the central nervous system caused by Treponema pallidum. The clinical manifestations of neurosyphilis are diverse and include early, late, and atypical forms. Syphilis can affect virtually any ocular structure and can oc cur at any stage of the disease, as well as otosyphilis. The diagnosis of these conditions is often challeng ing. However, it is important to consider them as a differential diagnosis, as most of these clinical mani festations are reversible with appropriate antibiotic treatment. A case series study of patients diagnosed with neurosyphilis, otosyphilis, and ocular syphilis, who were admitted to a tertiary-level hospital, is here presented: syphilitic meningitis with cranial nerve in volvement, and seizures (case 1), ocular syphilis (case 2), general paresis (case 3), and tabes dorsalis (case 4). Half of the patients presented bilateral sensori neural hearing loss; and also half of the patients had reactive VDRL in cerebrospinal fluid. All were treated with aqueous penicillin G, and in two of these cases, ceftriaxone was chosen to complete ambulatory treat ment. One patient had an unfavorable outcome and died (case 1); another was lost in follow-up (case 4); one completely resolved his symptoms (case 2); and another one experienced symptom relapse six months after treatment (case 3).

Functional electrical stimulation therapy controlled by a P300-based brain-computer interface, as a therapeutic alternative for upper limb motor function recovery in chronic post-stroke patients. A non-randomized pilot study.

Introduction: Up to 80% of post-stroke patients present upper-limb motor impairment (ULMI), causing functional limitations in daily activities and loss of independence. UMLI is seldom fully recovered after stroke when using conventional therapeutic approaches. Functional Electrical Stimulation Therapy (FEST) controlled by Brain-Computer Interface (BCI) is an alternative that may induce neuroplastic changes, even in chronic post-stroke patients. The purpose of this work was to evaluate the effects of a P300-based BCI-controlled FEST intervention, for ULMI recovery of chronic post-stroke patients. Methods: A non-randomized pilot study was conducted, including 14 patients divided into 2 groups: BCI-FEST, and Conventional Therapy. Assessments of Upper limb functionality with Action Research Arm Test (ARAT), performance impairment with Fugl-Meyer assessment (FMA), Functional Independence Measure (FIM) and spasticity through Modified Ashworth Scale (MAS) were performed at baseline and after carrying out 20 therapy sessions, and the obtained scores compared using Chi square and Mann-Whitney U statistical tests (𝛼 = 0.05). Results: After training, we found statistically significant differences between groups for FMA (p = 0.012), ARAT (p < 0.001), and FIM (p = 0.025) scales. Discussion: It has been shown that FEST controlled by a P300-based BCI, may be more effective than conventional therapy to improve ULMI after stroke, regardless of chronicity. Conclusion: The results of the proposed BCI-FEST intervention are promising, even for the most chronic post-stroke patients often relegated from novel interventions, whose expected recovery with conventional therapy is very low. It is necessary to carry out a randomized controlled trial in the future with a larger sample of patients.

Parálisis facial alternobárica: a propósito de un caso y revisión de la literatura / Alternobaric facial palsy: case report and literature review

La parálisis o paresia facial alternobárica es una neuropraxia del séptimo nervio cra-neal debido a cambios de presión. Se produce en el contexto de una disfunción de la trompa de Eustaquio, una dehiscencia canal del nervio facial y cambios en la presión atmosférica. Se considera una rara complicación de barotrauma. Su prevalencia es difícil de estimar y, probablemente, se encuentre subreportada. La forma de presentación más habitual incluye paresia facial, plenitud aural, hipoacusia, otalgia, parestesias faciales y linguales. La mayoría de los episodios son transitorios, con una duración entre minutos y algunas horas, con recuperación posterior completa. Entre los diagnósticos diferenciales se encuentran causas periféricas y centrales de paresia facial, las cuales hay que sospechar ante la persistencia de los síntomas en el tiempo o ante la presencia de otros signos o síntomas neurológicos. La evaluación inicial debe incluir un examen otoneurológico completo. La tomografía computarizada de hueso temporal favorece la visualización de posibles dehiscencias del canal del facial. La prevención de nuevos episodios incluye la práctica de ecualización efectiva, la resolución de la disfunción de la trompa de Eustaquio y en algunos casos específicos, métodos alternativos de ventilación del oído medio como la colocación de tubos de ventilación. Una vez instalada la parálisis facial, si no se produce recuperación espontánea, el uso de corticoides es una opción. Se presenta un caso de paresia facial alternobárica recurrente y una revisión de literatura.

Alternobaric facial palsy or paralysis is a neuropraxia of the seventh cranial nerve due to pressure changes. It occurs in the context of Eustachian tube dysfunction, facial nerve canal dehiscence, and changes in atmospheric pressure. It is considered a rare complication of barotrauma. Its prevalence is difficult to estimated, and this condition is probably underreported. The most common form of presentation includes facial weakness, ear fullness or pressure, hearing loss, otalgia, facial and lingual paresthesias. Most episodes are transient, lasting from minutes to a few hours, with a subsequent complete recovery. Among the possible differential diagnoses are peripheral and central causes of facial paralysis, which must be suspected due to the persistence of symptoms over time or the presence of other neurological signs or symptoms. The initial evaluation should include a complete otoneurological examination. Computed tomography of the temporal bone is useful for the visualization of facial canal dehiscence. Prevention of further episodes includes practicing effective equalization, Eustachian tube dysfunction treatment, and in certain specific cases, alternative middle ear ventilation methods such as tympanostomy tubes. Once facial paralysis is established, if spontaneous recovery does not occur, the use of corticosteroids is considered an option. A case of recurrent alternobaric facial paresis and a review of the literature are presented.

Parálisis abdominal unilateral posterior a herpes zóster. Reporte de caso / Unilateral abdominal paralysis following herpes zoster. Case report

Resumen Introducción: el virus de la varicela zoster (VVZ) es un alfa herpesvirus, que causa la varicela y el herpes zóster (HZ). El HZ se manifiesta por la reactivación del VVZ, que persiste de forma latente en los ganglios de las raíces sensoriales dorsales o craneales después de la infección primaria. El HZ causa un rash extremadamente doloroso y con lesiones vesiculares y pruriginosas autolimitadas. Presentación del caso: paciente masculino de 71 años de edad con cuadro clínico de 20 días de evolución consistente en dolor intenso de tipo urente, localizado en los dermatomas T11-T12 del lado derecho, intensidad 8/10 en escala subjetiva del dolor y asociado con lesiones vesiculares, eritematosas y muy pruriginosas. Además, el paciente presentaba distensión del flanco abdominal derecho. La electromiografía informó una lesión parcial del 50% de los nervios intercostales derechos, con fenómeno de denervación parcial. Conclusiones: la parálisis abdominal postherpética es una complicación rara del HZ y requiere su reconocimiento para emitir un diagnóstico correcto y evitar intervenciones innecesarias.

Abstract Introduction: varicella zoster virus (VZV) is an alpha herpesvirus, which causes chickenpox and herpes zoster (HZ). HZ is manifested by reactivation of VZV, which persists latently in dorsal or cranial sensory root ganglia after primary infection. HZ causes an extremely painful rash with self-limited vesicular and itchy lesions. Case presentation: a 71-year-old male patient with a clinical picture of 20 days of evolution consisting of intense burning pain, located in the T11-T12 dermatomes on the right side, intensity 8/10 on the subjective pain scale and associated with vesicular, erythematous and very itchy lesions. Moreover, the patient presented distension of the right abdominal flank. Electromyography reported a partial lesion of 50% of the right intercostal nerves, with a phenomenon of partial denervation. Conclusions: postherpetic abdominal paralysis is a rare complication of HZ and requires its recognition to issue a correct diagnosis and avoid unnecessary interventions.

Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets.

This report describes 2 events of degenerative myelopathy in 4- to 27-day-old piglets, with mortality rates reaching 40%. Sows were fed rations containing low levels of pantothenic acid. Piglets presented with severe depression, weakness, ataxia, and paresis, which were more pronounced in the pelvic limbs. No significant gross lesions were observed. Histologically, there were degeneration and necrosis of neurons in the spinal cord, primarily in the thoracic nucleus in the thoracic and lumbar segments, and motor neurons in nucleus IX of the ventral horn in the cervical and lumbar intumescence. Minimal-to-moderate axonal and myelin degeneration was observed in the dorsal funiculus of the spinal cord and in the dorsal and ventral nerve roots. Immunohistochemistry demonstrated depletion of acetylcholine neurotransmitters in motor neurons and accumulation of neurofilaments in the perikaryon of neurons in the thoracic nucleus and motor neurons. Ultrastructurally, the thoracic nucleus neurons and motor neurons showed dissolution of Nissl granulation. The topographical distribution of the lesions indicates damage to the second-order neurons of the spinocerebellar tract, first-order axon cuneocerebellar tract, and dorsal column-medial lemniscus pathway as the cause of the conscious and unconscious proprioceptive deficit, and damage to the alpha motor neuron as the cause of the motor deficit. Clinical signs reversed and no new cases occurred after pantothenic acid levels were corrected in the ration, and piglets received parenteral administration of pantothenic acid. This study highlights the important and practical use of detailed neuropathological analysis to refine differential diagnosis.

Paresias y parálisis de grupos musculares de miembro superior y miembro inferior en sujetos post infección por SARS-CoV-2 ingresados a kinesiología motora en un centro de rehabilitación en la Ciudad Autónoma de Buenos Aires. Estudio descriptivo / Paresis and paralysis of muscle groups in the upper limb and lower limb in subjects after SARS-CoV-2 infection admitted to physical therapy in a rehabilitation center in the Autonomous City of Buenos Aires. A descriptive study

RESUMEN Objetivo: Describir la incidencia de parálisis o paresias focalizadas de grupos musculares de miembro superior (MS) y de miembro inferior (MI) en sujetos post infección por SARS-CoV-2 al ingreso a kinesiología motora en un centro de rehabilitación en la Ciudad Autónoma de Buenos Aires (CABA), y describir las características clínico-demográficas de los sujetos. Materiales y método: Estudio descriptivo, observacional y retrospectivo. Los datos se obtuvieron de las historias clínicas de los sujetos internados. Las variables que se registraron fueron la presencia de paresias o parálisis de grupos musculares de MS y de MI, el tiempo de evolución de la COVID-19, los antecedentes, la medicación, la duración en decúbito prono, la edad y el sexo. Se consideró una significancia estadística de p<0,05. Resultados: Se incluyeron 84 sujetos. El 85% (n=71) fueron hombres, con una mediana de edad de 62 años. La incidencia total de paresias o parálisis focalizadas de grupos musculares de MS y de MI fue del 57% (n=84). El 49% (n=41) de los sujetos presentó hipertensión arterial (HTA); el 30% (n=25) diabetes y el 29% (n=24) obesidad. El 89% (n=75) de los sujetos tomaba 3 o más medicamentos y el 56% (n=47) estuvo en decúbito prono. Conclusión: La incidencia total de paresias o parálisis de grupos musculares de MS y de MI fue del 57% (n=84) en sujetos post infección por SARS-CoV-2 al ingreso a kinesiología motora en un centro de rehabilitación en la CABA. El 56% (n=47) estuvo en decúbito prono. La mayoría de los sujetos fueron hombres de 62 años, con 55 días de evolución de la COVID-19, HTA y polifarmacia.

ABSTRACT Objective: To describe the incidence of localized paralysis or paresis of muscle groups in the upper limb (UL) and lower limb (LL) in subjects after infection with SARS-CoV-2 upon admission to physical therapy in a rehabilitation center in the Autonomous City of Buenos Aires (CABA), and to describe the clinical-demographic characteristics of the subjects. Materials and methods: This is a descriptive, observational, and retrospective study. Data were obtained from the medical records of hospitalized subjects. The presence of paresis or paralysis of muscle groups in the UL and LL, time of COVID-19 clinical course, medical history, medication, duration in prone position, age, and sex were registered. A statistical significance of p<0.05 was considered. Results: A total of 84 subjects were included; of them, 85% (n=71) of the subjects were men, with a median age of 62 years. The total incidence of localized paralysis or paresis of the muscle groups in the UL and LL was 57% (n=84). Forty-nine percent (n=41) of the subjects had arterial hypertension (AHT); 30 (n=25) diabetes and 29% (n=24) obesity. Eighty-nine percent (n=75) of the subjects took 3 or more medications, and 56% (n=47) were in the prone position. Conclusion: The total incidence of paresis or paralysis of the muscle groups in the UL and LL was 57% (n=84) in subjects after infection with SARS-CoV-2 upon admission to physical therapy in a rehabilitation center in CABA. Fifty-six percent (n=47) of the subjects were in prone position. Most of the subjects were 62 years old, with a 55-day course of COVID-19, AHT, and polypharmacy.

The Facial Nerve Injury After Temporomandibular Joint Surgery after Endaural Approach with Sharp Dissection.

Several authors have extensively modified approaches to temporomandibular joint surgery throughout history to improve access, improve aesthetics, and decrease the risk of nerve damage. However, This is why this retrospective cross-sectional is carried out to show the rate of facial nerve injury after the endaural approach with sharp dissection for the temporomandibular joint with a low rate of facial nerve paresis our case series.

Tiempo de evolución y eliminación de la diplopía binocular en pacientes con paresia o parálisis oculomotoras / Evolution Time and Elimination of Binocular Diplopia in Patients with Oculomotor Paresis or Paralysis

Objetivo: Determinar la relación existente entre tiempo de evolución y eliminación de la diplopía binocular en pacientes con paresia o parálisis oculomotoras. Métodos: Se realizó un estudio descriptivo, longitudinal y prospectivo de una serie de casos que acudieron a la consulta del Servicio de Oftalmología Pediátrica del Instituto Cubano de Oftalmología Ramón Pando Ferrer y que cumplían con los criterios de inclusión en el periodo comprendido entre mayo del 2018 a junio del 2019. Se evaluaron las variables: sexo, tiempo de evolución, opciones de tratamiento, eliminación de diplopía, fusión y estereopsis. Resultados: El mayor número de casos acudieron a consulta entre una semana y menos de un mes de evolución de la enfermedad y más de seis meses. No resultó significativo la relación sexo, etiología y tiempo de evolución en acudir los pacientes a consulta externa. El 66,7 por ciento de la muestra estudiada resolvió solo con tratamiento médico, incluidos el 100 por ciento de los pacientes con menos de una semana de evolución. Todos los pacientes con tiempo de evolución menor de seis meses eliminaron la diplopía y se encontró diferencia estadística (p = 0,04) entre estas variables. El 76,7 por ciento logró fusión y el 56,7 por ciento estereopsis. Conclusiones: La mayor parte de los pacientes con tiempo de evolución menor de seis meses eliminaron la diplopía solo con tratamiento médico, incluidos el 100 por ciento de los pacientes con menos de una semana de evolución, observándose una relación entre la recuperación y la cronicidad de la diplopía(AU)

Objective: To determine the relationship between time of evolution and elimination of binocular diplopia in patients with oculomotor paresis or paralysis. Methods: A descriptive, longitudinal and prospective study was carried out, from May 2018 to June 2019, of a series of cases that were assisted in consultation of the Pediatric Ophthalmology Service at Ramón Pando Ferrer Cuban Institute of Ophthalmology and that met the inclusion criteria. The variables evaluated were sex, evolution time, treatment options, elimination of diplopia, fusion and stereopsis. Results: The largest number of cases were assisted in consultation between one week and less than one month of evolution of the disease and more than six months. The relationship between sex, etiology and time of evolution in attending the outpatient clinic was not significant. 66.7 percent of the studied sample solved only with medical treatment, including 100 percent of patients with less than one week of evolution. All patients with evolution time of lesser than six months eliminated diplopia and a statistical difference was found (p = 0.04) between these variables. 76.7 percent achieved fusion and 56.7 percent stereopsis. Conclusions: Most of the patients with evolution time of lesser than six months eliminated diplopia only with medical treatment, including 100 percent of patients with less than one week of evolution, observing a relationship between recovery and chronicity of diplopia. Diplopia(AU)

Etiología y evolución de la diplopía binocular en pacientes con paresia o parálisis oculomotoras / Etiology and Course of Binocular Diplopia in Patients with Oculomotor Paresis or Paralysis

Objetivo: Determinar la etiología y evolución de la diplopía binocular en pacientes con paresia o parálisis oculomotoras. Métodos: Se realizó un estudio descriptivo, longitudinal y prospectivo de una serie de casos que acudieron a la consulta del Servicio de Oftalmología Pediátrica del Instituto Cubano de Oftalmología Ramón Pando Ferrer y cumplían con los criterios de inclusión en el periodo comprendido entre mayo del 2018 a junio del 2019. Se evaluaron las variables: edad, sexo, factores de riesgo, etiología, opciones de tratamiento y eliminación de diplopía. Resultados: La edad media de la muestra estudiada fue de 56,8 años y predominó el sexo masculino (56,7 por ciento versus 43,3 por ciento). El factor de riesgo más frecuente fue el microvascular (86,7 por ciento), 14 pacientes con hipertensión arterial y 12 con diabetes mellitus. Predominó también la etiología microvascular en 18 pacientes de 30. El 66,7 por ciento de la muestra estudiada resolvió solo con tratamiento médico y el 86,7 por ciento de los casos eliminaron la diplopía en todas las posiciones diagnósticas de la mirada. Conclusiones: El nervio craneal más frecuente afectado es el sexto y prevaleció la etiología microvascular en el sexto y tercer nervio craneal, sin embargo, para el cuarto es la traumática la única causa encontrada, lo cual concuerdan con la literatura revisada(AU)

Objective: To determine the etiology and evolution of binocular diplopia in patients with oculomotor paresis or paralysis. Methods: A descriptive, longitudinal and prospective study was carried out, from May 2018 to June 2019, of a series of cases that were assisted in the consultation of the Pediatric Ophthalmology Service at Ramón Pando Ferrer Cuban Institute of Ophthalmology and met the inclusion criteria. The variables evaluated were age, sex, risk factors, etiology, treatment options and elimination of diplopia. Results: The mean age of the studied sample was 56.8 years and the male sex predominated (56.7 percent versus 43.3 percent). The most frequent risk factor was microvascular (86.7 percent), fourteen patients with arterial hypertension and 12 with diabetes mellitus. Microvascular etiology also predominated in 18 patients out of 30. The medical treatment only solved 66.7 percent of the studied sample and 86.7 percent of cases eliminated diplopia in all diagnostic gaze positions. Conclusions: The most frequently affected cranial nerve is the sixth and microvascular etiology prevailed in the sixth and third cranial nerves, however, for the fourth traumatic is the only cause found, which is consistent with the literature reviewed(AU)

Tuberculosis espinal: diagnóstico y manejo / Spinal tuberculosis: diagnosis and treatment

RESUMEN La tuberculosis espinal representa el 50 % de los casos de tuberculosis osteoarticular y, sin un tratamiento oportuno, puede ocasionar discapacidad (por complicaciones neurológicas) y deformidad. Se sospecha de esta enfermedad con base en los antecedentes del paciente, la clínica y los hallazgos radiológicos. El diagnóstico se establece con la identificación de Mycobacterium tuberculosis, las características histopatológicas y/o hallazgo de bacilos ácido-alcohol resistentes (BAAR) en el frotis. El diagnóstico diferencial más importante de la tuberculosis espinal es la espondilodiscitis piógena. La resonancia magnética es la prueba de imagen indicada para la valoración del compromiso neurológico y el estudio diagnóstico diferencial. El tratamiento principal es la quimioterapia antituberculosa, y la cirugía puede ser coadyuvante en los casos de tuberculosis espinal complicada, luego de evaluar el déficit neurológico y la deformidad resultante. Está contraindicado realizar solamente una laminectomía, y los implantes para la artrodesis se pueden utilizar en la infección activa. El 8 % de los pacientes con déficit neurológico no logra recuperarse, aun con el tratamiento.

ABSTRACT Spinal tuberculosis accounts for 50 % of all cases of osteoarticular tuberculosis, causing disability (due to neurological complications) and deformity if left untreated. This disease is suspected based on the patient's medical history, clinical manifestations and radiological findings. It is diagnosed by positive cultures for Mycobacterium tuberculosis, the histopathological characteristics of the condition and/or acid-fast bacilli (AFB)-positive smear tests. The main differential diagnosis of spinal tuberculosis is pyogenic spondylodiscitis. Magnetic resonance imaging is the appropriate imaging test to assess the neurological involvement and study the differential diagnosis of the disease. The main treatment is antituberculous chemotherapy, but surgery can be adjunctive in cases of complicated spinal tuberculosis. The decision of which treatment to implement depends on the neurological deficit and the resulting deformity. Laminectomy alone is contraindicated and arthrodesis implants can be used during the active infection. Despite treatment, 8 % of the patients with neurological deficit do not recover.

Diagnostic evolution of vestibular neuritis after long-term monitoring.

INTRODUCTION: The diagnosis of vestibular neuritis is based on clinical and laboratory findings after exclusion of other disease. There are occasional discrepancies between clinical impressions and laboratory results. It could be the first vertigo episode caused by other recurrent vestibular disease, other than vestibular neuritis. OBJECTIVE: This study aimed to analyze the clinical features and identify the diagnostic evolution of patients with clinically suspected vestibular neuritis. METHODS: A total of 201 patients clinically diagnosed with vestibular neuritis were included in this study. Clinical data on the symptoms and signs of vertigo along with the results of vestibular function test were analyzed retrospectively. Patients were categorized in terms of the results of caloric testing (CP - canal paresis) group; canal paresis ≥25%; (MCP -minimal canal paresis) group; canal paresis <25%). Clinical features were compared between the two groups and the final diagnosis was reviewed after long-term follow up of both groups. RESULTS: Out of 201 patients, 57 showed minimal canal paresis (CP<25%) and 144 showed definite canal paresis (CP≥25%). A total of 48 patients (23.8%) experienced another vertigo episode and were re-diagnosed. Recurring vestibular symptoms were seen more frequently in patients with minimal canal paresis (p=0.027). Repeated symptoms were observed on the same affected side more frequently in the CP group. The proportion of final diagnosis were not different between two groups. CONCLUSIONS: Patients with minimal CP are more likely to have recurrent vertigo than patients with definite CP. There was no significant difference in the distribution of the final diagnoses between two groups when the vertigo recurs.

Diagnostic evolution of vestibular neuritis after long-term monitoring / Evolução diagnóstica da neurite vestibular após monitoração de longo prazo

Abstract Introduction The diagnosis of vestibular neuritis is based on clinical and laboratory findings after exclusion of other disease. There are occasional discrepancies between clinical impressions and laboratory results. It could be the first vertigo episode caused by other recurrent vestibular disease, other than vestibular neuritis. Objective This study aimed to analyze the clinical features and identify the diagnostic evolution of patients with clinically suspected vestibular neuritis. Methods A total of 201 patients clinically diagnosed with vestibular neuritis were included in this study. Clinical data on the symptoms and signs of vertigo along with the results of vestibular function test were analyzed retrospectively. Patients were categorized in terms of the results of caloric testing (CP - canal paresis) group; canal paresis ≥25%; (MCP -minimal canal paresis) group; canal paresis <25%). Clinical features were compared between the two groups and the final diagnosis was reviewed after long-term follow up of both groups. Results Out of 201 patients, 57 showed minimal canal paresis (CP < 25%) and 144 showed definite canal paresis (CP ≥ 25%). A total of 48 patients (23.8%) experienced another vertigo episode and were re-diagnosed. Recurring vestibular symptoms were seen more frequently in patients with minimal canal paresis (p = 0.027). Repeated symptoms were observed on the same affected side more frequently in the CP group. The proportion of final diagnosis were not different between two groups. Conclusions Patients with minimal CP are more likely to have recurrent vertigo than patients with definite CP. There was no significant difference in the distribution of the final diagnoses between two groups when the vertigo recurs.

Resumo Introdução O diagnóstico de neurite vestibular é baseado em achados clínicos e laboratoriais após exclusão de outra doença. Existem discrepâncias ocasionais entre a impressão clínica e os resultados laboratoriais. Pode ser o primeiro episódio de vertigem causado por outra doença vestibular recorrente, além da neurite vestibular. Objetivo Analisar as características clínicas e identificar a evolução diagnóstica de pacientes com suspeita clínica de neurite vestibular. Método Foram incluídos neste estudo 201 pacientes com diagnóstico clínico de neurite vestibular. Os dados clínicos sobre os sintomas e sinais de vertigem e os resultados dos testes de função vestibular foram analisados retrospectivamente. Os pacientes foram categorizados de acordo com os resultados das provas calóricos (Grupo PC: paresia do canal ≥ 25%; Grupo PMC: paresia mínima do canal < 25%). As características clínicas foram comparadas entre os dois grupos e o diagnóstico final foi revisado após o acompanhamento de longo prazo de ambos os grupos. Resultados De 201 pacientes, 57 apresentaram paresia mínima do canal (PC < 25%) e 144 apresentaram paresia definitiva do canal (PC ≥ 25%). Quarenta e oito pacientes (23,8%) apresentaram outro tipo de vertigem e foram diagnosticados novamente. Sintomas vestibulares recorrentes foram observados com mais frequência nos pacientes com paresia mínima do canal (p = 0,027). Sintomas recorrentes no mesmo lado afetado foram observados com mais frequência no Grupo PC. A proporção de diagnóstico final não foi diferente entre os dois grupos. Conclusão Os pacientes com paresia mínima do canal foram mais propensos a apresentar vertigem recorrente que os pacientes com paresia do canal definitiva. Não houve diferença significante na distribuição dos diagnósticos finais entre os dois grupos quando houve recorrência da vertigem.

Constraint Induced Movement Therapy Increases Functionality and Quality of Life after Stroke.

This blind randomized clinical trial evaluated the effect of CIMT on the functionality and quality of life (QOL) of chronic hemiparetics. Thirty volunteers were divided into two groups: Control (CG) and CIMT (CIMTG); evaluated before and after 12 and 24 intervention sessions. The scales used were: adapted Fugl-Meyer Motor Assessment (FMA), Modified Ashworth, Stroke Specific Quality Of Life (SS-QOL) and the Functional Reach Test (FRT). The scores for all FMA variables in the CIMTG increased until the 24th session, differing from the pre-treatment. In the CG, the scores increased for pain, coordination/ speed and sensitivity. In the FRT there was an increase in the scores in both groups; after the 12th and 24th sessions, the result of the CIMTG was superior to the CG. For the SS-QOL in the CIMTG, the general score and most of the variables increased, as well as in the CG. Muscle tone in CIMTG was lower compared to CG after 24 sessions. Both protocols used in the study were effective, the CIMT protocol showed benefits in recovering the functionality of the paretic upper limb, in the functional range and in reducing muscle tone, with a consequent improvement in quality of life.

Luxaciones puras de codo en pacientes pediátricos: tratamiento conservador y complicaciones asociadas a una patología poco prevalente. Serie de 4 casos / Isolated elbow dislocation in pediatric patients: non-operative treatment and complications associated with an infrequent pathology. Series of 4 cases

Si bien el codo es la articulación más frecuentemente luxada en niños, representa el 3-6 % de las lesiones en ese sitio. Las luxaciones sin fracturas asociadas son muy raras y son producto de una caída con el codo en extensión. El paciente consulta por dolor, impotencia funcional y deformidad evidente. La finalidad del tratamiento es restaurar la congruencia articular, lograr estabilidad y minimizar los riesgos de posibles lesiones neurovasculares.Se presentan 4 pacientes tratados con manejo conservador con excelentes resultados funcionales, incluso aquel que presentó una neuropraxia del mediano con restitución ad integrum.Según nuestra experiencia, suelen ser lesiones con buena evolución. Se destaca la importancia de un rápido y preciso examen neurovascular, optando, de ser posible, por una conducta expectante ante las lesiones nerviosas. Se resalta la indicación de una inmovilización acotada con movilización temprana que evite rigidez del codo.

Even though the elbow is the most often dislocated joint in children, this injury accounts for 3-6 % of elbow pathology. Dislocations without associated fractures are extremely rare. They result from a fall onto an outstretched hand. The patient is always referred with a painful joint, movement impairment and even clinical deformity. Acute treatment aims to achieve quick reduction and adequate joint stability, avoiding neurovascular injuries.We sought to analyze the functional outcomes and the complications after non-operative treatment. Our 4 patien had excellent functional results at the latest follow-up, and one of them suffered from a median nerve palsy without further consequences.In our experience, these injuries presented excellent outcomes and we would like to highlight the importance of a quick and precise neurovascular examination with the possibility of non-surgical management of nerve injuries. A short period of immobilization with early rehabilitation should be indicated to avoid joint stiffness

[Isolated elbow dislocation in pediatric patients: non-operative treatment and complications associated with an infrequent pathology. Series of 4 cases]. / Luxaciones puras de codo en pacientes pediátricos: tratamiento conservador y complicaciones asociadas a una patología poco prevalente. Serie de 4 casos.

Even though the elbow is the most often dislocated joint in children, this injury accounts for 3-6 % of elbow pathology. Dislocations without associated fractures are extremely rare. They result from a fall onto an outstretched hand. The patient is always referred with a painful joint, movement impairment and even clinical deformity. Acute treatment aims to achieve quick reduction and adequate joint stability, avoiding neurovascular injuries. We sought to analyze the functional outcomes and the complications after non-operative treatment. Our 4 patients Luxaciones puras de codo en pacientes pediátricos: tratamiento conservador y complicaciones asociadas a una patología poco prevalente. Serie de 4 casos Isolated elbow dislocation in pediatric patients: non-operative treatment and complications associated with an infrequent pathology. Series of 4 cases had excellent functional results at the latest follow-up, and one of them suffered from a median nerve palsy without further consequences. In our experience, these injuries presented excellent outcomes and we would like to highlight the importance of a quick and precise neurovascular examination with the possibility of non-surgical management of nerve injuries. A short period of immobilization with early rehabilitation should be indicated to avoid joint stiffness.

Si bien el codo es la articulación más frecuentemente luxada en niños, representa el 3-6 % de las lesiones en ese sitio. Las luxaciones sin fracturas asociadas son muy raras y son producto de una caída con el codo en extensión. El paciente consulta por dolor, impotencia funcional y deformidad evidente. La finalidad del tratamiento es restaurar la congruencia articular, lograr estabilidad y minimizar los riesgos de posibles lesiones neurovasculares. Se presentan 4 pacientes tratados con manejo conservador con excelentes resultados funcionales, incluso aquel que presentó una neuropraxia del mediano con restitución ad integrum. Según nuestra experiencia, suelen ser lesiones con buena evolución. Se destaca la importancia de un rápido y preciso examen neurovascular, optando, de ser posible, por una conducta expectante ante las lesiones nerviosas. Se resalta la indicación de una inmovilización acotada con movilización temprana que evite rigidez del codo.

Hipocalcemia pós-parto em vacas de leite

A hipocalcemia se refere a um quadro causado por decúbito prolongado e persistente durante o puerpério, acometendo vacas de alta produção de leite. Para minimizar a redução da concentração de cálcio, o organismo tenta suprir essa perda através da absorção intestinal e reabsorção óssea. Os sinais clínicos variam conforme o estágio da doença e o tratamento deve ser imediato assim que observados os primeiros sinais. A prevenção é a melhor estratégia e a mais viável de manter a qualidade de vida do rebanho. O objetivo desse trabalho foi realizar uma revisão de literatura sobre hipocalcemia pós-parto em vacas de leite.

Hypocalcemia refers to a condition caused by prolonged and persistent recumbency during the puerperium, affecting cows with high milk production. To minimize the reduction in calcium concentration, the body tries to compensate for this loss through intestinal absorption and bone resorption. Clinical signs vary according to the stage of the disease and treatment should be immediate as soon as the first signs are observed. Prevention is the best and most viable strategy to maintain the herd's quality of life. The objective of this work was to carry out a literature review on postpartum hypocalcemia in dairy cows.