ABSTRACT
Objective:To investigate the clinical characteristics of esthesioneuroblastoma and the efficacy of endonasal endoscopic surgery combined with radiotherapy/chemotherapy. Methods:The clinical and surgical data of 17 patients with esthesioneuroblastoma who underwent endonasal endoscopic surgery in our department from September 2009 to June 2023 were retrospectively analyzed. Results:Among all patients, the modified Kadish stage B was identified in 4 patients, C in 10 patients, and D in 3 patients. Ten of them underwent endonasal endoscopic surgery without neck dissection in one day, whose average operation time is ï¼5.2±2.5ï¼ hours and average blood loss is ï¼192±162ï¼mL. Skull base reconstructions were performed in 15 patients, postoperative complications were observed in 3 patients, and negative margins were obtained in 13 patients. All 17 patients were followed up for an average of ï¼49.7±40.2ï¼ months. Three patients died and 6 had recurrence and/or metastasis. The 1-year, 2-year and 5-year overall survival rates were 88.2%, 80.2%, and 80.2%, respectively, and the 1-year, 2-year and 5-year disease-free survival rates were 82.4%, 82.4%, and 50.8%, respectively. The 2-year overall survival rates of patients with negative and positive margins were 100% and 25%, respectively, while the 2-year disease-free survival rates were 61.5% and 25.0%, respectively. Conclusion:Endonasal endoscopic surgery combined with radiotherapy/chemotherapy can achieve satisfactory effect in esthesioneuroblastoma, and the prognosis of patients with positive margins is poor.
Subject(s)
Esthesioneuroblastoma, Olfactory , Nose Neoplasms , Humans , Esthesioneuroblastoma, Olfactory/surgery , Female , Male , Retrospective Studies , Middle Aged , Nose Neoplasms/surgery , Adult , Endoscopy/methods , Nasal Cavity , Survival Rate , Treatment OutcomeABSTRACT
@#Congenital nasolacrimal duct obstruction(CNLDO)is one of the most common ocular disorders in infants, and the main feature is a membranous obstruction of the distal end of the nasolacrimal duct. Methods are considered to treat with CNLDO, including lacrimal sac massage, probing, silicone intubation, balloon dacryocystoplasty, and dacryohynostomy. Recently, the combination use of lacrimal endoscopes may increase the success rate of surgery. Because many CNLDOs can resolve spontaneously, there are still some controversies in the timing of surgery and the choice of treatment options. The aim of the review is to provide a reference for the treatment of CNLDO.
