Carcinoma sebáceo extraocular, reporte de un caso / Extraocular sebaceous carcinoma, case report

RESUMEN El carcinoma sebáceo es una neoplasia anexial poco común que puede originarse en cualquier lugar del cuerpo donde existan glándulas sebáceas, siendo la principal ubicación la cabeza y el cuello, existiendo la presentación ocular y extraocular. Alcanza entre 0,2% a 4,6% de todas las neoplasias cutáneas malignas, con mayor incidencia en los adultos mayores caucásicos. La presentación clínica habitual corresponde a un nódulo duro o quístico subcutáneo eritematoso o amarillento, indoloro, de crecimiento acelerado. Sin embargo, puede manifestarse como una amplia gama de lesiones cutáneas, lo que, agregado a su baja incidencia, sea altamente subdiagnosticado. Se presenta el caso de un paciente de 64 años con tumor exofítico malar izquierdo con ulceraciones y áreas de necrosis en la superficie, sin compromiso de párpado inferior, de agudeza visual ni motilidad ocular. Se realiza resección del tumor, cuya biopsia definitiva confirma diagnóstico de carcinoma sebáceo extraocular.

ABSTRACT Sebaceous carcinoma is a rare anexal neoplasm that can develop on any part of the body containing sebaceous glands, but nearly the 70% of sebaceous carcinoma occur on the head and neck, being two ways of presentation, ocular and extraocular. It represents 0.2-4.6 % of all malignant neoplastic cutaneous lesions, whit a peak incidence in the eighth decades of life, in caucasian people. Typical clinical presentation of sebaceous carcinoma is a painless, firm or cystic subcutaneous nodule described as pink to red-yellow, however clinical features can be quite varied, which added to its low incidence leads to the diagnosis is often delayed for months to years. We present the case of a 64 years old patient whit an exofitic malar tumor ulcerated and necrotic in the surface, without compromising the lower eyelid, vision or ocular mobility. The biopsy of the tumor resection shows an extraocular sebaceous carcinoma.

Sebaceous carcinoma in a mature teratoma of the ovary

The finding of a sebaceous carcinoma in a mature teratoma is rare in human pathology, with fewer than 10 cases currently reported in the literature. In this article, we report a case of sebaceous carcinoma in a mature teratoma of the ovary in a 59-year-old patient and discuss its histological findings.

Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases.

AIMS: Sebaceous carcinomas are uncommon malignant cutaneous tumours originating from the pilosebaceous unit. Although its occurrence is mostly common in peri-ocular glands, other anatomical regions of the head and neck may be affected, including major and minor salivary glands. METHODS AND RESULTS: We describe a series of sebaceous adenocarcinomas of the parotid and submandibular glands. The mean age was 62.1 (range = 31-90) years. Two patients (20%) presented regional or distant metastasis to mandible and lungs. All cases were positive for cytokeratins (AE1AE3 and CK-5), epithelial membrane antigen and adipophilin and negative for androgen receptor, Factor XIIIa, S-100, vimentin and perforin. MLH1 and MSH2 were expressed in the nuclei of most tumour cells, and one case showed loss of MSH2 expression. Proliferative index (assessed by Ki-67 expression) and microvessel density (CD34-positive vessels) were higher in metastasis-associated cases. P63 expression was noted in the periphery of the tumour nests, in the basaloid cells, with a mean of 69.2% nuclear positivity. CONCLUSIONS: The sebaceous adenocarcinoma of salivary glands is rare and may show an unfavourable outcome; therefore, its correct diagnosis may be challenging. For this reason, immunohistochemical studies, including adipophilin in particular, constitute an important diagnostic tool.

Cutaneous Metaplastic Carcinoma: Report of a Case With Sebaceous Differentiation.

In this study, a case of a 56-year-old woman with cutaneous metaplastic carcinoma in the neck is reported. It harbored basal cell carcinoma, squamous cell carcinoma, and sebaceous carcinoma, as well as osteosarcoma (with fibroblastic, osteoblastic, aneurysmal bone cyst-like, and chondroblastic patterns). To our knowledge, the literature does not mention sebaceous carcinoma in cutaneous metaplastic carcinoma. Epidemiology and intact mismatch repair proteins of this case support sporadic pathogenesis for this neoplasm. The patient has been followed up for 3 years after surgery with free margins, and no local recurrence or distant metastases have been observed.

Carcinoma sebáceo de párpado. Reporte de un caso / Sebaceous carcinoma of the eyelid. Case report

Objetivo: Reportar el caso de una paciente con carcinoma sebáceo de párpado y revisar la literatura. Diseño del estudio: Reporte de caso. Métodos: Se reporta un caso de una paciente con diagnóstico de carcinoma sebáceo de párpado que fue remitida a la Clínica de Oftalmología San Diego Medellín-Colombia, a la consulta de Oncología ocular en el año 2015. Se realizó una revisión detallada de la historia clínica, se tomaron fotos a color previa firma de consentimiento informado por parte de la paciente y se realizó biopsia e inmunohistoquímica respectiva. Se cuenta con la aprobación el comité de ética médica de la Universidad Pontificia Bolivariana. Resultados: Reporte de carcinoma sebáceo de párpado. Mujer de 66 años a la que se le hizo diagnóstico de carcinoma sebáceo de párpado luego de resección y se confirmó con el estudio anatomopatológico y de inmunohistoquímica. Se realizaron estudios de extensión en busca de metástasis a distancia. Conclusión: El carcinoma sebáceo de párpado es una entidad poco frecuente en la práctica clínica oftalmológica siendo estas lesiones fácilmente confundidas con lesiones benignas como chalazión y blefaroconjuntivitis por la poca familiaridad del especialista con la enfermedad. Es necesario tener un alto índice de sospecha y saber que existe para tratar esta entidad de manera oportuna evitando intervenciones no indicadas en este tipo de lesión.

Objective: To report the case of a patient with sebaceous carcinoma of the eyelid and literature review. Study Design: Case report. Methodology: A case of a patient diagnosed with sebaceous carcinoma of the eyelid which was referred to the oncology service to Clinic of Ophthalmology San Diego Medellin-Colombia in 2015. A detailed review of the medical history and photography documentation was done. Results: Sebaceous carcinoma of the eyelid was reported. A woman of 66 years old who has had diagnosis of eyelid sebaceous carcinoma after resection and confirmed with histopathologic and immunohistochemical study. Extension studies were conducted in order to rule out metastases. Conclusion: The sebaceous carcinoma of the eyelid is a rare entity in the ophthalmological setting and could be easily confused with benign lesions such as blepharitis and chalazion for those ophthalmologists unfamiliar with this condition. A high index of suspicion of this entity is recommended in a timely manner to avoid interventions that are not indicated in this type of lesion.

Sebaceous Carcinoma of the Ocular Region: The 2014 Professor Winifred Mao Lecture.

Sebaceous carcinoma is a malignancy arising in the periocular region that can lead to blindness and tumor-related metastases. This study is a review of published literature and personal experience. This malignancy can arise from the sebaceous units in the tarsus (meibomian glands), in association with the cilia (Zeis glands), in the brow, and in the caruncle. There is a tendency for diffuse intraepithelial growth (pagetoid spread) that can be clinically invisible. Detection before lymph node metastasis is critical. This malignancy often masquerades as chronic unilateral conjunctivitis or blepharitis, typically in older patients. Management includes a 2-step approach with step 1 focused on eyelid and conjunctival map biopsies to determine the full extent of solid deep tumor and pagetoid spread. After complete review of all biopsies, step 2 is performed using local resection for all deep tumor, cryotherapy to pagetoid disease, and reconstruction. In most cases, the posterior lamella of eyelid is sacrificed with tumor removal, whereas the anterior lamella of the eyelid can be saved. After removal and cryotherapy, immediate reconstruction, using clean instruments, with buccal membrane graft for the posterior lamella and skin flap for the anterior lamella, is developed. For persistent or recurrent pagetoid disease, cryotherapy, topical mitomycin C, or plaque radiotherapy is provided. Exenteration is sometimes necessary. Sebaceous carcinoma, if detected early, can be managed with carefully planned map biopsy to determine tumor extent, followed by local resection, cryotherapy, and eyelid reconstruction. Orbital exenteration is occasionally necessary.

Cuerno cutáneo y carcinoma sebáceo: diagnóstico diferencial a propósito de un caso / Cutaneous horn and sebaceous carcinoma: differential diagnosis of a case report

El cuerno cutáneo es un concepto semiológico. Se define como una lesión tumoral hiperqueratósica de aspecto cónico y tamaño variable, que puede tener como base una lesión de origen benigno, premaligno o maligno. El tratamiento consiste en la resección completa de la lesión, seguido de un estudio histopatológico para precisar el diagnóstico. El carcinoma sebáceo, neoplasia maligna derivada del epitelioanexial de las glándulas sebáceas, se ha descrito como una etiología poco frecuente de cuerno cutáneo. Su diagnóstico es difícil, ya que carece de elementos clínicos característicos y su histología puede ser similar al carcinoma espinocelular o basocelular, pero importante ya que constituye una neoplasia agresiva, con riesgo de recurrencia local y metástasis. A continuación, presentamos el caso de un hombre de 68 años con diagnóstico clínico de cuerno cutáneo palpebral y diagnóstico histopatológico de carcinoma sebáceo.

The cutaneous horn is a semiological concept. It is defined as an hyperkeratotic tumor of conical appearance and variable size, which may be based on benign, premalignant or malignant lesion. The treatment is the complete resection followed by an histopathology study to clarify the diagnosis. Sebaceous carcinoma, malignant neoplasm derived from adnexal epithelium of sebaceous glands, has been described as a rare etiology of cutaneous horn. Diagnosis is difficult because it doesn’t have characteristic clinical features and histology may be similar to squamous or basal cell carcinoma, but it is important because is an aggressive neoplasm with risk of local recurrence and metastasis. We present a case of a 68-year-old man, with a clinical diagnosis of eyelid cutaneous horn and histopathological diagnosis of sebaceous carcinoma.

Extra ocular sebaceous adenocarcinoma in HIV-positive patient--case report.

Sebaceous adenocarcinoma is a rare adnexal tumor that can affect the skin and is divided into ocular, a more common form and extra ocular, of a rarer occurrence. We report the case of a patient diagnosed with Acquired Immune Deficiency Syndrome (AIDS) who developed an extra ocular, bulky and fast-growing sebaceous adenocarcinoma on the face. The literature has suggested that transplanted patients and HIV-positive patients have an excess risk for developing adnexal tumors, including sebaceous adenocarcinoma.

Extra ocular sebaceous adenocarcinoma in HIV-positive patient - case report / Adenocarcinoma sebaceo extra-ocular em paciente HIV positivo - relato de caso

Sebaceous adenocarcinoma is a rare adnexal tumor that can affect the skin and is divided into ocular, a more common form and extra ocular, of a rarer occurrence. We report the case of a patient diagnosed with Acquired Immune Deficiency Syndrome (AIDS) who developed an extra ocular, bulky and fast-growing sebaceous adenocarcinoma on the face. The literature has suggested that transplanted patients and HIV-positive patients have an excess risk for developing adnexal tumors, including sebaceous adenocarcinoma.

Adenocarcinoma sebáceo é um tumor anexial raro que pode envolver a pele e é dividido em ocular, mais comum e extraocular, mais raro. Relatamos o caso de um paciente com diagnóstico de Síndrome da Imunodeficiência Adquirida que desenvolveu um adenocarcinoma sebáceo extra-ocular, na face, volumoso, de rápido crescimento. A literatura tem sugerido que pacientes transplantados e portadores do vírus da imunodeficiência humana têm um excesso de risco para o desenvolvimento de tumores anexiais, incluindo o Adenocarcinoma sebáceo.

Giant extraocular sebaceous carcinoma: case report and a brief review of a literature.

Extraocular sebaceous carcinoma (ESC) is a rare, aggressive malignant tumor that originates from the adnexal epithelium of the sebaceous gland. We present herein one of the largest cases reported in the literature until now. We also review briefly the relevant aspects including clinical presentation, differential diagnosis, histopathological features, inmunohistochemical profile, and therapeutic options.

Carcinoma sebáceo de la glándula parótida / Sebaceous carcinoma of the parotid gland

Introduction: Sebaceous carcinoma of the parotid gland is an extremely rare neoplasm, whose treatment is complex by the possible consequences that may occur due to its location. Material and Methods: We report a case of a 54 year old patient with a left parotid tumor without facial nerve dysfunction. The imaging study reports the presence of a left parotid tumor of 2.3 cm, without lymphadenopathy. Results: We performed a left partial parotidectomy whose final pathological diagnosis was a sebaceous carcinoma of the parotid gland.

Introducción: El carcinoma sebáceo de la glándula parótida es una neoplasia extremadamente infrecuente, cuyo manejo es complejo por las posibles secuelas que pueden suceder dada su localización. Material y Método: Se reporta el caso de una paciente de 54 años con un tumor parotídeo izquierdo de larga data sin compromiso de la función del VII par. Resultados: El estudio por imágenes informó la presencia de un tumor parotídeo izquierdo de 2,2 cm, sin linfoadenopatías regionales. Se realizó una parotidectomía parcial izquierda cuyo diagnóstico patológico definitivo fue un carcinoma sebáceo de glándula parótida.

[Eyelid tumor in anophthalmic socket due to retinoblastoma: report of two cases]. / Carcinoma de Meibômio como segundo tumor em portadores de retinobastoma: relato de dois casos.

Retinoblastoma is a unilateral or bilateral intraocular tumor, occurring as a hereditary or sporadic tumor. Another not ocular lesion is a possibility for retinoblastoma carriers. The authors report the cases of two patients: a son with bilateral anophthalmic socket due to retinoblastoma, who presented unilateral upper eyelid tumor; and his father with unilateral anophthalmic socket secondary to enucleation due to retinoblastoma and a tumor growing fast in the upper eyelid at the same side of the anophthalmic cavity. Lesions were diagnosed as sebaceous carcinoma confirmed by immunohistochemical exam. Both patients had the eyelid tumors removed, with good resolution. None of them have presented either signs of recurrence or metastasis.

Sebaceous carcinoma of the eyelid - different diagnostic times, different outcomes: case reports / Carcinoma de glândulas sebáceas palpebral - diferentes momentos de diagnósticos, diferentes resultados cirúrgicos: relatos de casos

Sebaceous carcinoma of the eyelid is a very rare slow-growing tumor and is considered an aggressive eyelid neoplasm. It can reach mortality rate of about 6 percent. Diagnosis is often delayed because of its ability to masquerade as other periocular lesions, both clinically and histologically. We present three cases of sebaceous carcinoma, with different surgical outcomes, showing the importance of early diagnosis.

Carcinoma sebáceo é um tumor raro de crescimento lento considerado uma das mais agressivas neoplasias palpebrais. Pode alcançar taxa de mortalidade de aproximadamente 6 por cento. O diagnóstico tardio é comum devido a sua habilidade de se confundir com outras lesões perioculares tanto clinicamente quanto histologicamente. Relatamos três casos de carcinoma sebáceo da pálpebra com diferentes resultados cirúrgicos, enfatizando a importância do diagnóstico precoce.

Carcinoma de Meibômio como segundo tumor em portadores de retinobastoma: relato de dois casos / Eyelid tumor in anophthalmic socket due to retinoblastoma: report of two cases

O retinoblastoma pode acometer um ou os dois olhos, ocorrendo de forma hereditária ou esporádica. O portador dessa doença pode desenvolver, a longo prazo, outros tipos de tumores não oculares. Relatamos dois pacientes: o filho, portador de cavidade anoftálmica bilateral após remoção dos olhos devido ao retinoblastoma, que apresentou segundo tumor palpebral unilateral, afetando a pálpebra superior; e o pai, portador de cavidade anoftálmica unilateral também por remoção de retinoblastoma e que apresentou tumoração de crescimento rápido na pálpebra superior ipsilateral ao olho enucleado. O exame imuno-histoquímico de ambas as lesões excisadas revelou que se tratava de carcinoma de glândulas sebáceas. Os pacientes evoluíram bem após a remoção do tumor palpebral e, até o momento, não apresentam sinais de recidiva ou metástase.

Retinoblastoma is a unilateral or bilateral intraocular tumor, occurring as a hereditary or sporadic tumor. Another not ocular lesion is a possibility for retinoblastoma carriers. The authors report the cases of two patients: a son with bilateral anophthalmic socket due to retinoblastoma, who presented unilateral upper eyelid tumor; and his father with unilateral anophthalmic socket secondary to enucleation due to retinoblastoma and a tumor growing fast in the upper eyelid at the same side of the anophthalmic cavity. Lesions were diagnosed as sebaceous carcinoma confirmed by immunohistochemical exam. Both patients had the eyelid tumors removed, with good resolution. None of them have presented either signs of recurrence or metastasis.

Sebaceous carcinoma of the eyelid - different diagnostic times, different outcomes: case reports.

Sebaceous carcinoma of the eyelid is a very rare slow-growing tumor and is considered an aggressive eyelid neoplasm. It can reach mortality rate of about 6%. Diagnosis is often delayed because of its ability to masquerade as other periocular lesions, both clinically and histologically. We present three cases of sebaceous carcinoma, with different surgical outcomes, showing the importance of early diagnosis.

Adenocarcinoma sebáceo em Gerbil (Meriones unguiculatus Milne-Edwards, 1867) Relato de caso / Sebaceous adenocarcinoma in Gerbil (Meriones unguiculatus Milne-Edwards, 1867) - Case Report

As lesões proliferativas da glândula sebácea abdominal ventral têm sido descritas em gerbil (M. unguiculatus)oriundos de vida livre e laboratórios. Sua prevalência é relativamente baixa, mas aumentaem animais com mais de 2 anos de idade, sendo a neoplasia mais comum em M. unguiculatus machos.Relata-se um caso de adenocarcinoma sebáceo em M. unguiculatus, fêmea, 1 ano e 7 meses, com formaçãonodular, sólida, móvel, não aderida ao tecido subcutâneo, não ulcerada, indolor à palpação e comaproximadamente 2,0cm de diâmetro. Foi realizada a exérese do tumor. O diagnóstico foi confirmadopor exame histopatológico, caracterizado pela proliferação de células epiteliais, com vacuolizaçãointracitoplasmática, organizadas ora em ninhos ora em cordões, apresentando moderados pleomorfismo,atipia e índice mitótico. As células neoplásicas também apresentaram graus variáveis de diferenciaçãosebácea e diferenciação escamosa focal. Também foram encontradas pérolas de queratinadiscretas e multifocais(AU)

Proliferative lesions of the ventral abdominal sebaceous gland have been described in free-living andlaboratory gerbils (M. unguiculatus). Their prevalence is relatively low, but increases in animals withmore than 2 years old, being the most common type of tumor in M. unguiculatus males. This case reportis about a sebaceous gland carcinoma in a female M. unguiculatus, 1 year 7 months old. It was shownas a nodular formation, solid, not adhered to the subcutaneous tissue, no ulcerated surface, painlessto palpation and two centimeters in diameter. The tumor was excised. Diagnosis was confirmed byhistopathologic examination, as the sample was characterized by proliferation of epithelial cells withintracytoplasmic vacuolization, organized in cords or clusters, with moderate pleomorphism, atypiaand mitotic index. The neoplasic cells also showed varying degrees of sebaceous differentiation andfocal squamous differentiation. Mild and multifocal pearls of keratin were noted also(AU)

Adenocarcinoma sebáceo em Gerbil (Meriones unguiculatus Milne-Edwards, 1867) – Relato de caso / Sebaceous adenocarcinoma in Gerbil (Meriones unguiculatus Milne-Edwards, 1867) - Case Report

As lesões proliferativas da glândula sebácea abdominal ventral têm sido descritas em gerbil (M. unguiculatus)oriundos de vida livre e laboratórios. Sua prevalência é relativamente baixa, mas aumentaem animais com mais de 2 anos de idade, sendo a neoplasia mais comum em M. unguiculatus machos.Relata-se um caso de adenocarcinoma sebáceo em M. unguiculatus, fêmea, 1 ano e 7 meses, com formaçãonodular, sólida, móvel, não aderida ao tecido subcutâneo, não ulcerada, indolor à palpação e comaproximadamente 2,0cm de diâmetro. Foi realizada a exérese do tumor. O diagnóstico foi confirmadopor exame histopatológico, caracterizado pela proliferação de células epiteliais, com vacuolizaçãointracitoplasmática, organizadas ora em ninhos ora em cordões, apresentando moderados pleomorfismo,atipia e índice mitótico. As células neoplásicas também apresentaram graus variáveis de diferenciaçãosebácea e diferenciação escamosa focal. Também foram encontradas pérolas de queratinadiscretas e multifocais

Proliferative lesions of the ventral abdominal sebaceous gland have been described in free-living andlaboratory gerbils (M. unguiculatus). Their prevalence is relatively low, but increases in animals withmore than 2 years old, being the most common type of tumor in M. unguiculatus males. This case reportis about a sebaceous gland carcinoma in a female M. unguiculatus, 1 year 7 months old. It was shownas a nodular formation, solid, not adhered to the subcutaneous tissue, no ulcerated surface, painlessto palpation and two centimeters in diameter. The tumor was excised. Diagnosis was confirmed byhistopathologic examination, as the sample was characterized by proliferation of epithelial cells withintracytoplasmic vacuolization, organized in cords or clusters, with moderate pleomorphism, atypiaand mitotic index. The neoplasic cells also showed varying degrees of sebaceous differentiation andfocal squamous differentiation. Mild and multifocal pearls of keratin were noted also