Role of eating disorders-related polymorphisms in obesity pathophysiology.

Human biological system provides innumerable neuroendocrine inputs for food intake control, with effects on appetite's modulation and the satiety signs. Its regulation is very complex, engaging several molecular interactions with many tissues, hormones, and neural circuits. Thus, signaling molecules that control food intake are critical for normal energy homeostasis and a deregulation of these pathways can lead to eating disorders and obesity. In line of this, genetic factors have a significantly influence of the regulation of neural circuits controlling the appetite and satiety pathways, as well as the regulation of brain reward systems. Single Nucleotide Polymorphisms (SNPs) in genes related to hypothalamic appetite and satiety mechanisms, further in multiple neurotransmitter systems may contribute to the development of major Eating Disorders (EDs) related to obesity, among them Binge Eating Disorder (BED) and Bulimia Nervosa (BN), which are discussed in this review.

Entre 8 e 80, qual a medida certa? Os caminhos e descaminhos da libido no trajeto entre a obesidade e a magreza / Between 8 and 80, which is the right measure? Directions and misdirections of libido between obesity and thinness

Hybris pode ser entendida como uma ultrapassagem do metron. Este artigo se inicia com a articulação desse conceito com a mitologia, a noção filosófica de pecado e a psicopatologia. Discute a compulsão alimentar na obesidade e exemplifica por meio da observação clínica algumas manifestações psíquicas decorrentes do uso da cirurgia bariátrica. Dois casos clínicos ilustram caminhos distintos tomados pela energia psíquica quando esta é retirada abruptamente do alimento em decorrência do procedimento cirúrgico. No primeiro caso, observamos a progressão da libido que se desloca do alimento para o corpo. No segundo, sintomas como depressão e perda do significado da vida apontam para a regressão da libido (AU)

Hybris may be understood as the overtaking of the metron. This paper articulates this concept with mythology, the philosophical concept of sin andn psychopathology. It discusses the binge eating in obesity and exemplifies through clinical observation some psychic manifestations that arise from bariatric surgery. Two clinical reports show the different paths taken by psychic energy when it is abruptly removed from food as a result of surgery. On the first case libido's progression is dislocated from food to the body. On the second case symptoms such as depression and loss of the meaning of life point to the regression of libido (AU)