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2.
Front Endocrinol (Lausanne) ; 14: 1155638, 2023.
Article in English | MEDLINE | ID: mdl-36936169

ABSTRACT

Chorea is a movement disorder involving involuntary movements of muscles of the face, neck, and limbs, usually caused by basal ganglia lesions. As an important part of the presentation of many neurological diseases, chorea is also an unusual manifestation of endocrine diseases and can be challenging to diagnose. Although the most common etiology of chorea is genetic, it is vital to identify acquired or symptomatic chorea, as these are potentially treatable conditions. This review summarizes the latest developments in various endocrine disease-related chorea, which will help clinicians to correctly identify and accurately treat it.


Subject(s)
Chorea , Endocrine System Diseases , Humans , Chorea/diagnosis , Chorea/etiology , Chorea/therapy , Endocrine System Diseases/pathology , Basal Ganglia
3.
Equine Vet J ; 55(3): 350-375, 2023 May.
Article in English | MEDLINE | ID: mdl-36847165

ABSTRACT

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture-associated laminitis have an insulin-dysregulated phenotype (endocrinopathic laminitis, EL) and that prolonged insulin and glucose infusions can experimentally induce laminar pathology and functional failure are seminal discoveries in this field. Researchers have studied the molecular basis for disease pathogenesis in models of EL, sepsis-related laminitis and supporting limb laminitis and generated much data over the last 15 years. This review attempts to synthesise those data, drawing comparisons between models and naturally occurring laminitis. A hypothesis is proposed that the basal epithelial cell stress is a central event in each category of laminitis. Furthermore, in naturally occurring pasture-associated laminitis, pathways that predominate in each type of laminitis contribute to laminar lamellar pathology to varying extents. Based on the molecular mechanisms determined in experimental models, interactions between these pathways are identified.


Subject(s)
Foot Diseases , Hoof and Claw , Horse Diseases , Animals , Endocrine System Diseases/pathology , Endocrine System Diseases/veterinary , Foot Diseases/pathology , Foot Diseases/veterinary , Hoof and Claw/pathology , Horse Diseases/pathology , Horses , Insulin , Sepsis/complications , Sepsis/veterinary , Male , Female
4.
Zhonghua Gan Zang Bing Za Zhi ; 30(4): 352-356, 2022 Apr 20.
Article in Chinese | MEDLINE | ID: mdl-35545559

ABSTRACT

As a secondary endocrine organ, the liver is closely related to the endocrine system. Liver involvement is not uncommon in endocrine diseases, such as hyper/hypothyroidism, diabetes, dysfunction of adrenal and gonadal. It can be manifested in a variety of forms, including hepatocyte injury (elevated transaminase), bile duct injury (cholestasis), hepatocyte steatosis, vascular injury and liver tumor. Direct and indirect liver injury caused by abnormal hormone levels and side effects of drugs for the treatment of endocrine diseases are common pathogenesis. In addition, endocrine diseases can be concomitant with liver diseases, such as autoimmune thyroiditis and autoimmune hepatitis. Systemic diseases can also involve the endocrine system and liver at the same time, such as systemic lupus erythematosus and IgG4 related diseases. For patients with unexplained liver injury, endocrine system diseases should be considered as the differential diagnosis.


Subject(s)
Cholestasis , Endocrine System Diseases , Hepatitis, Autoimmune , Liver Diseases , Cholestasis/pathology , Endocrine System Diseases/complications , Endocrine System Diseases/pathology , Hepatitis, Autoimmune/pathology , Humans , Liver/pathology , Liver Diseases/pathology
5.
HNO ; 70(5): 333-344, 2022 May.
Article in English | MEDLINE | ID: mdl-35364686

ABSTRACT

BACKGROUND: Ultrasonography has become an essential tool for the evaluation and management of thyroid and parathyroid diseases. Its applications extend beyond neck endocrine conditions to a multitude of pathologies within the head and neck region. OBJECTIVES: Our study aimed to: (1) provide a broad review of neck ultrasonography and key findings in neck endocrine diseases; (2) support skilled performance office-based diagnostic ultrasonography and its varied applications. MATERIALS AND METHODS: A review of the current literature was supplemented with clinical examples of key ultrasonographic findings. RESULTS: Current applications and key findings of ultrasonography in the diagnosis and management of neck endocrine conditions are reviewed. CONCLUSION: Ultrasonography is a fundamental component in the evaluation and management of neck endocrine diseases. The reader is encouraged to use this review to enhance office-based performance and application of ultrasonography.


Subject(s)
Endocrine System Diseases , Thyroid Diseases , Endocrine System Diseases/pathology , Humans , Neck/diagnostic imaging , Parathyroid Glands/diagnostic imaging , Parathyroid Glands/pathology , Thyroid Diseases/diagnostic imaging , Thyroid Gland/diagnostic imaging , Ultrasonography
6.
Chinese Journal of Hepatology ; (12): 352-356, 2022.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-935953

ABSTRACT

As a secondary endocrine organ, the liver is closely related to the endocrine system. Liver involvement is not uncommon in endocrine diseases, such as hyper/hypothyroidism, diabetes, dysfunction of adrenal and gonadal. It can be manifested in a variety of forms, including hepatocyte injury (elevated transaminase), bile duct injury (cholestasis), hepatocyte steatosis, vascular injury and liver tumor. Direct and indirect liver injury caused by abnormal hormone levels and side effects of drugs for the treatment of endocrine diseases are common pathogenesis. In addition, endocrine diseases can be concomitant with liver diseases, such as autoimmune thyroiditis and autoimmune hepatitis. Systemic diseases can also involve the endocrine system and liver at the same time, such as systemic lupus erythematosus and IgG4 related diseases. For patients with unexplained liver injury, endocrine system diseases should be considered as the differential diagnosis.


Subject(s)
Humans , Cholestasis/pathology , Endocrine System Diseases/pathology , Hepatitis, Autoimmune/pathology , Liver/pathology , Liver Diseases/pathology
7.
Front Immunol ; 12: 711741, 2021.
Article in English | MEDLINE | ID: mdl-34539642

ABSTRACT

COVID-19 is widespread worldwide and seriously affects the daily life and health of humans. Countries around the world are taking necessary measures to curb the spread. However, COVID-19 patients often have at least one organ complication and sequelae in addition to respiratory symptoms. Controlling the epidemic is only a phased victory, and the complication and sequelae of COVID-19 will need more attention in the post-epidemic era. We collected general information from over 1000 articles published in 2020 after the COVID-19 outbreak and systematically analyzed the complication and sequelae associated with eight major systems in COVID-19 patients caused by ACE2 intervention in the RAS regulatory axis. The autoimmune response induced by 2019-nCoV attacks and damages the normal tissues and organs of the body. Our research will help medical workers worldwide address COVID-19 complication and sequelae.


Subject(s)
COVID-19/pathology , Cardiovascular Diseases/pathology , Endocrine System Diseases/pathology , Gastrointestinal Diseases/pathology , Nervous System Diseases/pathology , Urologic Diseases/pathology , COVID-19/complications , Cardiovascular Diseases/virology , Disease Outbreaks , Disease Progression , Endocrine System Diseases/virology , Gastrointestinal Diseases/virology , Humans , Nervous System Diseases/virology , SARS-CoV-2 , Urologic Diseases/virology
8.
Front Endocrinol (Lausanne) ; 12: 704620, 2021.
Article in English | MEDLINE | ID: mdl-34335475

ABSTRACT

Hydrogen sulfide (H2S), as one of the three known gaseous signal transduction molecules in organisms, has attracted a surging amount of attention. H2S is involved in a variety of physiological and pathological processes in the body, such as dilating blood vessels (regulating blood pressure), protecting tissue from ischemia-reperfusion injury, anti-inflammation, carcinogenesis, or inhibition of cancer, as well as acting on the hypothalamus and pancreas to regulate hormonal metabolism. The change of H2S concentration is related to a variety of endocrine disorders, and the change of hormone concentration also affects the synthesis of H2S. Understanding the effect of biosynthesis and the concentration of H2S on the endocrine system is useful to develop drugs for the treatment of hypertension, diabetes, and other diseases.


Subject(s)
Endocrine System Diseases/pathology , Hydrogen Sulfide/metabolism , Animals , Endocrine System Diseases/etiology , Endocrine System Diseases/metabolism , Humans
9.
Nat Rev Endocrinol ; 17(8): 497-510, 2021 08.
Article in English | MEDLINE | ID: mdl-34135504

ABSTRACT

The death of endocrine cells is involved in type 1 diabetes mellitus, autoimmunity, adrenopause and hypogonadotropism. Insights from research on basic cell death have revealed that most pathophysiologically important cell death is necrotic in nature, whereas regular metabolism is maintained by apoptosis programmes. Necrosis is defined as cell death by plasma membrane rupture, which allows the release of damage-associated molecular patterns that trigger an immune response referred to as necroinflammation. Regulated necrosis comes in different forms, such as necroptosis, pyroptosis and ferroptosis. In this Perspective, with a focus on the endocrine environment, we introduce these cell death pathways and discuss the specific consequences of regulated necrosis. Given that clinical trials of necrostatins for the treatment of autoimmune conditions have already been initiated, we highlight the therapeutic potential of such novel therapeutic approaches that, in our opinion, should be tested in endocrine disorders in the future.


Subject(s)
Endocrine System Diseases/etiology , Necrosis/physiopathology , Animals , Apoptosis/physiology , Cell Death/physiology , Endocrine System Diseases/pathology , Endocrine System Diseases/physiopathology , Endocrine System Diseases/therapy , Humans , Signal Transduction/physiology , Therapies, Investigational/methods , Therapies, Investigational/trends
11.
Anticancer Res ; 41(2): 557-565, 2021 Feb.
Article in English | MEDLINE | ID: mdl-33517261

ABSTRACT

Long non-coding RNAs (lncRNAs) are over 200 nucleotides long recently discovered RNA molecules that are not involved in the translation process. Accumulating evidence shows that H19 lncRNA is an important regulator of gene expression and its altered expression contributes to carcinogenesis. The aim of this review was to reveal current knowledge about H19 lncRNA and its impact on tumours of the endocrine system. We present findings about H19 altered regulation and its association with tumorigenesis, cancer progression and differentiation, and its potential use in diagnostics, prognostics and therapy. The mechanism and molecular pathways involved in these processes are discussed.


Subject(s)
Cell Transformation, Neoplastic/metabolism , Endocrine System Diseases/metabolism , Endocrine System/metabolism , Neoplasms/metabolism , RNA, Long Noncoding/metabolism , Animals , Cell Differentiation , Cell Proliferation , Cell Transformation, Neoplastic/genetics , Cell Transformation, Neoplastic/pathology , Endocrine System/pathology , Endocrine System Diseases/genetics , Endocrine System Diseases/pathology , Gene Expression Regulation, Neoplastic , Humans , Neoplasms/genetics , Neoplasms/pathology , RNA, Long Noncoding/genetics , Signal Transduction
12.
Nucleic Acids Res ; 49(D1): D1218-D1224, 2021 01 08.
Article in English | MEDLINE | ID: mdl-32941628

ABSTRACT

Infertility is a complex multifactorial disease that affects up to 10% of couples across the world. However, many mechanisms of infertility remain unclear due to the lack of studies based on systematic knowledge, leading to ineffective treatment and/or transmission of genetic defects to offspring. Here, we developed an infertility disease database to provide a comprehensive resource featuring various factors involved in infertility. Features in the current IDDB version were manually curated as follows: (i) a total of 307 infertility-associated genes in human and 1348 genes associated with reproductive disorder in 9 model organisms; (ii) a total of 202 chromosomal abnormalities leading to human infertility, including aneuploidies and structural variants; and (iii) a total of 2078 pathogenic variants from infertility patients' samples across 60 different diseases causing infertility. Additionally, the characteristics of clinically diagnosed infertility patients (i.e. causative variants, laboratory indexes and clinical manifestations) were collected. To the best of our knowledge, the IDDB is the first infertility database serving as a systematic resource for biologists to decipher infertility mechanisms and for clinicians to achieve better diagnosis/treatment of patients from disease phenotype to genetic factors. The IDDB is freely available at http://mdl.shsmu.edu.cn/IDDB/.


Subject(s)
Chromosome Aberrations , Databases, Factual , Endocrine System Diseases/genetics , Infertility, Female/genetics , Infertility, Male/genetics , Mutation , Animals , Chromosome Mapping , Disease Models, Animal , Endocrine System Diseases/metabolism , Endocrine System Diseases/pathology , Female , Gene Expression Profiling , Gene Expression Regulation , Genetic Predisposition to Disease , Genome, Human , Humans , Infertility, Female/metabolism , Infertility, Female/pathology , Infertility, Male/metabolism , Infertility, Male/pathology , Internet , Male , Oocytes/metabolism , Oocytes/pathology , Software , Spermatozoa/metabolism , Spermatozoa/pathology
13.
J Steroid Biochem Mol Biol ; 206: 105797, 2021 02.
Article in English | MEDLINE | ID: mdl-33259940

ABSTRACT

For several decades now, the analysis of steroids has been a key tool in the diagnosis and monitoring of numerous endocrine pathologies. Thus, the available methods used to analyze steroids in biological samples have dramatically evolved over time following the rapid pace of technology and scientific knowledge. This review aims to synthetize the advances in steroids' analysis, from classical approaches considering only a few steroids or a limited number of steroid ratios, up to the new steroid profiling strategies (steroidomics) monitoring large sets of steroids in biological matrices. In this context, the use of liquid chromatography coupled to mass spectrometry has emerged as the technique of choice for the simultaneous determination of a high number of steroids, including phase II metabolites, due to its sensitivity and robustness. However, the large dynamic range to be covered, the low natural abundance of some key steroids, the selectivity of the analytical methods, the extraction protocols, and the steroid ionization remain some of the current challenges in steroid analysis. This review provides an overview of the different analytical workflows available depending on the number of steroids under study. Special emphasis is given to sample treatment, acquisition strategy, data processing, steroid identification and quantification using LC-MS approaches. This work also outlines how the availability of steroid standards, the need for complementary analytical strategies and the improvement of calibration approaches are crucial for achieving complete steroidome quantification.


Subject(s)
Chromatography, Liquid/trends , Endocrine System Diseases/blood , Steroids/isolation & purification , Tandem Mass Spectrometry/trends , Chromatography, High Pressure Liquid , Endocrine System Diseases/pathology , Humans , Steroids/blood
14.
Pediatr Blood Cancer ; 68(2): e28815, 2021 02.
Article in English | MEDLINE | ID: mdl-33226170

ABSTRACT

The treatment of malignancy in cancer predisposition syndromes that also confer exquisite sensitivity to standard chemotherapy and radiation regimens remains a challenge. Bloom syndrome is one such disorder that is caused by a defect in DNA repair, predisposing to the development of early-onset age-related medical conditions and malignancies. We report on two patients with Bloom syndrome who responded well to chemotherapy despite significant alterations to standard protocols necessitated by hypersensitivity. Both patients experienced severe toxicities and exacerbation of endocrine comorbidities during chemotherapy. A multidisciplinary team of oncologists and endocrinologists is best suited to care for this patient population.


Subject(s)
Antineoplastic Agents/therapeutic use , Bloom Syndrome/pathology , Endocrine System Diseases/pathology , Neoplasms/drug therapy , Antineoplastic Agents/adverse effects , Bloom Syndrome/genetics , DNA Repair/genetics , Female , Humans , Male , Neoplasms/pathology , RecQ Helicases/genetics , Young Adult
15.
J Clin Endocrinol Metab ; 106(2): e907-e916, 2021 01 23.
Article in English | MEDLINE | ID: mdl-33150438

ABSTRACT

CONTEXT: The rare hypoparathyroidism-retardation-dysmorphism (HRD) syndrome (OMIM #241410) is caused by the mutated tubulin chaperone E (TBCE) gene. This gene encodes a critical protein in the microtubule assembly pathway. OBJECTIVE: To evaluate the endocrine profile of patients with HRD. METHODS: The study used a retrospective analysis of a large cohort of patients in a single university medical center. Sixty-three patients were diagnosed with HRD during 1990 to 2019; 58 of them had an endocrine evaluation. MAIN OUTCOME MEASURES: We investigated somatic growth parameters, the prevalence of hypoglycemia, growth hormone deficiency, hypothyroidism, hypogonadism, and cortisol deficiency. RESULTS: All patients were born small for gestational age, and severe growth retardation was found in all patients with mean height standard deviation score (SDS) of -8.8 (range: -5.1 to -15.1) and weight SDS -18 (range: -5.1 to -61.2). Serum insulin-like growth factor-1 concentrations were very low among the 21 studied patients: -2.32 SDS (range: -0.6 to -2.7). Four out of 14 (28%) investigated patients had growth hormone deficiency, and 55% of patients were hospitalized due to symptomatic hypoglycemia. Adrenal glucocorticoid insufficiency was diagnosed in 22% of those tested. Hypothyroidism was found in 36% of patients. Both hypogonadotrophic and hypergonadotrophic hypogonadism were observed. The main magnetic resonance imaging findings were small anterior pituitary gland, small hippocampus, brain atrophy, thin corpus callosum, Chiari type I malformation, and septo-optic dysplasia. CONCLUSION: Multiple endocrine abnormalities are common in patients with HRD syndrome. Periodic screening of thyroid and adrenal functions is recommended.


Subject(s)
Abnormalities, Multiple/pathology , Endocrine System Diseases/pathology , Growth Disorders/complications , Hypoparathyroidism/complications , Intellectual Disability/complications , Osteochondrodysplasias/complications , Seizures/complications , Abnormalities, Multiple/epidemiology , Abnormalities, Multiple/etiology , Adolescent , Adult , Child , Child, Preschool , Endocrine System Diseases/epidemiology , Endocrine System Diseases/etiology , Female , Follow-Up Studies , Humans , Incidence , Infant , Infant, Newborn , Israel/epidemiology , Male , Prognosis , Retrospective Studies , Risk Factors , Young Adult
16.
Probl Radiac Med Radiobiol ; 25: 402-420, 2020 Dec.
Article in English, Ukrainian | MEDLINE | ID: mdl-33361850

ABSTRACT

OBJECTIVE: Analysis of comorbid pathology based on the use of methods for its quantitative assessment in personswho were exposed to radiation because of the Chornobyl accident. MATERIALS AND METHODS: Comorbid pathology was studied in 608 men, including 420 clean-up workers (CW) of theaccident consequences at the Chornobyl NPP (main group) and 188 non-irradiated persons (control group - CG). Allpatients had cardiovascular diseases as their main pathology and were examined in the cardiology department ofthe NRCRM hospital during 2011-2019. The groups did not differ by age, either at the beginning of the accident orat the time of their last examination. Patients of both groups before the accident were practically healthy peopleand were not registered at the dispensary. The Cumulative Illness Rating Scale (CIRS) was used to quantify comorbid pathology. RESULTS: Comorbid pathology was detected in 418 CW (99.5 %) and 183 patients of CG (99.3 %). The total score inCW (10.3 ± 2.9) units significantly (р = 0.000) exceeded the same index in non-irradiated patients (8.8 ± 3.0) units,as well as the mean number of CIRS categories, whose level severity was 1 point (3.3 ± 1.7 vs. 2.6 ± 1.5, р = 0.000),2 points (1.8 ± 1.0 vs. 1.6 ± 1.0, p = 0.032) and 3-4 points (1.2 ± 0.8 vs. 1.0 ± 0.9, р = 0.062). In contrast, the meanvalue of the categories with zero score, i.e. without diseases, was more common in CG (7.8 ± 1.8 vs. 8.8 ± 1.7,р = 0.000). The most common pathology in CW and CG were heart (98.3 % vs. 94.7 %, р < 0.05) and vascular diseases(92.9 % vs. 87.8 %, р > 0.05), followed by diseases of nervous system (79.0 % vs. 57.4 %, р <0.001), musculoskeletal system and skin (69.8 % vs. 56.9 %, р < 0.01), endocrine (56.0 % vs. 49,5 %, р > 0.05) and the respiratory system (53.8 % vs. 53.7 %, р > 0.05) and liver (51.2 % vs. 36.2 %, р < 0.001), which were detected more than in halfpatients of the main group. Diseases of the kidneys (3.3 % vs. 4.8 %, р > 0.05) and lower gastrointestinal tract(3.3 % vs. 0.5 %, р < 0.01) were quite rare. The incidence of the other four CIRS categories was 18.6-34 %. The totalscore in subgroups with different ages varied in descending order of mean values as follows: CW > 65 years (10.5 ± 2.9)units, CW < 65 years (9.9 ± 2.8) units, CG > 65 years (9.5 ± 2.8) units and CG < 65 years (7.8 ± 2.9) units with significant differences both between age subgroups in each of the groups and between CW and CG older subgroups. CONCLUSIONS: Quantitative assessment of comorbidity by CIRS showed that in persons irradiated during their emergency work due to the Chornobyl accident, the incidence of combined pathology of such organ systems as cardiovascular, nervous, endocrine, hematopoietic, urogenital, musculoskeletal, gastrointestinal, liver and kidneys wassignificantly higher than in non-irradiated patients. In irradiated patients, the course of comorbid pathology wasmore severe for each system and in general, reflecting higher values of the total CIRS score. Both among CW andnon-irradiated controls, higher values of the total comorbidity score were observed in patients 65 years and older,compared with younger individuals. In both age subgroups of CW the total score was higher than in patients of thecontrol group.


Subject(s)
Cardiovascular Diseases/pathology , Chernobyl Nuclear Accident , Endocrine System Diseases/pathology , Liver Diseases/pathology , Lung Diseases/pathology , Musculoskeletal Diseases/pathology , Nervous System Diseases/pathology , Radiation Injuries/pathology , Age Factors , Aged , Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/etiology , Case-Control Studies , Comorbidity , Emergency Responders , Endocrine System Diseases/epidemiology , Endocrine System Diseases/etiology , Humans , Liver Diseases/epidemiology , Liver Diseases/etiology , Lung Diseases/epidemiology , Lung Diseases/etiology , Male , Middle Aged , Musculoskeletal Diseases/epidemiology , Musculoskeletal Diseases/etiology , Nervous System Diseases/epidemiology , Nervous System Diseases/etiology , Radiation Exposure/adverse effects , Radiation Injuries/epidemiology , Radiation Injuries/etiology , Severity of Illness Index , Ukraine/epidemiology
17.
Article in English | MEDLINE | ID: mdl-32849305

ABSTRACT

McCune-Albright syndrome is a rare and challenging congenital sporadic disease involving the skin and skeletal and endocrine systems with a prevalence ranges from one in 100,000 to 1,000,000. In addition to the classical triad of fibrous dysplasia of bone, café au lait pigmented skin lesions and precocious puberty, other multiple endocrinological features, including hyperthyroidism, growth hormone excess, hypercortisolism, and hypophosphatemic rickets, have been reported. A brief review of the syndrome in children is here reported.


Subject(s)
Endocrine System Diseases/pathology , Fibrous Dysplasia, Polyostotic/physiopathology , Growth Disorders/pathology , Child , Humans
19.
Head Neck ; 42(6): 1325-1328, 2020 06.
Article in English | MEDLINE | ID: mdl-32437031

ABSTRACT

BACKGROUND: In the face of the COVID-19 pandemic, cancer care has had to adapt rapidly given the Centers for Disease Control and Prevention and the American College of Surgeons (ACS) issuing recommendations to postpone nonurgent surgeries. METHODS: An institutional multidisciplinary group of Head and Neck Surgical Oncology, Surgical Endocrinology, and Medical Endocrinology devised Surgical Triaging Guidelines for Endocrine Surgery during COVID-19, aligned with phases of care published by the ACS. RESULTS: Phases of care with examples of corresponding endocrine cases are outlined. Most cases can be safely postponed with active surveillance, including most differentiated and medullary thyroid cancers. During the most acute phase, all endocrine surgeries are deferred, except thyroid tumors requiring acute airway management. CONCLUSIONS: These guidelines provide context for endocrine surgery within the spectrum of surgical oncology, with the goal of optimal individualized multidisciplinary patient care and the expectation of significant resource diversion to care for patients with COVID-19.


Subject(s)
Betacoronavirus , Coronavirus Infections/epidemiology , Endocrine System Diseases/surgery , Patient Selection , Pneumonia, Viral/epidemiology , Triage , Algorithms , COVID-19 , Coronavirus Infections/prevention & control , Coronavirus Infections/transmission , Endocrine System Diseases/pathology , Humans , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Pneumonia, Viral/transmission , Practice Guidelines as Topic , SARS-CoV-2
20.
Eur J Endocrinol ; 182(6): R101, 2020 Jun.
Article in English | MEDLINE | ID: mdl-32234976

ABSTRACT

Sexual function is an important component of either general health and quality of life in both genders. Many studies have focused on the different risk factors for sexual dysfunctions, proving an association with several medical conditions. Endocrine disorders have been often mentioned in the pathogenesis of female and male sexual dysfunctions; however, particularly in women, sexual function is rarely addressed during clinical, in general, and endocrinological, in particular, consultations. As a thorough diagnosis is required in order to provide an adequately tailored treatment, knowing how each endocrine dysfunction can impair sexual health is of the utmost importance, considering the high prevalence of conditions such as disorders of pituitary, thyroid, adrenal, gonads, as well as metabolic disorders. We performed a thorough review of existing literature on the different mechanisms involved in the pathogenesis of female sexual dysfunctions secondary to endocrine disorders in order to provide an up-to-date reference.


Subject(s)
Sexual Dysfunction, Physiological/pathology , Sexual Dysfunctions, Psychological/pathology , Disease Management , Endocrine System Diseases/complications , Endocrine System Diseases/pathology , Female , Humans , Sexual Dysfunction, Physiological/etiology , Sexual Dysfunctions, Psychological/etiology
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