Subject(s)
Carbapenem-Resistant Enterobacteriaceae , Cross Infection , Enterobacter cloacae , Enterobacteriaceae Infections , Ertapenem/pharmacology , Infection Control , Anti-Bacterial Agents/classification , Anti-Bacterial Agents/pharmacology , Bacterial Proteins/analysis , Brazil/epidemiology , Carbapenem-Resistant Enterobacteriaceae/isolation & purification , Carbapenem-Resistant Enterobacteriaceae/physiology , Cross Infection/diagnosis , Cross Infection/epidemiology , Cross Infection/microbiology , Cross Infection/prevention & control , Drug Resistance, Bacterial/drug effects , Enterobacter cloacae/isolation & purification , Enterobacter cloacae/physiology , Enterobacteriaceae Infections/diagnosis , Enterobacteriaceae Infections/epidemiology , Enterobacteriaceae Infections/microbiology , Enterobacteriaceae Infections/prevention & control , Humans , Infection Control/methods , Infection Control/statistics & numerical data , Microbial Sensitivity Tests/methods , beta-Lactamases/analysisABSTRACT
INTRODUCTION: Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. METHODS: A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. RESULTS: The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). CONCLUSION: Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.