Your browser doesn't support javascript.
loading
: 20 | 50 | 100
1 - 20 de 18.623
1.
J Med Case Rep ; 18(1): 240, 2024 May 11.
Article En | MEDLINE | ID: mdl-38730409

BACKGROUND: People with achondroplasia exhibit distinct physical characteristics, but their cognitive abilities remain within the normal range. The challenges encountered during surgical procedures and perioperative care for achondroplastic individuals, are underrepresented in the existing literature. CASE PRESENTATION: In this report, the management of a 26-year-old North-African achondroplastic male is highlighted. The patient suffered a complete intra-articular distal femur fracture (AO/OTA 33-C1) and an ipsilateral patella fracture (AO/OTA 34-C1). The patient's unusual anatomical variations and the lack of suitable orthopedic implants posed significant surgical challenges, particularly in the context of a resource-limited developing country. Facial and spinal deformities, which are common in patients with achondroplasia, further complicated the anesthetic approach. CONCLUSIONS: The limited information on operative management of fractures in achondroplastic patients necessitated independent decision-making and diverging from the convenient approach where clear guidance is available in the literature.


Achondroplasia , Femoral Fractures , Patella , Humans , Adult , Male , Achondroplasia/complications , Femoral Fractures/surgery , Femoral Fractures/diagnostic imaging , Patella/injuries , Patella/surgery , Patella/diagnostic imaging , Intra-Articular Fractures/surgery , Intra-Articular Fractures/diagnostic imaging , Fracture Fixation, Internal/methods
2.
BMJ Case Rep ; 17(5)2024 May 02.
Article En | MEDLINE | ID: mdl-38697682

Tumour-induced osteomalacia is caused by tumorous production of fibroblast growth factor 23 (FGF23) leading to urinary phosphate wasting, hypophosphataemia and decreased vitamin D activation. The resulting osteomalacia presents with muscle weakness and bone pain but progresses to multiple pathological fractures. Patients often remain undiagnosed for years with severe physical, psychological and economic ramifications. A young woman presented with multiple spontaneous fractures including bilateral femoral fractures. Laboratory tests revealed severe hypophosphataemia, elevated bone turnover markers and low to normal calcium and 25-hydroxy-vitamin D levels. Treatment with phosphate, alfalcalcidol, calcium and magnesium was initiated. 68Gallium-DOTATOC positron emission tomography imaging revealed a mass in the right foot and venous sampling of FGF23 from all extremities confirmed this tumour as the culprit. Biopsy and histology were consistent with a phosphaturic mesenchymal tumour, which was surgically resected. Phosphate levels quickly normalised postoperatively but a long convalescence with hungry bone syndrome, fracture healing and physical therapy followed.


Fibroblast Growth Factor-23 , Neoplasms, Connective Tissue , Osteomalacia , Humans , Osteomalacia/etiology , Female , Neoplasms, Connective Tissue/diagnosis , Neoplasms, Connective Tissue/surgery , Adult , Paraneoplastic Syndromes/diagnosis , Hypophosphatemia/etiology , Fibroblast Growth Factors/blood , Femoral Fractures/surgery , Femoral Fractures/diagnostic imaging , Fractures, Spontaneous/etiology , Fractures, Spontaneous/surgery , Fractures, Spontaneous/diagnostic imaging , Phosphates/blood
3.
Sci Rep ; 14(1): 12046, 2024 05 27.
Article En | MEDLINE | ID: mdl-38802519

Hip fractures exceed 250,000 cases annually in the United States, with the worldwide incidence projected to increase by 240-310% by 2050. Hip fractures are predominantly diagnosed by radiologist review of radiographs. In this study, we developed a deep learning model by extending the VarifocalNet Feature Pyramid Network (FPN) for detection and localization of proximal femur fractures from plain radiography with clinically relevant metrics. We used a dataset of 823 hip radiographs of 150 subjects with proximal femur fractures and 362 controls to develop and evaluate the deep learning model. Our model attained 0.94 specificity and 0.95 sensitivity in fracture detection over the diverse imaging dataset. We compared the performance of our model against five benchmark FPN models, demonstrating 6-14% sensitivity and 1-9% accuracy improvement. In addition, we demonstrated that our model outperforms a state-of-the-art transformer model based on DINO network by 17% sensitivity and 5% accuracy, while taking half the time on average to process a radiograph. The developed model can aid radiologists and support on-premise integration with hospital cloud services to enable automatic, opportunistic screening for hip fractures.


Deep Learning , Radiography , Humans , Female , Male , Aged , Radiography/methods , Hip Fractures/diagnostic imaging , Middle Aged , Aged, 80 and over , Femoral Fractures/diagnostic imaging , Sensitivity and Specificity , Neural Networks, Computer , Proximal Femoral Fractures
4.
Eur Rev Med Pharmacol Sci ; 28(8): 3165-3175, 2024 Apr.
Article En | MEDLINE | ID: mdl-38708475

OBJECTIVE: Periprosthetic fractures following total knee replacement are rare but challenging. The goal of the treatment is to achieve the most stable fixation that allows early mobilization. Therefore, the aim of this study was to evaluate the biomechanical results of the use of different fixation systems in the treatment of distal femur periprosthetic fractures with finite element analysis. MATERIALS AND METHODS: A total knee prosthesis was implanted in Sawbone femur models. A transverse fracture line was created in the supracondylar region and was fixed in four different groups. In group 1, fracture line fixation was fixed using retrograde intramedullary nailing. In group 2, fixation was applied using a lateral anatomic distal femoral. In group 3, in addition to the fixation made in group 1, a lateral anatomic distal femoral plate was used. In group 4, in addition to the fixation made in group 2, a 3.5 mm Limited Contact Dynamic Compression Plate (LC-DCP) was applied medially. Computed Tomography (CT) scans were taken of the created models and were converted to three-dimensional models. Axial and rotational loading forces were applied to all the created models. RESULTS: The least deformation with axial loading was observed in the double plate group. Group 3 was determined to be more advantageous against rotational forces. The greatest movement in the fracture line was found in group 2. The application of the medial plate was determined to reduce the tension on the lateral plate and increase stability in the fracture line. CONCLUSIONS: Combining a lateral anatomic plate with intramedullary nailing or a medial plate was seen to be biomechanically more advantageous than using a lateral plate or intramedullary nailing alone in the treatment of distal femoral periprosthetic fractures.


Arthroplasty, Replacement, Knee , Bone Nails , Bone Plates , Femoral Fractures , Finite Element Analysis , Fracture Fixation, Intramedullary , Periprosthetic Fractures , Arthroplasty, Replacement, Knee/adverse effects , Femoral Fractures/surgery , Humans , Periprosthetic Fractures/surgery , Fracture Fixation, Intramedullary/instrumentation , Bone Screws , Biomechanical Phenomena
5.
Medicina (Kaunas) ; 60(5)2024 Apr 26.
Article En | MEDLINE | ID: mdl-38792901

Background and Objectives: This retrospective cohort study analyzes mechanical complications in hip fracture surgery using the Trochanteric Fixation Nail-Advanced (TFNA) implant. It investigates the correlation of these complications with demographic, intraoperative, and radiological factors, aiming to identify associated risk factors and suggest improvements in clinical surveillance and treatment strategies. Materials and Methods: We enrolled 253 patients diagnosed with pertrochanteric hip fractures treated between 2017 and 2021, with 126 meeting the criteria for a minimum 6-month follow-up. Data on demographics, American Anesthesia Association Classification (ASA), comorbidities, AO/OTA [AO (Arbeitsgemeinschaft für Osteosynthesefragen)/OTA (Orthopedic Trauma Association)] fracture classification, procedural details, and time to failure were collected. Radiographs were evaluated for reduction quality, the tip-apex distance (TAD), progressive varus deviation, and identification of mechanical complications. Statistical analysis was performed using SPSS software. Results: The predominant AO/OTA fracture classification was 31A2 in 67 cases (52.7%). Reduction quality was deemed good or acceptable in 123 cases (97.6%). The mean time to failure was 4.5 months (range: 2.2-6). The average TAD was 18 mm (range: 1.2-36), with a mean progressive varus deviation of 2.44° (range: 1.30-4.14). A good or acceptable reduction quality was observed in 97.6% of cases. Mechanical complications occurred in 21.4% of patients, with significant associations found with the lateral cortex fracture, use of a TFNA implant with a 130° angle, open reduction, and absence of prior osteoporosis treatment. Conclusions: The study provides insights into mechanical complications in proximal femur fractures treated with the TFNA nail, emphasizing the need for enhanced clinical and radiographic surveillance, especially in patients without osteoporosis treatment. Our findings support the necessity for further clinical studies comparing these outcomes with other implant designs and underscore the importance of personalized treatment strategies to reduce complication rates.


Fracture Fixation, Intramedullary , Postoperative Complications , Humans , Retrospective Studies , Female , Male , Fracture Fixation, Intramedullary/methods , Fracture Fixation, Intramedullary/adverse effects , Fracture Fixation, Intramedullary/instrumentation , Aged , Aged, 80 and over , Middle Aged , Postoperative Complications/etiology , Hip Fractures/surgery , Bone Nails , Cohort Studies , Femoral Fractures/surgery , Risk Factors , Proximal Femoral Fractures
6.
BMC Musculoskelet Disord ; 25(1): 413, 2024 May 27.
Article En | MEDLINE | ID: mdl-38802816

BACKGROUND: Femoral fractures significantly contribute to disability, predominantly in the elderly. Despite this, data on postoperative pneumonia following femoral fracture surgeries remains sparse. Our study sought to explore the incidence and impact of postoperative pneumonia on outcomes following such surgeries. METHODS: A retrospective study analyzed femoral fracture patients hospitalized from 2016 to 2022. We scrutinized postoperative outcomes, including pneumonia, hospital stay duration, intensive care unit (ICU) admissions, and in-hospital mortality. We established stringent diagnostic criteria for postoperative pneumonia, incorporating both clinical signs and radiological evidence, excluding patients with prior infections or those discharged within 24 h post-surgery. Statistical analyses involved Chi-square and t-tests, linear regression, and logestic regression using SPSS. RESULTS: Out of 636 patients, 10.8% were diagnosed with postoperative pneumonia. The average age was 79.55 ± 8.57 years, with a male prevalence of 47.8%. Common comorbidities were hypertension (78.3%), diabetes (60.9%), and cardiovascular diseases (40.6%). Surgical interventions were categorized as intramedullary nailing (40.6%), partial hip replacement (37.7%), and dynamic hip screw (21.7%). Postoperative pneumonia was associated with older age (AOR = 1.053, 95% CI 1.020 to 1.087, p = 0.002), ICU admission (AOR = 2.283, 95% CI 1.256 to 4.148, p = 0.007), and longer length of hospital stay (AOR = 1.079, 95% CI 1.030 to 1.130, p = 0.001). The presence of pneumonia was associated with a 2.621-day increase in hospitalization after adjusting for other variables (p < 0.001, 95% CI: 1.454 to 3.789). CONCLUSION: This study accentuates the clinical significance of postoperative pneumonia in femoral fracture patients, with a noted incidence of 10.8%. A notable association with older age, prolonged hospital stays, and ICU admissions was observed, underscoring the necessity of addressing this complication to improve patient outcomes and healthcare resource allocation.


Femoral Fractures , Length of Stay , Pneumonia , Postoperative Complications , Humans , Male , Retrospective Studies , Female , Aged , Femoral Fractures/surgery , Femoral Fractures/epidemiology , Pneumonia/epidemiology , Pneumonia/etiology , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Aged, 80 and over , Length of Stay/statistics & numerical data , Incidence , Hospital Mortality , Risk Factors , Middle Aged , Fracture Fixation, Intramedullary/adverse effects , Prevalence , Intensive Care Units/statistics & numerical data , Arthroplasty, Replacement, Hip/adverse effects
7.
Open Vet J ; 14(4): 1012-1018, 2024 Apr.
Article En | MEDLINE | ID: mdl-38808286

Background: The bone regeneration potential of erythropoietin (EPO) is not yet fully investigated, but some previous experimental studies demonstrated that its application activated the differentiation of osteoblasts and promoted bone formation. Aim: The aim of the present study was to evaluate the effects of recombinant human erythropoietin (rhEpo) on bone healing in cats with fragmented long bone fractures. Methods: Twelve cats were divided into two groups-control (n = 6) in which physiological saline was applied at the fracture gap site and EPO (n = 6) with the application of 1,000 IU rhEpo. The effects of EPO on blood erythrocyte counts, hemoglobin content, and hematocrit were monitored by serial complete blood cell tests, whereas bone formation was evaluated by clinical and radiographic examinations on post-operative weeks 1, 2, 3, 4, 6, and 8. Results: All tested blood parameters were within the reference range. A faster fracture healing and full limb weight-bearing were observed in the EPO group, with statistically significant differences with respect to the control group. Conclusion: The obtained results confirmed that the local application of rhEpo promoted bone healing in cats with fragmented femoral fractures and increased bone callus strength without having significant systemic effects.


Erythropoietin , Femoral Fractures , Fracture Healing , Recombinant Proteins , Animals , Cats , Erythropoietin/pharmacology , Erythropoietin/administration & dosage , Recombinant Proteins/administration & dosage , Fracture Healing/drug effects , Femoral Fractures/veterinary , Femoral Fractures/drug therapy , Male , Female , Cat Diseases/drug therapy , Humans
8.
JBJS Case Connect ; 14(2)2024 Apr 01.
Article En | MEDLINE | ID: mdl-38728526

CASE: A 58-year-old woman with medical history of a left total hip arthroplasty performed by the direct anterior (DA) approach 2 years prior presented with left hip pain. She was found to have sustained a transverse Vancouver C periprosthetic femur fracture and an unstable periprosthetic pelvic fracture. CONCLUSIONS: This patient's case represents a previously not reported injury about a total hip arthroplasty-with disruption distal to the femoral implant and proximal to the acetabular implant, with the implant-to-bone interface unaffected. This case may guide future treatment of similar injuries.


Arthroplasty, Replacement, Hip , Periprosthetic Fractures , Humans , Female , Arthroplasty, Replacement, Hip/adverse effects , Middle Aged , Periprosthetic Fractures/surgery , Periprosthetic Fractures/etiology , Periprosthetic Fractures/diagnostic imaging , Femoral Fractures/surgery , Femoral Fractures/diagnostic imaging , Femoral Fractures/etiology
9.
Am J Case Rep ; 25: e943136, 2024 May 06.
Article En | MEDLINE | ID: mdl-38706183

BACKGROUND Hoffa fractures are an uncommon form of coronal fracture that impact the femoral condyle. As a result, they are not very prevalent. It is necessary to perform anatomical reduction and rigorous fixation on these fractures; however, there is no consensus among medical professionals on the surgical procedure and implant that would be the most successful in treating these fractures. CASE REPORT A 50-year-old woman who had poliomyelitis in her right lower limb presented with a displaced medial Hoffa fracture of her left knee. She had fallen and was suffering from poliomyelitis. The trauma that caused this fracture had a modest energy level. Open reduction and internal fixation with 2 retrograde cannulated screws were included in her surgical procedure. An approach known as the medial parapatellar route was used for this treatment. As part of her postoperative rehabilitation, she participated in physiotherapy, exercises that did not require weight bearing, exercises that used passive and active assistance, activities that involved partial and full weight bearing, and exercises that involved complete weight bearing. At the 2-year follow-up, the patient's left knee continued to be painless and stable, and it had unrestricted range of motion across the whole extremity. It was determined via radiographs that the fracture had healed without any problems or arthritic changes developing. She was able to walk without help and carry out her daily tasks since she was able to walk with the use of a cane. CONCLUSIONS Retrograde cannulated screws can be a reliable and successful choice for treatment of medial Hoffa fractures, with positive results according to both clinical and radiographic characteristics. Further research is needed to analyze the outcomes over a longer period of time and make comparisons between this technique and others.


Femoral Fractures , Fracture Fixation, Internal , Humans , Female , Middle Aged , Fracture Fixation, Internal/methods , Femoral Fractures/surgery , Femoral Fractures/diagnostic imaging , Bone Screws , Open Fracture Reduction , Poliomyelitis/complications , Hoffa Fracture
10.
BMC Vet Res ; 20(1): 188, 2024 May 10.
Article En | MEDLINE | ID: mdl-38730373

Femoral fractures are often considered lethal for adult horses because femur osteosynthesis is still a surgical challenge. For equine femur osteosynthesis, primary stability is essential, but the detailed physiological forces occurring in the hindlimb are largely unknown. The objective of this study was to create a numerical testing environment to evaluate equine femur osteosynthesis based on physiological conditions. The study was designed as a finite element analysis (FEA) of the femur using a musculoskeletal model of the loading situation in stance. Relevant forces were determined in the musculoskeletal model via optimization. The treatment of four different fracture types with an intramedullary nail was investigated in FEA with loading conditions derived from the model. The analyzed diaphyseal fracture types were a transverse (TR) fracture, two oblique fractures in different orientations (OB-ML: medial-lateral and OB-AP: anterior-posterior) and a "gap" fracture (GAP) without contact between the fragments. For the native femur, the most relevant areas of increased stress were located distally to the femoral head and proximally to the caudal side of the condyles. For all fracture types, the highest stresses in the implant material were present in the fracture-adjacent screws. Maximum compressive (-348 MPa) and tensile stress (197 MPa) were found for the GAP fracture, but material strength was not exceeded. The mathematical model was able to predict a load distribution in the femur of the standing horse and was used to assess the performance of internal fixation devices via FEA. The analyzed intramedullary nail and screws showed sufficient stability for all fracture types.


Femoral Fractures , Fracture Fixation, Internal , Hindlimb , Animals , Horses/physiology , Biomechanical Phenomena , Femoral Fractures/veterinary , Femoral Fractures/surgery , Fracture Fixation, Internal/veterinary , Fracture Fixation, Internal/methods , Hindlimb/surgery , Finite Element Analysis , Femur/surgery , Models, Biological , Weight-Bearing , Fracture Fixation, Intramedullary/veterinary , Fracture Fixation, Intramedullary/instrumentation
11.
J Orthop Surg Res ; 19(1): 303, 2024 May 20.
Article En | MEDLINE | ID: mdl-38769547

INTRODUCTION: The incidence of periprosthetic distal femur fractures (PDFF) is increasing as the number of total knee replacements becomes more common. This study compared the demographics, fracture characteristics, treatment, and outcomes of periprosthetic versus native distal femur fractures (NDFF). MATERIALS AND METHODS: This was a retrospective cohort study of patients ≥ 18 who underwent surgical fixation of NDFF or PDFF from 2012 to 2020 at a level-1 trauma center. The main variables collected included demographics, AO/OTA fracture classification, fixation construct, concomitant fractures, polytrauma rates, bone density, and reduction quality. Primary outcomes were unexpected return to the operating room (UROR), hospital length of stay, and quality of reduction. T-tests, Fisher's exact tests, and multivariate analyses were used for statistical analysis. RESULTS: 209 patients were identified, including 70 PDFF and 139 NDFF. PDFF patients were elderly females (81%) with isolated (80%) and comminuted (85%) 33 A.3 (71%) fractures. NDFF patients included 53% females, were commonly middle-aged, and displayed comminuted (92%) 33 C.2 fractures. 48% of NDFF patients had concomitant fractures. Intramedullary nailing was the primary fixation for both groups, followed by nail-plate combination (37%) for PDFF and lateral locking plates (21%) for NDFF. NDFF patients experienced significantly longer hospital stays, higher UROR rates, and worse quality of reduction (p < 0.05). PDFF patients had a significantly greater prevalence of low bone density (p < 0.05). CONCLUSION: PDFF occur as isolated injuries with significant metaphyseal comminution in elderly females with low bone quality. NDFF commonly occurs in younger patients with less metaphyseal comminution and concomitant fractures. Intramedullary nailing was the most common treatment for both groups, although preference for nail-plate combination fixation is increasing. NDFF type 33 C fractures are at greater risk of UROR.


Femoral Fractures , Fracture Fixation, Intramedullary , Periprosthetic Fractures , Humans , Female , Male , Retrospective Studies , Femoral Fractures/surgery , Aged , Middle Aged , Periprosthetic Fractures/etiology , Periprosthetic Fractures/surgery , Periprosthetic Fractures/epidemiology , Fracture Fixation, Intramedullary/methods , Aged, 80 and over , Arthroplasty, Replacement, Knee/adverse effects , Length of Stay/statistics & numerical data , Treatment Outcome , Adult , Cohort Studies , Femoral Fractures, Distal
12.
BMC Musculoskelet Disord ; 25(1): 389, 2024 May 18.
Article En | MEDLINE | ID: mdl-38762453

BACKGROUND: Several methods have been used for the treatment of pediatric distal femoral fractures, such as elastic stable intramedullary nail (ESIN), external fixator (EF) and plate osteosynthesis, but there has been no consensus about the optimal method. The purpose of this study was to compare the clinical outcome between EF and ESIN techniques used in metaphyseal-diaphyseal junction (MDJ) fractures of the pediatric distal femur. METHODS: We retrospectively analyzed operatively treated MDJ fractures of pediatric distal femur between January 2015 and January 2022. Patient charts were reviewed for demographics, injury and data of radiography. All of the patients were divided into EF and ESIN groups according to the operation techniques. Malalignment was defined as more than 5 degrees of angular deformity in either plane. Clinical outcomes were measured by Flynn scoring system. RESULTS: Thirty-eight patients were included in this study, among which, 23 were treated with EF, and 15 with ESIN. The mean follow-up time was 18 months (12-24 months). At the final follow-up, all of the fractures were healed. Although there were no statistical differences between the two groups in demographic data, length of stay, estimated blood loss (EBL), rate of open reduction, time to fracture healing and Flynn score, the EF was superior to ESIN in operative time, fluoroscopic exposure and time to partial weight-bearing. The EF group had a significantly higher rate of skin irritation, while the ESIN had a significantly higher rate of malalignment. CONCLUSION: EF and ESIN are both effective methods in the treatment of MDJ fractures of the pediatric distal femur. ESIN is associated with lower rates of skin irritation. However, EF technique has the advantages of shorter operative time, reduced fluoroscopic exposure, and shorter time to partial weight-bearing, as well as lower incidence of malalignment. LEVEL OF EVIDENCE: Level III.


Bone Nails , External Fixators , Femoral Fractures , Fracture Fixation, Intramedullary , Humans , Female , Male , Retrospective Studies , Femoral Fractures/surgery , Femoral Fractures/diagnostic imaging , Child , Fracture Fixation, Intramedullary/instrumentation , Fracture Fixation, Intramedullary/methods , Treatment Outcome , Case-Control Studies , Fracture Healing , Diaphyses/injuries , Diaphyses/surgery , Diaphyses/diagnostic imaging , Child, Preschool , Follow-Up Studies , Adolescent , Femur/surgery , Femur/diagnostic imaging
13.
Orthop Clin North Am ; 55(3): 311-321, 2024 Jul.
Article En | MEDLINE | ID: mdl-38782503

This report provides an updated analysis for patients with osteoporosis following total hip arthroplasty (THA). The comorbidities of alcohol abuse, chronic kidney disease, cerebrovascular disease, obesity, and rheumatoid arthritis continue to be significant risk factors for periprosthetic femur fracture (PPFFx) and aseptic loosening in the population with osteoporosis. Patients with dual-energy x-ray absorptiometric (DEXA) scans were at risk for PPFFx regardless of femoral fixation method, and patients with DEXA scans with cementless fixation were at risk of aseptic loosening after THA. The patient population with severe osteoporosis may have higher risks for aseptic loosening and PPFFx than previously recognized.


Arthroplasty, Replacement, Hip , Femoral Fractures , Osteoporosis , Periprosthetic Fractures , Prosthesis Failure , Humans , Arthroplasty, Replacement, Hip/adverse effects , Periprosthetic Fractures/etiology , Periprosthetic Fractures/epidemiology , Osteoporosis/etiology , Osteoporosis/complications , Risk Factors , Femoral Fractures/surgery , Femoral Fractures/etiology , Female , Male , Aged , Hip Prosthesis/adverse effects , Absorptiometry, Photon , Middle Aged
14.
J Am Acad Orthop Surg ; 32(11): e514-e522, 2024 Jun 01.
Article En | MEDLINE | ID: mdl-38626351

Subtrochanteric femur fractures have a reputation as difficult orthopaedic injuries to treat. Strong deforming forces, including the hip musculature and high physiologic forces, must be counteracted to obtain and maintain reduction. Adding to the complexity is a wide variety of fracture morphologies that must be recognized to execute an appropriate surgical plan. The challenging nature of this injury is demonstrated by nonunion rates of 4% to 5%, but some series have reports of up to 15% and malunion rates of 10% to 15%. Improved outcomes have been shown to be dependent on appropriate reduction and stable fixation, which can be achieved with less surgical insult. The treating surgeon must have a thorough understanding of the injury characteristics and reduction techniques to appropriately execute minimally invasive techniques for these difficult fractures.


Bone Nails , Fracture Fixation, Intramedullary , Hip Fractures , Minimally Invasive Surgical Procedures , Humans , Minimally Invasive Surgical Procedures/methods , Hip Fractures/surgery , Fracture Fixation, Intramedullary/methods , Fracture Fixation, Internal/methods , Femoral Fractures/surgery
15.
Ortop Traumatol Rehabil ; 26(1): 369-373, 2024 Feb 29.
Article En | MEDLINE | ID: mdl-38646902

BACKGROUND: Pediatric femoral fractures are common in emergency rooms, with treatment options varying by age. This study compares elastic stable intramedullary nailing (ESIN) and plate fixation for diaphyseal femoral fractures in children aged 5-10. MATERIAL AND METHODS: Conducted at Al-Kindi Teaching Hospital, Baghdad, from December 2017 to December 2019, this prospective study included 32 children with closed transverse diaphyseal femoral fractures. Patients were divided into two groups: 16 treated with ESIN (Group 1) and 16 with plate fixation (Group 2). Criteria excluded comminuted, open, or pathological fractures. RESULTS: Group 1 had a mean age of 7.1 years and weight of 23.7 kg; Group 2 had a mean age of 7.8 years and weight of 30.9 kg. ESIN resulted in shorter operative times (58.4 minutes), earlier weight-bearing, and quicker fracture union (8.8 weeks) compared to plate fixation (76.3 minutes, 11.9 weeks). Blood loss was significantly less in Group 1 (32.8 ml) versus Group 2 (205.0 ml). No significant differences in wound healing or leg length discrepancies were observed. CONCLUSIONS: 1. Our study indicates a preference for Elastic Stable Intramedullary Nailing (ESIN) over plate fixation for pediatric femoral shaft fractures in children aged 5-10 years. 2. ESIN is associated with shorter operative times and faster commencement of weight-bearing, critical in pediatric recovery. 3. While ESIN is generally preferable, plate fixation may be better suited in certain clinical scenarios, emphasizing the importance of personalized treatment. 4. Based on our findings, ESIN is recommended for treating transverse diaphyseal femur fractures in the specified pediatric age group. 5. Recommends further studies, including randomized controlled trials, for a more comprehensive understanding of these treatments' long-term outcomes.


Bone Plates , Femoral Fractures , Fracture Fixation, Intramedullary , Humans , Child , Fracture Fixation, Intramedullary/methods , Fracture Fixation, Intramedullary/instrumentation , Femoral Fractures/surgery , Prospective Studies , Female , Male , Child, Preschool , Treatment Outcome , Fracture Healing
16.
J Am Acad Orthop Surg ; 32(9): 373-380, 2024 May 01.
Article En | MEDLINE | ID: mdl-38639649

Pediatric femur fractures in children aged 5 to 11 years are typically classified as length-stable versus length-unstable. For length-stable fracture patterns, there is frequent consensus among pediatric orthopaedic specialists regarding the appropriateness of flexible intramedullary nails, submuscular plates (SMP), or lateral-entry rigid intramedullary nails (LE-RIMN). With length-unstable fracture patterns, however, the decision is more complex. Age, weight, fracture pattern, fracture location, surgical technique, surgeon experience, several implant-specific details, and additional factors are all important when choosing between flexible intramedullary nail, SMP, and LE-RIMN. These familiar methods of fixation may all be supported by conflicting and sometimes heterogeneous data. When planning to treat length-unstable fractures in young children, surgeons should understand evidence-based details associated with each implant and how each patient-specific scenario affects perioperative decisions.


Femoral Fractures , Fracture Fixation, Intramedullary , Humans , Child , Child, Preschool , Femoral Fractures/surgery , Fracture Fixation, Intramedullary/methods , Bone Nails , Bone Plates , Femur/surgery , Treatment Outcome , Retrospective Studies
17.
Zhongguo Gu Shang ; 37(4): 406-10, 2024 Apr 25.
Article Zh | MEDLINE | ID: mdl-38664213

OBJECTIVE: To investigate the efficacy of antibiotic cement column combined with iliac bone graft in the treatment of open fracture with bone defect of distal femur. METHODS: From October 2014 to March 2021, 16 patients of open fracture bone defect of distal femur were treated with antibiotic bone cement column and iliac bone graft, including 12 males and 4 females. The age ranged from 28 to 68 years old. There were 11 cases of traffic accident injury, 5 cases of falling injury, 3 cases as Gustilo type Ⅰ, 5 cases as type Ⅱ and 8 cases as type ⅢA. AO classification was used:9 cases of C2 type and 7 cases of C3 type. The time from injury to final bone grafting ranged from 4 to 119 days. The length of bone defect ranged from 2 to10 cm. Fractures healing time, complications and knee function Merchan score were recorded. RESULTS: All the 16 patients were followed up from 9 to 29 months. The incisions of 16 patients healed in one stage without postoperative infection, plate fracture, limb shortening and valgus and varus deformity. The healing time randed from 4 to 10 months . Knee joint function according to the Merchant scoring standard, showed that 8 cases were excellent, 4 cases were good, 3 cases were fair, and 1 case was poor. CONCLUSION: The use of antibiotic bone cement column combined with iliac bone graft in the treatment of open and complex bone defects of distal femur is an effective surgical method to prevent infection, assist fracture reduction, increase fixation strength and significantly reduce the amount of bone grafting.


Anti-Bacterial Agents , Bone Cements , Bone Transplantation , Fractures, Open , Humans , Male , Female , Middle Aged , Adult , Bone Transplantation/methods , Aged , Fractures, Open/surgery , Anti-Bacterial Agents/administration & dosage , Femur/surgery , Femoral Fractures/surgery
18.
PLoS One ; 19(4): e0298086, 2024.
Article En | MEDLINE | ID: mdl-38626076

Non-thermal atmospheric-pressure plasma (NTAPP) is attracting widespread interest for use in medical applications. The tissue repair capacity of NTAPP has been reported in various fields; however, little is known about its effect on fracture healing. Non-union or delayed union after a fracture is a clinical challenge. In this study, we aimed to investigate how NTAPP irradiation promotes fracture healing in a non-union fracture model and its underlying mechanism, in vitro and in vivo. For the in vivo study, we created normal and non-union fracture models in LEW/SsNSlc rats to investigate the effects of NTAPP. To create a fracture, a transverse osteotomy was performed in the middle of the femoral shaft. To induce the non-union fracture model, the periosteum surrounding the fracture site was cauterized after a normal fracture model was created. The normal fracture model showed no significant difference in bone healing between the control and NTAPP-treated groups. The non-union fracture model demonstrated that the NTAPP-treated group showed consistent improvement in fracture healing. Histological and biomechanical assessments confirmed the fracture healing. The in vitro study using pre-osteoblastic MC3T3-E1 cells demonstrated that NTAPP irradiation under specific conditions did not reduce cell proliferation but did enhance osteoblastic differentiation. Overall, these results suggest that NTAPP is a novel approach to the treatment of bone fractures.


Femoral Fractures , Fractures, Bone , Plasma Gases , Rats , Animals , Fracture Healing , Plasma Gases/pharmacology , Plasma Gases/therapeutic use , Cell Differentiation , Cell Proliferation , Femoral Fractures/surgery
19.
Sci Rep ; 14(1): 8364, 2024 04 10.
Article En | MEDLINE | ID: mdl-38600312

This study retrospectively assessed radiographic outcomes and risk factors associated with non-union in femoral shaft fragmentary segmental fractures (AO/OTA 32C3) treated with reamed antegrade intra-medullary nailing. Radiological outcomes, including union and alignment, were evaluated. The risk factors for non-union were investigated, including demographics and treatment-related characteristics, such as the number of interlocking screws, segmentation length, main third fragment length, distance of the main third fragment, width ratio and exposed nail length in one cortex from immediate post-operative radiographs. Multivariate logistic regression was used for statistical analysis. Among 2295 femoral shaft fracture patients from three level-1 trauma centers, 51 met the inclusion criteria. The radiological union was achieved in 37 patients (73%) with a mean union time of 10.7 ± 4.8 months. The acceptable axial alignment was observed in 30 patients (59%). Multiple logistic regression analysis identified only exposed nail length as a significant risk factor for non-union (odds ratio: 1.599, p = 0.003) and the cut-off value was 19.1 mm (sensitivity, 0.786; specificity, 0.811). The study revealed high rates of non-union (27%) and malalignment (41%). Therefore, patients who underwent intramedullary nailing with an exposed nail length greater than 19.1 mm or about twice the nail diameter should be cautioned of the potential non-union.


Femoral Fractures , Fracture Fixation, Intramedullary , Humans , Fracture Fixation, Intramedullary/adverse effects , Retrospective Studies , Bone Nails/adverse effects , Femoral Fractures/diagnostic imaging , Femoral Fractures/surgery , Femoral Fractures/etiology , Radiography , Treatment Outcome , Fracture Healing
20.
Georgian Med News ; (347): 149-150, 2024 Feb.
Article En | MEDLINE | ID: mdl-38609132

Traditionally, it was believed that both proximal and distal locking are essential for achieving stability during intra-medullary fixation for extra-capsular hip fractures. However, recent literature has presented varying perspectives on the necessity of distal locking. Distal locking plays a significant role in managing hip fractures with uncertainties regarding longitudinal and rotational stability. This includes cases of comminuted intertrochanteric fractures with subtrochanteric extension, reverse oblique and high oblique fractures, broad medullary canals, comminution of the lateral wall, diaphyseal fractures, and large posteromedial fragments extending below the level of the lesser trochanter. In stable pertrochanteric fractures, with the lag screw passing through the lateral cortex of the distal fragment, may not require a distal locking screw. Distal locking has been associated with potential complications, including irritation of the fascia lata, prolonged operation time, increased radiation exposure, greater blood loss, implant loosening, secondary femoral stress fractures, and damage to the femoral artery. Thus, although distal locking is of doubtful significance in stable pertrochanteric fractures it is essential in unstable fracture patterns.


Femoral Fractures , Fracture Fixation, Intramedullary , Hip Fractures , Humans , Hip Fractures/diagnostic imaging , Hip Fractures/surgery , Bone Screws , Femoral Artery
...