Sintomas de ansiedade e depressão em crianças: associações com o funcionamento familiar / Depression and anxiety symptoms in children: associations with family functioning / Síntomas de ansiedad y depresión en niños: asociaciones con el funcionamiento familiar

Sintomas de ansiedade e depressão na infância têm sido amplamente investigados na atualidade. Os estudos apontam que esses sintomas têm natureza multifatorial, sendo os fatores ambientais, como as caraterísticas do funcionamento familiar, alvo de atenção dos pesquisadores. Por isso, este estudo avaliou a correlação e o poder preditivo dos fatores da parentalidade e da coparentalidade em sintomas clínicos de ansiedade e depressão nos filhos. Os participantes, 50 indivíduos que vivem em coabitação com o parceiro e têm pelo menos um filho com idade entre 7 e 11 anos, preencheram um instrumento composto por seis escalas, que avaliaram a parentalidade, a coparentalidade e a sintomatologia na prole. Os resultados indicaram correlações baixas e moderadas entre os fatores da parentalidade e da coparentalidade e os sintomas emocionais e comportamentais dos filhos. O conflito familiar coparental e a supervisão do comportamento foram preditores de 16% dos sintomas de ansiedade generalizada na prole e a triangulação familiar de 17% dos sintomas de depressão. Evidencia-se, como indica a literatura, que os filhos são suscetíveis à qualidade do funcionamento dos subsistemas parental e coparental.(AU)

Anxiety and depression symptoms in the early childhood have been investigated extensively in current times. Studies have point out that these symptoms have a multifactorial nature, with environment factors, such as the characteristics of the familiar functioning, as the researchers' target. Therefore, this study evaluated the correlation and the predictive power of parenting and co-parenting factors on clinical symptoms of anxiety and depression in the children. The participants, 50 individuals who lived in cohabitation with their partners and that had at least one child aged between 7 and 11 years old, filled in a form composed of six scales; which evaluated the parenting, the coparenting, and the offspring symptomatology. The results revealed low and moderate correlations between the parenting and coparenting variables and the emotional and behavioral symptoms of the children. The coparental familiar conflict and the behavior monitoring were predictors of 16% of the generalized anxiety symptom in the offspring, and the familiar triangulation of 17% of the depression symptoms. It shows, as the literature suggests, that the children are vulnerable to the quality of the functioning of the parental and coparental subsystems.(AU)

Los síntomas de ansiedad y depresión en la infancia son ampliamente investigados en la actualidad. Los estudios demuestran que los síntomas son multifactoriales, de los cuales los factores ambientales y las características de funcionamiento de la familia están en el centro de la atención de los investigadores. Por lo tanto, este estudio evaluó la correlación y el poder predictivo de los factores de la parentalidad y de la coparentalidad en los síntomas clínicos de ansiedad y depresión en los niños. Los participantes, 50 individuos que conviven con su pareja y tienen al menos un hijo, de entre 7 y 11 años, completaron una herramienta que se compone de seis escalas que evaluaban la crianza, la coparentalidad y la sintomatología en sus hijos. Los resultados indicaron correlaciones bajas y moderadas entre los factores de la parentalidad y de la coparentalidad y los síntomas emocionales y conductuales de los niños. El conflicto familiar coparental y la supervisión del comportamiento fueron predictores del 16% de los síntomas de ansiedad generalizada en la descendencia y la triangulación familiar del 17% de los síntomas de depresión. Esto coincide con la literatura al indicar que los niños son susceptibles a la calidad del funcionamiento de los subsistemas parental y coparental.(AU)

Estimation of genetic parameters and relationships between type traits and milk yield of Holstein cows in Turkey / [Estimativa de parâmetros genéticos e relações entre características de tipo e produção de leite das vacas Holstein na Turquia]

In this study, milk yield, reproductive yield, and type traits of 533 Holstein cows in the first lactation raised in 54 farms were examined. In the three-year study, phenotypic (rP) and genetic (rG) correlations between type traits and milk yield were estimated based on the variance elements and heritability of the type traits of Holstein cows in the first lactation. Linear identification and scoring systems have been applied to classify the cows according to type traits. Heritability and correlations were estimated with ASREML models. The type traits included stature, angularity, rump width, hocks, rear udder height, central ligament, teat length, body capacity, feet and legs, udder composite and final score for genetic correlations with 305-day milk yield were estimated as -0.49, -0.14, -0.93, 0.35, 0.40, 0.11, -0.65, 0.70, 0.31, 0.54, and 0.70, for phenotypic correlations were estimated as 0.28, 0.28, 0.30, 0.21, 0.35, 0.39, -0.06, 0.46, 0.48, 0.56, and 0.58 respectively. Among the phenotypic correlations between the type traits, especially the phenotypic correlations between the final score and various type traits were found to be high and significant. The fact that these traits are in high correlation with other traits and milk yield may enable these to be used as indirect selection criteria in the selection for milk yield.(AU)

Neste estudo, foram examinadas a produção de leite, a produção reprodutiva e as características de tipo de 533 vacas Holstein na primeira lactação criadas em 54 fazendas. No estudo trienal, as correlações fenotípicas (rP) e genéticas (rG) entre características de tipo e produção de leite foram estimadas com base nos elementos de variação e hereditariedade das características de tipo das vacas Holstein na primeira lactação. Sistemas de identificação linear e de pontuação foram aplicados para classificar as vacas de acordo com os traços de tipo. A hereditariedade e correlações foram estimadas com os modelos ASREML. Os traços de tipo incluíam estatura, angularidade, largura da alcatra, jarretes, altura do úbere traseiro, ligamento central, comprimento das tetas, capacidade corporal, pés e patas, composição do úbere e pontuação final para correlações genéticas com a produção de leite de 305 dias foram estimados como -0. 49, -0,14, -0,93, 0,35, 0,40, 0,11, -0,65, 0,70, 0,31, 0,54, e 0,70, para correlações fenotípicas foram estimadas como 0,28, 0,28, 0,30, 0,21, 0,35, 0,39, -0,06, 0,46, 0,48, 0,56, e 0,58 respectivamente. Dentre as correlações fenotípicas entre os traços de tipo, especialmente as correlações fenotípicas entre a pontuação final e vários traços de tipo foram encontradas como altas e significativas. O fato destes traços estarem em alta correlação com outros traços e a produção de leite pode permitir que sejam usados como critérios de seleção indiretos na seleção para a produção de leite.(AU)

Evolutionary rate and genetic load in an emblematic Mediterranean tree following an ancient and prolonged population collapse.

Severe bottlenecks significantly diminish the amount of genetic diversity and the speed at which it accumulates (i.e., evolutionary rate). They further compromise the efficiency of natural selection to eliminate deleterious variants, which may reach fixation in the surviving populations. Consequently, expanding and adapting to new environments may pose a significant challenge when strong bottlenecks result in genetic pauperization. Herein, we surveyed the patterns of nucleotide diversity, molecular adaptation and genetic load across 177 gene-loci in a circum-Mediterranean conifer (Pinus pinea L.) that represents one of the most extreme cases of genetic pauperization in widespread outbreeding taxa. We found very little genetic variation in both hypervariable nuclear microsatellites (SSRs) and gene-loci, which translated into genetic diversity estimates one order of magnitude lower than those previously reported for pines. Such values were consistent with a strong population decline that began some ~1 Ma. Comparisons with the related and parapatric maritime pine (Pinus pinaster Ait.) revealed reduced rates of adaptive evolution (α and ωa ) and a significant accumulation of genetic load. It is unlikely that these are the result from differences in mutation rate or linkage disequilibrium between the two species; instead they are the presumable outcome of contrasting demographic histories affecting both the speed at which these taxa accumulate genetic diversity, and the global efficacy of selection. Future studies, and programs for conservation and management, should thus start testing for the effects of genetic load on fitness, and integrating such effects into predictive models.

Diferenciación genética de las poblaciones de Felis catus en los municipios de Restrepo y Darién del Valle del Cauca, Colombia / Genetic differentiation of Felis catus populations in the municipalities Restrepo and Darién of Valle del Cauca, Colombia

Los genes implicados en los rasgos del pelaje de los gatos son útiles para el análisis de la estructura genética que presentan sus poblaciones. El objetivo de este trabajo fue determinar si existe diferenciación genética entre las poblaciones de gato doméstico de los municipios de Restrepo y Darién, los cuales se encuentran separados por el "Lago Calima". Para esto se estimaron las frecuencias alélicas de diversos marcadores del pelaje y se determinó si estas poblaciones presentaban diferencias significativas en su estructura génica o si se encontraban en equilibrio Hardy­Weinberg, además, se realizó una comparación con otras poblaciones inventariadas en el Valle del Cauca. Posteriormente, se llevó a cabo un análisis de componentes principales (ACP-Biplot), para conocer la correlación entre las frecuencias alélicas y los aportes de cada una de ellas a la variabilidad. También se realizó una prueba de Mantel para estimar si existía correlación entre los índices de fijación (FST) y las distancias geográficas. La prueba de Mantel mostró que el gen Orange es el único que muestra una correlación positiva entre los índices de diferenciación FST y las distancias geográficas. La comparación de las poblaciones de interés con las del Valle del Cauca, evidenció que los genes que aportaron más a la variabilidad fueron Dilution (19,08%), Long hair (16,09%), Agouti (16,06%) e Inhibitor (14,04%). Sin embargo, se encontró que las poblaciones de Restrepo y Darién tienen perfiles genéticos similiares y se comportan como una sola según los valores del equilibrio Hardy-Weinberg y los FST. Debido a que no hay diferencias significativas entre las poblaciones estudiadas, se concluye que, aunque el Lago Calima sea una barrera geográfica, no tiene un efecto significativo en la diferenciación genética entre las poblaciones de gatos de Restrepo y Darién.

The genes involved in cat coat traits are useful for the analysis of genetic structure within a population. The objective of this paper was to determine if any genetic differences exist among domestic cat populations from the municipalities of Restrepo and Darien, which are separated by Calima Lake. To analyze population structure, we estimated allelic frequencies of several coat markers, tested for alignment with the Hardy-Weinberg equilibrium, and compared our populations of interest to others from the Valle del Cauca region. Subsequently, we performed a principal components analysis (PCA-Biplot) to determine the correlation between allelic frequencies and their contributions to variability. A Mantel test was also used to estimate possible correlation among differentiation indexes (FST) and geographic distances. We performed the Mantel test on the Orange gene and identified a positive correlation among differentiation indexes (FST) and geographical distances. After comparing our populations of interest to others in the Valle del Cauca, we observed that the genes with the greatest contribution to variability were Dilution (19,08%), Long hair (16,09%), Agouti (16,06%) and Inhibitor (14,04%). However, we also found that the Restrepo and Darien populations of interest had similar genetic profiles, and aligned with the Hardy-Weinberg equilibrium, and the FST. Due to the absence of significant differentiation between the populations studied, we conclude that Calima Lake does not have a significant effect on any differentiation between the cat populations of Restrepo and Darien.

Frecuencia de enfermedades huérfanas en Cartagena de Indias, Colombia / Frequency for genetic orphan diseases in Cartagena de Indias, Colombia

RESUMEN Objetivo Estimar la frecuencia de enfermedades huérfanas (EH) o raras (ER) de origen genético en Cartagena de Indias, Colombia. Metodología Se realizó un estudio descriptivo con datos de los Registros Individuales de Prestación de Servicios (RIPS), del periodo 2003-2010, conservados por el Departamento Administrativo Distrital de Salud-DADIS. Fueron escogidas las EH de origen genético a partir de la clasificación del Ministerio de Salud Colombiano, y que se identifican con la referencia Q en los Códigos Internacionales de Enfermedad (CIE10). Resultados En total se registraron 522 181 personas que consultaron al sistema de salud. El 0,8 % (n=16 527) tuvieron algún diagnóstico Q. Finalmente, 391 personas (0,075 %) tuvieron impresión diagnóstica de EH de origen genético. En esta población se encontraron 75 impresiones diagnósticas distintas. Las Malformaciones y Deformidades Congénitas del Sistema Osteomuscular (Q65-Q79) fueron las más frecuentes (38,6 %), seguidas por Otras Malformaciones Congénitas (Q080-089) con 16,6 %. Conclusiones Se obtuvo el primer reporte de la frecuencia de las EH de origen genético en la segunda ciudad más poblada sobre el litoral del Caribe Colombiano. Es posible que en los RIPS haya un subregistro de las ER que dificulta conocer la prevalencia real.(AU)

ABSTRACT Objective Estimating the frequency of genetic orphan diseases in Cartagena de Indias (Colombia). Methodology A cross-sectional study was carried out employing data from the Health Care Service Individual Records (RIPS) of 2003-2010, kept by the District Administrative Department of Health-DADIS- in Cartagena de Indias. Genetic ODs included in national classification from Colombian Ministry of Health were chosen, and those identify by the Q reference according to the International Codes of Disease (ICD10) were finally selected for descriptive analysis. Results A total of 522 181 people who consulted the health system were recorded. 0.8 % (n=16 527) had a diagnosis Q. Finally, 391 people (0.075 %) had diagnostic impression of genetic OD. Within this population, 75 different diagnostic impressions were found. Congenital malformations and deformities of the musculoskeletal system (Q65-Q79) were the most frequent (38.6 %), followed by Other Congenital Malformations (Q080-089) with 16.6 %. Conclusions It was obtained the first report of the frequency of genetic orphan diseases from the second largest on the Colombian Caribbean coast city. It is suspected that misreporting in RIPS database is reducing actual frequency of OD. Further active search could reveal complete prevalence.(AU)

DNA profiles of Salmonella spp. isolated from chicken products and from broiler and human feces

Salmonella species have been isolated from various kinds of food and are accountable for outbreaks of foodborne diseases in humans. This study aimed at identifying the similarities between the DNA profiles of Salmonella isolated from chicken feces, chicken products, and human feces in southern Brazil. Six hundred samples were collected (200 from chicken products, 200 from broiler chicken feces, and 200 from human feces) and tested for the presence of Salmonella. Isolates proven to be Salmonella compatible by biochemical and serological tests were tested by the Polymerase Chain Reaction. Their DNA profiles were then analyzed by PFGE and rep-PCR. Salmonella was isolated from 16 out of 600 analyzed samples, with Schwarzengrund serotype presenting the highest incidence, followed by Mbandaka in chicken meat and fecal samples, and Panama in human fecal samples. Some strains isolated from chicken fecal and product samples were indistinguishable by the molecular methods used in the study, suggesting that that the contamination of the broilers on the farm can be transmitted the processed products.

DNA profiles of Salmonella spp. isolated from chicken products and from broiler and human feces

Salmonella species have been isolated from various kinds of food and are accountable for outbreaks of foodborne diseases in humans. This study aimed at identifying the similarities between the DNA profiles of Salmonella isolated from chicken feces, chicken products, and human feces in southern Brazil. Six hundred samples were collected (200 from chicken products, 200 from broiler chicken feces, and 200 from human feces) and tested for the presence of Salmonella. Isolates proven to be Salmonella compatible by biochemical and serological tests were tested by the Polymerase Chain Reaction. Their DNA profiles were then analyzed by PFGE and rep-PCR. Salmonella was isolated from 16 out of 600 analyzed samples, with Schwarzengrund serotype presenting the highest incidence, followed by Mbandaka in chicken meat and fecal samples, and Panama in human fecal samples. Some strains isolated from chicken fecal and product samples were indistinguishable by the molecular methods used in the study, suggesting that that the contamination of the broilers on the farm can be transmitted the processed products.(AU)

Seleção para a produção de ovos em períodos parciais e acumulados em linhagem de frango de corte comercial / Egg production selection in partial and accumulated periods in a commercial broiler line

Objetivou-se com este estudo estimar parâmetros genéticos para produções parciais e acumuladas de ovos em uma linha fêmea de frangos de corte comercial. Foram considerados 10 períodos mensais entre 25 e 64 semanas, três períodos parciais de 25 a 32, 33 a 48 e 49 a 64 semanas, e três períodos acumulados de 25 até 30, 40 e 50 semanas de idade. Os componentes de covariância e parâmetros genéticos foram obtidos pelo método da máxima verossimilhança restrita, sob o modelo animal considerando o efeito fixo de incubação e os efeitos aleatórios genético aditivo e residual. As estimativas de herdabilidade variaram de 0,12 a 0,41. Evidenciou-se que os períodos anteriores e posteriores ao maior nível de produção apresentam maior variabilidade genética. As correlações genéticas entre os períodos de produção de ovos estudados variaram de -0,12 a 0,98. De modo geral, o padrão de variação foi semelhante entre as estratégias avaliadas, e todas foram geneticamente associadas com a produção total. Os resultados deste estudo mostraram que a melhoria da produção total é viável por meio de seleção de registros parciais. No entanto, caso se considere a eficiência relativa de seleção, o segundo mês e os períodos a partir da quadragésima semana de produção seriam os mais indicados.

The aim of this study was to estimate genetic parameters for partial and cumulative egg production in a commercial broiler female line. Ten monthly periods between 25 and 64 weeks, three partial periods of 25 to 32, 33 to 48 and 49 to 64 cumulative weeks and three periods of 25 to 30, 40 and 50 weeks of age and total egg production were considered. The restricted maximum likelihood method under the animal model was used to estimate the covariance components and genetic parameters. The fixed effect of incubation and the additive genetic and residual random effects were considered. The estimated heritability ranged from 0.12 to 0.41. These estimates showed that the anterior and posterior periods of the higher production have greater genetic variability. The genetic correlations between periods of the egg production studied ranged from -0.12 to 0.98. In general, the pattern of variation was similar between the strategies evaluated and all were genetically associated with the total egg production. The results of this study showed that the improvement of the total egg production is feasible by selection of partial records. However, considering the relative efficiency of selection, the second month and the periods from the fortieth week of production would be the most suitable.

Taxa de fertilidade de novilhas de diferentes grupos genéticos com primeiro serviço aos 14 meses de idade / Fertility rate of heifers of different genetic groups with 1st service at 14 months of age

Foram avaliadas as taxas de reconcepção de 98 novilhas primíparas (34 Guzerá - G, 32, 1/2 Guzerá x 1/2 Nelore - GN e 32,1/2 Red Angus x 1/2 Nelore - AN) com 14 meses de idade e peso médio de aproximadamente 249,65kg, criadas em pastos de Brachiaria brizantha cv Marandu. Na segunda estação de monta (EM), foram utilizadas apenas as 36 primíparas gestantes na primeira EM (três G, nove GN e 24 AN), com média de idade de 26 meses e peso corporal de 313,67±25,01kg, 336,50±45,84kg e 399,86±44,45kg, respectivamente, para as fêmeas dos grupos G, GN e AN. O grupo AN apresentou ganho médio diário (GMD) de 0,30±0,06 (kg/dia) e maiores taxas (58,33) de reconcepção (P<0,05), comprovando que a heterose resultante do cruzamento entre raças distintas com maior distância genética (Bos taurus taurus x Bos taurus indicus) proporciona maior desempenho produtivo e reprodutivo.

A total of 98 heifers of three genetic groups: 34 Guzerá (G), 32, 1/2 Guzerá x 1/2 Nelore (GN) and 32 1/2 Red Angus x 1/2 Nelore (AN), 14 month old and average body weight of 249,65kg, raised in Brachiaria brizantha cv Marandu were used to evaluate reconception rates. In the second breeding season (BS), only those 36 pregnant in the first BS (three G, nine GN and 24 AN), age 26 months and body weight of 313.67±25.01kg, 336.50±45.84kg and 399.86±44.45kg, respectively, G , GN and AN were evaluated. The highest reconception rate (58.33%, P<0.05) was registered for the AN group and showed that average daily gain of 0.30±0.06kg, showing that crosses between Bos taurus taurus x Bos taurus indicus leads to higher reproductive and productive performances.

Seleção para a produção de ovos em períodos parciais e acumulados em linhagem de frango de corte comercial / Egg production selection in partial and accumulated periods in a commercial broiler line

Objetivou-se com este estudo estimar parâmetros genéticos para produções parciais e acumuladas de ovos em uma linha fêmea de frangos de corte comercial. Foram considerados 10 períodos mensais entre 25 e 64 semanas, três períodos parciais de 25 a 32, 33 a 48 e 49 a 64 semanas, e três períodos acumulados de 25 até 30, 40 e 50 semanas de idade. Os componentes de covariância e parâmetros genéticos foram obtidos pelo método da máxima verossimilhança restrita, sob o modelo animal considerando o efeito fixo de incubação e os efeitos aleatórios genético aditivo e residual. As estimativas de herdabilidade variaram de 0,12 a 0,41. Evidenciou-se que os períodos anteriores e posteriores ao maior nível de produção apresentam maior variabilidade genética. As correlações genéticas entre os períodos de produção de ovos estudados variaram de -0,12 a 0,98. De modo geral, o padrão de variação foi semelhante entre as estratégias avaliadas, e todas foram geneticamente associadas com a produção total. Os resultados deste estudo mostraram que a melhoria da produção total é viável por meio de seleção de registros parciais. No entanto, caso se considere a eficiência relativa de seleção, o segundo mês e os períodos a partir da quadragésima semana de produção seriam os mais indicados.(AU)

The aim of this study was to estimate genetic parameters for partial and cumulative egg production in a commercial broiler female line. Ten monthly periods between 25 and 64 weeks, three partial periods of 25 to 32, 33 to 48 and 49 to 64 cumulative weeks and three periods of 25 to 30, 40 and 50 weeks of age and total egg production were considered. The restricted maximum likelihood method under the animal model was used to estimate the covariance components and genetic parameters. The fixed effect of incubation and the additive genetic and residual random effects were considered. The estimated heritability ranged from 0.12 to 0.41. These estimates showed that the anterior and posterior periods of the higher production have greater genetic variability. The genetic correlations between periods of the egg production studied ranged from -0.12 to 0.98. In general, the pattern of variation was similar between the strategies evaluated and all were genetically associated with the total egg production. The results of this study showed that the improvement of the total egg production is feasible by selection of partial records. However, considering the relative efficiency of selection, the second month and the periods from the fortieth week of production would be the most suitable.(AU)

Taxa de fertilidade de novilhas de diferentes grupos genéticos com primeiro serviço aos 14 meses de idade / Fertility rate of heifers of different genetic groups with 1st service at 14 months of age

Foram avaliadas as taxas de reconcepção de 98 novilhas primíparas (34 Guzerá - G, 32, 1/2 Guzerá x 1/2 Nelore - GN e 32,1/2 Red Angus x 1/2 Nelore - AN) com 14 meses de idade e peso médio de aproximadamente 249,65kg, criadas em pastos de Brachiaria brizantha cv Marandu. Na segunda estação de monta (EM), foram utilizadas apenas as 36 primíparas gestantes na primeira EM (três G, nove GN e 24 AN), com média de idade de 26 meses e peso corporal de 313,67±25,01kg, 336,50±45,84kg e 399,86±44,45kg, respectivamente, para as fêmeas dos grupos G, GN e AN. O grupo AN apresentou ganho médio diário (GMD) de 0,30±0,06 (kg/dia) e maiores taxas (58,33) de reconcepção (P<0,05), comprovando que a heterose resultante do cruzamento entre raças distintas com maior distância genética (Bos taurus taurus x Bos taurus indicus) proporciona maior desempenho produtivo e reprodutivo.(AU)

A total of 98 heifers of three genetic groups: 34 Guzerá (G), 32, 1/2 Guzerá x 1/2 Nelore (GN) and 32 1/2 Red Angus x 1/2 Nelore (AN), 14 month old and average body weight of 249,65kg, raised in Brachiaria brizantha cv Marandu were used to evaluate reconception rates. In the second breeding season (BS), only those 36 pregnant in the first BS (three G, nine GN and 24 AN), age 26 months and body weight of 313.67±25.01kg, 336.50±45.84kg and 399.86±44.45kg, respectively, G , GN and AN were evaluated. The highest reconception rate (58.33%, P<0.05) was registered for the AN group and showed that average daily gain of 0.30±0.06kg, showing that crosses between Bos taurus taurus x Bos taurus indicus leads to higher reproductive and productive performances.(AU)

Modelos lineares generalizados mistos na avaliação genética da prenhez precoce na raça Nelore / Generalized linear mixed models on genetic evaluation of early pregnancy in Nellore breed

Utilizaram-se os modelos lineares generalizados com as funções de ligação probit e logit na avaliação da prenhez precoce, e observaram-se os efeitos na variabilidade genética e na seleção de reprodutores quando diferentes idades são adotadas na definição dessa característica. A prenhez precoce foi estudada aos 15 (PP15) e 21 meses (PP21). Correlações entre os valores genéticos preditos e a porcentagem de touros em comum, considerando 10% dos touros com maiores valores genéticos (TOP10), entre a classificação dos modelos com função de ligação logit e probit e em cada modelo entre PP15 e PP21, foram calculadas. As herdabilidades para PP15 e PP21 foram próximas entre os modelos, exceto para PP15 utilizando a função de ligação probit. Aquelas entre os modelos e a TOP/10 foram altas. Os critérios de Akaike e Bayesiano apresentaram-se semelhantes entre os modelos. As correlações entre PP15 e PP21 e a TOP10, considerando o mesmo modelo, foram de média magnitude.(AU)

This study aimed to use the generalized linear models with probit and logit link function to evaluate early pregnancy, and to observe the effects on genetic variability and on sire selection when different ages are adopted in the definition of this trait. Early pregnancy was studied at 15 (EP15), and 21 (EP21) months. The analysis was done in R software. Pearson correlations (PC), between genetic predicted values and percentage of bulls in common considering only 10% of bulls with higher genetic values (TOP 10), between classification by logit and probit models and in each model among EP15 and EP21, were calculated. The heritability for EP15 and EP21 were close between models, except for EP15 using probit link function. PC and TOP10 among models were high. The Akaike and Bayesian criteria reported was similar between models. TOP10, considering the same model, among EP15-EP21 were moderated between EP15-EP21.(AU)

Reduced inbreeding depression in peripheral relative to central populations of a monocarpic herb.

Many temperate taxa were confined to warmer latitudes during the last glacial maximum. As their ranges expanded when climates warmed, genetic drift and inbreeding in relatively small peripheral populations are expected to have reduced genetic diversity and the segregating genetic load. Therefore, inbreeding depression in peripheral populations might be lower than in centrally located sites. We evaluated the consequences of inbreeding for fitness traits in six central and six northern peripheral populations of the herb Campanulastrum americanum. Inbreeding reduced performance for all traits. Inbreeding depression in peripheral populations was lower than in central populations. This difference increased across the life cycle from similar levels for germination, to central populations having three times the inbreeding depression for adult traits. Geographical patterns of inbreeding depression suggest that mating system variation and potential future mating system evolution in many temperate taxa might reflect, at least in part, nonequilibrium conditions associated with historic range changes.

Estimativas de componentes de (co)variância para peso e escores visuais de conformação frigorífica em bovinos Nelore / Variance component estimates for weight and visual scores of slaughter conformation in Nellore cattle

Estimaram-se os componentes de (co)variância e herdabilidade da conformação frigorífica à desmama (CFD), conformação frigorífica ao sobreano (CFS), peso à desmama (PD) e peso ao sobreano (PS) de animais Nelore, e as correlações genéticas entre essas características. Um modelo animal multicaracterística foi proposto para analisar 6.397 informações de peso e escores visuais de conformação frigorífica, obtidas à desmama e ao sobreano. Esse modelo incluiu os efeitos aleatórios genético aditivo direto, genético aditivo materno, ambiente permanente materno e residual, além dos efeitos fixos de grupo contemporâneo e das covariáveis idade da mãe ao parto - para peso e conformação frigorífica à desmama e ao sobreano - e idade do animal à data da avaliação - para conformação frigorífica, à desmama e ao sobreano. As herdabilidades estimadas para CFD, CFS, PD e PS foram, respectivamente, 0,13, 0,25, 0,22 e 0,29. Correlações genéticas positivas e de alta magnitude entre as características de peso e as características de avaliação visual sugerem que a seleção para uma delas pode resultar em resposta indireta na outra. A característica de conformação frigorífica pode ser selecionada em idade mais precoce em razão da correlação genética alta e positiva entre mensurações feitas nas duas idades estudadas.(AU)

The aim of this study was to estimate variance components, heritability and genetic correlation for slaughter conformation at weaning (SCW), slaughter conformation at yearling age (SCY), weaning weight (WW) and yearling age weight (YW) of Nellore cattle. A total of 6,397 records of all traits measured at weaning and at yearling age were used in the analysis. A multiple trait animal model which included the direct genetic additive, maternal genetic additive, maternal permanent environmental and residual random effects, as well as the fixed effect of contemporary group and the covariates age at calving (for weight and slaughter conformation at weaning and yearling age) and age at the evaluation time (slaughter conformation at weaning and yearling age) was proposed. The heritability estimates for SCW, SCY, WW and YW were, respectively, 0.13, 0.25, 0.22 and 0.29. Positive and high genetic correlations between body weight traits and visual evaluation traits suggested that direct selection for one trait results in positive indirect response in the remaining trait. Slaughter conformation trait can be selected at earlier age due to the high and positive genetic correlation between conformation scores at different age.(AU)

Etiopatogenia de la obesidad / Etiopathogenesis of obesity

La investigación de los factores etiopatogénicos de la obesidad, sean estos ambientales o genéticos, ha influido fuertemente en el desarrollo de las estrategias para controlar la enfermedad. Se considera a la obesidad como una enfermedad en la cual confluyen factores genéticos y ambientales, pero no se han dilucidado cabalmente los mecanismos de regulación del balance energético, cuyas alteraciones favorecen el incremento de la adiposidad en humanos. Entre los factores ambientales, además de la alimentación alta en calorías y el sedentarismo, se describen factores predisponentes sociales, culturales y familiares, así como situaciones o etapas fisiológicas de la vida que pueden gatillar aumento de peso. Aunque los factores y patologías genéticas se pueden evidenciar en un bajo porcentaje de los sujetos obesos, la predisposición genética a la obesidad se puede expresar a través de algunas características metabólicas, como un bajo gasto energético de reposo, mala oxidación de grasas o un bajo nivel de actividad física espontánea.

The investigation of the etiological factors of obesity, whether genetic or environmental, has strongly influenced the development of strategies to control the disease. Obesity must be considered as a disease in which genetic and environmental factors converge. However, the mechanisms of regulation of the energy balance, which changes favoring increased adiposity in humans, are not fully elucidated. Among environmental factors, in addition to high-calorie diet and sedentary lifestyle, it has been described social, cultural and family predisposing factors, as well as physiological conditions or stages of life that can trigger weight gain. Although genetic factors and pathologies can be evidenced in a low percentage of obese subjects, genetic predisposition to obesity can be expressed through some metabolic characteristics such as low metabolic rate, poor oxidation of fats or a low level of spontaneous physical activity.

Estimativas de parâmetros genéticos e estudo comparativo de índices de seleção fenotípico e genético em provas de ganho de peso na raça Nelore / Estimation of genetic parameters and comparison study of phenotypic and genetic selection indexes of performance tests of Nellore beef cattle

O presente estudo teve como objetivos estimar os parâmetros genéticos para características de crescimento e perímetro escrotal, bem como avaliar as alterações no ranking dos animais participantes de provas de ganho de peso (PGP) quando diferentes índices de seleção são usados e identificar eventuais erros de seleção. Os índices fenotípicos utilizaram os valores fenotípicos das características e os índices genéticos utilizaram os valores genéticos aditivos para a classificação dos animais. Como dados de crescimento foi analisado o peso aos 120 dias (p120), ao desmame (pdes), aos 12 meses (p12) e aos 18 meses (p18) de 3149, 3958, 2484 e 1872 animais, respectivamente, bem como o ganho de peso do desmame aos 12 meses (gpdes-12) e dos 12 aos 18 meses (gp12-18) com 1455 e 1465 animais, respectivamente. Foi analisado o perímetro escrotal ao desmame (pedes), 12 meses (pe12), 15 meses (pe15) e 18 meses (pe18) de 1535, 1166, 1212 e 852 animais, respectivamente. Os componentes de (co)variância, os parâmetros genéticos e as soluções para os efeitos fixos e aleatórios foram estimados pelo método REML, com o programa VCE6 sob modelo animal e utilizando um arquivo de pedigree com 15.522 animais. Para a comparação de ranking foram utilizados dados de 793 machos nascidos em 2008 e 2009 participantes das PGP. Dois critérios foram usados para a comparação de ranking dos animais, a correlação de ranking de Spearman e os erros de seleção. Para avaliar os erros de seleção duas estratégias foram adotadas: animais que apresentaram índices iguais ou acima da média mais um desvio padrão foram selecionados e os animais que apresentaram índices acima da média, reduzindo com isso a pressão de seleção. As estimativas dos coeficientes de herdabilidade direta foram 0,26, 0,25, 0,13 e 0,15 e materna de 0,20, 0,16, 0,09 e 0,15 para p120, pdes, p12 e p18, respectivamente. As estimativas de herdabilidade direta para gpdes-12 e gp12-18 foram de 0,13 e 0,20, respectivamente. Para as características pedes, pe12, pe15 e pe18 as estimativas de herdabilidade direta foram de 0,56, 0,59, 0,54 e 0,50, e materna de 0,29, 0,29, 0,26 e 0,05, nesta ordem. Em sua maioria, as estimativas estão de acordo com as descritas na literatura. As correlações genéticas entre p120, pdes e p12 com o p18, ficaram abaixo da relatada na literatura. As correlações de ranking apresentaram-se relativamente altas entre os índices fenotípicos e genéticos. Erros de seleção de 19,3 a 73,2% foram observados com a classificação dos animais sendo igual ou maior que um desvio padrão acima da média. Quando a seleção foi obtida nos animais com índice igual ou maior que a média, os erros de seleção permaneceram entre 9,0 e 22,1%. Os resultados deste estudo indicam que a seleção de touros jovens pelos índices fenotípicos pode acarretar em erros na escolha de reprodutores, principalmente quanto maior a pressão de seleção.

The objectives of this study were estimate genetic parameters of growth traits and scrotal circumference, as well evaluate changes on ranking of animals submitted to performance tests (PGP) and selection error when two selection indexes were used. The phenotypic index used the phenotypic values, deviated from the mean of the group, to rank the animals and the genetic index used the combined additive genetic values for animals' ranking. Growth traits comprehended weights at 120 days (p120), at weaning (pdes), at 12 months (p12) and at 18 months (p18) of 3149, 3958, 2484 e 1872 animals, respectively, along with weight gain from weaning to 12 months (gpdes-12) and from 12 to 18 months (gp12-18) measured in 1455 e 1465 animals, in that order. It was analyzed the scrotal circumference at weaning (pedes), at 12 months (pe12), at 15 months (pe15) and at 18 months of 1535, 1166, 1212 e 852 animals, respectively. (Co)variance components, genetic parameters and fixed and random effects solutions were estimated by REML method by VCE program under an animal model methodology and using a pedigree data file composed by 15.522 animals. For animals' ranking comparison performance test data of 793 animals born in 2008 and 2009 were used. Two criteria were assumed to rank comparison: Spearman ranking correlation and selection error. The evaluation of selection error was realized based on two strategies: animals that presented index equal or greater than the mean plus one standard deviation were selected and animals with index greater than the mean were selected; in this case the selection pressure was reduced. Direct heritability coefficients were estimates as 0.26, 0.25, 0.13 e 0.15, and maternal heritability coefficients estimates were 0.20, 0.16, 0.09 e 0.15 for p120, pdes, p12 and p18, respectively. For gpdes-12 and gp12-18, the estimates of heritability were 0.13 e 0.20, in that order. For scrotal circumference at weaning, 12 months, 15 months and 18 months, the estimates of direct heritability were 0.56, 0.59, 0.54 e 0.50 and for maternal heritability were 0.29, 0.29, 0.26 e 0.05, respectively. In general, those estimations were in agreement with estimation on literature. The genetic correlations between p120, pdes and p12 with p18 were slightly lower than described on other studies. Spearman ranking correlation between phenotypic and genetic index were high. Selection errors between 19.3 and 73.2% were observed when selected animals presented indexes equal or greater than the mean plus one standard deviation. When selecting animals with index greater than the mean, the selection errors observed were between 9.0 and 22.1%. The results indicate that young replacement animals' selection based on phenotypic index can lead to selection errors, especially when the selection pressure is reduced.