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1.
Am J Med Genet ; 47(1): 59-64, 1993 Aug 01.
Article in English | MEDLINE | ID: mdl-8368254

ABSTRACT

Misoprostol, a synthetic analog of prostaglandin, has been widely used in Brazil as an abortifacient. Abortion is illegal in Brazil. An uncertain number of these abortion attempts are unsuccessful and the pregnancy continues. We report on 7 patients whose mothers attempted to abort using this drug in the first trimester of gestation without success. The 7 patients presented with limb defects and in 4 of them a diagnosis of Möbius sequence was made.


Subject(s)
Abnormalities, Drug-Induced , Abnormalities, Multiple/chemically induced , Cranial Nerve Diseases/congenital , Ectromelia/chemically induced , Facial Paralysis/congenital , Misoprostol/adverse effects , Abortion, Criminal , Brazil , Cranial Nerve Diseases/chemically induced , Facial Paralysis/chemically induced , Female , Foot Deformities, Congenital/chemically induced , Hand Deformities, Congenital/chemically induced , Humans , Infant, Newborn , Male , Pregnancy , Syndrome
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