1.
J Rheumatol
; 16(6): 837-41, 1989 Jun.
Article
in English
| MEDLINE
| ID: mdl-2778769
ABSTRACT
In comparison to normal fibroblasts cultured in parallel, scleromyxedema fibroblasts grew less well, synthesized increased amounts of glycosaminoglycans (GAG) in vitro and had ultrastructural abnormalities. Serum obtained from a patient with scleromyxedema increased in vitro fibroblast proliferation but not the GAG synthesis per cell. Serum obtained after therapy, at the time when clinical improvement was observed, continued to stimulate fibroblast proliferation. Thus the serum factor stimulating the fibroblast proliferation did not modulate their GAG synthesis and had no direct relationship to disease activity.
Subject(s)
Fibroblasts/metabolism , Glycosaminoglycans/biosynthesis , Scleroderma, Localized/metabolism , Female , Fibroblasts/ultrastructure , Humans , Middle Aged , Myxedema/metabolism , Skin/metabolism
2.
Rev Hosp Clin Fac Med Sao Paulo
; 28(1): 3-8, 1973.
Article
in Portuguese
| MEDLINE
| ID: mdl-4699130
Subject(s)
Lipid Metabolism , Myxedema/metabolism , Adult , Female , Heparin , Humans , Injections, Intravenous , Lipids/blood , Male , Myxedema/blood , Myxedema/therapy
3.
Adv Exp Med Biol
; 30: 161-74, 1972.
Article
in English
| MEDLINE
| ID: mdl-4122801
Subject(s)
Congenital Hypothyroidism/diagnosis , Thyroid Function Tests , Thyroid Gland/physiopathology , Brazil , Congenital Hypothyroidism/drug therapy , Congenital Hypothyroidism/physiopathology , Democratic Republic of the Congo , Ecuador , Goiter, Nodular/metabolism , Humans , Iodine/metabolism , Iodine Radioisotopes , Iodized Oil/therapeutic use , Myxedema/metabolism , New Guinea , Radioimmunoassay , Switzerland , Thyroid Gland/metabolism , Thyrotropin/blood
4.
Medicina (B Aires)
; 30(4): 380-3, 1970.
Article
in Spanish
| MEDLINE
| ID: mdl-5487694
5.
Medicina (B Aires)
; 29(4): 259-62, 1969.
Article
in Spanish
| MEDLINE
| ID: mdl-5382839