ABSTRACT
OBJECTIVE: Computer aided diagnostics (CAD) systems can automate the differentiation of maxillary sinus (MS) with and without opacification, simplifying the typically laborious process and aiding in clinical insight discovery within large cohorts. METHODS: This study uses Hamburg City Health Study (HCHS) a large, prospective, long-term, population-based cohort study of participants between 45 and 74 years of age. We develop a CAD system using an ensemble of 3D Convolutional Neural Network (CNN) to analyze cranial MRIs, distinguishing MS with opacifications (polyps, cysts, mucosal thickening) from MS without opacifications. The system is used to find correlations of participants with and without MS opacifications with clinical data (smoking, alcohol, BMI, asthma, bronchitis, sex, age, leukocyte count, C-reactive protein, allergies). RESULTS: The evaluation metrics of CAD system (Area Under Receiver Operator Characteristic: 0.95, sensitivity: 0.85, specificity: 0.90) demonstrated the effectiveness of our approach. MS with opacification group exhibited higher alcohol consumption, higher BMI, higher incidence of intrinsic asthma and extrinsic asthma. Male sex had higher prevalence of MS opacifications. Participants with MS opacifications had higher incidence of hay fever and house dust allergy but lower incidence of bee/wasp venom allergy. CONCLUSION: The study demonstrates a 3D CNN's ability to distinguish MS with and without opacifications, improving automated diagnosis and aiding in correlating clinical data in population studies. LEVEL OF EVIDENCE: 3 Laryngoscope, 134:3927-3934, 2024.
Subject(s)
Diagnosis, Computer-Assisted , Magnetic Resonance Imaging , Maxillary Sinus , Humans , Male , Middle Aged , Female , Aged , Prospective Studies , Maxillary Sinus/diagnostic imaging , Diagnosis, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Paranasal Sinus Diseases/diagnostic imaging , Paranasal Sinus Diseases/epidemiology , Paranasal Sinus Diseases/diagnosis , Neural Networks, Computer , Sensitivity and SpecificityABSTRACT
Se realizó una investigación observacional, descriptiva y transversal de 132 pacientes con afecciones no traumáticas de los senos paranasales, atendidos en el Servicio de Otorrinolaringología del Hospital Provincial Docente Saturnino Lora Torres de Santiago de Cuba, desde enero del 2013 hasta diciembre del 2015, a fin de caracterizarles según variables epidemiológicas, clínicas y tomográficas de interés. En la serie predominaron los afectados de 39-58 años de edad (42,4 por ciento), el hábito de fumar (62,1 por ciento) y las infecciones dentarias (59,1 por ciento) como los principales factores de riesgo, así como los procesos inflamatorios sinusales (62,1 por ciento) que afectaron preferentemente el seno maxilar. Se halló coincidencia entre el diagnóstico definitivo y los signos tomográficos en 66 pacientes, con un coeficiente de Kappa de 0,80.
An observational, descriptive and cross-sectional investigation of 132 patients with non traumatic disorders of the paranasal sinuses, assisted in the Otolaryngology Service of Saturnino Lora Torres Teaching Provincial Hospital in Santiago de Cuba, was carried out from January, 2013 to December, 2015, in order to characterize them according to clinical, epidemiological and tomographic variables of interest. In the series there was a prevalence of the affected patients aged 39-58 (42.4 percent), the smoking habit (62.1 percent) and dental infections (59.1 percent) as the main risk factors, as well as the sinusal inflammatory processes (62.1 percent) that preferably affected the maxillary sinus. There was a coincidence between the definitive diagnosis and the tomographic signs in 66 patients, with a Kappa coefficient of 0.80.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Paranasal Sinuses/injuries , Paranasal Sinus Diseases , Paranasal Sinus Diseases/epidemiology , Sinusitis/drug therapy , Paranasal Sinus Diseases/diagnostic imaging , Epidemiology, Descriptive , Cross-Sectional Studies , Observational StudyABSTRACT
Introducción: El velamiento de una cavidad paranasal representa un desafío diagnóstico y puede ser causado por diversas patologías. El examen clínico generalmente es insuficiente para orientar la conducta siendo necesario un estudio completo que incluya endoscopía, imágenes e histología para lograr un diagnóstico definitivo. Objetivo: Describir la impresión clínica, imagenológica, quirúrgica e histológica de pacientes con patología unilateral de senos paranasales. Material y método: Serie retrospectiva de 32 pacientes con patología sinusal unilateral operados en Hospital Clínico de la Universidad de Chile entre 2012 y 2014. Se consideró como criterio de inclusión el compromiso predominante de un seno paranasal en el estudio imagenológico. Se describen las variables: síntoma principal, impresión diagnóstica; clínica, imagenológica, quirúrgica, seno comprometido, entre otras. Resultados: El síntoma principal más frecuente fue obstrucción nasal (56%). Los diagnósticos más frecuentes fueron: patología inflamatoria (84%): pólipo antrocoanal (31%), mucocele (22%) y bola fúngica (22%) y patología tumoral benigna: papiloma invertido (16%), siendo el seno maxilar el más afectado (90%). La impresión diagnóstica quirúrgica fue más precisa que la imagenológica en determinar el diagnóstico definitivo, aunque esta diferencia no alcanzó significancia estadística. Discusión: Patología compleja que requiere estudio completo incluyendo endoscopía. Las imágenes son el segundo pilar en el diagnóstico y deben solicitarse de acuerdo a los hallazgos. El diagnóstico quirúrgico provee una mayor precisión diagnóstica. Conclusiones: Se incluyen varias patologías bajo este concepto, la patología inflamatoria predomina pero se debe tener alto índice de sospecha dado la relativa frecuencia de patología tumoral.
Introduction: Paranasal sinus opacity represents a diagnostic challenge and can be caused by diverse pathologies. Clinical examination is generally insufficient to achieve a definitive diagnosis and it is necessary a complete study including endoscopy, imaging and histology. Aim: To describe clinical, radiographical, surgical and histological diagnostic impressions of patients with unilateral sinus disease. Material and method: 32 retrospective serie with unilateral sinus disease treated at Hospital Clínico de la Universidad de Chile, between 2012 and 2014. The predominant commitment of one sinus on the tomography was considered as inclusion criterion. Principal symtom, clinical, radiographical and surgical diagnostic impressions, committed sinus, among others variables were studied. Results: The most frequent symtom was nasal obstruction (56%). The most frequent diagnoses were: inflammatory disease (84%): antrochoanal polyp (31%), mucocele (22%) and fungus ball (22%) and benign tumor: inverted papilloma (16%). The maxillary sinus was affected in 90%. Surgical diagnostic impression was more precise than radiographical impression in determining the definitive diagnosis, although this difference did not reach statistics significance. Discussion: Unilateral sinus disease is a complex pathology that requires comprehensive study including endoscopy. Images are the second pillar in the diagnosis and should be requested according to the findings. Surgical diagnostic impression provides greater diagnostic presicion. Conclusions: Several pathologies are included under this concept, inflammatory disease prevails but it is necessary to have high index of suspicion in view of the relative frequency of tumour pathology.
Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Paranasal Sinus Diseases/diagnosis , Paranasal Sinus Diseases/epidemiology , Paranasal Sinus Diseases/surgery , Retrospective StudiesABSTRACT
Presentamos el Documento de consenso sobre sinusitis de la Sociedad de Infectología Pediátrica (SEIP), la Asociación Española de Pediatría de Atención Primaria (AEPap), la Sociedad Española de Pediatría Extrahospitalaria y de Atención Primaria (SEPEAP) y la Sociedad Española de Otrorrinolaringología Pediátrica (SEORL). La sinusitis es una enfermedad de diagnóstico difícil, a menudo no reconocida. Se analiza la etiología, la clínica y los criterios diagnósticos más aceptados, y se realizan recomendaciones terapéuticas acordes con la situación epidemiológica actual. Se propone la amoxicilina por vía oral como tratamiento antibiótico de elección en dosis de 80 mg/kg/día repartidas cada 8 horas. Se indican tratamientos alternativos en casos especiales y en ausencia de eficacia de la amoxicilina. Se revisan las principales complicaciones de esta entidad (AU)
The Spanish National Consensus (Spanish Society of Pediatric Infectious Diseases,Spanish Association of Primary Care Pediatrics, Spanish Society of Pediatric Outpatient and Primary Care, Spanish Society of Otorhinolaryngology and Cervical-Facial Pathology) on Sinusitisis presented. Rhinosinusitis is a difficult to diagnose and often unrecognised disease. The document discusses the aetiology, the clinical signs and symptoms, and the diagnostic criteria. Aproposal for treatment is made based on the epidemiological situation in our country. Oral amoxicillin is the treatment of choice (80 mg/kg/day divided every 8 hours). Alternative treatment is proposed in special cases and when amoxicillin is not sufficient. The main complications are reviewed (AU)
Subject(s)
Humans , Male , Female , Child , Sinusitis/diagnosis , Sinusitis/etiology , Sinusitis/therapy , Amoxicillin/therapeutic use , Paranasal Sinuses/pathology , Paranasal Sinus Diseases/epidemiology , Paranasal Sinus Diseases/prevention & control , Diagnosis, Differential , Primary Health Care/methods , Primary Health Care/trends , Primary Health Care , Ethmoid Sinus/pathology , Drug Resistance/immunologyABSTRACT
El objetivo de este trabajo es presentar la incidencia, frecuencia, características clínicas y evolución de los pacientes con mucormicosis atendidos en el Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, entre los años 1982 y 2010. Durante ese período se diagnosticaron 10 casos de mucormicosis. Los tres primeros entre 1982 y 2004 y los últimos 7 entre 2005 y 2010. La incidencia y frecuencia de esta enfermedad, para el período 1980-2004 fue 0.13 pacientes/año y 0.1 casos/10 000 egresos (IC 95%: 0.00 a 0.3) respectivamente. En el período 2005-2010 la incidencia fue 0.86 pacientes/año y la frecuencia de 1.1 casos/10 000 egresos (IC 95%: 0.5 a 2.4). Hubo nueve casos de mucormicosis rinosinuso-orbitaria, siete en pacientes con diabetes mellitus, uno en una paciente con una hemopatía maligna y neutropenia, y el restante en un paciente con HIV/sida que además estaba neutropénico y con un síndrome hemofagocítico. En una paciente se realizó el diagnóstico post mortem de mucormicosis pulmonar. El diagnóstico se efectuó por la observación de filamentos cenocíticos en los diez casos. Hubo desarrollo de mucorales en los cultivos de 8/9 pacientes; cinco Rhizopus spp y tres Mucor spp. Todos los pacientes recibieron un tratamiento inicial con anfotericina B deoxicolato, que en tres de ellos fue continuado con anfotericina B liposomal, y cirugía. Tres enfermos recibieron además un tratamiento adyuvante con oxigeno hiperbárico. La mortalidad fue 30%.
Mucormycosis is an opportunistic infection caused by fungi of the order Mucorales. It is characterized by rapid progression and high morbidity and mortality in the absence of early diagnosis and prompt treatment. It was an infrequent disease, but in recent years, its incidence appears to have increased. The aim of this paper is to report the cases of mucormycosis diagnosed from 1982 to 2010 at the Hospital de Clinicas José de San Martín, University of Buenos Aires. We diagnosed 10 cases of mucormycosis; the first three between 1982 and 2004 and the last 7 between 2005 and 2010. The incidence from 1980 to 2004 was 0.13 patient-years and the frequency 0.1/10 000 discharges (95% CI 0.00- 0.3). In the period 2005 to 2010, the incidence was 0.86 patients per year with 1.1/10 000 discharges (95% CI 0.5-2.4). There was a pulmonary mucormycosis case (in a patient treated with corticosteroids) and nine rhinocerebral cases, two in neutropenic and seven in diabetic patients. The diagnosis was made by observation of cenocytic hyphae in 10/10 patients. Mucorales were recovered in 8/9 cultures (5 Rhizopus spp and 3 Mucor spp.). In one case diagnosis of pulmonary mucormycosis was made post-mortem. Nine patients were treated with amphotericin B deoxycholate (in 3 patients supplemented with liposomal amphotericin B) and surgery. Three patients underwent hyperbaric chamber. Seven patients had favorable outcome. In conclusion, mucormycosis is a rare disease, but its incidence has increased over the past five years. A good evolution of the patients is linked to early diagnosis and treatment.
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Mucormycosis/epidemiology , Nose Diseases/epidemiology , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Argentina/epidemiology , Drug Combinations , Deoxycholic Acid/therapeutic use , Eye Infections, Fungal/drug therapy , Eye Infections, Fungal/epidemiology , Eye Infections, Fungal/microbiology , Incidence , Lung Diseases, Fungal/drug therapy , Lung Diseases, Fungal/epidemiology , Lung Diseases, Fungal/pathology , Mucormycosis/drug therapy , Mucormycosis/pathology , Nose Diseases/drug therapy , Nose Diseases/microbiology , Paranasal Sinus Diseases/drug therapy , Paranasal Sinus Diseases/epidemiology , Paranasal Sinus Diseases/microbiologyABSTRACT
El objetivo de este trabajo es presentar la incidencia, frecuencia, características clínicas y evolución de los pacientes con mucormicosis atendidos en el Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, entre los años 1982 y 2010. Durante ese período se diagnosticaron 10 casos de mucormicosis. Los tres primeros entre 1982 y 2004 y los últimos 7 entre 2005 y 2010. La incidencia y frecuencia de esta enfermedad, para el período 1980-2004 fue 0.13 pacientes/año y 0.1 casos/10 000 egresos (IC 95%: 0.00 a 0.3) respectivamente. En el período 2005-2010 la incidencia fue 0.86 pacientes/año y la frecuencia de 1.1 casos/10 000 egresos (IC 95%: 0.5 a 2.4). Hubo nueve casos de mucormicosis rinosinuso-orbitaria, siete en pacientes con diabetes mellitus, uno en una paciente con una hemopatía maligna y neutropenia, y el restante en un paciente con HIV/sida que además estaba neutropénico y con un síndrome hemofagocítico. En una paciente se realizó el diagnóstico post mortem de mucormicosis pulmonar. El diagnóstico se efectuó por la observación de filamentos cenocíticos en los diez casos. Hubo desarrollo de mucorales en los cultivos de 8/9 pacientes; cinco Rhizopus spp y tres Mucor spp. Todos los pacientes recibieron un tratamiento inicial con anfotericina B deoxicolato, que en tres de ellos fue continuado con anfotericina B liposomal, y cirugía. Tres enfermos recibieron además un tratamiento adyuvante con oxigeno hiperbárico. La mortalidad fue 30%.(AU)
Mucormycosis is an opportunistic infection caused by fungi of the order Mucorales. It is characterized by rapid progression and high morbidity and mortality in the absence of early diagnosis and prompt treatment. It was an infrequent disease, but in recent years, its incidence appears to have increased. The aim of this paper is to report the cases of mucormycosis diagnosed from 1982 to 2010 at the Hospital de Clinicas José de San Martín, University of Buenos Aires. We diagnosed 10 cases of mucormycosis; the first three between 1982 and 2004 and the last 7 between 2005 and 2010. The incidence from 1980 to 2004 was 0.13 patient-years and the frequency 0.1/10 000 discharges (95% CI 0.00- 0.3). In the period 2005 to 2010, the incidence was 0.86 patients per year with 1.1/10 000 discharges (95% CI 0.5-2.4). There was a pulmonary mucormycosis case (in a patient treated with corticosteroids) and nine rhinocerebral cases, two in neutropenic and seven in diabetic patients. The diagnosis was made by observation of cenocytic hyphae in 10/10 patients. Mucorales were recovered in 8/9 cultures (5 Rhizopus spp and 3 Mucor spp.). In one case diagnosis of pulmonary mucormycosis was made post-mortem. Nine patients were treated with amphotericin B deoxycholate (in 3 patients supplemented with liposomal amphotericin B) and surgery. Three patients underwent hyperbaric chamber. Seven patients had favorable outcome. In conclusion, mucormycosis is a rare disease, but its incidence has increased over the past five years. A good evolution of the patients is linked to early diagnosis and treatment.(AU)
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Mucormycosis/epidemiology , Nose Diseases/epidemiology , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Argentina/epidemiology , Deoxycholic Acid/therapeutic use , Drug Combinations , Eye Infections, Fungal/drug therapy , Eye Infections, Fungal/epidemiology , Eye Infections, Fungal/microbiology , Incidence , Lung Diseases, Fungal/drug therapy , Lung Diseases, Fungal/epidemiology , Lung Diseases, Fungal/pathology , Mucormycosis/drug therapy , Mucormycosis/pathology , Nose Diseases/drug therapy , Nose Diseases/microbiology , Paranasal Sinus Diseases/drug therapy , Paranasal Sinus Diseases/epidemiology , Paranasal Sinus Diseases/microbiologyABSTRACT
El objetivo de este trabajo es presentar la incidencia, frecuencia, características clínicas y evolución de los pacientes con mucormicosis atendidos en el Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, entre los años 1982 y 2010. Durante ese período se diagnosticaron 10 casos de mucormicosis. Los tres primeros entre 1982 y 2004 y los últimos 7 entre 2005 y 2010. La incidencia y frecuencia de esta enfermedad, para el período 1980-2004 fue 0.13 pacientes/año y 0.1 casos/10 000 egresos (IC 95%: 0.00 a 0.3) respectivamente. En el período 2005-2010 la incidencia fue 0.86 pacientes/año y la frecuencia de 1.1 casos/10 000 egresos (IC 95%: 0.5 a 2.4). Hubo nueve casos de mucormicosis rinosinuso-orbitaria, siete en pacientes con diabetes mellitus, uno en una paciente con una hemopatía maligna y neutropenia, y el restante en un paciente con HIV/sida que además estaba neutropénico y con un síndrome hemofagocítico. En una paciente se realizó el diagnóstico post mortem de mucormicosis pulmonar. El diagnóstico se efectuó por la observación de filamentos cenocíticos en los diez casos. Hubo desarrollo de mucorales en los cultivos de 8/9 pacientes; cinco Rhizopus spp y tres Mucor spp. Todos los pacientes recibieron un tratamiento inicial con anfotericina B deoxicolato, que en tres de ellos fue continuado con anfotericina B liposomal, y cirugía. Tres enfermos recibieron además un tratamiento adyuvante con oxigeno hiperbárico. La mortalidad fue 30%.(AU)
Mucormycosis is an opportunistic infection caused by fungi of the order Mucorales. It is characterized by rapid progression and high morbidity and mortality in the absence of early diagnosis and prompt treatment. It was an infrequent disease, but in recent years, its incidence appears to have increased. The aim of this paper is to report the cases of mucormycosis diagnosed from 1982 to 2010 at the Hospital de Clinicas José de San Martín, University of Buenos Aires. We diagnosed 10 cases of mucormycosis; the first three between 1982 and 2004 and the last 7 between 2005 and 2010. The incidence from 1980 to 2004 was 0.13 patient-years and the frequency 0.1/10 000 discharges (95% CI 0.00- 0.3). In the period 2005 to 2010, the incidence was 0.86 patients per year with 1.1/10 000 discharges (95% CI 0.5-2.4). There was a pulmonary mucormycosis case (in a patient treated with corticosteroids) and nine rhinocerebral cases, two in neutropenic and seven in diabetic patients. The diagnosis was made by observation of cenocytic hyphae in 10/10 patients. Mucorales were recovered in 8/9 cultures (5 Rhizopus spp and 3 Mucor spp.). In one case diagnosis of pulmonary mucormycosis was made post-mortem. Nine patients were treated with amphotericin B deoxycholate (in 3 patients supplemented with liposomal amphotericin B) and surgery. Three patients underwent hyperbaric chamber. Seven patients had favorable outcome. In conclusion, mucormycosis is a rare disease, but its incidence has increased over the past five years. A good evolution of the patients is linked to early diagnosis and treatment.(AU)
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Mucormycosis/epidemiology , Nose Diseases/epidemiology , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Argentina/epidemiology , Deoxycholic Acid/therapeutic use , Drug Combinations , Eye Infections, Fungal/drug therapy , Eye Infections, Fungal/epidemiology , Eye Infections, Fungal/microbiology , Incidence , Lung Diseases, Fungal/drug therapy , Lung Diseases, Fungal/epidemiology , Lung Diseases, Fungal/pathology , Mucormycosis/drug therapy , Mucormycosis/pathology , Nose Diseases/drug therapy , Nose Diseases/microbiology , Paranasal Sinus Diseases/drug therapy , Paranasal Sinus Diseases/epidemiology , Paranasal Sinus Diseases/microbiologyABSTRACT
A doença nasossinusal é extremamente prevalente em pacientes com sorologia positiva para o vírus da imunodeficiência humana (HIV +), por isso a necessidade de que muitos estudos sejam realizados sobre esta doença, principalmente com o advento das novas drogas anti-retrovirais. Foi realizado um estudo de revisão bibliográfica buscando razões para justificar esta alta prevalência, sendo determinada a alteração da imunidade humoral e celular, distúrbios da mobilidade ciliar e alterações anatômicas prévias como fatores etiológicos. Verificou-se que o diagnóstico é eminentemente clínico e a conduta terapêutica inicial é semelhante a da população não infectada. Nestes pacientes se faz necessário um acompanhamento mais criterioso e atenção especial deve ser dada ao nível de linfócitos T helper (CD4), pois tem se verificado casos de dificil manejo terapêutico e aparecimento de complicações nasossinusais em pacientes com níveis de células CD4 abaixo de 200 por milímetro cúbico(mm3). Os autores relatam que a ausência de resposta ao tratamento clínico após punção, lavagem e cultura da secreção dos seios maxilares determina a indicação do tratamento cirúrgico que, na maioria dos casos, melhora a qualidade de vida destes pacientes.