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1.
Langenbecks Arch Surg ; 409(1): 280, 2024 Sep 17.
Article in English | MEDLINE | ID: mdl-39287782

ABSTRACT

PURPOSE: Blind tunneling of subfascial femoropopliteal bypass grafts may result in inadvertent graft passage through the sartorius. The purpose of this study was to determine whether intramuscular passage of femoropopliteal bypass grafts affects primary patency. METHODS: Patients undergoing femoropopliteal bypass at a Veterans Administration hospital and associated university medical center over a recent 13-year period who also had postoperative cross-sectional imaging adequate to determine graft location were examined. Five-year primary patency of grafts circumferentially enveloped by the muscle was compared with that of both extramuscular subfascial grafts and subcutaneous grafts. RESULTS: 370 femoropopliteal grafts were identified, among which 258 (70%) were subfascial. Vein grafts comprised 51% of the subfascial grafts, and 53% were inserted above the knee. Available postoperative imaging in 110 subfascial grafts demonstrated 74 (67%) to lie completely within the muscle at some point. Among imaged subfascial grafts, primary patency at five years for intramuscular grafts was not significantly worse than extramuscular grafts (P = 0.31). This remained true whether grafts were vein (P = 0.39) or prosthetic (P = 0.31) and whether grafts inserted to the above-knee (P = 0.43) or below-knee (P = 0.21) popliteal artery. Multivariable Cox regression revealed a significant relationship between use of vein grafts (P = 0.013), active smoking (P = 0.01), and hypertension (P = 0.041) and primary patency, but not intramuscular graft location (P = 0.31). CONCLUSION: This study failed to demonstrate significantly inferior primary patency among subfascial femoropopliteal grafts tunneled intramuscularly. Larger studies may be required to adequately detect any differences in patency by muscular entrapment, especially among subgroups.


Subject(s)
Femoral Artery , Popliteal Artery , Vascular Patency , Humans , Popliteal Artery/surgery , Femoral Artery/surgery , Male , Aged , Female , Middle Aged , Muscle, Skeletal/transplantation , Muscle, Skeletal/blood supply , Retrospective Studies , Graft Occlusion, Vascular/etiology , Treatment Outcome
2.
EuroIntervention ; 20(18): e1163-e1172, 2024 Sep 16.
Article in English | MEDLINE | ID: mdl-39279518

ABSTRACT

BACKGROUND: Although femoropopliteal-specific stents have durable patency, stent thrombosis (ST) may occur, which can lead to acute limb ischaemia (ALI). AIMS: We aimed to investigate the clinical features and outcomes of ALI caused by femoropopliteal ST in patients with lower extremity artery disease. METHODS: This multicentre retrospective study included 499 patients with ALI - of whom 108 patients had ALI caused by femoropopliteal ST (ST-ALI) and 391 patients had ALI caused by other aetiologies (de novo ALI) - who underwent treatment between September 2011 and March 2023. Clinical features and outcomes were compared between the two groups. The primary outcome measure was 12-month amputation-free survival; factors associated with amputation or death were investigated using multivariate Cox proportional hazards regression analysis. RESULTS: Patients with ST-ALI were significantly more likely to exhibit conventional atherosclerotic risk factors, including diabetes mellitus (63% vs 26%) and haemodialysis (51% vs 10%) compared to patients with de novo ALI, whereas patients with de novo ALI were older (80 years vs 74 years) and more likely to have atrial fibrillation (49% vs 18%) than patients with ST-ALI. The 12-month amputation-free survival rate was significantly lower in the ST-ALI group than that in the de novo ALI group (51% vs 76%; p<0.001). Multivariate analysis revealed that ST-ALI, older age, haemodialysis, atrial fibrillation, the presence of a wound, peak C-reactive protein level, and non-ambulatory status all have an independent, positive association with death or major amputation. CONCLUSIONS: The current study revealed that patients with ST-ALI had worse clinical outcomes than those with de novo ALI, highlighting the need to maximise ST prevention.


Subject(s)
Amputation, Surgical , Femoral Artery , Ischemia , Peripheral Arterial Disease , Popliteal Artery , Stents , Thrombosis , Humans , Male , Aged , Female , Retrospective Studies , Popliteal Artery/surgery , Ischemia/therapy , Ischemia/mortality , Ischemia/etiology , Ischemia/surgery , Femoral Artery/surgery , Peripheral Arterial Disease/therapy , Peripheral Arterial Disease/complications , Peripheral Arterial Disease/surgery , Peripheral Arterial Disease/mortality , Aged, 80 and over , Middle Aged , Thrombosis/etiology , Thrombosis/mortality , Treatment Outcome , Risk Factors , Limb Salvage , Endovascular Procedures/instrumentation , Endovascular Procedures/adverse effects , Lower Extremity/blood supply , Acute Disease , Vascular Patency
3.
EuroIntervention ; 20(18): e1154-e1162, 2024 Sep 16.
Article in English | MEDLINE | ID: mdl-39279516

ABSTRACT

BACKGROUND: Endovascular therapy (EVT) has become the preferred treatment modality for femoropopliteal disease. However, there is limited evidence regarding its procedural and clinical outcomes according to the affected area. AIMS: The aim of this study is to investigate clinical outcomes and device effectiveness according to treatment extent in the superficial femoral artery (SFA), popliteal artery (PA), or both. METHODS: In this study, we analysed EVT for SFA (2,404 limbs), PA (155 limbs), SFA/PA (383 limbs) using the population in the K-VIS ELLA (Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Diseases) registry. The primary endpoint was target lesion revascularisation (TLR) at 2 years. RESULTS: The SFA/PA group exhibited a higher prevalence of anatomical complexity, characterised by long lesions, moderate to severe calcification, and total occlusion. The procedures were successful in 97.2% of SFA, 92.9% of PA, and 95.6% of SFA/PA EVTs. The 2-year TLR rates were 21.1%, 18.6%, and 32.7% in the SFA, PA, and SFA/PA groups, respectively. SFA/PA EVT was associated with a significantly increased risk for TLR compared to the SFA group (adjusted hazard ratio [HR] 1.48 [1.09-2.00]; p=0.008) and a trend towards an increased risk compared to the PA group (adjusted HR 1.80 [1.00-3.27]; p=0.052). After overlap weighting, the use of a drug-coated balloon (DCB) was shown to be beneficial, with the lowest TLR rate after SFA and SFA/PA EVT. CONCLUSIONS: In this large real-world registry, SFA/PA EVT was associated with an increased risk for TLR at 2 years compared to the SFA or PA EVT groups, with favourable outcomes when using a DCB or drug-eluting stent in the SFA/PA EVT group.


Subject(s)
Endovascular Procedures , Femoral Artery , Peripheral Arterial Disease , Popliteal Artery , Humans , Popliteal Artery/surgery , Endovascular Procedures/instrumentation , Endovascular Procedures/adverse effects , Endovascular Procedures/methods , Peripheral Arterial Disease/therapy , Male , Female , Aged , Treatment Outcome , Middle Aged , Registries , Aged, 80 and over , Risk Factors , Vascular Patency
4.
Nat Commun ; 15(1): 7903, 2024 Sep 10.
Article in English | MEDLINE | ID: mdl-39256371

ABSTRACT

While chronic limb-threatening ischemia is a serious peripheral artery disease, the lack of an appropriate stent significantly limits the potential of interventional treatment. In spite of much progress in coronary stents, little is towards peripheral stents, which are expected to be both long and biodegradable and thus require a breakthrough in core techniques. Herein, we develop a long and biodegradable stent with a length of up to 118 mm based on a metal-polymer composite material. To achieve a well-prepared homogeneous coating on a long stent during ultrasonic spraying, a magnetic levitation is employed. In vivo degradation of the stent is investigated in rabbit abdominal aorta/iliac arteries, and its preclinical safety is evaluated in canine infrapopliteal arteries. First-in-man implantation of the stent is carried out in the below-the-knee artery. The 13 months' follow-ups demonstrate the feasibility of the long and biodegradable stent in clinical applications.


Subject(s)
Absorbable Implants , Peripheral Arterial Disease , Stents , Animals , Rabbits , Dogs , Peripheral Arterial Disease/therapy , Iliac Artery/surgery , Aorta, Abdominal/surgery , Polymers/chemistry , Male , Popliteal Artery/surgery , Humans
5.
Sci Rep ; 14(1): 21173, 2024 09 11.
Article in English | MEDLINE | ID: mdl-39256427

ABSTRACT

Because there is a lack of comparative studies assessing drug-coated balloon (DCB) and drug-eluting stent (DES) outcomes with respect to intraluminal (IL) and subintimal (SI) approaches in femoropopliteal (FP) total occlusive lesions, we compared the outcomes between DCB (including bailout stenting) and DES treatments for this lesion. A total of 487 limbs (434 patients) were divided into the IL (n = 344, DCB: n = 268, DES: n = 76) and SI (n = 143, DCB: n = 83, DES: n = 60) approach groups. The primary outcome was a major adverse limb event (MALE), defined as above-ankle amputation or repeat revascularization of the index limb. Secondary outcomes included clinically driven target lesion revascularization (TLR), loss of clinical patency, and all-cause death. After adjustment, in each IL and SI approach, the 2-year rates of MALE (p = 0.180 and p = 0.236, respectively), TLR, loss of clinical patency, and all-cause death were similar between the DCB and DES groups. In the DCB and DES groups, both primary and secondary outcomes were similar between the IL and SI approaches. DCB and DES strategies for patients presenting with FP total occlusive lesions demonstrated similar outcomes regardless of the IL or SI approach.Clinical Trial Registration: NCT02748226.


Subject(s)
Drug-Eluting Stents , Femoral Artery , Popliteal Artery , Humans , Male , Female , Aged , Popliteal Artery/surgery , Femoral Artery/surgery , Treatment Outcome , Middle Aged , Peripheral Arterial Disease/therapy , Angioplasty, Balloon/methods , Aged, 80 and over , Retrospective Studies , Vascular Patency
6.
BMJ Open ; 14(8): e080560, 2024 Aug 07.
Article in English | MEDLINE | ID: mdl-39117410

ABSTRACT

INTRODUCTION: Endovascular therapy has emerged as a prominent strategy for managing femoropopliteal peripheral artery disease, offering acceptable safety and efficacy compared with open surgical bypass. Both paclitaxel-eluting stents and heparin-bonded covered stents have exhibited enhanced clinical outcomes compared with bare metal stents. However, there is currently a lack of level I evidence comparing the safety and efficacy of paclitaxel-eluting stents and heparin-bonded covered stents. Therefore, the primary objective of this study is to systematically evaluate the efficacy and safety outcomes of these two types of stents. METHODS AND ANALYSIS: The ELITE trial is a prospective, multicentre, parallel, randomised controlled trial. A total of 450 patients will be recruited. The primary endpoints of the study include primary patency at 1 year post-index procedure. ETHICS AND DISSEMINATION: Ethical approval for this study was obtained from the Ethics Committee of West China Hospital of Sichuan University (approval number: 2023-1186). The results will be submitted to a major clinical journal for peer review and publication. TRIAL REGISTRATION: ELITE trial was registered on 27 September 2023 in the Chinese Clinical Trials Registry (ChiCTR2300076236).


Subject(s)
Drug-Eluting Stents , Femoral Artery , Heparin , Peripheral Arterial Disease , Popliteal Artery , Humans , Heparin/administration & dosage , Heparin/therapeutic use , Peripheral Arterial Disease/therapy , Peripheral Arterial Disease/surgery , Popliteal Artery/surgery , Prospective Studies , Femoral Artery/surgery , China , Paclitaxel/administration & dosage , Paclitaxel/therapeutic use , Randomized Controlled Trials as Topic , Multicenter Studies as Topic , Treatment Outcome , Endovascular Procedures/methods , Male , Female , Stents , Vascular Patency
7.
Int Angiol ; 43(3): 358-366, 2024 06.
Article in English | MEDLINE | ID: mdl-38990277

ABSTRACT

BACKGROUND: The purpose of this study was to compare femoropopliteal bypass (FPB) and remote endarterectomy (RE) for long femoropopliteal lesions. METHODS: Single center retrospective propensity matching analysis of the symptomatic patients with long occlusion of the femoro-popliteal segment (>250 mm), who underwent femoro-popliteal bypass above the knee or remote endarterectomy from 2014 to 2020. Primary endpoints: primary patency (PP), secondary patency (SP), target lesion revascularization (TLR). Secondary endpoints: MALE, MACE, clinical improvement and survival. RESULTS: Four hundred patients were divided into two groups: 200 in the FPB group and 200 in the RE group. As a result of propensity score matching, 110 (FPB) and 109 (RE) patients remained. Three-year primary patency rates were 62% for FPB vs. 53% for RE, P=0.16. Secondary patency rates were 84% for FPB vs. 75% for RE, P=0.10. Freedom from TLR were 61% for FPB vs. 71% for RE P=0.21. Survival and amputation-free survival (AFS) also did not differ (93% vs. 94%, P=0.81 and 87% vs. 92%, P=0.19 respectively). Primary patency of the GSV higher than RE (P=0.00) and PTFE (P=0.00). It was established statistically advantages of RE and great saphenous vein (GSV) bypass over a PTFE bypass in SP (P=0.01 P=0.03), TLR (P=0.02 P=0.00) and AFS (P=0.03 P=0.01). CONCLUSIONS: Surgical treatment of long femoropopliteal occlusions with an autovenous bypass or remote endarterectomy showed significantly better results in secondary patency, TLR and AFS than the use of PTFE prostheses. GSV remains the gold standard for femoropopliteal bypass surgery.


Subject(s)
Endarterectomy , Femoral Artery , Peripheral Arterial Disease , Popliteal Artery , Propensity Score , Vascular Patency , Humans , Male , Popliteal Artery/surgery , Popliteal Artery/physiopathology , Femoral Artery/surgery , Femoral Artery/physiopathology , Retrospective Studies , Female , Aged , Endarterectomy/adverse effects , Peripheral Arterial Disease/surgery , Peripheral Arterial Disease/physiopathology , Middle Aged , Treatment Outcome , Limb Salvage , Time Factors , Risk Factors
8.
Ann Vasc Surg ; 108: 287-294, 2024 Nov.
Article in English | MEDLINE | ID: mdl-39004277

ABSTRACT

BACKGROUND: Injury to the popliteal artery after knee dislocation, if not promptly diagnosed and properly treated, can have devastating results. The purpose of this retrospective study was to describe the diagnostic and the treatment protocol we use, as well as provide long-term outcomes for a series of patients treated in our tertiary hospital, emphasizing on the importance of ankle-brachial index (ABI) measurement as an integral component of the diagnostic approach. METHODS: A retrospective analysis of all admissions to our hospital trauma center between November 1996 and July 2023, with a diagnosis of knee dislocation and the presence or absence of concomitant arterial injury resulting from blunt high-energy trauma, was conducted. Before 2006, digital subtraction angiography (DSA) and/or computed tomography angiography (CTA) were part of the diagnostic approach (group A). After 2006, the ABI was used as a first-line test to diagnose arterial damage (group B). The Tegner and Lysholm scores were chosen to assess patients' postoperative impairment between groups, taking also into account the presence or absence of vascular injury. The Mann-Whitney U test and a univariate analysis of variance were used for the statistical analysis of scores. RESULTS: Overall, 55 patients were identified, and 21 of them (38.2%) had injuries to the popliteal artery, all of which were treated with a reversed great saphenous venous bypass. Out of the 21 patients, 4 (4.3%) developed compartment syndrome, which was treated with fasciotomies, and 1 leg (1.8%) was amputated above the knee. With no patients lost to follow-up, all but one (95%) of the vascular repairs are still patent, and the limbs show no signs of ischemia after a mean follow-up of 6 years. The Tegner and Lysholm score means were similar between groups A and B and independent of the presence of vascular injury and the diagnostic protocol used. Interestingly, an ABI below 0.9 proved to be predictive of arterial injury. CONCLUSIONS: A high level of awareness for the presence of popliteal artery injury should exist and an ABI measurement should be routinely performed in the management of all cases of knee dislocation. This way, fewer patients will undergo unnecessary CTA scanning, and hardly any popliteal artery injuries can go missing, as suggested by our study.


Subject(s)
Ankle Brachial Index , Knee Dislocation , Popliteal Artery , Vascular System Injuries , Wounds, Nonpenetrating , Humans , Popliteal Artery/injuries , Popliteal Artery/diagnostic imaging , Popliteal Artery/surgery , Popliteal Artery/physiopathology , Retrospective Studies , Male , Female , Knee Dislocation/diagnostic imaging , Knee Dislocation/complications , Knee Dislocation/surgery , Knee Dislocation/etiology , Knee Dislocation/therapy , Wounds, Nonpenetrating/diagnostic imaging , Wounds, Nonpenetrating/therapy , Wounds, Nonpenetrating/complications , Wounds, Nonpenetrating/surgery , Vascular System Injuries/diagnostic imaging , Vascular System Injuries/surgery , Vascular System Injuries/etiology , Vascular System Injuries/therapy , Treatment Outcome , Adult , Time Factors , Middle Aged , Angiography, Digital Subtraction , Young Adult , Computed Tomography Angiography , Vascular Surgical Procedures/adverse effects , Risk Factors , Predictive Value of Tests , Aged , Adolescent , Amputation, Surgical , Recovery of Function
9.
Ann Vasc Surg ; 108: 459-465, 2024 Nov.
Article in English | MEDLINE | ID: mdl-39025212

ABSTRACT

BACKGROUND: To assess the safety and efficacy of ultrasound-assisted sagittal view for retrograde puncture of the P2 segment of popliteal artery (PA) for treating femoropopliteal lesions. METHODS: A retrospective study was conducted on consecutive patients who underwent retrograde puncture of the PA for the recanalization of femoropopliteal lesions. A retrograde access was made to either the P2 or P3 segment of the PA in 23 cases. In 10 cases (8 men; mean age 68 ± 9 years), ultrasound-guided retrograde PA (P2 segment) puncture using the long-axis in-the-plane approach was performed, and in 13 cases (11 men; mean age 69 ± 5 years), angiography-guided retrograde PA (P3 segment) puncture was performed. Clinical data was compared preintraoperatively and postoperatively in the 2 groups. RESULTS: All occluded lesions were successfully recanalized via dual channel intervention. Puncture success were 100% (10/10) in the P2 group compared with 92.3% (12/13) in the P3 group (P > 0.05). The mean puncture time in the P2 group was significantly shorter when compared to the P3 group (4.70 ± 0.95 mins vs 11.33 ± 6.37 mins; P < 0.05). There was no difference in mean hemostasis time between the 2 groups (6.11 ± 2.20 mins vs 8.46 ± 3.76 mins; P > 0.05). There were no in-hospital deaths in all patients. The occurrence of puncture-related complications in the P2 group was 10% compared with 15% in the P3 group (P > 0.05). A low-flow arteriovenous fistula was observed in one case in the P3 group. None of the patients reported any access-related complication at a mean follow-up of 11.3 ± 5.5 months. CONCLUSIONS: Ultrasound-assisted sagittal view for retrograde puncture of the P2 segment of PA is at least as safe as angiography-guided retrograde puncture of the P3 segment for femoropopliteal lesions. Furthermore, this technique appears to be more suitable for patients with tandem iliofemoral artery occlusion, as it allows for the creation of a retrograde access.


Subject(s)
Femoral Artery , Peripheral Arterial Disease , Popliteal Artery , Punctures , Ultrasonography, Interventional , Humans , Popliteal Artery/diagnostic imaging , Popliteal Artery/physiopathology , Popliteal Artery/surgery , Male , Femoral Artery/diagnostic imaging , Femoral Artery/physiopathology , Aged , Retrospective Studies , Female , Treatment Outcome , Peripheral Arterial Disease/diagnostic imaging , Peripheral Arterial Disease/physiopathology , Peripheral Arterial Disease/therapy , Middle Aged , Time Factors , Vascular Patency , Constriction, Pathologic
10.
Minerva Anestesiol ; 90(7-8): 618-625, 2024.
Article in English | MEDLINE | ID: mdl-39021137

ABSTRACT

BACKGROUND: A high tibial osteotomy is usually associated with severe postoperative pain. Both adductor canal block (ACB) and interspace between the popliteal artery and capsule of the posterior knee (IPACK) have been described as effective block techniques for providing analgesia after knee surgeries, with few comparisons in wedge osteotomy cases. We aim to compare the postoperative analgesic profile of the previously mentioned two block techniques in patients undergoing tibial osteotomies. METHODS: Sixty patients were enrolled in this randomized prospective trial (30 received IPACK and 30 received ACB). Both blocks were installed before the spinal anesthesia after infiltration of 2 mL lidocaine 2%. Twenty mL of bupivacaine 0.25% mixed with dexamethasone as anesthetic adjuvant were used for both blocks. The postoperative analgesic profiles were compared between the two groups. RESULTS: Postoperative pain scores were lower in the IPACK group, and that decrease was evident throughout the first 10 hours postoperatively. Additionally, the duration of analgesia was much prolonged with the same block (487.50±82.39 vs. 301.93±92.06 minutes with ACB). There was a significant decline in postoperative analgesic consumption (1.27±0.45 vs. 1.8±0.61 gm, P=0.000), and a significant increase in the ambulation distance (19.10±0.60 vs. 17.73±0.45 m, P=0.000) with a significant decline in the duration of hospitalization (43.27±7.61 vs. 54±8.35 hours) in the IPACK group compared to the ACB group. CONCLUSIONS: IPACK is a superior block technique compared to ACB in patients undergoing high tibial osteotomy regarding postoperative analgesia, ambulation distance, and patient satisfaction with little rate of adverse events in both groups.


Subject(s)
Anesthetics, Local , Nerve Block , Osteotomy , Pain, Postoperative , Popliteal Artery , Tibia , Humans , Pain, Postoperative/drug therapy , Male , Anesthetics, Local/administration & dosage , Anesthetics, Local/therapeutic use , Female , Nerve Block/methods , Osteotomy/methods , Tibia/surgery , Prospective Studies , Adult , Popliteal Artery/surgery , Middle Aged
11.
BMJ Case Rep ; 17(6)2024 Jun 05.
Article in English | MEDLINE | ID: mdl-38839404

ABSTRACT

Popliteal artery entrapment syndrome (PAES) is a rare cause of intermittent claudication in the young. Aberrant embryological development results in entrapment of the popliteal artery by myofascial structures of the popliteal fossa. Type 4 PAES is due to aberrant development of the popliteus muscle superficial to the popliteal artery. We present a case of bilateral type 4 PAES, along with intraoperative photography highlighting the anatomical cause for this pathology. Both limbs in this patient were treated successfully with surgical release of the entrapping popliteus muscle via a posterior surgical approach to the popliteal fossa. This report emphasises the importance of determining popliteal artery integrity and entrapment subtype to guide the management of this condition.


Subject(s)
Muscle, Skeletal , Popliteal Artery , Humans , Popliteal Artery/surgery , Popliteal Artery/diagnostic imaging , Muscle, Skeletal/surgery , Muscle, Skeletal/blood supply , Intermittent Claudication/surgery , Intermittent Claudication/etiology , Arterial Occlusive Diseases/surgery , Male , Adult
12.
Am J Cardiol ; 226: 40-49, 2024 Sep 01.
Article in English | MEDLINE | ID: mdl-38834142

ABSTRACT

Use of peripheral vascular intervention (PVI) for intermittent claudication (IC) continues to expand, but there is uncertainty whether baseline demographics, procedural techniques and outcomes differ by sex, race, and ethnicity. This study aimed to examine amputation and revascularization rates up to 4 years after femoropopliteal (FP) PVI for IC by sex, race, and ethnicity. Patients who underwent FP PVI for IC between 2016 and 2020 from the PINC AI Healthcare Database were analyzed. The primary outcome was any index limb amputation, assessed by Kaplan-Meier estimate. Secondary outcomes included index limb major amputation, repeat revascularization, and index limb repeat revascularization. Unadjusted and adjusted hazard ratios (HRs) were estimated using Cox proportional hazard regression models. This study included 19,324 patients with IC who underwent FP PVI, with 41.2% women, 15.6% Black patients, and 4.7% Hispanic patients. Women were less likely than men to be treated with atherectomy (45.1% vs 47.8%, p = 0.0003); Black patients were more likely than White patients to receive atherectomy (50.7% vs 44.9%, p <0.001), and Hispanic patients were less likely than non-Hispanic patients to receive atherectomy (41% vs 47%, p = 0.0004). Unadjusted rates of any amputation were similar in men and women (6.4% for each group, log-rank p = 0.842), higher in Black patients than in White patients (7.8% vs 6.1%, log-rank p = 0.007), and higher in Hispanic patients than in non-Hispanic patients (8.8% vs 6.3%, log-rank p = 0.031). After adjustment for baseline characteristics, Black race was associated with higher rates of repeat revascularization (adjusted HR 1.13, 95% confidence interval 1.04 to 1.22) and any FP revascularization (adjusted HR 1.10, 95% confidence interval 1.01 to 1.20). No statistical difference in amputation rate was observed among comparison groups. Women and men with IC had similar crude and adjusted amputation and revascularization outcomes after FP PVI. Black patients had higher repeat revascularization and any FP revascularization rates than did White patients. Black and Hispanic patients had higher crude amputation rates, but these differences were attenuated by adjustment for baseline characteristics. Black patients were more likely to receive atherectomy and had higher rates of any repeat revascularization and specifically FP revascularization. Further study is necessary to determine whether these patterns are related to disease-specific issues or practice-pattern differences among different populations.


Subject(s)
Amputation, Surgical , Femoral Artery , Intermittent Claudication , Peripheral Arterial Disease , Popliteal Artery , Humans , Intermittent Claudication/surgery , Intermittent Claudication/ethnology , Male , Amputation, Surgical/statistics & numerical data , Female , Popliteal Artery/surgery , Aged , Femoral Artery/surgery , Middle Aged , Peripheral Arterial Disease/surgery , Peripheral Arterial Disease/ethnology , Comorbidity , Sex Factors , United States/epidemiology , Retrospective Studies , Atherectomy/statistics & numerical data , Ethnicity/statistics & numerical data , Reoperation/statistics & numerical data , Endovascular Procedures
15.
J Orthop Surg (Hong Kong) ; 32(2): 10225536241265445, 2024.
Article in English | MEDLINE | ID: mdl-38896879

ABSTRACT

OBJECTIVE: Local infiltration analgesia (LIA), adductor canal block (ACB), and infiltration between the popliteal artery and the capsule of the posterior knee (IPACK) are popular multimodal analgesia techniques used during total knee arthroplasty (TKA). This study aimed to explore the efficacy of adding the IPACK technique to ACB and LIA in patients undergoing TKA. METHODS: In this retrospective cohort study, patients who underwent primary unilateral TKA were divided into two groups based on their date of admission. Sixty-three patients underwent IPACK, ACB and LIA (IPACK group) during surgery, while 60 patients underwent ACB and LIA (control group). The primary outcome was the postoperative administration of morphine hydrochloride as a rescue analgesic. Secondary outcomes included time to first rescue analgesia, postoperative pain assessed using the visual analog scale (VAS), functional recovery assessed by knee range of motion and ambulation distance, time until hospital discharge, and complication rates. RESULTS: The two groups were similar in average postoperative 0-to-24-h morphine consumption (11.8 mg for the control group vs 12.7 mg for the IPACK group, p = .428) and average total morphine consumption (18.2 mg vs 18.0 mg, p = .983) during hospitalization. There were also no significant differences in the secondary outcomes. CONCLUSIONS: The addition of IPACK to ACB and LIA did not provide any clinical analgesic benefits. Orthopedic surgeons and anesthesiologists are justified in using ACB and LIA without IPACK for TKA.


Subject(s)
Arthroplasty, Replacement, Knee , Nerve Block , Pain, Postoperative , Popliteal Artery , Humans , Retrospective Studies , Arthroplasty, Replacement, Knee/methods , Male , Female , Aged , Popliteal Artery/surgery , Nerve Block/methods , Pain, Postoperative/prevention & control , Pain, Postoperative/etiology , Pain, Postoperative/diagnosis , Pain, Postoperative/drug therapy , Middle Aged , Analgesics, Opioid/administration & dosage , Morphine/administration & dosage , Anesthetics, Local/administration & dosage , Pain Measurement , Anesthesia, Local/methods , Analgesia/methods , Pain Management/methods
17.
Ann Vasc Surg ; 108: 257-265, 2024 Nov.
Article in English | MEDLINE | ID: mdl-38942374

ABSTRACT

BACKGROUND: There is a paucity of data evaluating outcomes of lower extremity bypass (LEB) using supra-inguinal inflow for revascularization of infra-inguinal vessels. The purpose of this study is to report outcomes after LEB originating from aortoiliac arteries to infra-femoral targets. METHODS: The Vascular Quality Initiative database (2003-2020) was queried for patients undergoing LEB from the aortoiliac arteries to the popliteal and tibial arteries. Patients were stratified into 3 cohorts based on outflow targets (above-knee [AK] popliteal, below-knee [BK] popliteal, and tibial arteries). Perioperative and 1-year outcomes including primary patency, amputation-free survival (AFS), and major adverse limb events (MALEs) were compared. A Cox proportional hazards model was used to estimate the independent prognostic factors of outcomes. RESULTS: Of 403 LEBs, 389 (96.5%) originated from the external iliac artery, while the remaining used the aorta or common iliac artery as inflow. In terms of the distal target, the AK popliteal was used in 116 (28.8%), the BK popliteal in 151 (27.5%), and tibial vessels in 136 (43.7%) cases. BK popliteal and tibial bypasses, compared to AK popliteal bypasses, were more commonly performed in patients with chronic limb-threatening ischemia (69.5% and 69.9% vs. 48.3%; P < 0.001). Vein conduit was more often used for tibial bypass than for AK and BK popliteal bypasses (46.3% vs. 21.9% and 16.3%; P < 0.001). In the perioperative period, BK popliteal and tibial bypass patients had higher reoperation rates (16.9% and 13.2% vs. 5.2%; P = 0.02) and lower primary patency (89.4% and 89% vs. 95.7%; P = 0.04) than AK bypass patients. At 1 year, compared with AK popliteal bypasses, BK and tibial bypasses demonstrated lower primary patency (81.9% vs. 56.7% vs. 52.4%, P < 0.001) and freedom from MALE (77.6% vs. 70.2% vs. 63.1%, P = 0.04), although AFS was not significantly different (89.7% vs. 90.6% vs. 83.8%, P = 0.19).On multivariable analysis, compared with AK popliteal bypasses, tibial bypasses were independently associated with increased loss of primary patency (hazard ratio 1.9, 95% confidence interval, 1.03-3.51, P = 0.04). Subanalysis of patients with chronic limb-threatening ischemia demonstrated significantly higher primary patency in the AK popliteal cohort at discharge and 1 year, but no difference in AFS or freedom from MALE between the cohorts at follow-up. CONCLUSIONS: LEB with supra-inguinal inflow appear to have acceptable rates of 1-year patency and limb salvage in patients at high risk of bypass failure. Tibial outflow target was independently associated with worse primary patency but not with MALE or AFS.


Subject(s)
Amputation, Surgical , Databases, Factual , Limb Salvage , Peripheral Arterial Disease , Vascular Patency , Humans , Male , Aged , Female , Retrospective Studies , Peripheral Arterial Disease/physiopathology , Peripheral Arterial Disease/surgery , Peripheral Arterial Disease/diagnostic imaging , Time Factors , Risk Factors , Middle Aged , Risk Assessment , Popliteal Artery/surgery , Popliteal Artery/physiopathology , Popliteal Artery/diagnostic imaging , Vascular Grafting/adverse effects , Progression-Free Survival , Iliac Artery/surgery , Iliac Artery/physiopathology , Iliac Artery/diagnostic imaging , Regional Blood Flow , Tibial Arteries/physiopathology , Tibial Arteries/surgery , Tibial Arteries/diagnostic imaging , Lower Extremity/blood supply , Treatment Outcome , Aged, 80 and over
18.
J Am Heart Assoc ; 13(12): e034429, 2024 Jun 18.
Article in English | MEDLINE | ID: mdl-38879461

ABSTRACT

BACKGROUND: Popliteal artery aneurysms (PAAs) are the most common peripheral aneurysm. However, due to its rarity, the cumulative body of evidence regarding patient patterns, treatment strategies, and perioperative outcomes is limited. This analysis aims to investigate distinct phenotypical patient profiles and associated treatment and outcomes in patients with a PAA by performing an unsupervised clustering analysis of the POPART (Practice of Popliteal Artery Aneurysm Repair and Therapy) registry. METHODS AND RESULTS: A cluster analysis (using k-means clustering) was performed on data obtained from the multicenter POPART registry (42 centers from Germany and Luxembourg). Sensitivity analyses were conducted to explore validity and stability. Using 2 clusters, patients were primarily separated by the absence or presence of clinical symptoms. Within the cluster of symptomatic patients, the main difference between patients with acute limb ischemia presentation and nonemergency symptomatic patients was PAA diameter. When using 6 clusters, patients were primarily grouped by comorbidities, with patients with acute limb ischemia forming a separate cluster. Despite markedly different risk profiles, perioperative complication rates appeared to be positively associated with the proportion of emergency patients. However, clusters with a higher proportion of patients having any symptoms before treatment experienced a lower rate of perioperative complications. CONCLUSIONS: The conducted analyses revealed both an insight to the public health reality of PAA care as well as patients with PAA at elevated risk for adverse outcomes. This analysis suggests that the preoperative clinic is a far more crucial adjunct to the patient's preoperative risk assessment than the patient's epidemiological profile by itself.


Subject(s)
Aneurysm , Popliteal Artery , Registries , Humans , Popliteal Artery/surgery , Aneurysm/epidemiology , Aneurysm/surgery , Aneurysm/diagnosis , Male , Female , Aged , Cluster Analysis , Germany/epidemiology , Risk Factors , Middle Aged , Treatment Outcome , Risk Assessment , Aged, 80 and over , Endovascular Procedures , Postoperative Complications/epidemiology , Popliteal Artery Aneurysm
19.
Medicine (Baltimore) ; 103(26): e38693, 2024 Jun 28.
Article in English | MEDLINE | ID: mdl-38941441

ABSTRACT

Isolated popliteal artery occlusions are rare compared with femoropopliteal occlusive diseases. Although endovascular procedures have gained importance in treatment, conventional surgery remains the gold standard. In this study, we reviewed popliteal endarterectomy and patch plasty using a posterior approach. Fourteen patients who underwent surgery for isolated popliteal artery occlusions were retrospectively examined. Patients were assessed in terms of age, sex, and risk factors, such as accompanying diseases and smoking, surgical method and anesthesia, incision type, preoperative and postoperative pulse examination, ankle-brachial indices, patency, wound infection, postoperative complications, and the treatment applied. Twelve (85.7%) patients were male, and 2 (14.3%) were female. Limb ischemia was critical (ABI < 0.7) in 11 (78.5%) patients. The average duration of postoperative hospitalization was 8 ±â€…3.7 days on average, and the average length of follow-up was 17 ±â€…3.4 months. Thrombosis and complications requiring secondary intervention did not develop during the early postoperative period. While the patency rate in the first 6 months of follow-up was 100%, it was 92.8% in the 1st year and 85.7% in the 2nd year. Surgical treatment with the posterior approach in isolated popliteal artery lesions is preferred by vascular surgeons as a prioritized treatment method, with a sufficient recanalization rate and low perioperative morbidity and mortality rates. Furthermore, it is promising because it does not prevent below-knee femoropopliteal bypass, which is the subsequent stage of treatment. Moreover, the great saphenous vein was protected, and the acceptable early- and mid-term results were encouraging.


Subject(s)
Endarterectomy , Popliteal Artery , Humans , Popliteal Artery/surgery , Male , Female , Endarterectomy/methods , Retrospective Studies , Aged , Middle Aged , Arterial Occlusive Diseases/surgery , Constriction, Pathologic/surgery , Treatment Outcome , Postoperative Complications/epidemiology , Vascular Patency
20.
J Orthop Surg Res ; 19(1): 347, 2024 Jun 10.
Article in English | MEDLINE | ID: mdl-38858784

ABSTRACT

BACKGROUND: Among arterial traumas, osteoarticular traumas are particularly dangerous, and those involving the popliteal artery are associated with a high amputation rate. Despite representing a minority of arterial traumas, with an incidence that varies considerably by population and geographic location, traumatic lesions of the popliteal artery are challenging. This study aimed to verify the impact of body mass index (BMI) on arterial trauma damage and patient outcomes. METHODS: Data were retrospectively collected from the electronic medical reports of all patients with osteoarticular and vascular associated lesions treated in the emergency operating room at our institution between 1 January 2005 and 1 May 2022. Forty-one patients presented with lower limb arterial trauma (43.2%); popliteal artery lesions occurred in 11 of these patients (26.8%), who were eligible for inclusion in the study. The lesion mechanism was dislocation by high-velocity trauma in 9 patients and dislocation by low-velocity trauma in 3 patients. All 7 males (63.6%) experienced high-velocity trauma, and 2 of the 3 females experienced low-velocity trauma. Only one patient had an isolated popliteal artery lesion associated with fractures in the leg or the contralateral limb. Patients with low-velocity trauma were older than 54 years, while those with high-velocity trauma were aged 22 to 71 years. RESULTS: In 10/11 patients (90.9%), revascularization was performed after osteoarticular stabilization and reduction of the dislocation or fracture. Intraoperative angiography was selectively used. Two patients required above-the-knee amputation after the procedure: one due to infection of the surgical access point and the other due to severe soft tissue injury. One patient died during hospitalization due to trauma-related complications and comorbidities. CONCLUSIONS: High-velocity trauma and low-velocity trauma in patients with a body mass index > 35 kg/m2 and knee lesions are associated with popliteal artery lesions. Revascularization success is not associated with high- or low-velocity trauma.


Subject(s)
Body Mass Index , Knee Injuries , Popliteal Artery , Humans , Popliteal Artery/injuries , Popliteal Artery/surgery , Popliteal Artery/diagnostic imaging , Male , Female , Middle Aged , Adult , Retrospective Studies , Young Adult , Aged , Knee Injuries/surgery , Knee Injuries/complications , Knee Injuries/diagnostic imaging , Vascular System Injuries/surgery , Vascular System Injuries/diagnostic imaging , Vascular System Injuries/etiology , Vascular System Injuries/complications , Amputation, Surgical
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