Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 49
Filter
1.
J Neurol ; 271(5): 2509-2520, 2024 May.
Article in English | MEDLINE | ID: mdl-38265470

ABSTRACT

Amygdala atrophy has been found in frontotemporal dementia (FTD), yet the specific changes of its subregions across different FTD phenotypes remain unclear. The aim of this study was to investigate the volumetric alterations of the amygdala subregions in FTD phenotypes and how they evolve with disease progression. Patients clinically diagnosed with behavioral variant FTD (bvFTD) (n = 20), semantic dementia (SD) (n = 20), primary nonfluent aphasia (PNFA) (n = 20), Alzheimer's disease (AD) (n = 20), and 20 matched healthy controls underwent whole brain structural MRI. The patient groups were followed up annually for up to 3.5 years. Amygdala nuclei were segmented using FreeSurfer, corrected by total intracranial volumes, and grouped into the basolateral, superficial, and centromedial subregions. Linear mixed effects models were applied to identify changes in amygdala subregional volumes over time. At baseline, bvFTD, SD, and AD displayed global amygdala volume reduction, whereas amygdala volume appeared to be preserved in PNFA. Asymmetrical amygdala atrophy (left > right) was most pronounced in SD. Longitudinally, SD and PNFA showed greater rates of annual decline in the right basolateral and superficial subregions compared to bvFTD and AD. The findings provide comprehensive insights into the differential impact of FTD pathology on amygdala subregions, revealing distinct atrophy patterns that evolve over disease progression. The characterization of amygdala subregional involvement in FTD and their potential role as biomarkers carry substantial clinical implications.


Subject(s)
Amygdala , Frontotemporal Dementia , Aged , Female , Middle Aged , Alzheimer Disease/pathology , Amygdala/diagnostic imaging , Amygdala/pathology , Atrophy/diagnostic imaging , Atrophy/pathology , Cross-Sectional Studies , Disease Progression , Frontotemporal Dementia/classification , Frontotemporal Dementia/diagnostic imaging , Frontotemporal Dementia/pathology , Frontotemporal Dementia/physiopathology , Longitudinal Studies , Magnetic Resonance Imaging , Organ Size , Primary Progressive Nonfluent Aphasia/pathology , Time Factors , Humans , Male
2.
Neuropathology ; 44(2): 154-160, 2024 Apr.
Article in English | MEDLINE | ID: mdl-37717977

ABSTRACT

Progressive nonfluent aphasia (PNFA) is a form of frontotemporal lobar degeneration (FTLD) caused by tau and transactive response DNA-binding protein of 43 kDa (TDP-43) accumulation. Here we report the autopsy findings of a 64-year-old right-handed man with an atypical TDP-43 proteinopathy who presented with difficulties with speech, verbal paraphasia, and dysphagia that progressed over the 36 months prior to his death. He did not show pyramidal tract signs until his death. At autopsy, macroscopic brain examination revealed atrophy of the left dominant precentral, superior, and middle frontal gyri and discoloration of the putamen. Spongiform change and neuronal loss were severe on the cortical surfaces of the precentral, superior frontal, and middle frontal gyri and the temporal tip. Immunostaining with anti-phosphorylated TDP-43 revealed neuronal cytoplasmic inclusions and long and short dystrophic neurites in the frontal cortex, predominantly in layers II, V, and VI of the temporal tip, amygdala, and transentorhinal cortex. Immunoblot analysis of the sarkosyl-insoluble fractions showed hyperphosphorylated TDP-43 bands at 45 kDa and phosphorylated C-terminal fragments at approximately 25 kDa. The pathological distribution and immunoblot band pattern differ from the major TDP-43 subtype and therefore may represent a new FTLD-TDP phenotype.


Subject(s)
Frontotemporal Dementia , Frontotemporal Lobar Degeneration , Primary Progressive Nonfluent Aphasia , TDP-43 Proteinopathies , Male , Humans , Middle Aged , Primary Progressive Nonfluent Aphasia/pathology , Frontotemporal Lobar Degeneration/pathology , TDP-43 Proteinopathies/pathology , DNA-Binding Proteins/metabolism
3.
Hum Brain Mapp ; 44(14): 4833-4847, 2023 10 01.
Article in English | MEDLINE | ID: mdl-37516916

ABSTRACT

Overlapping clinical presentations in primary progressive aphasia (PPA) variants present challenges for diagnosis and understanding pathophysiology, particularly in the early stages of the disease when behavioral (speech) symptoms are not clearly evident. Divergent atrophy patterns (temporoparietal degeneration in logopenic variant lvPPA, frontal degeneration in nonfluent variant nfvPPA) can partially account for differential speech production errors in the two groups in the later stages of the disease. While the existing dogma states that neurodegeneration is the root cause of compromised behavior and cortical activity in PPA, the extent to which neurophysiological signatures of speech dysfunction manifest independent of their divergent atrophy patterns remain unknown. We test the hypothesis that nonword deficits in lvPPA and nfvPPA arise from distinct patterns of neural oscillations that are unrelated to atrophy. We use a novel structure-function imaging approach integrating magnetoencephalographic imaging of neural oscillations during a non-word repetition task with voxel-based morphometry-derived measures of gray matter volume to isolate neural oscillation abnormalities independent of atrophy. We find reduced beta band neural activity in left temporal regions associated with the late stages of auditory encoding unique to patients with lvPPA and reduced high-gamma neural activity over left frontal regions associated with the early stages of motor preparation in patients with nfvPPA. Neither of these patterns of reduced cortical oscillations was explained by cortical atrophy in our statistical model. These findings highlight the importance of structure-function imaging in revealing neurophysiological sequelae in early stages of dementia when neither structural atrophy nor behavioral deficits are clinically distinct.


Subject(s)
Aphasia, Primary Progressive , Primary Progressive Nonfluent Aphasia , Humans , Aphasia, Primary Progressive/diagnostic imaging , Neurophysiology , Magnetic Resonance Imaging , Gray Matter/pathology , Atrophy/pathology , Primary Progressive Nonfluent Aphasia/diagnostic imaging , Primary Progressive Nonfluent Aphasia/complications , Primary Progressive Nonfluent Aphasia/pathology
4.
Alzheimers Res Ther ; 15(1): 58, 2023 03 21.
Article in English | MEDLINE | ID: mdl-36941645

ABSTRACT

BACKGROUND: Cortical and subcortical microstructural modifications are critical to understanding the pathogenic changes in frontotemporal lobar degeneration (FTLD) subtypes. In this study, we investigated cortical and subcortical microstructure underlying cognitive and language impairments across behavioral variant of frontotemporal dementia (bvFTD), semantic variant of primary progressive aphasia (svPPA), and nonfluent variant of primary progressive aphasia (nfvPPA) subtypes. METHODS: The current study characterized 170 individuals with 3 T MRI structural and diffusion-weighted imaging sequences as portion of the Frontotemporal Lobar Degeneration Neuroimaging Initiative study: 41 bvFTD, 35 nfvPPA, 34 svPPA, and 60 age-matched cognitively unimpaired controls. To determine the severity of the disease, clinical dementia rating plus national Alzheimer's coordinating center behavior and language domains sum of boxes scores were used; other clinical measures, including the Boston naming test and verbal fluency test, were also evaluated. We computed surface-based cortical thickness and cortical and subcortical microstructural metrics using tract-based spatial statistics and explored their relationships with clinical and cognitive assessments. RESULTS: Compared with controls, those with FTLD showed substantial cortical mean diffusivity alterations extending outside the regions with cortical thinning. Tract-based spatial statistics revealed that anomalies in subcortical white matter diffusion were widely distributed across the frontotemporal and parietal areas. Patients with bvFTD, nfvPPA, and svPPA exhibited distinct patterns of cortical and subcortical microstructural abnormalities, which appeared to correlate with disease severity, and separate dimensions of language functions. CONCLUSIONS: Our findings imply that cortical and subcortical microstructures may serve as sensitive biomarkers for the investigation of neurodegeneration-associated microstructural alterations in FTLD subtypes. Flowchart of the study design (see materials and methods for detailed description).


Subject(s)
Cognitive Dysfunction , Frontotemporal Dementia , Frontotemporal Lobar Degeneration , Language Development Disorders , Primary Progressive Nonfluent Aphasia , Humans , Frontotemporal Dementia/pathology , Frontotemporal Lobar Degeneration/complications , Frontotemporal Lobar Degeneration/diagnostic imaging , Frontotemporal Lobar Degeneration/pathology , Primary Progressive Nonfluent Aphasia/pathology , Cognitive Dysfunction/diagnostic imaging , Patient Acuity
5.
Neuropathology ; 42(3): 232-238, 2022 Jun.
Article in English | MEDLINE | ID: mdl-35434847

ABSTRACT

Progressive supranuclear palsy (PSP) with predominant frontal presentation (PSP-F) is a clinical phenotype of PSP that is characterized by frontal cognitive impairment and behavioral changes. Here, we report on a patient with pathologically diagnosed PSP-F in whom we were able to observe temporal changes of the clinical manifestations. A 77-year-old right-handed man developed progressive nonfluent aphasia (PNFA) at the age of 69 years, festinating gait, and clumsiness of his left arm at age 75, disinhibition at age 76, and unprovoked falls at age 77. Neurological examination at age 77 revealed limb-kinetic apraxia of the left upper and lower limbs, rigidity, cortical sensory loss, and vertical supranuclear gaze palsy. According to the Movement Disorder Society clinical diagnostic criteria for PSP, his clinical manifestations shifted from suggestive PSP with predominant speech/language disorder to probable PSP-F over nine years. Cerebral atrophy on brain magnetic resonance imaging and decreased accumulation of 99m Tc-ECD on cerebral blood flow single-photon emission computed tomography were noted with right side predominance. Pathologically, 4-repeat tau-immunoreactive globose-type neurofibrillary tangles, coiled bodies, tufted astrocytes, and neuropil threads were observed predominantly in the frontal cortex. Tau pathology of the substantia nigra, locus coeruleus and subthalamic nucleus was mild. These findings suggested that localized tau pathology involving the pars opercularis extended to the precentral gyrus, prefrontal cortex, and brainstem. This case report demonstrates that PSP-F can present as a PNFA due to crossed aphasia.


Subject(s)
Aphasia , Primary Progressive Nonfluent Aphasia , Supranuclear Palsy, Progressive , Aphasia/pathology , Humans , Magnetic Resonance Imaging , Neurofibrillary Tangles/pathology , Primary Progressive Nonfluent Aphasia/complications , Primary Progressive Nonfluent Aphasia/pathology , Supranuclear Palsy, Progressive/complications , Supranuclear Palsy, Progressive/pathology
6.
Neurology ; 95(24): e3190-e3202, 2020 12 15.
Article in English | MEDLINE | ID: mdl-32989107

ABSTRACT

OBJECTIVE: To characterize longitudinal MRI and PET abnormalities in autopsy-confirmed Pick disease (PiD) and determine how patterns of neurodegeneration differ with respect to clinical syndrome. METHODS: Seventeen patients with PiD were identified who had antemortem MRI (8 with behavioral variant frontotemporal dementia [bvFTD-PiD], 6 with nonfluent/agrammatic primary progressive aphasia [naPPA-PiD], 1 with semantic primary progressive aphasia, 1 with unclassified primary progressive aphasia, and 1 with corticobasal syndrome). Thirteen patients had serial MRI for a total of 56 MRIs, 7 had [18F]fluorodeoxyglucose PET, 4 had Pittsburgh compound B (PiB) PET, and 1 patient had [18F]flortaucipir PET. Cross-sectional and longitudinal comparisons of gray matter volume and metabolism were performed between bvFTD-PiD, naPPA-PiD, and controls. Cortical PiB summaries were calculated to determine ß-amyloid positivity. RESULTS: The bvFTD-PiD and naPPA-PiD groups showed different foci of volume loss and hypometabolism early in the disease, with bvFTD-PiD involving bilateral prefrontal and anterior temporal cortices and naPPA-PiD involving left inferior frontal gyrus, insula, and orbitofrontal cortex. However, patterns merged over time, with progressive spread into prefrontal and anterior temporal lobe in naPPA-PiD, and eventual involvement of posterior temporal lobe, motor cortex, and parietal lobe in both groups. Rates of frontotemporal atrophy were faster in bvFTD-PiD than naPPA-PiD. One patient was ß-amyloid-positive on PET with low Alzheimer neuropathologic changes at autopsy. Flortaucipir PET showed elevated uptake in frontotemporal white matter. CONCLUSION: Patterns of atrophy and hypometabolism differ in PiD according to presenting syndrome, although patterns of neurodegeneration appear to converge over time.


Subject(s)
Amyloid beta-Peptides/metabolism , Aphasia, Primary Progressive , Cerebral Cortex , Gray Matter , Pick Disease of the Brain , White Matter , Aged , Aphasia, Primary Progressive/diagnostic imaging , Aphasia, Primary Progressive/metabolism , Aphasia, Primary Progressive/pathology , Atrophy/pathology , Cerebral Cortex/diagnostic imaging , Cerebral Cortex/metabolism , Cerebral Cortex/pathology , Cross-Sectional Studies , Female , Gray Matter/diagnostic imaging , Gray Matter/metabolism , Gray Matter/pathology , Humans , Longitudinal Studies , Magnetic Resonance Imaging , Male , Middle Aged , Phenotype , Pick Disease of the Brain/diagnostic imaging , Pick Disease of the Brain/metabolism , Pick Disease of the Brain/pathology , Positron-Emission Tomography , Primary Progressive Nonfluent Aphasia/diagnostic imaging , Primary Progressive Nonfluent Aphasia/metabolism , Primary Progressive Nonfluent Aphasia/pathology , White Matter/diagnostic imaging , White Matter/metabolism , White Matter/pathology
7.
J Int Neuropsychol Soc ; 26(3): 322-330, 2020 03.
Article in English | MEDLINE | ID: mdl-31658919

ABSTRACT

OBJECTIVES: The logopenic variant of primary progressive aphasia (lvPPA) has disparate pathological and anatomical features when compared to the semantic (svPPA) and non-fluent (nfvPPA) variants of PPA. As such, there is increasing need for measures that improve diagnostic accuracy particularly when etiology-specific treatments become available. In the current study, we used meta-analytic methods to establish the neuropsychological profile of lvPPA and compare it to recent findings in svPPA and nfvPPA. METHODS: We extracted neuropsychological data from 51 publications representing 663 lvPPA patients and 1379 controls. We calculated Hedges' g effect sizes for nine domains of neuropsychological functioning in lvPPA and assessed the influence of demographic, disease, and task characteristics on effect size magnitude. Results obtained in lvPPA were compared to findings in svPPA and nfvPPA. RESULTS: In lvPPA, the magnitude of deficits in attention, math, visuospatial memory, and executive functioning were as prominent as language deficits. Within the language domain, lvPPA patients demonstrated greater naming than repetition deficits. Compared to svPPA and nfvPPA, lvPPA patients demonstrated greater neuropsychological deficits overall and greater impairment on attention, math, and visual set-shifting tests. CONCLUSIONS: Tests of attention, delayed visuospatial memory, visual set-shifting, and math distinguish lvPPA from svPPA and nfvPPA likely reflecting the posterior temporoparietal atrophy observed early in the course of lvPPA. These findings support the inclusion of these measures in the clinical neuropsychological assessment of lvPPA and underscore the need for additional clinicopathological and longitudinal studies of arithmetic and visuospatial memory across the PPA variants.


Subject(s)
Aphasia, Primary Progressive/physiopathology , Attention/physiology , Executive Function/physiology , Mathematical Concepts , Memory Disorders/physiopathology , Space Perception/physiology , Visual Perception/physiology , Aphasia, Primary Progressive/classification , Aphasia, Primary Progressive/pathology , Humans , Memory Disorders/pathology , Primary Progressive Nonfluent Aphasia/pathology , Primary Progressive Nonfluent Aphasia/physiopathology
8.
Neurocase ; 25(1-2): 39-47, 2019.
Article in English | MEDLINE | ID: mdl-31033382

ABSTRACT

A 66-year-old woman presented with agrammatism and apraxia of speech, meeting criteria for non-fluent/agrammatic variant primary progressive aphasia (nfvPPA). However, three years later, she developed frontal/executive, short-term phonological memory, visuospatial, and visual memory deficits suggesting involvement of multiple brain networks. Multimodal neuroimaging showed damage of both fronto-striatal and posterior brain regions. She was found to have multiple pathological processes: corticobasal degeneration (CBD), Alzheimer's disease (AD), and TAR DNA-binding protein (TDP)-43 type A. We hypothesize that cognitive and neuroimaging findings consistent with damage to multiple brain networks, each associated with vulnerability to certain molecular disease subtypes, could indicate mixed pathology.


Subject(s)
Alzheimer Disease/complications , Basal Ganglia Diseases/complications , Frontotemporal Dementia/complications , Primary Progressive Nonfluent Aphasia/etiology , Aged , Alzheimer Disease/pathology , Alzheimer Disease/physiopathology , Basal Ganglia Diseases/pathology , Basal Ganglia Diseases/physiopathology , Female , Frontotemporal Dementia/pathology , Frontotemporal Dementia/physiopathology , Humans , Neuroimaging , Primary Progressive Nonfluent Aphasia/pathology , Primary Progressive Nonfluent Aphasia/physiopathology
9.
Curr Opin Neurol ; 32(2): 255-265, 2019 04.
Article in English | MEDLINE | ID: mdl-30694922

ABSTRACT

PURPOSE OF REVIEW: Knowledge on primary progressive aphasia (PPA) has expanded rapidly in the past few decades. Clinical characteristics, neuroimaging correlates, and neuropathological features of PPA are better delineated. This facilitates scientific studies on the disease pathophysiology and allows speech and language therapy to be more precisely targeted. This review article begins with a summary of the current understanding of PPA and discusses how PPA can serve as a model to promote scientific discovery in neurodegenerative diseases. RECENT FINDINGS: Studies on the different variants of PPA have demonstrated the high compatibility between clinical presentations and neuroimaging features, and in turn, enhances the understanding of speech and language neuroanatomy. In addition to the traditional approach of lesion-based or voxel-based mapping, scientists have also adopted functional connectivity and network topology approaches that permits a more multidimensional understanding of neuroanatomy. As a result, pharmacological and cognitive therapeutic strategies can now be better targeted towards specific pathological/molecular and cognitive subtypes. SUMMARY: Recent scientific advancement in PPA potentiates it to be an optimal model for studying brain network vulnerability, neurodevelopment influences and the effects of nonpharmacological intervention in neurodegenerative diseases.


Subject(s)
Aphasia, Primary Progressive/pathology , Neurodegenerative Diseases/pathology , Animals , Aphasia, Primary Progressive/diagnostic imaging , Humans , Models, Theoretical , Neurodegenerative Diseases/diagnostic imaging , Primary Progressive Nonfluent Aphasia/diagnostic imaging , Primary Progressive Nonfluent Aphasia/pathology
10.
Alzheimer Dis Assoc Disord ; 33(3): 282-284, 2019.
Article in English | MEDLINE | ID: mdl-30640253

ABSTRACT

The use of biomarkers has recently supported the association between Alzheimer disease (AD) pathology and the logopenic variant of primary progressive aphasia (PPA). We aim to investigate possible differences in cerebrospinal fluid (CSF) biomarker concentrations in the three PPA variants, and to assess any agreement between CSF biomarkers and (18)F-florbetapir PET. A group of 10 PPA were retrospectively enrolled. Patients with logopenic variant (lvPPA) showed different levels of Aß1-42 and p-tau compared to nonfluent/agrammatic and semantic variants (nfv/svPPA). All nfv/svPPA patients had negative amyloid PET. Among the lvPPA group, a negative amyloid PET was found only in one patient, who was also the only one to display a normal CSF. Thus, this small cohort appeared to display an excellent agreement between CSF and (18)F-florbetapir PET and suggest that these examinations may have the same validity in detecting in vivo evidence of AD pathology in PPA clinical variants.


Subject(s)
Aniline Compounds , Aphasia, Primary Progressive , Biomarkers/cerebrospinal fluid , Ethylene Glycols , Positron-Emission Tomography , Alzheimer Disease/diagnostic imaging , Alzheimer Disease/pathology , Amyloid beta-Peptides/analysis , Amyloid beta-Peptides/cerebrospinal fluid , Aphasia, Primary Progressive/diagnostic imaging , Aphasia, Primary Progressive/pathology , Brain/pathology , Female , Humans , Male , Middle Aged , Neuropsychological Tests , Peptide Fragments/analysis , Peptide Fragments/cerebrospinal fluid , Primary Progressive Nonfluent Aphasia/diagnostic imaging , Primary Progressive Nonfluent Aphasia/pathology , Retrospective Studies
11.
Article in English | MEDLINE | ID: mdl-30668155

ABSTRACT

Objective: Behavioral variant frontotemporal dementia (bvFTD), is commonly considered the cognitive presentation of the frontotemporal dementia-motor neuron disease (FTD-MND) spectrum disorder. We evaluated the prevalence of primary progressive aphasia in a series of pathologically confirmed cases of FTD-MND spectrum. Methods: Pathologically confirmed cases of frontotemporal lobar degeneration-motor neuron disease (FTLD-MND) were obtained from the UCSF brain bank. Cases were analyzed for presence of language impairment via retrospective chart review of research visits that include neurologic exam, in-depth cognitive testing and magnetic resonance imaging (MRI) imaging. Forty one cases were included. Thirty two were diagnosed with FTD-MND, while nine cases were diagnosed as MND-only from clinical evaluation. Results: Ten FTLD-MND cases (31%) presented with prominent or isolated language involvement consistent with a diagnosis of primary progressive aphasia (PPA), which we called progressive aphasia with motor neuron disease (PA-MND). Of these, three cases that mirrored the non-fluent variant of PPA (nfvPPA) were named nfvPA-MND. The imaging pattern of these nfvPA-MND showed atrophy strictly confined to the frontal and anterior temporal language cortical areas. Another group of seven cases that resembled patients with the semantic variant PPA (svPPA) were named svPA-MND. The group of svPPA-MND on imaging analysis showed selective atrophy of the temporal lobe and orbitofrontal cortex. Conclusions: Language impairment was a frequent phenotype of FTD-MND associated with focal atrophy patterns within the language networks. This data suggest patients with FTD-MND can present quite often with language phenotype of nfvPPA and svPPA, as opposed to exclusive bvFTD symptoms.


Subject(s)
Frontotemporal Dementia/diagnostic imaging , Frontotemporal Dementia/pathology , Motor Neuron Disease/diagnostic imaging , Motor Neuron Disease/pathology , Primary Progressive Nonfluent Aphasia/diagnostic imaging , Primary Progressive Nonfluent Aphasia/pathology , Aged , Atrophy , Autopsy , Cerebral Cortex/diagnostic imaging , Cerebral Cortex/pathology , Cohort Studies , Female , Frontotemporal Dementia/therapy , Humans , Language Disorders/etiology , Magnetic Resonance Imaging , Male , Middle Aged , Motor Neuron Disease/therapy , Neuroimaging , Neurologic Examination , Neuropsychological Tests , Primary Progressive Nonfluent Aphasia/therapy , Retrospective Studies , Tissue Banks
13.
J Neurol Neurosurg Psychiatry ; 88(5): 418-424, 2017 05.
Article in English | MEDLINE | ID: mdl-28235777

ABSTRACT

BACKGROUND: We performed an observational study of laughter during seminaturalistic conversations between patients with dementia and familial caregivers. Patients were diagnosed with (1) behavioural variant frontotemporal dementia (bvFTD), (2) right temporal variant frontotemporal dementia (rtFTD), (3) semantic variant of primary progressive aphasia (svPPA), (4) non-fluent variant primary progressive aphasia (nfvPPA) or (5) early onset Alzheimer's disease (eoAD). We hypothesised that those with bvFTD would laugh less in response to their own speech than other dementia groups or controls, while those with rtFTD would laugh less regardless of who was speaking. METHODS: Patients with bvFTD (n=39), svPPA (n=19), rtFTD (n=14), nfvPPA (n=16), eoAD (n=17) and healthy controls (n=156) were recorded (video and audio) while discussing a problem in their relationship with a healthy control companion. Using the audio track only, laughs were identified by trained coders and then further classed by an automated algorithm as occurring during or shortly after the participant's own vocalisation ('self' context) or during or shortly after the partner's vocalisation ('partner' context). RESULTS: Individuals with bvFTD, eoAD or rtFTD laughed less across both contexts of self and partner than the other groups. Those with bvFTD laughed less relative to their own speech comparedwith healthy controls. Those with nfvPPA laughed more in the partner context compared with healthy controls. CONCLUSIONS: Laughter in response to one's own vocalisations or those of a conversational partner may be a clinically useful measure in dementia diagnosis.


Subject(s)
Frontotemporal Dementia/pathology , Frontotemporal Dementia/psychology , Laughter/psychology , Speech , Aged , Alzheimer Disease/pathology , Aphasia, Primary Progressive/pathology , Brain/pathology , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neuropsychological Tests , Primary Progressive Nonfluent Aphasia/pathology
14.
Ann Neurol ; 81(3): 430-443, 2017 Mar.
Article in English | MEDLINE | ID: mdl-28133816

ABSTRACT

OBJECTIVE: To characterize in vivo signatures of pathological diagnosis in a large cohort of patients with primary progressive aphasia (PPA) variants defined by current diagnostic classification. METHODS: Extensive clinical, cognitive, neuroimaging, and neuropathological data were collected from 69 patients with sporadic PPA, divided into 29 semantic (svPPA), 25 nonfluent (nfvPPA), 11 logopenic (lvPPA), and 4 mixed PPA. Patterns of gray matter (GM) and white matter (WM) atrophy at presentation were assessed and tested as predictors of pathological diagnosis using support vector machine (SVM) algorithms. RESULTS: A clinical diagnosis of PPA was associated with frontotemporal lobar degeneration (FTLD) with transactive response DNA-binding protein (TDP) inclusions in 40.5%, FTLD-tau in 40.5%, and Alzheimer disease (AD) pathology in 19% of cases. Each variant was associated with 1 typical pathology; 24 of 29 (83%) svPPA showed FTLD-TDP type C, 22 of 25 (88%) nfvPPA showed FTLD-tau, and all 11 lvPPA had AD. Within FTLD-tau, 4R-tau pathology was commonly associated with nfvPPA, whereas Pick disease was observed in a minority of subjects across all variants except for lvPPA. Compared with pathologically typical cases, svPPA-tau showed significant extrapyramidal signs, greater executive impairment, and severe striatal and frontal GM and WM atrophy. nfvPPA-TDP patients lacked general motor symptoms or significant WM atrophy. Combining GM and WM volumes, SVM analysis showed 92.7% accuracy to distinguish FTLD-tau and FTLD-TDP pathologies across variants. INTERPRETATION: Each PPA clinical variant is associated with a typical and most frequent cognitive, neuroimaging, and neuropathological profile. Specific clinical and early anatomical features may suggest rare and atypical pathological diagnosis in vivo. Ann Neurol 2017;81:430-443.


Subject(s)
Alzheimer Disease , Aphasia, Primary Progressive , Frontotemporal Lobar Degeneration , Gray Matter/diagnostic imaging , White Matter/diagnostic imaging , Aged , Aged, 80 and over , Alzheimer Disease/classification , Alzheimer Disease/pathology , Alzheimer Disease/physiopathology , Aphasia, Primary Progressive/classification , Aphasia, Primary Progressive/pathology , Aphasia, Primary Progressive/physiopathology , Atrophy/pathology , Female , Frontotemporal Lobar Degeneration/classification , Frontotemporal Lobar Degeneration/pathology , Frontotemporal Lobar Degeneration/physiopathology , Humans , Male , Middle Aged , Pick Disease of the Brain/pathology , Pick Disease of the Brain/physiopathology , Primary Progressive Nonfluent Aphasia/pathology , Primary Progressive Nonfluent Aphasia/physiopathology , Support Vector Machine , tau Proteins/metabolism
15.
J Alzheimers Dis ; 50(2): 359-71, 2016.
Article in English | MEDLINE | ID: mdl-26682693

ABSTRACT

BACKGROUND: The language profile of behavioral variant frontotemporal dementia (bvFTD) remains to be fully defined. OBJECTIVE: We aimed to quantify the extent of language deficits in this patient group. METHODS: We assessed a cohort of patients with bvFTD (n = 24) in relation to patients with semantic variant primary progressive aphasia (svPPA; n = 14), nonfluent variant primary progressive aphasia (nfvPPA; n = 18), and healthy age-matched individuals (n = 24) cross-sectionally and longitudinally using a comprehensive battery of language and general neuropsychological tests. Neuroanatomical associations of language performance were assessed using voxel-based morphometry of patients' brain magnetic resonance images. RESULTS: Relative to healthy controls, and after accounting for nonverbal executive performance, patients with bvFTD showed deficits of noun and verb naming and single word comprehension, diminished spontaneous propositional speech, and deterioration in naming performance over time. Within the bvFTD group, patients with MAPT mutations had more severe impairments of noun naming and single word comprehension than patients with C9orf72 mutations. Overall the bvFTD group had less severe language deficits than patients with PPA, but showed a language profile that was qualitatively similar to svPPA. Neuroanatomical correlates of naming and word comprehension performance in bvFTD were identified predominantly in inferior frontal and antero-inferior temporal cortices within the dominant hemispheric language network. CONCLUSIONS: bvFTD is associated with a language profile including verbal semantic impairment that warrants further evaluation as a novel biomarker.


Subject(s)
Aphasia, Primary Progressive/psychology , Brain/pathology , Frontotemporal Dementia/psychology , Primary Progressive Nonfluent Aphasia/psychology , Aged , Aphasia, Primary Progressive/pathology , Atrophy/pathology , Cognition/physiology , Comprehension/physiology , Female , Frontotemporal Dementia/pathology , Humans , Language , Magnetic Resonance Imaging , Male , Middle Aged , Neuroimaging , Neuropsychological Tests , Primary Progressive Nonfluent Aphasia/pathology
16.
Brain ; 138(Pt 11): 3360-72, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26463677

ABSTRACT

Symptoms suggesting altered processing of pain and temperature have been described in dementia diseases and may contribute importantly to clinical phenotypes, particularly in the frontotemporal lobar degeneration spectrum, but the basis for these symptoms has not been characterized in detail. Here we analysed pain and temperature symptoms using a semi-structured caregiver questionnaire recording altered behavioural responsiveness to pain or temperature for a cohort of patients with frontotemporal lobar degeneration (n = 58, 25 female, aged 52-84 years, representing the major clinical syndromes and representative pathogenic mutations in the C9orf72 and MAPT genes) and a comparison cohort of patients with amnestic Alzheimer's disease (n = 20, eight female, aged 53-74 years). Neuroanatomical associations were assessed using blinded visual rating and voxel-based morphometry of patients' brain magnetic resonance images. Certain syndromic signatures were identified: pain and temperature symptoms were particularly prevalent in behavioural variant frontotemporal dementia (71% of cases) and semantic dementia (65% of cases) and in association with C9orf72 mutations (6/6 cases), but also developed in Alzheimer's disease (45% of cases) and progressive non-fluent aphasia (25% of cases). While altered temperature responsiveness was more common than altered pain responsiveness across syndromes, blunted responsiveness to pain and temperature was particularly associated with behavioural variant frontotemporal dementia (40% of symptomatic cases) and heightened responsiveness with semantic dementia (73% of symptomatic cases) and Alzheimer's disease (78% of symptomatic cases). In the voxel-based morphometry analysis of the frontotemporal lobar degeneration cohort, pain and temperature symptoms were associated with grey matter loss in a right-lateralized network including insula (P < 0.05 corrected for multiple voxel-wise comparisons within the prespecified anatomical region of interest) and anterior temporal cortex (P < 0.001 uncorrected over whole brain) previously implicated in processing homeostatic signals. Pain and temperature symptoms accompanying C9orf72 mutations were specifically associated with posterior thalamic atrophy (P < 0.05 corrected for multiple voxel-wise comparisons within the prespecified anatomical region of interest). Together the findings suggest candidate cognitive and neuroanatomical bases for these salient but under-appreciated phenotypic features of the dementias, with wider implications for the homeostatic pathophysiology and clinical management of neurodegenerative diseases.


Subject(s)
Alzheimer Disease/physiopathology , Frontotemporal Dementia/physiopathology , Pain Perception , Primary Progressive Nonfluent Aphasia/physiopathology , Somatosensory Disorders/physiopathology , Thalamus/pathology , Thermosensing , Aged , Aged, 80 and over , Alzheimer Disease/pathology , Brain/pathology , C9orf72 Protein , Case-Control Studies , Female , Frontotemporal Dementia/pathology , Frontotemporal Lobar Degeneration/pathology , Frontotemporal Lobar Degeneration/physiopathology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neuropsychological Tests , Nociception , Perception , Perceptual Disorders/pathology , Perceptual Disorders/physiopathology , Primary Progressive Nonfluent Aphasia/pathology , Proteins/genetics , Somatosensory Disorders/pathology , tau Proteins/genetics
17.
Neuroimage Clin ; 8: 640-51, 2015.
Article in English | MEDLINE | ID: mdl-26236629

ABSTRACT

Impairments of social cognition are often leading features in frontotemporal lobar degeneration (FTLD) and likely to reflect large-scale brain network disintegration. However, the neuroanatomical basis of impaired social cognition in FTLD and the role of white matter connections have not been defined. Here we assessed social cognition in a cohort of patients representing two core syndromes of FTLD, behavioural variant frontotemporal dementia (bvFTD; n = 29) and semantic variant primary progressive aphasia (svPPA; n = 15), relative to healthy older individuals (n = 37) using two components of the Awareness of Social Inference Test, canonical emotion identification and sarcasm identification. Diffusion tensor imaging (DTI) was used to derive white matter tract correlates of social cognition performance and compared with the distribution of grey matter atrophy on voxel-based morphometry. The bvFTD and svPPA groups showed comparably severe deficits for identification of canonical emotions and sarcasm, and these deficits were correlated with distributed and overlapping white matter tract alterations particularly affecting frontotemporal connections in the right cerebral hemisphere. The most robust DTI associations were identified in white matter tracts linking cognitive and evaluative processing with emotional responses: anterior thalamic radiation, fornix (emotion identification) and uncinate fasciculus (sarcasm identification). DTI associations of impaired social cognition were more consistent than corresponding grey matter associations. These findings delineate a brain network substrate for the social impairment that characterises FTLD syndromes. The findings further suggest that DTI can generate sensitive and functionally relevant indexes of white matter damage in FTLD, with potential to transcend conventional syndrome boundaries.


Subject(s)
Diffusion Tensor Imaging/methods , Frontotemporal Dementia/pathology , Frontotemporal Dementia/physiopathology , Primary Progressive Nonfluent Aphasia/pathology , Primary Progressive Nonfluent Aphasia/physiopathology , Social Perception , White Matter/pathology , Aged , Atrophy/pathology , Female , Gray Matter/pathology , Humans , Male , Middle Aged
18.
J Neurol ; 262(10): 2336-45, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26194195

ABSTRACT

Crossed aphasia has been reported mainly as post-stroke aphasia resulting from brain damage ipsilateral to the dominant right hand. Here, we described a case of a crossed nonfluent/agrammatic primary progressive aphasia (nfvPPA), who developed a corticobasal syndrome (CBS). We collected clinical, cognitive, and neuroimaging data for four consecutive years from a 55-year-old right-handed lady (JV) presenting with speech disturbances. 18-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) and DaT-scan with (123)I-Ioflupane were obtained. Functional MRI (fMRI) during a verb naming task was acquired to characterize patterns of language lateralization. Diffusion tensor MRI was used to evaluate white matter damage within the language network. At onset, JV presented with prominent speech output impairment and right frontal atrophy. After 3 years, language deficits worsened, with the occurrence of a mild agrammatism. The patient also developed a left-sided mild extrapyramidal bradykinetic-rigid syndrome. The clinical picture was suggestive of nfvPPA with mild left-sided extrapyramidal syndrome. At this time, voxel-wise SPM analyses of (18)F-FDG PET and structural MRI showed right greater than left frontal hypometabolism and damage, which included the Broca's area. DaT-scan showed a reduced uptake in the right striatum. FMRI during naming task demonstrated bilateral language activations, and tractography showed right superior longitudinal fasciculus (SLF) involvement. Over the following year, JV became mute and developed frank left-sided motor signs and symptoms, evolving into a CBS clinical picture. Brain atrophy worsened in frontal areas bilaterally, and extended to temporo-parietal regions, still with a right-sided asymmetry. Tractography showed an extension of damage to the left SLF and right inferior longitudinal fasciculus. We report a case of crossed nfvPPA followed longitudinally and studied with advanced neuroimaging techniques. The results highlight a complex interaction between individual premorbid developmental differences and the clinical phenotype.


Subject(s)
Aphasia, Broca/diagnosis , Disease Progression , Primary Progressive Nonfluent Aphasia/diagnosis , Aphasia, Broca/pathology , Aphasia, Broca/physiopathology , Female , Humans , Magnetic Resonance Imaging , Middle Aged , Multimodal Imaging , Positron-Emission Tomography , Primary Progressive Nonfluent Aphasia/pathology , Primary Progressive Nonfluent Aphasia/physiopathology
19.
Neuroimage Clin ; 8: 345-55, 2015.
Article in English | MEDLINE | ID: mdl-26106560

ABSTRACT

The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period. Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression.


Subject(s)
Aphasia, Primary Progressive/pathology , Disease Progression , Executive Function/physiology , Gray Matter/pathology , Magnetic Resonance Imaging/methods , Aged , Aphasia, Primary Progressive/physiopathology , Atrophy/pathology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Primary Progressive Nonfluent Aphasia/pathology , Primary Progressive Nonfluent Aphasia/physiopathology
20.
Cortex ; 67: 95-105, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25929717

ABSTRACT

Patients with dementia may exhibit abnormally altered liking for environmental sounds and music but such altered auditory hedonic responses have not been studied systematically. Here we addressed this issue in a cohort of 73 patients representing major canonical dementia syndromes (behavioural variant frontotemporal dementia (bvFTD), semantic dementia (SD), progressive nonfluent aphasia (PNFA) amnestic Alzheimer's disease (AD)) using a semi-structured caregiver behavioural questionnaire and voxel-based morphometry (VBM) of patients' brain MR images. Behavioural responses signalling abnormal aversion to environmental sounds, aversion to music or heightened pleasure in music ('musicophilia') occurred in around half of the cohort but showed clear syndromic and genetic segregation, occurring in most patients with bvFTD but infrequently in PNFA and more commonly in association with MAPT than C9orf72 mutations. Aversion to sounds was the exclusive auditory phenotype in AD whereas more complex phenotypes including musicophilia were common in bvFTD and SD. Auditory hedonic alterations correlated with grey matter loss in a common, distributed, right-lateralised network including antero-mesial temporal lobe, insula, anterior cingulate and nucleus accumbens. Our findings suggest that abnormalities of auditory hedonic processing are a significant issue in common dementias. Sounds may constitute a novel probe of brain mechanisms for emotional salience coding that are targeted by neurodegenerative disease.


Subject(s)
Affect , Alzheimer Disease/physiopathology , Auditory Perception , Brain/pathology , Frontotemporal Dementia/physiopathology , Music/psychology , Primary Progressive Nonfluent Aphasia/physiopathology , Aged , Aged, 80 and over , Alzheimer Disease/pathology , Alzheimer Disease/psychology , Emotions , Female , Frontotemporal Dementia/pathology , Frontotemporal Dementia/psychology , Gyrus Cinguli/pathology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Nucleus Accumbens/pathology , Phenotype , Primary Progressive Nonfluent Aphasia/pathology , Primary Progressive Nonfluent Aphasia/psychology , Temporal Lobe/pathology
SELECTION OF CITATIONS
SEARCH DETAIL