Esquadrinhando corpos, mutilando histórias: as psicocirurgias aplicadas nas mulheres internadas no Hospício de Juquery / Scrutinizing bodies, mutilating histories: the psychosurgeries undergone by women at Juquery Mental Asylum

Ao longo de seus quatro capítulos, faz um percurso sobre a conformação da psiquiatria organicista, sobre o contexto histórico da sociedade paulista do segundo quartel do século XX, dedicando especial atenção às questões endógenas do Juquery no que tange ao perfil de seus psiquiatras e pacientes. Desse modo, Eliza Toledo lança luz sobre personagens destacados nesse contexto que, até então, careciam de maior atenção da historiografia, como, a título de exemplo, os médicos Mário Yahn e Aloysio de Mattos Pimenta. Ambos desenvolveram variações das técnicas propostas por Egas Moniz e angariaram prestígio entre seus pares ao publicar, em importantes periódicos nacionais e internacionais, uma série de artigos sobre as psicocirurgias, aplicadas invariavelmente em mulheres.

Thermocoagulation as a Surgical Approach for the Treatment of Obsessive-Compulsive Disorder in Refractory Patients: Systematic Review

Obsessive-compulsive disorder (OCD), a disabling chronic neuropsychiatric disease, entails high economic costs to society and has high morbidity and mortality rates. The first-line treatments for OCD are selective serotonin reuptake inhibitors and cognitivebehavioral therapy. However, this disorder has the highest refractory index to noninvasive treatment. Alternatively, ablative thermocoagulation neurosurgical techniques have shown efficacy and few adverse effects. The present systematic review aimed to identify validated protocols to observe the effectiveness of ablative procedures in the treatment of severe and refractory OCD, as well as their possible adverse effects and benefits. This review supports the effectiveness of ablative methods by presenting them as a safe non-experimental therapeutic option for cases of highlyrefractory OCD. Additional relevant findings were the improvement in cognitive function, functional capacity, affective orientation, and quality of life, which contribute to the destigmatization of this surgical technique. Further controlled studies may lead to the individualization of recommendations of targets for ablative thermocoagulation.

[Hypothalamotomy in patients with treatment-resistant aggressiveness: functional outcomes]. / Hipotalamotomía en pacientes con agresividad refractaria: resultados funcionales.

INTRODUCTION: Aggressiveness is part of the behavioural manifestations associated with some mental disorders; it is a symptom that is difficult to manage and is often resistant to pharmacological measures. Surgery for behavioural disorders emerges as a therapeutic alternative. This procedure consists in performing interventions on different structures of the limbic system in order to correct the alteration of the circuit involved in producing the symptoms. AIM: To describe the clinical outcomes of a posterior hypothalamotomy with gamma knife to control aggressiveness in 20 patients resistant to treatment, who underwent surgery at the Imbanaco Medical Centre between 2013 and 2018. PATIENTS AND METHODS: The severity of the aggressiveness was quantified using the Overt Aggression Scale (OAS) and the Clinical Global Impression Scale (CGI-SI), and its functional impact is evaluated using the Global Assessment of Functioning scale (GAF). RESULTS: Control over aggressiveness was observed in all patients treated by posterior hypothalamotomy with gamma knife, evidenced by a decrease in the scores on the OAS and CGI-SI and an improvement in the GAF. CONCLUSIONS: Posterior hypothalamotomy gives rise to few complications, is a safe procedure and offers good results, suggesting that it could be a good alternative treatment in cases of treatment-resistant aggressiveness where it seems that all the possible pharmacological and therapeutic measures have failed.

TITLE: Hipotalamotomía en pacientes con agresividad refractaria: resultados funcionales.Introducción. La agresividad forma parte de las manifestaciones comportamentales asociadas a algunos trastornos mentales, es un síntoma de difícil manejo y, con frecuencia, es refractaria a las medidas farmacológicas. La cirugía de los trastornos del comportamiento surge como una alternativa terapéutica. Este procedimiento consiste en realizar intervenciones sobre distintas estructuras del sistema límbico, con el fin de corregir la alteración del circuito que estaría implicado en la producción de los síntomas. Objetivo. Describir los resultados clínicos de la hipotalamotomía posterior con gamma knife en el control de la agresividad en 20 pacientes refractarios al tratamiento, intervenidos en el Centro Médico Imbanaco entre 2013 y 2018. Pacientes y métodos. La gravedad de la agresividad se cuantificó mediante la escala de agresividad manifiesta (OAS) y la escala de impresión clínica global (CGI-SI), y su impacto funcional, a través de la escala de evaluación de la actividad global (EEAG). Resultados. El control de la agresividad se observó en todos los pacientes tratados con hipotalamotomía posterior con gamma knife, evidenciado por la disminución en las puntuaciones de la OAS y la CGI-SI y la mejoría en la EEAG. Conclusiones. La hipotalamotomía posterior muestra bajas complicaciones, seguridad en el procedimiento y buenos resultados, lo cual sugiere que podría ser una buena alternativa de tratamiento en los casos de agresividad refractaria donde las medidas farmacológicas y terapéuticas parecen agotarse.

Neurosurgery for Refractory Schizophrenia: A Systematic Literature Review

Schizophrenia is a chronic and disabling psychiatric disease that can be refractory to conventional treatment. The present study aims to gather information about the circuitry related to schizophrenia to describe possible surgical targets, and to establish whether psychosurgery can be a safe and effective treatment option for refractory schizophrenia. A systematic review of the literature was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. An electronic search was performed in the Pubmed and BVSalud databases using medical subject headings (MeSH) combined with Boolean operators. Out of the 724 studies retrieved, 13 were included in the review. Regarding leucotomy without a stereotactic approach, we found side effects such as irritability, nervous excitement, cases of disinhibition, and compromised normal social control. In other stereotactic procedures, there was some improvement, mainly regarding aggressiveness and positive symptoms; an anterior capsulotomy had an efficacy rate of 74% according to the Clinical Global Impression (CGI) rating scales. The only deep brain stimulation (DBS) case report found in our study described a significant improvement in the positive and negative symptoms. The use of a stereotactic approach enables psychosurgery to be a safe and effective treatment option in cases of refractory schizophrenia, improving the quality of life and the symptoms. Cognitive and negative symptoms remain a challenge in the treatment of schizophrenia, revealing that more targets in the circuitrymust be surgically explored. Furthermore,more clinical trials are needed to compare these many surgical techniques and targets, using a standard evaluation parameter. The results show that DBS has a promising future in the treatment of refractory schizophrenia.

Effect of unilateral amygdalotomy and hypothalamotomy in patients with refractory aggressiveness.

BACKGROUND: Neurosurgical treatment, although controversial, is considered a useful resource in the treatment of chronic psychiatric diseases such as refractory aggressiveness. OBJECTIVE: To evaluate the clinical results and side effects of posteromedial hypothalamotomy associated with amygdalotomy in patients with refractory aggressiveness. METHOD: A clinical trial was conducted in patients with chronic aggressiveness and refractory to pharmacological treatment. A central amygdalotomy associated with posteromedial hypothalamotomy was performed using thermo-coagulation by radiofrequency. The degree of aggressiveness was quantified by the Yudofsky's global scale of aggression. Postoperative changes in aggressive behavior continued to be evaluated every 6 months for at least 36 months. RESULTS: A statistically significant change in aggressive behavior was observed during 36 months of follow-up. The collateral effects of the association of both procedures are described, the most frequent being drowsiness and some cases of reduction in sexual behavior. CONCLUSION: Symmetric and simultaneous unilateral lesions of the central nucleus of the amygdala and the posteromedial hypothalamus contralateral to motor dominance give the same clinical effect in the reduction of the pathological aggression that the bilateral lesions.

[Efecto de la amigdalotomía e hipotalamotomía unilateral en pacientes con agresividad refractaria].

BACKGROUND: Neurosurgical treatment, although controversial, is considered a useful resource in the treatment of chronic psychiatric diseases such as refractory aggressiveness. OBJECTIVE: To evaluate the clinical results and side effects of posteromedial hypothalamotomy associated with amygdalotomy in patients with refractory aggressiveness. METHOD: A clinical trial was conducted in patients with chronic aggressiveness and refractory to pharmacological treatment. A central amygdalotomy associated with posteromedial hypothalamotomy was performed using thermo-coagulation by radiofrequency. The degree of aggressiveness was quantified by the Yudofsky's global scale of aggression. Postoperative changes in aggressive behavior continued to be evaluated every 6 months for at least 36 months. RESULTS: A statistically significant change in aggressive behavior was observed during 36 months of follow-up. The collateral effects of the association of both procedures are described, the most frequent being drowsiness and some cases of reduction in sexual behavior. CONCLUSION: Symmetric and simultaneous unilateral lesions of the central nucleus of the amygdala and the posteromedial hypothalamus contralateral to motor dominance give the same clinical effect in the reduction of the pathological aggression that the bilateral lesions.

ANTECEDENTES: El tratamiento neuroquirúrgico, aunque polémico, se considera un recurso útil en el tratamiento de enfermedades psiquiátricas crónicas como la agresividad refractaria. OBJETIVO: Evaluar los resultados clínicos y los efectos colaterales de la hipotalamotomía posteromedial (HPM) asociada a amigdalotomía en pacientes con agresividad refractaria. MÉTODO: Se realizó un ensayo clínico en pacientes con agresividad crónica y refractaria a tratamiento farmacológico. Se les realizó amigdalotomía central asociada a HPM mediante termocoagulación por radiofrecuencia. El grado de agresividad se cuantificó mediante la escala global de agresividad de Yudofsky. Los cambios postoperatorios en la conducta agresiva continuaron siendo evaluados cada 6 meses durante al menos 36 meses. RESULTADOS: Se observó un cambio estadísticamente significativo de la conducta agresiva, a lo largo de 36 meses de seguimiento. Se describen los efectos colaterales de la asociación de ambos procedimientos, siendo el de mayor frecuencia la somnolencia y algunos casos de reducción en la conducta sexual. CONCLUSIÓN: Las lesiones unilaterales simétricas y simultáneas del núcleo central de la amígdala y del hipotálamo posteromedial contralaterales a la dominancia motora dan el mismo efecto clínico en la reducción de la agresividad patológica que las lesiones bilaterales.

[Treatment of refractory aggressiveness by amygdalotomy and posteromedial hypothalamotomy by radiofrequency]. / Tratamiento de la agresividad refractaria mediante amigdalotomia e hipotalamotomia posteromedial por radiofrecuencia.

INTRODUCTION: Since, under certain circumstances, defensive or attacking behaviours display a pattern of motor dominance, as observed in subjects who participate in contact or fighting sports, aggressive behaviour was considered to have a dominant motor pattern. With the aim of preventing the functional problems reported with bilateral lesion procedures involving both the central nucleus of the amygdala and the posteromedial hypothalamus, the decision was made to combine them; thus, an amygdalotomy of the central nucleus of the amygdala and a posteromedial hypothalamotomy were to be performed simultaneously and unilaterally, on the basis of the motor dominance of the patient determined by means of the Edinburgh test. PATIENTS AND METHODS: This study describes the surgical experience in a series of nine patients diagnosed with refractory neuroaggressive syndrome. As part of the study protocol, a magnetic resonance brain scan was performed to rule out the presence of neoplasms, vascular diseases, infections and degenerative disorders. The degree of aggressiveness was quantified using Yudofsky's Overt Aggression Scale. Additionally, manual dominance was determined by means of the Edinburgh test. RESULTS AND CONCLUSIONS: Good control of aggressiveness was seen immediately. In some cases it was necessary to reduce the antipsychotic or benzodiazepine medication, as it was seen to increase aggressiveness. Only one case required a second surgical intervention. Follow-up was achieved in 100% of the cases at 24 months and 78% at 36 months.

TITLE: Tratamiento de la agresividad refractaria mediante amigdalotomia e hipotalamotomia posteromedial por radiofrecuencia.Introduccion. Dado que, en algunas circunstancias, las conductas defensivas o de ataque muestran un patron de dominancia motora, tal como se observa en los sujetos dedicados a los deportes de contacto o de lucha, se considero que la conducta agresiva tiene un patron motor dominante. Con el fin de evitar los problemas funcionales descritos con los procedimientos de lesion bilateral tanto del nucleo central de la amigdala como del hipotalamo posteromedial, se decidio combinarlos; es decir, realizar amigdalotomia del nucleo central de la amigdala e hipotalamotomia posteromedial de manera unilateral y simultanea, basandose en la dominancia motora del paciente mediante la prueba de Edimburgo. Pacientes y metodos. Este estudio muestra la experiencia quirurgica en una serie de nueve pacientes con el diagnostico de sindrome neuroagresivo resistente al tratamiento farmacologico. Dentro del protocolo de estudio, se les realizo resonancia magnetica cerebral para descartar la presencia de neoplasias, enfermedades vasculares, infecciones y trastornos degenerativos. El grado de agresividad se cuantifico mediante la escala global de agresividad de Yudofsky. Adicionalmente, se determino la dominancia manual a traves de la prueba de Edimburgo. Resultados y conclusiones. El buen control de la agresividad se observo de modo inmediato. En algunos casos fue necesario reducir la medicacion de antipsicoticos o benzodiacepinas, ya que aumentaban la agresividad. Solo un caso requirio una segunda cirugia. Se logro seguimiento del 100% de los casos en 24 meses y del 78% en 36 meses.

A circulação e aplicação da psicocirurgia no Hospital Psiquiátrico do Juquery / The circulation and application of psychosurgery at Juquery's Psychiatric Hospital

Esta tese discute historicamente o uso da psicocirurgia em um dos maiores hospitais da América Latina entre os anos 1930 e 1950: o Hospital Psiquiátrico do Juquery, situado no estado de São Paulo, onde ocorriam cerca de um terço das internações psiquiátricas do Brasil naquele período. Foi naquela instituição que a terapêutica psiquiátrica, uma das mais controversas do século XX, encontrou seu primeiro espaço de aplicação após as tentativas cirúrgicas começadas em Portugal, em 1936. Na dianteira da recepção da psicocirurgia em nível internacional, o Juquery apresentou um intenso investimento na utilização da terapêutica, o que foi possível graças a especificidades da população internada, à estrutura e aos profissionais da instituição asilar, à organização sociopolítica do contexto e aos princípios científicos orientadores da prática psiquiátrica. Concomitantemente, os registros médicos indicam que questões de gênero permearam a racionalidade terapêutica que organizou a utilização da psicocirurgia no Juquery, refletidas em níveis de tolerância distintos para comportamentos disruptivos de homens e mulheres que puderam ser analisadas nas indicações e resultados das intervenções cirúrgicas. As fontes primárias nos permitiram, ainda, ter acesso ao impacto de novas demandas de ética médica e direitos humanos sobre o uso da terapêutica em nível local, refletindo no seu decrescimento pouco antes da inserção do uso de psicotrópicos na instituição.(AU)

Efecto de la amigdalotomía e hipotalamotomía unilateral en pacientes con agresividad refractaria / Effect of tonsillotomy and unilateral hypothalamotomy in patients with refractory aggressiveness

Resumen Antecedentes: El tratamiento neuroquirúrgico, aunque polémico, se considera un recurso útil en el tratamiento de enfermedades psiquiátricas crónicas como la agresividad refractaria. Objetivo: Evaluar los resultados clínicos y los efectos colaterales de la hipotalamotomía posteromedial (HPM) asociada a amigdalotomía en pacientes con agresividad refractaria. Método: Se realizó un ensayo clínico en pacientes con agresividad crónica y refractaria a tratamiento farmacológico. Se les realizó amigdalotomía central asociada a HPM mediante termocoagulación por radiofrecuencia. El grado de agresividad se cuantificó mediante la escala global de agresividad de Yudofsky. Los cambios postoperatorios en la conducta agresiva continuaron siendo evaluados cada 6 meses durante al menos 36 meses. Resultados: Se observó un cambio estadísticamente significativo de la conducta agresiva, a lo largo de 36 meses de seguimiento. Se describen los efectos colaterales de la asociación de ambos procedimientos, siendo el de mayor frecuencia la somnolencia y algunos casos de reducción en la conducta sexual. Conclusión: Las lesiones unilaterales simétricas y simultáneas del núcleo central de la amígdala y del hipotálamo posteromedial contralaterales a la dominancia motora dan el mismo efecto clínico en la reducción de la agresividad patológica que las lesiones bilaterales.

Abstract Background: Neurosurgical treatment, although controversial, is considered a useful resource in the treatment of chronic psychiatric diseases such as refractory aggressiveness. Objective: To evaluate the clinical results and side effects of posteromedial hypothalamotomy associated with amygdalotomy in patients with refractory aggressiveness. Method: A clinical trial was conducted in patients with chronic aggressiveness and refractory to pharmacological treatment. A central amygdalotomy associated with posteromedial hypothalamotomy was performed using thermo-coagulation by radiofrequency. The degree of aggressiveness was quantified by the Yudofsky's global scale of aggression. Postoperative changes in aggressive behavior continued to be evaluated every 6 months for at least 36 months. Results: A statistically significant change in aggressive behavior was observed during 36 months of follow-up. The collateral effects of the association of both procedures are described, the most frequent being drowsiness and some cases of reduction in sexual behavior. Conclusion: Symmetric and simultaneous unilateral lesions of the central nucleus of the amygdala and the posteromedial hypothalamus contralateral to motor dominance give the same clinical effect in the reduction of the pathological aggression that the bilateral lesions.

Migration of Oxidized Cellulose to the Ventricle as a Complication of Endoscopic Third Ventriculostomy: A Case Report

Endoscopic third ventriculostomy (ETV) is an increasingly common neurosurgical procedure. Hemostatic agentes (porcine gelatin and oxidized cellulose) are normally placed to plug the cortical hole after ETV to avoid cerebral spinal fluid leakage, subdural hygroma, and hemorrhage. Here we report the case of a 6-year-old boy with hydrocephalus who underwent ETV and which oxidized cellulose was placed to plug the cortical hole.Magnetic resonance imaging of the head performed 3 months after the procedure showed the presence of oxidized cellulose in the ventricle. After an unsuccessful attempt to remove the cellulose, it was decided that the patient should be kept under observation. Twoyears later, the child is in good health and without any complaints. Hemostatic agents (especially oxidized cellulose) used on the cortical hole after ETV can migrate to the ventricle and compromise the procedure. Follow-up should be performedfor such patients, and the main focus should be on not causing further injury.

Egas Moniz: twice a double life.

Egas Moniz is credited with the discovery in 1927 of radioarteriography, for which he was, on three occasions, nominated for the Nobel Prize, and in all three denied the award. In 1949 he was awarded the Nobel Prize for Medicine for having designed leucotomy, a brain surgery to treat some forms of severe metal disorders. He was also an successful politician and accomplished statesman.

Egas Moniz: twice a double life / Egas Moniz: uma dupla vida dupla

Egas Moniz is credited with the discovery in 1927 of radioarteriography, for which he was, on three occasions, nominated for the Nobel Prize, and in all three denied the award. In 1949 he was awarded the Nobel Prize for Medicine for having designed leucotomy, a brain surgery to treat some forms of severe metal disorders. He was also an successful politician and accomplished statesman.

Egas Moniz foi o inventor da radioarteriografia, em 1927. Devido a essa descoberta, seu nome foi, por três vezes, indicado para receber o Prêmio Nobel de Medicina e, nas três, não foi considerado merecedor do prêmio. Em 1949 finalmente ele recebeu o Nobel por ter concebido a leucotomia, um procedimento cirúrgico para “tratar certos transtornos mentais graves”. Ele foi, ainda, um homem político e um estadista de sucesso.

Prefrontal lobotomy on Evita was done for behavior/personality modification, not just for pain control.

Eva Perón, best known as Evita, underwent a prefrontal lobotomy in 1952. Although the procedure was said to have been performed to relieve the pain of metastatic cancer, the author carried out a search for evidence that suggests that the procedure was prescribed to decrease violence and to modify Evita's behavior and personality, and not just for pain control. To further elucidate the circumstances surrounding the treatment of this well-known historic figure, the author reviewed the development of the procedure known as prefrontal lobotomy and its three main indications: management of psychiatric illness, control of intractable pain from terminal cancer, and mind control and behavior/personality modification. The role of pioneering neurosurgeons in the development of prefrontal lobotomy, particularly in Connecticut and at Yale University, was also studied, and the political and historical conditions in Argentina in 1952 and to the present were analyzed. Evita was the wife of Juan Perón, who was the supreme leader of the Peronist party as well as president of Argentina. In 1952, however, the Peronist government in Argentina was bicephalic because Evita led the left wing of the party and ran the Female Peronist Party and the Eva Perón Foundation. She was followed by a group of hardcore loyalists interested in accelerating the revolution. Evita was also suffering from metastatic cervical cancer, and her illness increased her anxiety and moved her to purchase weapons to start training workers' militias. Although the apparent purpose was to fight her husband's enemies, this was done without his knowledge. She delivered fiery political speeches and wrote incendiary documents that would have led to a fierce clash in the country at that time. Notwithstanding the disreputable connotation of conspiracy theories, evidence was found of a potentially sinister political conspiracy, led by General Perón, to quiet down his wife Evita and modify her behavior/personality to decrease her belligerence, in addition to treating her cancer-related pain. Psychosurgery was purportedly intended to calm Evita and thus avoid a bloody civil war in Argentina. It was carried out in maximum secrecy and involved a distinguished American neurosurgeon, Dr. James L. Poppen, from the Lahey Clinic in Boston. A recorded and videotaped interview with a former scrub nurse and confidante of Dr. James L. Poppen revealed that prior to the lobotomy on Eva Perón, he performed lobotomies on a few prisoners in the prison system in Buenos Aires. Later, Dr. Poppen seems to have regretted his involvement and participation in this sad chapter in Argentine history. The treatment of Evita at the end of her life was influenced by extraordinary circumstances of time and place but also involved general issues of medical professionalism, the ethics of neuroscience, and the risks of being manipulated by labyrinthine byzantine politics. This story serves as a reminder that any physician, even one considered to be one of the best in the world, may act naively and become a pawn in a game he cannot begin to fathom.

Cirugía de los trastornos del comportamiento: el estado del arte / Surgery for Behavioral Disorders: The state of the art

INTRODUCCIÓN: la cirugía de los trastornos del comportamiento (CTC) se está convirtiendo en un tratamiento más común desde el desarrollo de la neuromodulación. Podemos dividir su historia en 3 etapas: la primera comienza en los inicios de la psicocirugía y termina con el desarrollo de las técnicas estereotácticas, cuando comienza la segunda etapa. Ésta se caracteriza por la realización de lesiones estereotácticas. Nos encontramos transitando la tercera etapa, que comienza cuando la estimulación cerebral profunda (ECP) empieza a ser usada en CTC. OBJETIVO: el propósito de este artículo es realizar una revisión no sistemática de la historia, indicaciones actuales, técnicas y blancos quirúrgicos de la CTC. RESULTADOS: a pesar de los errores graves cometidos en el pasado, hoy en día, la CTC está renaciendo. Los trastornos psiquiátricos que más frecuentemente se tratan con cirugía y los blancos estereotácticos preferidos para cada uno de ellos son: cápsula interna/estriado ventral para trastorno obsesivo-compulsivo, cíngulo subgenual para depresión y complejo centromediano/parafascicular del tálamo para síndrome de Tourette. CONCLUSIÓN: los resultados de la ECP en estos trastornos parecen alentadores. Sin embargo, se necesitan más estudios randomizados para establecer la efectividad de la CTC. Debe tenerse en cuenta que una apropiada selección de pacientes nos ayudará a realizar un procedimiento más seguro así como también a lograr mejores resultados quirúrgicos, conduciendo a la CTC a ser más aceptada por psiquiatras, pacientes y sus familias. Se necesita mayor investigación en vários temas como: fisiopatología de los trastornos del comportamiento, indicaciones de CTC y nuevos blancos quirúrgicos

BACKGROUND: Surgery for behavioral disorders (SBD) is becoming a more commonly-used treatment since the development of neuromodulation techniques. We can divide the history of SBD into 3 stages: the first stage spanned from the dawn of psychosurgery to the initial development of stereotactic techniques. The second stage was characterized by the recognition of stereotactic lesions. We are currently traveling through the third stage, which began when deep brain stimulation (DBS) started to be used for SBD.OBJECTIVE: This article reviews the history, current indications, techniques and surgical targets of SBD. RESULTS: Despite serious errors committed in the past, SBD is now re-emerging as an accepted therapeutic approach. The psychiatric disorders that are most frequently treated by surgery and the preferred stereotactic targets for treating them are: the internal capsule/ventral striatum for obsessive-compulsive disorder; the subgenual cingulate for treatment-resistant depression; and the centromedianum/parafascicularis complex of the thalamus for Tourette syndrome. CONCLUSIONS: Early results for DBS in these disorders are encouraging. However, more randomized trials are needed to establish the effectiveness of SBD. It must be taken into account that ensuring proper patient selection will enhance both procedural safety and effectiveness, leading to SBD being more accepted by psychiatrists, patients and their families. Further research is needed in several areas, like the physiopathology of behavioral disorders, indications for SBD, and new surgical targets

O conflito sexual infantil abordado de um ponto de vista psicanalítico por Egas oniz, o pai da psicocirurgia / Infantile sexual conflict approached from a psychoanalytic point of view by Egas moniz, the father of psychosurgery / Le conflit sexuel infantile étudié d'un point de vue psychanalytique par Egas Moniz, le père de la psychochirurgie / El conflicto sexual infantil desde el punto de vista psicoanalítico de Egas Moniz, padre de la psicocirurjía

Em sua conferência sobre O conflito sexual, proferida no Congresso Luso-Espanhol das Associações para o Progresso das Ciências e publicada em 1921, Egas Moniz aplica o método psicanalítico em dois casos clínicos, utilizando para isso o divã e fazendo uso da associação livre, da associação de ideias, assim como da análise dos sonhos. Esse neurocirurgião, principalmente reconhecido por seus estudos sobre a leucotomia pré-frontal, foi a primeira pessoa a se referir e a recorrer à psicanálise em Portugal. De fato, tal como Freud, Egas Moniz analisou dois casos da literatura apoiando-se no método analítico: o caso de Júlio Dinis em 1924 e o de Camilo em 1925. No entanto, sua contribuição à psicopatologia parece assombrada por seu trabalho sobre a leucotomia, que lhe valeu o Prêmio Nobel de Fisiologia em 1949.

During his conference on sexual conflict, given at the in Luso-Spanish Congress of Associations for Progress of Science, and published in 1921, Egas Moniz explained his use of the analytic method and device (the couch) to present the study of two clinical cases. He also discussed the principle of free association, association of ideas and the interpretation of dreams. Moniz was a neurosurgeon known primarily for his studies on prefrontal leucotomy, and was the first author to refer to and use psychoanalysis in Portugal. Like Freud, Moniz analyzed two cases in the literature in support of the analytical method: the case of Júlio Dinis in 1924 and that of Camilo in 1925. Nevertheless, his work on leucotomy, which earned him the Nobel Prize in Physiology in 1949, appears to have cast a shadow on his contributions to psychopathology.

Dans sa conférence "Le conflit sexuel", tenue au Congrès Luso-Espagnol des Associations pour le Progrès des Sciences et publiée en 1921, Egas Moniz applique la méthode psychanalytique à deux cas cliniques en utilisant le dispositif du divan, le principe des associations libres, l'association d'idées ainsi que l'analyse des rêves. Ce neurochirurgien, reconnu en premier lieu pour ses études sur la leucotomie préfrontale, fut le premier auteur à faire référence et à recourir à la psychanalyse au Portugal. En effet, tout comme Freud, Egas Moniz analysa deux cas de la littérature à l'aide de la méthode analytique: le cas de Júlio Dinis en 1924 et celui de Camilo en 1925. Néanmoins, ses travaux sur la leucotomie, qui lui ont valu l'attribution du prix Nobel de physiologie en 1949, semblent avoir offusqué sa contribution à la psychopathologie.

En una conferencia sobre el conflicto sexual proferida en el Congreso Luso-español de las Asociaciones para el Progreso de las Ciencias y publicada en 1921, Egas Moniz aplica el método psicoanalítico en dos casos clínicos, utilizando para eso el diván, haciendo uso de la asociación libre de ideas, así como del análisis de sueños. Este neurocirurjano, reconocido principalmente por sus estudios sobre la leucotomia pre-frontal, fue la primera persona a referirse y recurrir al psicoanálisis en Portugal. De hecho, tal como Freíd, Egas Moniz analisó dos casos de la literatura apoyándose en el método psicoanalítico: el caso de Julio Dinis en 1924 y el de Camilo en 1925. Sin embargo, su contribución a la sicopatología parece ensombrecida por su trabajo sobre la leucotomia, lo que le valió el Premio Nobel de Fisiología en 1949.

O conflito sexual infantil abordado de um ponto de vista psicanalítico por Egas Moniz, o pai da psicocirurgia / Infantile sexual conflict approached from a psychoanalytic point of view by egas moniz, the father of psychosurgery / Le conflit sexuel infantile étudié d'un point de vue psychanalytique par Egas Moniz, le père de la psychochirurgie / El conflicto sexual infantil desde el punto de vista psicoanalítico de Egas Moniz, padre de la psicocirurjía

Em sua conferência sobre O conflito sexual, proferida no Congresso Luso-Espanhol das Associações para o Progresso das Ciências e publicada em 1921, Egas Moniz aplica o método psicanalítico em dois casos clínicos, utilizando para isso o divã e fazendo uso da associação livre, da associação de ideias, assim como da análise dos sonhos. Esse neurocirurgião, principalmente reconhecido por seus estudos sobre a leucotomia pré-frontal, foi a primeira pessoa a se referir e a recorrer à psicanálise em Portugal. De fato, tal como Freud, Egas Moniz analisou dois casos da literatura apoiando-se no método analítico: o caso de Júlio Dinis em 1924 e o de Camilo em 1925. No entanto, sua contribuição à psicopatologia parece assombrada por seu trabalho sobre a leucotomia, que lhe valeu o Prêmio Nobel de Fisiologia em 1949.(AU)

During his conference on sexual conflict, given at the in Luso-Spanish Congress of Associations for Progress of Science, and published in 1921, Egas Moniz explained his use of the analytic method and device (the couch) to present the study of two clinical cases. He also discussed the principle of free association, association of ideas and the interpretation of dreams. Moniz was a neurosurgeon known primarily for his studies on prefrontal leucotomy, and was the first author to refer to and use psychoanalysis in Portugal. Like Freud, Moniz analyzed two cases in the literature in support of the analytical method: the case of Júlio Dinis in 1924 and that of Camilo in 1925. Nevertheless, his work on leucotomy, which earned him the Nobel Prize in Physiology in 1949, appears to have cast a shadow on his contributions to psychopathology.(AU)

Dans sa conférence "Le conflit sexuel", tenue au Congrès Luso-Espagnol des Associations pour le Progrès des Sciences et publiée en 1921, Egas Moniz applique la méthode psychanalytique à deux cas cliniques en utilisant le dispositif du divan, le principe des associations libres, l'association d'idées ainsi que l'analyse des rêves. Ce neurochirurgien, reconnu en premier lieu pour ses études sur la leucotomie préfrontale, fut le premier auteur à faire référence et à recourir à la psychanalyse au Portugal. En effet, tout comme Freud, Egas Moniz analysa deux cas de la littérature à l'aide de la méthode analytique: le cas de Júlio Dinis en 1924 et celui de Camilo en 1925. Néanmoins, ses travaux sur la leucotomie, qui lui ont valu l'attribution du prix Nobel de physiologie en 1949, semblent avoir offusqué sa contribution à la psychopathologie.(AU)

En una conferencia sobre el conflicto sexual proferida en el Congreso Luso-español de las Asociaciones para el Progreso de las Ciencias y publicada en 1921, Egas Moniz aplica el método psicoanalítico en dos casos clínicos, utilizando para eso el diván, haciendo uso de la asociación libre de ideas, así como del análisis de sueños. Este neurocirurjano, reconocido principalmente por sus estudios sobre la leucotomia pre-frontal, fue la primera persona a referirse y recurrir al psicoanálisis en Portugal. De hecho, tal como Freíd, Egas Moniz analisó dos casos de la literatura apoyándose en el método psicoanalítico: el caso de Julio Dinis en 1924 y el de Camilo en 1925. Sin embargo, su contribución a la sicopatología parece ensombrecida por su trabajo sobre la leucotomia, lo que le valió el Premio Nobel de Fisiología en 1949.(AU)

Egas Moniz (1874-1955): cultura e ciência / Egas Moniz (1874-1955): culture and science

Por ocasião do sexagésimo aniversário da atribuição, em 1949, do prêmio Nobel da Medicina ou Fisiologia a Egas Moniz e a Walter Rudolf Hess, foram evocadas as circunstâncias que explicam a singular nobelização. Chama-se atenção para os traços biográficos de Egas Moniz, que são também os de muitos médicos da sua geração, asssim como dos pormenores que se prendem com o processo de nomeação e avaliação científica visando à candidatura ao prêmio Nobel. São também discutidos aspectos de ligação entre a cultura e a ciência, designadamente as controvérsias à volta do prêmio que lhe foi atribuído.

On the occasion of the sixtieth anniversary of the award in 1949, the Nobel Prize in Physiology or Medicine granted to Egas Moniz and Walter Rudolf Hess, the circumstances that explain the unique Nobel award require elucidation. Attention is drawn to the biographical traits of Egas Moniz, which are also those of many doctors of his generation, as well as the details which relate to the process of nomination and scientific appraisal to be eligible for the Nobel Prize. Aspects of the link between culture and science are also discussed, including the controversies surrounding the award conferred upon him.