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2.
Acta Neurochir (Wien) ; 166(1): 348, 2024 Aug 23.
Article in English | MEDLINE | ID: mdl-39177697

ABSTRACT

BACKGROUND: Stereotactic radiosurgery (SRS) represents a minimally invasive and valuable alternative for jugular foramen schwannomas (JFS), both as upfront and/or adjuvant treatment (in hybrid approaches). METHODS: We conducted a retrospective review of our cases treated at the Lausanne University Hospital (CHUV) from June 2010 to October 2023. Eleven patients underwent SRS, among whom three had prior surgery, two in our center in the frame of a planned combined approach and one in another center. Two patients received "volume-staged" SRS. The mean age at SRS was 60 years (median 68; range 29-83). Cranial nerve (CN) symptoms were present in six patients, while five were asymptomatic. The mean tumor volume at SRS was 2.1 cc (median 1.2; range 0.068-7.3 cc), with a 12 Gy marginal dose prescribed in all cases. RESULTS: The mean follow-up period was 3.9 years (median 2, range 1-7). Cranial nerve function improved after SRS in six patients, while five remained stable. At the last follow-up, all tumors showed a decrease in volume, except for one patient, who underwent surgery at 18 months after SRS, for volumetric increase at 6 and 12 months, with further XII-th CN palsy and medulla oblongata compression. Although tumor decreased at 18 months, such patient needed microsurgical resection for symptom persistence and was further controlled. The mean tumor volume at 1 year post-SRS was 1.6 cc (median 0.55; range 0.028-7.77 cc), at 2 years was 1.31 cc (median 0.76; range 0.19-5), and at 3 years was 1.32 cc (median 0.59; range 0.23-4.8). No adverse radiation events were observed. CONCLUSIONS: Stereotactic radiosurgery is considered a safe and effective treatment for jugular foramen schwannomas, ensuring high rates of tumor control in all patients over the long term. The cranial nerve function improved after SRS in the 6 patients who had deficits and the other 5 patients who had no deficits remained asymptomatic. For larger tumors, combined/hybrid approaches can be a valuable alternative, to obtain tumor control and to preserve neurological function.


Subject(s)
Jugular Foramina , Neurilemmoma , Radiosurgery , Humans , Radiosurgery/methods , Middle Aged , Neurilemmoma/surgery , Neurilemmoma/diagnostic imaging , Neurilemmoma/radiotherapy , Aged , Male , Female , Adult , Retrospective Studies , Aged, 80 and over , Jugular Foramina/surgery , Treatment Outcome , Skull Base Neoplasms/surgery , Skull Base Neoplasms/radiotherapy , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/pathology , Follow-Up Studies
3.
Acta Neurochir (Wien) ; 166(1): 311, 2024 Jul 31.
Article in English | MEDLINE | ID: mdl-39085521

ABSTRACT

BACKGROUND: For a minimally invasive treatment approach to the anteromedial part of the anterior cranial fossa (ACF), a small incision and craniotomy of the posterolateral part of the ACF are preferable. METHOD: We described the concept and technique of suprapterional keyhole approach (SPKA), which uses an exoscope and endoscope to treat ACF lesions. CONCLUSION: The SPKA enables ACF observation from the lateral direction; the endoscope's extended viewing angles enable the observation of the anteromedial part of the ACF, including the bilateral olfactory groove. Facial skin and large scalp incisions are avoided, making this approach efficient for ACF lesions.


Subject(s)
Cranial Fossa, Anterior , Craniotomy , Skull Base Neoplasms , Humans , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging , Craniotomy/methods , Cranial Fossa, Anterior/surgery , Skull Base/surgery , Skull Base/diagnostic imaging , Minimally Invasive Surgical Procedures/methods , Neurosurgical Procedures/methods , Male , Female , Middle Aged
4.
Zh Vopr Neirokhir Im N N Burdenko ; 88(3): 111-119, 2024.
Article in Russian | MEDLINE | ID: mdl-38881024

ABSTRACT

To date, treatment of chordomas involves maximal tumor resection followed by proton therapy. Various approaches are used depending on location of tumor (transcranial and through natural anatomical openings (nose, mouth), as well as their combinations). Although transoral approach has been introduced into neurosurgical practice for a long time, it is routinely used in patients with chordoma only in certain hospitals in the world. OBJECTIVE: To analyze postoperative outcomes in patients with chordomas of skull base and craniovertebral joint after transoral surgery. MATERIAL AND METHODS: We analyzed literature data devoted to patients with chordomas of skull base and craniovertebral joint after transoral surgery or another approach combined with transoral access. Among 111 primary articles, we selected 38 manuscripts including description of 109 patients with skull base chordoma who underwent transoral surgery or combination of approaches including transoral one. RESULTS: Gross total resection was achieved in 45.9% (n=50) of cases including 1 patient after en bloc resection. Subtotal resection was carried out in 28.4% of cases, partial - in 24.8%, biopsy - in 0.9% of cases. The complication rate in this group was 30%. The most common events were swelling of the tongue (10%) and diastasis of posterior pharyngeal wall sutures (8.2%) that required redo surgery. CSF leakage and meningitis were rare (1.8% and 3.6%, respectively). CONCLUSION: Transoral access allows for gross total resection of midline tumors with low incidence of severe complications. Combination of transoral and transcranial approaches is advisable to increase extent of resection.


Subject(s)
Chordoma , Skull Base Neoplasms , Humans , Chordoma/surgery , Chordoma/diagnostic imaging , Chordoma/pathology , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/pathology , Female , Neurosurgical Procedures/methods , Male
5.
Clin Neurol Neurosurg ; 243: 108382, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38944020

ABSTRACT

OBJECTIVE: Tumors located within the Meckel's cave (MC) pose a significant surgical challenge. Although several corridors to access this complex region have been described, the endoscopic transpterygoid approach (ETPA) and the endoscopic transorbital superior eyelid approach (ETOA) have emerged in recent years, as viable alternatives to traditional microsurgical transcranial approaches (MTA). To date, there is a limited literature on surgical series considering endoscopic-assisted approaches to the MC. METHODS: We conducted a retrospective analysis of patients with primary MC tumors treated at our Institution between 2015 and 2022, specifically those managed via the ETPA assisted by intraoperative Endoscopic Diving Technique (EDT). Lesion resection extent was evaluated using pre- and post-intervention radiological images and surgical videos. Moreover, a literature review on ETPA was performed. RESULTS: This series comprises 7 patients affected by 4 trigeminal schwannomas, 1 benign notochordal cell tumor, 1 dermoid cyst and 1 mesenchymal tumor. In 71 % of cases, trigeminal neuralgia was the presenting symptom. Post-operative clinical improvement was observed in all but one case. Notably, 85.7 % of patients achieved total or near-total resection (NTR), with the remaining case undergoing subtotal resection (STR). No significant intraoperative complications occurred, and no recurrences were observed during the mean follow-up period of 41 months. CONCLUSIONS: In selected cases, the ETPA offers a direct and safe path to lesions located into the MC. This approach circumvents complications and constraints associated with ETOA or MTA. Moreover, the use of the EDT reduces manipulation of critical neurovascular structures, enhancing the efficacy of the ETPA.


Subject(s)
Neuroendoscopy , Humans , Retrospective Studies , Male , Female , Middle Aged , Adult , Neuroendoscopy/methods , Aged , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging , Neurosurgical Procedures/methods , Cranial Nerve Neoplasms/surgery , Cranial Nerve Neoplasms/diagnostic imaging , Young Adult , Neurilemmoma/surgery , Neurilemmoma/diagnostic imaging
6.
Acta Neurochir (Wien) ; 166(1): 265, 2024 Jun 14.
Article in English | MEDLINE | ID: mdl-38874622

ABSTRACT

BACKGROUND: Samii Type-D jugular foramen schwannomas (JFSs) are the most challenging for neurosurgeons because of anatomical complexity. Various neurosurgical approaches have been described to gain access to JF. METHODS: We present a female with incidental diagnosis of the Type-D JFS. Complete radical resection was achieved via the carotid triangle approach without any bony structure removal. And the patient was discharged asymptomatic and without new-developed neurological deficits. CONCLUSIONS: The carotid triangle is a secure and appropriate approach for some cases of selected Type-D JFSs. However, the specific indications of this approach should be further explored and investigated.


Subject(s)
Jugular Foramina , Neurilemmoma , Humans , Female , Neurilemmoma/surgery , Neurilemmoma/diagnostic imaging , Neurilemmoma/pathology , Jugular Foramina/surgery , Microsurgery/methods , Neurosurgical Procedures/methods , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/pathology , Treatment Outcome , Magnetic Resonance Imaging , Middle Aged , Adult
7.
BMJ Case Rep ; 17(5)2024 May 21.
Article in English | MEDLINE | ID: mdl-38772871

ABSTRACT

Brain metastases (BMs) arising from ovarian cancer remain rare. Spinal cord metastases are even rarer, accounting for just 0.4% of total metastatic spinal cord compressions. In this report, we describe a case of a woman in her 70s who developed sequential brain and spinal cord metastases during her treatment for high-grade serous ovarian cancer, without a germline or somatic BRCA mutation. Following completion of neoadjuvant chemotherapy, interval debulking surgery and adjuvant chemotherapy, relapsed disease was ultimately identified as a single BM, curiously mimicking an acoustic neuroma. Subsequently, spinal cord metastases rapidly developed. Throughout, multidisciplinary team meetings guided decisions on patient management. In this report, we highlight the rarity of such a presentation and discuss the possible role of disease pathophysiology, associated systemic anticancer therapy resistance, and treatment possibilities for both cerebral and spinal metastases.


Subject(s)
Ovarian Neoplasms , Humans , Female , Ovarian Neoplasms/pathology , Ovarian Neoplasms/secondary , Ovarian Neoplasms/therapy , Aged , Spinal Cord Neoplasms/secondary , Spinal Cord Neoplasms/therapy , Spinal Cord Neoplasms/diagnostic imaging , Skull Base Neoplasms/secondary , Skull Base Neoplasms/therapy , Skull Base Neoplasms/diagnostic imaging , Cystadenocarcinoma, Serous/secondary , Cystadenocarcinoma, Serous/therapy , Cystadenocarcinoma, Serous/drug therapy
8.
Adv Tech Stand Neurosurg ; 49: 201-229, 2024.
Article in English | MEDLINE | ID: mdl-38700686

ABSTRACT

Paragangliomas are the most common tumors at jugular foramen and pose a great surgical challenge. Careful clinical history and physical examination must be performed to adequately evaluate neurological deficits and its chronologic evolution, also to delineate an overview of the patient performance status. Complete imaging evaluation including MRI and CT scans should be performed, and angiography is a must to depict tumor blood supply and sigmoid sinus/internal jugular vein patency. Screening for multifocal paragangliomas is advisable, with a whole-body imaging. Laboratory investigation of endocrine function of the tumor is necessary, and adrenergic tumors may be associated with synchronous lesions. Preoperative prepare with alpha-blockage is advisable in norepinephrine/epinephrine-secreting tumors; however, it is not advisable in exclusively dopamine-secreting neoplasms. Best surgical candidates are young otherwise healthy patients with smaller lesions; however, treatment should be individualized each case. Variations of infratemporal fossa approach are employed depending on extensions of the mass. Regarding facial nerve management, we avoid to expose or reroute it if there is preoperative function preservation and prefer to work around facial canal in way of a fallopian bridge technique. If there is preoperative facial nerve compromise, the mastoid segment of the nerve is exposed, and it may be grafted if invaded or just decompressed. A key point is to preserve the anteromedial wall of internal jugular vein if there is preoperative preservation of lower cranial nerves. Careful multilayer closure is essential to avoid at most cerebrospinal fluid leakage. Residual tumors may be reoperated if growing and presenting mass effect or be candidate for adjuvant stereotactic radiosurgery.


Subject(s)
Jugular Foramina , Paraganglioma , Skull Base Neoplasms , Humans , Jugular Foramina/pathology , Neurosurgical Procedures/methods , Paraganglioma/surgery , Paraganglioma/diagnostic imaging , Paraganglioma/diagnosis , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging
9.
Neurosurg Focus ; 56(5): E10, 2024 05.
Article in English | MEDLINE | ID: mdl-38691855

ABSTRACT

OBJECTIVE: Chordoma is a primary bone tumor with limited literature on its management because of its rarity. Resection, while considered the first-line treatment, does not always provide adequate tumor control. In this systematic review, the authors aimed to provide comprehensive insights by managing these tumors with stereotactic radiosurgery (SRS). METHODS: A systematic review was conducted according to PRISMA guidelines using the PubMed, Scopus, Web of Science, Embase, and Cochrane Library databases. Search terms included chordoma and radiosurgery and their equivalent terms. Data on baseline characteristics, SRS details, and outcomes were extracted. The Joanna Briggs Institute checklist was used to assess risk of bias. A meta-analysis was performed on relevant variables. RESULTS: A total of 33 eligible studies encompassing 714 patients with skull base chordomas were included. Most studies had a low risk of bias. Patients, predominantly male (57.37%) with a mean age of 46.54 years, exhibited a conventional chordoma subtype (74.77%) and primary lesions (77.91%), mainly in the clivus (98.04%). The mean lesion volume was 13.49 cm3, and 96.68% of patients had undergone prior surgical attempts. Gamma Knife radiosurgery (88.76%) was the predominant SRS method. Radiologically, 27.19% of patients experienced tumor regression, while 55.02% showed no signs of disease progression at the latest follow-up. Progression occurred after a mean of 48.02 months. Symptom improvement was noted in 27.98% of patients. Radiosurgery was associated with a relatively low overall adverse event rate (11.94%), mainly cranial nerve deficits (8.72%). Meta-regression revealed that age and primary lesion type influenced symptom improvement, while factors like extent of resection, radiotherapy, and SRS type affected adverse event rates. CONCLUSIONS: This systematic review provides evidence on the safety and effectiveness of radiosurgery in the management of skull base chordomas. Local tumor control was achieved in the majority of patients treated with SRS. Various baseline characteristics and SRS features have been analyzed to identify modifying factors for each outcome to provide a framework for informed decision-making when managing these patients.


Subject(s)
Chordoma , Radiosurgery , Skull Base Neoplasms , Radiosurgery/methods , Humans , Chordoma/surgery , Chordoma/radiotherapy , Chordoma/diagnostic imaging , Skull Base Neoplasms/surgery , Skull Base Neoplasms/radiotherapy , Skull Base Neoplasms/diagnostic imaging , Treatment Outcome
10.
Neurosurg Focus ; 56(5): E3, 2024 05.
Article in English | MEDLINE | ID: mdl-38691859

ABSTRACT

OBJECTIVE: The mainstay of treatment for skull base chordoma (SBC) is maximal safe resection followed by radiotherapy. However, even after gross-total resection (GTR), the recurrence rate is high due to microscopic disease in the resection margins. Therefore, supramarginal resection (SMR) could be beneficial, as has been shown for sacral chordoma. The paradigm of postoperative radiation therapy for every patient has also begun to change, as molecular profiling has shown variability in the risk of recurrence. The aim of this study was to present the concept of SMR applied to SBC, along with an individualized decision for postoperative radiation therapy. METHODS: This is a retrospective analysis of all SBCs operated on by the senior author between 2018 and 2023. SMR was defined as negative histological margins of bone and/or dura mater, along with evidence of bone resection beyond the tumor margins in the craniocaudal and lateral planes on postoperative imaging. Tumors were classified into 3 molecular recurrence risk groups (group A, low risk; group B, intermediate risk; and group C, high risk). Postoperative radiation therapy was indicated in group C tumors, in group B chordomas without SMR, or in cases of patient preference. RESULTS: Twenty-two cases of SBC fulfilled the inclusion criteria. SMR was achieved in 12 (55%) cases, with a mean (range) amount of bone resection beyond the tumor margins of 10 (2-20) mm (+40%) in the craniocaudal axis and 6 (1-15) mm (+31%) in the lateral plane. GTR and near-total resection were each achieved in 5 (23%) cases. Three (19%) tumors were classified as group A, 12 (75%) as group B, and 1 (6%) as group C. Although nonsignificant due to the small sample size, the trends showed that patients in the SMR group had smaller tumor volumes (13.9 vs 19.6 cm3, p = 0.35), fewer previous treatments (33% vs 60% of patients, p = 0.39), and less use of postoperative radiotherapy (25% vs 60%, p = 0.19) compared to patients in the non-SMR group. There were no significant differences in postoperative CSF leak (0% vs 10%, p = 0.45), persistent cranial nerve palsy (8% vs 20%, p = 0.57), and tumor recurrence (8% vs 10%, p = 0.99; mean follow-up 15 months) rates between the SMR and non-SMR groups. CONCLUSIONS: In select cases, SMR of SBC appears to be feasible and safe. Larger cohorts and longer follow-up evaluations are necessary to explore the benefit of SMR and individualized postoperative radiation therapy on progression-free survival.


Subject(s)
Chordoma , Skull Base Neoplasms , Humans , Chordoma/surgery , Chordoma/radiotherapy , Chordoma/diagnostic imaging , Skull Base Neoplasms/surgery , Skull Base Neoplasms/radiotherapy , Skull Base Neoplasms/diagnostic imaging , Male , Female , Middle Aged , Adult , Retrospective Studies , Aged , Treatment Outcome , Neurosurgical Procedures/methods , Neoplasm Recurrence, Local/surgery , Neoplasm Recurrence, Local/diagnostic imaging , Young Adult , Margins of Excision
11.
Neurosurg Focus ; 56(5): E2, 2024 05.
Article in English | MEDLINE | ID: mdl-38691870

ABSTRACT

OBJECTIVE: The aim of this study was to describe the natural history of incidental benign-appearing notochordal lesions of the skull base with specific attention to features that can make differentiation from low-grade chordoma more difficult, namely contrast uptake and bone erosion. METHODS: In this retrospective case series, the authors describe the clinical outcomes of 58 patients with incidental benign-appearing notochordal lesions of the clivus, including those with minor radiological features of bone erosion or contrast uptake. RESULTS: All lesions remained stable during a median follow-up of almost 3 years. Thirty-seven (64%) patients underwent contrast-enhanced MRI; lesions in 14 (38%) of these patients exhibited minimal contrast enhancement. Twenty-seven (47%) patients underwent CT; lesions in 6 (22%) of these patients exhibited minimal bone erosion. CONCLUSIONS: These data make the case for monitoring selected cases of benign-appearing notochordal lesions of the clivus in the first instance even when there is minor contrast uptake or minimal bone erosion.


Subject(s)
Incidental Findings , Magnetic Resonance Imaging , Notochord , Skull Base Neoplasms , Humans , Male , Female , Middle Aged , Retrospective Studies , Adult , Notochord/diagnostic imaging , Aged , Skull Base Neoplasms/diagnostic imaging , Magnetic Resonance Imaging/methods , Chordoma/diagnostic imaging , Tomography, X-Ray Computed/methods , Follow-Up Studies , Young Adult , Cranial Fossa, Posterior/diagnostic imaging
12.
Neurosurg Focus ; 56(5): E8, 2024 05.
Article in English | MEDLINE | ID: mdl-38691866

ABSTRACT

OBJECTIVE: Skull base chordomas are rare, locally osseo-destructive lesions that present unique surgical challenges due to their involvement of critical neurovascular and bony structures at the craniovertebral junction (CVJ). Radical cytoreductive surgery improves survival but also carries significant morbidity, including the potential for occipitocervical (OC) destabilization requiring instrumented fusion. The published experience on OC fusion after CVJ chordoma resection is limited, and the anatomical predictors of OC instability in this context remain unclear. METHODS: PubMed and Embase were systematically searched according to the PRISMA guidelines for studies describing skull base chordoma resection and OC fusion. The search strategy was predefined in the authors' PROSPERO protocol (CRD42024496158). RESULTS: The systematic review identified 11 surgical case series describing 209 skull base chordoma patients and 116 (55.5%) who underwent OC instrumented fusion. Most patients underwent lateral approaches (n = 82) for chordoma resection, followed by midline (n = 48) and combined (n = 6) approaches. OC fusion was most often performed as a second-stage procedure (n = 53), followed by single-stage resection and fusion (n = 38). The degree of occipital condyle resection associated with OC fusion was described in 9 studies: total unilateral condylectomy reliably predicted OC fusion regardless of surgical approach. After lateral transcranial approaches, 4 studies cited at least 50%-70% unilateral condylectomy as necessitating OC fusion. After midline approaches-most frequently the endoscopic endonasal approach (EEA)-at least 75% unilateral condylectomy (or 50% bilateral condylectomy) led to OC fusion. Additionally, resection of the medial atlantoaxial joint elements (the C1 anterior arch and tip of the dens), usually via EEA, reliably necessitated OC fusion. Two illustrative cases are subsequently presented, further exemplifying how the extent of CVJ bony elements removed via EEA to achieve complete chordoma resection predicts the need for OC fusion. CONCLUSIONS: Unilateral total condylectomy, 50% bilateral condylectomy, and resection of the medial atlantoaxial joint elements were the most frequently described independent predictors of OC fusion in skull base chordoma resection. Additionally, consistent with the occipital condyle harboring a significantly thicker joint capsule at its posterolateral aspect, an anterior midline approach seems to tolerate a greater degree of condylar resection (75%) than a lateral transcranial approach (50%-70%) prior to generating OC instability.


Subject(s)
Cervical Vertebrae , Chordoma , Occipital Bone , Skull Base Neoplasms , Spinal Fusion , Humans , Chordoma/surgery , Chordoma/diagnostic imaging , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging , Occipital Bone/surgery , Occipital Bone/diagnostic imaging , Spinal Fusion/methods , Cervical Vertebrae/surgery , Cervical Vertebrae/diagnostic imaging , Female , Atlanto-Occipital Joint/surgery , Atlanto-Occipital Joint/diagnostic imaging , Male , Adult , Middle Aged
13.
Acta Neurochir (Wien) ; 166(1): 158, 2024 Apr 01.
Article in English | MEDLINE | ID: mdl-38558198

ABSTRACT

BACKGROUND: Petroclival meningiomas are one of the most challenging tumors to be operated in the realm of neurosurgery. Many approaches have been developed over the years. METHOD: The authors describe the Half & Half (H&H) approach whose main indication is petroclival meningiomas with suprasellar extension. The part of the tumor located above CN III and in the retrochiasmatic space is addressed through a trans-sylvian, while the petroclival portion is through an extradural anterior petrosectomy approach. The wide surgical corridor given by this approach allows extensive tumor resection while avoiding the risk associated with the manipulation of intracavernous neurovascular structures. CONCLUSION: The H&H approach is an effective strategy to maximize the safe resection of petroclival meningiomas.


Subject(s)
Meningeal Neoplasms , Meningioma , Skull Base Neoplasms , Humans , Meningioma/diagnostic imaging , Meningioma/surgery , Meningioma/pathology , Meningeal Neoplasms/diagnostic imaging , Meningeal Neoplasms/surgery , Meningeal Neoplasms/pathology , Petrous Bone/diagnostic imaging , Petrous Bone/surgery , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/surgery , Skull Base Neoplasms/pathology , Neurosurgical Procedures
14.
BMC Oral Health ; 24(1): 420, 2024 Apr 05.
Article in English | MEDLINE | ID: mdl-38580965

ABSTRACT

BACKGROUND: Interstitial brachytherapy is a form of intensive local irradiation that facilitates the effective protection of surrounding structures and the preservation of organ functions, resulting in a favourable therapeutic response. As surgical robots can perform needle placement with a high level of accuracy, our team developed a fully automatic radioactive seed placement robot, and this study aimed to evaluate the accuracy and feasibility of fully automatic radioactive seed placement for the treatment of tumours in the skull base. METHODS: A fully automatic radioactive seed placement robot was established, and 4 phantoms of skull base tumours were built for experimental validation. All the phantoms were subjected to computed tomography (CT) scans. Then, the CT data were imported into the Remebot software to design the preoperative seed placement plan. After the phantoms were fixed in place, navigation registration of the Remebot was carried out, and the automatic seed placement device was controlled to complete the needle insertion and particle placement operations. After all of the seeds were implanted in the 4 phantoms, postoperative image scanning was performed, and the results were verified via image fusion. RESULTS: A total of 120 seeds were implanted in 4 phantoms. The average error of seed placement was (2.51 ± 1.44) mm. CONCLUSION: This study presents an innovative, fully automated radioactive particle implantation system utilizing the Remebot device, which can successfully complete automated localization, needle insertion, and radioactive particle implantation procedures for skull base tumours. The phantom experiments showed the robotic system to be reliable, stable, efficient and safe. However, further research on the needle-soft tissue interaction and deformation mechanism of needle puncture is still needed.


Subject(s)
Dental Implants , Robotics , Skull Base Neoplasms , Humans , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/radiotherapy , Skull Base Neoplasms/surgery , Phantoms, Imaging , Tomography, X-Ray Computed
16.
World Neurosurg ; 187: 70-81, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38561034

ABSTRACT

BACKGROUND: Phosphaturic Mesenchymal Tumors (PMTs) are rare mesenchymal neoplasms known for producing Tumor-induced Osteomalacia (TIO). TIO is an uncommon paraneoplastic syndrome characterized by radiographic evidence of inadequate bone mineralization and analytical abnormalites. METHODS: We sought to present a case of TIO caused by skull base PMT with intracranial extension, manifesting with pain, progressive weakness, and multiple bone fractures. Furthermore, a systematic review was performed, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. A search was conducted in PubMed database with title/abstract keywords "Phosphaturic mesenchymal tumor" and "Osteomalacia." Search results were reviewed looking for intracranial or skull base tumors. RESULTS: Our systematic review included 29 reported cases of intracranial PMT. In the reviewed cases there was a significative female predominance with 22 cases (75,86%). Osteomalacia was presented in 25 cases (86,20%). Bone fractures were present in 10 cases (34,48%). The most common site of involvement was the anterior cranial fossa in 14 cases (48,27%). Surgery was performed in 27 cases (93,10%) with previous tumor embolization in 4 cases (13,79%). Total recovery of the presenting symptoms in the first year was achieved in 21 cases (72,41%). Recurrence of the disease was described in 6 cases (25%). CONCLUSIONS: Skull base PMTs with intracranial extension are extremely rare tumors. Most patients are middle-aged adults with a PMT predominantly located in anterior cranial fossa. Surgery is the current treatment of choice with optimal outcome at 1-year follow-up, although recurrence could be present in almost 25% of the cases.


Subject(s)
Osteomalacia , Paraneoplastic Syndromes , Female , Humans , Male , Brain Neoplasms/complications , Brain Neoplasms/surgery , Brain Neoplasms/diagnostic imaging , Mesenchymoma/surgery , Mesenchymoma/complications , Mesenchymoma/pathology , Mesenchymoma/diagnostic imaging , Neoplasms, Connective Tissue/diagnostic imaging , Neoplasms, Connective Tissue/surgery , Osteomalacia/etiology , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/complications
17.
World Neurosurg ; 187: 101, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38616026

ABSTRACT

Due to deep location and for being adjacent to neurovascular structures, petroclival meningiomas (PCMs) are generally considered to be associated with a high rate of recurrence and cranial nerve deficits.1 This video presents a 49-year-old female patient reporting right trigeminal neuralgia for more than 1 year. The incidence of this symptom with PCMs is about 5%.2 According to the classification system proposed by Kawase et al.3 and Ichimura et al.,4 this is a tentorium type PCM. A modified anterior petrosectomy approach was adopted based on the tumor size and its origin. The case presentation, surgical technique, postoperative outcome are reviewed. The treatments to the intraoperative trochlear nerve injury and temporal bridging vein occlusion are displayed (Video 1). The patient gave verbal consent for participating in the procedure and surgical video.


Subject(s)
Meningeal Neoplasms , Meningioma , Neurosurgical Procedures , Petrous Bone , Skull Base Neoplasms , Humans , Meningioma/surgery , Female , Middle Aged , Meningeal Neoplasms/surgery , Neurosurgical Procedures/methods , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging , Petrous Bone/surgery , Postoperative Complications/etiology , Trigeminal Neuralgia/surgery , Trigeminal Neuralgia/etiology , Cranial Fossa, Posterior/surgery
18.
World Neurosurg ; 187: e321-e330, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38649026

ABSTRACT

OBJECTIVE: To assess the impact of tumor extension into the occipital condyle (OC) in lower clival chordoma management and the need for occipito-cervical fusion (OCF). METHODS: A retrospective analysis was conducted on 35 patients with lower clival chordoma. The preoperative area of the intact OCs, Hounsfield units, and the integrity of the apical ligament and the tectorial membrane were assessed using preoperative imaging. RESULTS: Seven (20%) patients were in the OCF group. The OCF group exhibited a higher prevalence of preoperative pain in the neck or head (P = 0.006), ligament absence (P = 0.022), and increased propensity for postoperative wound issues (P = 0.022) than the non-OCF group. The OCF group had less intact OCs (P < 0.001) and higher spinal instability neoplastic score (P = 0.002) than the non-OCF group. All patients with intact OCs < 60% underwent OCF, and those with OCs ≥ 70% were treated without OCF. Those with OCs between 60% and 69% underwent OCF if the ligaments were eroded, and did not undergo OCF if the ligaments were intact. Treatment strategies varied, with endoscopic endonasal approach alone being common. Radiation therapy was administered to 89% of patients. All 3 patients treated with OCF after tumor resection had wound issues; none treated with OCF before resection had wound issues. None developed atlanto-occipital instability. Survival rates did not significantly differ between groups. CONCLUSIONS: In the absence of mobility-related neck pain, patients with lower clival chordoma and intact OC ≥ 60%, intact apical ligament, and intact tectorial membrane, may not require OCF.


Subject(s)
Cervical Vertebrae , Chordoma , Occipital Bone , Skull Base Neoplasms , Spinal Fusion , Humans , Chordoma/surgery , Chordoma/diagnostic imaging , Female , Male , Retrospective Studies , Middle Aged , Spinal Fusion/methods , Adult , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging , Occipital Bone/surgery , Occipital Bone/diagnostic imaging , Aged , Cervical Vertebrae/surgery , Cranial Fossa, Posterior/surgery , Cranial Fossa, Posterior/diagnostic imaging , Treatment Outcome , Young Adult
19.
World Neurosurg ; 187: e501-e508, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38679376

ABSTRACT

OBJECTIVE: The objective of this study was to investigate the role of the foramen of Vesalius (FV) in the pathogenesis of skull base meningioma by analyzing data from various multi-image modalities. METHODS: For this single-center retrospective study, 39 consecutive patients with skull base meningioma who underwent tumor resection between January 2020 and March 2023 were enrolled. The anatomical and pathological characteristics of the FV were evaluated using computed tomography and 3-dimensional digital subtraction angiography. The clinical significance of the FV in tumor hemodynamics and treatment, such as preoperative tumor embolization, was investigated using the 3-dimensional digital subtraction angiography/computed tomography fusion images. RESULTS: We identified FV in 52% (17/27) of the finally included patients. In 10 (30%) patients, the FV was found bilaterally with no significant variation in appearance between the healthy and tumor-affected sides (P = 0.786). The mean FV diameter was significantly larger on the tumor-affected side (P = 0.010). No significant anatomical differences, like duplication and partial assimilation with the foramen ovale, were observed between the 2 sides. The FV was involved in venous skull base perfusion around the tumor in 9 cases. In 4 cases where it was the pathway for tumor feeders, preoperative tumor embolization via the FV resulted in disappearance of the tumor stain. No complications associated with endovascular treatment were observed. CONCLUSIONS: This study elucidated the anatomical asymmetry of the FV and its role in the hemodynamics of skull base meningioma. Our findings highlight the significance of performing anatomical and pathological evaluations of the FV in determining treatment strategies, including preoperative embolization, for skull base lesions.


Subject(s)
Angiography, Digital Subtraction , Embolization, Therapeutic , Meningeal Neoplasms , Meningioma , Skull Base Neoplasms , Humans , Meningioma/surgery , Meningioma/diagnostic imaging , Meningioma/therapy , Female , Male , Middle Aged , Skull Base Neoplasms/surgery , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/therapy , Embolization, Therapeutic/methods , Retrospective Studies , Meningeal Neoplasms/diagnostic imaging , Meningeal Neoplasms/surgery , Meningeal Neoplasms/therapy , Aged , Adult , Preoperative Care/methods , Imaging, Three-Dimensional , Tomography, X-Ray Computed
20.
Acta Neurochir (Wien) ; 166(1): 178, 2024 Apr 16.
Article in English | MEDLINE | ID: mdl-38625597

ABSTRACT

BACKGROUND: Petroclival meningiomas are challenging tumors. Several skull base approaches have been proposed in the last decades, with variable rates of postoperative morbidity and extent of resection. METHODS: We herein reported the step-by-step microsurgical resection of a large petroclival meningioma through an extended retrosigmoid approach. Detailed surgical technique has been accompanied by a 2D operative video. CONCLUSION: The extended retrosigmoid approach allowed for a safe gross total resection of the tumor, as confirmed by the postoperative MRI. The patient did not experience any new postoperative deficit, despite a transient diplopia, and was discharged on postoperative day 7.


Subject(s)
Meningeal Neoplasms , Meningioma , Skull Base Neoplasms , Humans , Meningioma/diagnostic imaging , Meningioma/surgery , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/surgery , Head , Patient Discharge , Meningeal Neoplasms/diagnostic imaging , Meningeal Neoplasms/surgery
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