Pessoas com transtornos alimentares e isolamento social na pandemia de COVID-19 / People with eating disorders and social isolation in the COVID-19 pandemic

Introdução: Este estudo tem como objeto avaliar as consequências geradas pelas medidas de isolamento social na saúde mental de pessoas com transtornos alimentares atendidas em um ambulatório especializados no município do Rio de Janeiro. Objetivos: descrever características sociodemográficas e clínicas de pessoas com transtornos alimentares em um ambulatório especializado; analisar as consequências da pandemia de COVID-19 na saúde mental de pessoas com transtornos alimentares em acompanhamento ambulatorial; discutir as ferramentas de acompanhamento em saúde mental no período de isolamento social em um ambulatório especializado em transtornos alimentares. Método: Pesquisa descritiva de caráter qualitativo com usuários de 18 a 60 anos diagnosticados com anorexia nervosa, bulimia nervosa ou transtorno de compulsão alimentar e suas formas subclínicas, em tratamento especializado durante a pandemia de COVID-19. O cenário foi o ambulatório do Grupo de Obesidade e Transtornos Alimentares (GOTA) de um Instituto de Psiquiatria universitário. Foram utilizados dados retrospectivos sobre características clínicas e demográficas dos usuários, coletados nos prontuários clínicos e de entrevistassemi-estruturadas aplicadas de forma remota. Os dados foram analisados através dos softwares ALCESTE e Microsoft Excel 2019 e discutidos a partir da literatura científica sobre o tema. As análises realizadas pelo ALCESTE evidenciaram 4 classes de palavras predominantes, sendo a de impactos socioeconômicos a mais relevante, seguida da classe referente ao suporte profissional em saúde mental recebido durante a pandemia, da classe referente aos impactos na autoestima e autopercepção dos participantes e por fim, da classe referente aos impactos na rotina de alimentação. Resultados: A amostra foi constituída de 16 mulheres com predomínio da cor branca, com faixa etária de 18 à 30 anos, sendo o diagnóstico de transtorno de compulsão alimentar o mais frequente. A pandemia resultou em sensação de perda de controle devido a modificações na rotina, tendo culminado em piora do comportamento alimentar e aumento de mecanismos compensatórios. Em alguns casos, o isolamento social foi considerado pelos participantes como ferramenta para reestruturação emocional. Os impactos socioeconômicos ocorreram de maneira indiferente a estrato social. A introdução do atendimento remoto no serviço foi considerado um fator protetor na manutenção do tratamento, com vantagens como economia financeira e maior flexibilidade de horário. Foram apontadas desvantagens como dificuldade de monitoramento de dados antropométricos e exame físico. Conclusão: Os desdobramentos do isolamento social refletiram em diferentes campos da vida dos participantes, tais como saúde física, mental, convivência intradomiciliar, impactos socioeconômicos e modificações no suporte profissional para o transtorno alimentar. O atendimento remoto foi apontado como uma estratégia promissora para prestação de assistência a esse público, necessitando melhor sistematização para o futuro, com potencial de permanência não somente em períodos pandêmicos. Para os profissionais de saúde, a pesquisa indica que os usuários com transtornos alimentares reconhecem o valor do atendimento no ambulatório, o que requer capacitação e maior participação da enfermagem na equipe interdisciplinar.

Introduction: This research has as aim to evaluate the consequences caused by social restriction measures in the mental health of clients with eating disorders attended in a specialized ambulatory in the city of Rio de Janeiro. Objectives: to describe sociodemographic and clinical characteristics of people with eating disorders in a specialized ambulatory; to analyse the consequences of the COVID-19 pandemic in the mental health of people with eating disorders; to discuss tools of mental health support during the social isolation in an ambulatory specialized on eating disorders. Methods: Descriptive study with qualitative design including clients between 18-60 years old diagnosed with anorexia nervosa, bulimia nervosa or binge eating disorders and its subclinical presentations in specialized treatment during the pandemic. The place of the study it was the Grupo de Obesidade e Transtornos Alimentares (GOTA) ambulatory of an academic psychiatric institute. It was used restropective data about clinical and demographical characteristics collected of the medical records and it was applied a semi-structured interview by remote mode. Data was analysed by the softwares ALCESTE and Microsoft Excel 2019, and discussed by the cientific literature about the subject. The analysis presented 4 classes of predominant words, within the socioeconomical impacts one being the most relevant, followed by the class referring to the professional mental health support during the pandemic, by the class referring to the impacts on self steem and self perception of the participants and finally, by the class referring to impacts on the food routine. Results: The sample was constituted by 16 women, with white skin color predominance, ages between 18 to 30 years old, with binge eating disorder being the most frequent diagnose. The pandemic resulted in a sense of loss of controle because of changes in the routine, resulting in worsening of food behaviour and increasing in compensatory behaviour. In some cases, social restriction was considered by participants as a tool for emotional reestructuration. The socioeconomical impacts existed regardless of social stratum. The introduction of the remote consultation was considered a protective factor on the treatment maintenance, including benefits such as financial economy and greater time flexibility. It were considered disadvantagens such as difficulty on monitoring anthropometric data and physical examination. Conclusion: The outspread of social restriction reflected in diverse life fields of the participants, such as physical health, mental health, household coexistency and changes on the professional support to eating disorders. The remote consultation was pointed as a promissory strategy to provide assistance to this public, and it needs better systematization to the future, within potential of implementation not only in pandemic periods. To healthcare professionals, the study indicates that users with eating disorders recognize the value of an ambulatory assistance, which requires training courses and a bigger participation of nursing on interdisciplinary teams.

Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder.

OBJECTIVES: The objective of this study was to present a broad view of how genetic polymorphisms in genes that control the rhythmicity and function of circadian rhythm may influence the etiology, pathophysiology and treatment of bipolar disorder (BD). METHODS: A bibliographic search was performed to identify and select papers reporting studies on variations in circadian genes and BD. A search of Medline, Google Scholar, Scopus, and Web of Science was carried out to review the literature. RESULTS: Several studies provide evidence of contributions of variations in circadian genes to disease etiology, pathophysiological variations and lithium drug response. Dysfunction of the sleep-wake cycle, an important brain function regulator, is indicated as the primary means by which circadian gene variations act in mood disorders. CONCLUSIONS: Investigations of the effects of circadian genes have suggested that the chronotype offers hope for guiding and improving management of patients with BD. However, BD is a disease of a complex nature and presents multiple endophenotypes determined by different associations between genetics and the environment. Thus, new genomic studies to delimit variations that may help improve the clinical condition of these patients are extremely important.

Association between sleep quality and quality of life in nursing professionals working rotating shifts.

OBJECTIVE: To analyze the association between sleep quality and quality of life of nursing professionals according to their work schedules. METHODS: A prospective, cross-sectional, observational study was conducted between January and December 2010, with 264 nursing professionals, drawn from 989 subjects at Botucatu General Hospital and stratified by professional category. The Pittsburg Sleep Quality Index and the WHOQOL-bref were administered to evaluate sleep quality and quality of life, respectively. Self-reported demographic data were collected with a standard form. Continuous variables were reported as means and standard deviations, and categorical variables were expressed as proportions. Associations were evaluated using Spearman's correlation coefficient. The association of night-shift work and gender with sleep disturbance was evaluated by logistic regression analysis using a model adjusted for age and considering sleep disturbance the dependent variable. The level of significance was p < 0.05. RESULTS: Night-shift work was associated with severe worsening of at least one component of sleep quality in the model adjusted for age (OR = 1.91; 95%CI 1.04;3.50; p = 0.036). Female gender was associated with sleep disturbance (OR = 3.40; 95%CI 1.37;8.40; p = 0.008). Quality of life and quality of sleep were closely correlated (R = -0.56; p < 0.001). CONCLUSIONS: Characteristics of the nursing profession affect sleep quality and quality of life, and these two variables are associated.

Association between sleep quality and quality of life in nursing professionals working rotating shifts / Associação entre qualidade do sono e qualidade de vida de profissionais de enfermagem que trabalham em turnos

OBJECTIVE To analyze the association between sleep quality and quality of life of nursing professionals according to their work schedules. METHODS A prospective, cross-sectional, observational study was conducted between January and December 2010, with 264 nursing professionals, drawn from 989 subjects at Botucatu General Hospital and stratified by professional category. The Pittsburg Sleep Quality Index and the WHOQOL-bref were administered to evaluate sleep quality and quality of life, respectively. Self-reported demographic data were collected with a standard form. Continuous variables were reported as means and standard deviations, and categorical variables were expressed as proportions. Associations were evaluated using Spearman’s correlation coefficient. The association of night-shift work and gender with sleep disturbance was evaluated by logistic regression analysis using a model adjusted for age and considering sleep disturbance the dependent variable. The level of significance was p < 0.05. RESULTS Night-shift work was associated with severe worsening of at least one component of sleep quality in the model adjusted for age (OR = 1.91; 95%CI 1.04;3.50; p = 0.036). Female gender was associated with sleep disturbance (OR = 3.40; 95%CI 1.37;8.40; p = 0.008). Quality of life and quality of sleep were closely correlated (R = -0.56; p < 0.001). CONCLUSIONS Characteristics of the nursing profession affect sleep quality and quality of life, and these two variables are associated. .

OBJETIVO Analisar a associação entre a qualidade do sono e a qualidade de vida dos profissionais de enfermagem segundo organização do trabalho. MÉTODOS Estudo transversal, observacional e prospectivo, com 264 profissionais de enfermagem em Botucatu, SP, entre janeiro e dezembro de 2010. Os sujeitos foram sorteados entre os 989 indivíduos que trabalhavam no Hospital Geral de Botucatu e estratificados por categoria profissional. O Índice de Qualidade de Sono de Pittsburgh e o WHOQOL-bref foram aplicados para avaliar qualidade do sono e qualidade de vida, respectivamente. Os dados demográficos foram coletados por meio de formulário padrão. Variáveis contínuas foram apresentadas como média e desvio padrão e variáveis categóricas, como proporções. As associações foram avaliadas por meio do coeficiente de correlação de Spearman. As associações entre turno e sexo com a qualidade do sono foram analisadas por meio de regressão logística, no modelo corrigido para idade. Distúrbio do sono foi a variável dependente. O nível de significância adotado foi p < 0,05. RESULTADOS Trabalho noturno foi associado com prejuízo importante de pelo menos um componente da qualidade do sono (OR = 1,91; IC95% 1,04;3,50, p = 0,036). O prejuízo da qualidade do sono também se associou com o sexo feminino (OR = 3,40; IC95% 1,37;8,40; p = 0,008). Houve correlação estreita entre a qualidade de vida e qualidade do sono (r = -0,56, p < 0,001). CONCLUSÕES Características próprias da profissão de enfermagem podem afetar a qualidade do sono e a qualidade de vida, e essas duas variáveis estão associadas entre si. .

Dietary patterns, metabolic markers and subjective sleep measures in resident physicians.

Shiftwork is common in medical training and is necessary for 24-h hospital coverage. Shiftwork poses difficulties not only because of the loss of actual sleep hours but also because it can affect other factors related to lifestyle, such as food intake, physical activity level, and, therefore, metabolic patterns. However, few studies have investigated the nutritional and metabolic profiles of medical personnel receiving training who are participating in shiftwork. The aim of the present study was to identify the possible negative effects of food intake, anthropometric variables, and metabolic and sleep patterns of resident physicians and establish the differences between genders. The study included 72 resident physicians (52 women and 20 men) who underwent the following assessments: nutritional assessment (3-day dietary recall evaluated by the Adapted Healthy Eating Index), anthropometric variables (height, weight, body mass index, and waist circumference), fasting metabolism (lipids, cortisol, high-sensitivity C-reactive protein [hs-CRP], glucose, and insulin), physical activity level (Baecke questionnaire), sleep quality (Pittsburgh Sleep Quality Index; PSQI), and sleepiness (Epworth Sleepiness Scale; ESS). We observed a high frequency of residents who were overweight or obese (65% for men and 21% for women; p = 0.004). Men displayed significantly greater body mass index (BMI) values (p = 0.002) and self-reported weight gain after the beginning of residency (p = 0.008) than women. Poor diet was observed for both genders, including the low intake of vegetables and fruits and the high intake of sweets, saturated fat, cholesterol, and caffeine. The PSQI global scores indicated significant differences between genders (5.9 vs. 7.5 for women and men, respectively; p = 0.01). Women had significantly higher mean high-density lipoprotein cholesterol (HDL-C; p < 0.005), hs-CRP (p = 0.04), and cortisol (p = 0.009) values than men. The elevated prevalence of hypertriglyceridemia and abnormal values of low-density lipoprotein cholesterol (LDL-C; >100 mg/dL) were observed in most individuals. Higher than recommended hs-CRP levels were observed in 66% of the examined resident physicians. Based on current recommendations, a high prevalence of low sleep quality and excessive daytime sleepiness was identified. These observations indicate the need to monitor health status and develop actions to reassess the workload of medical residency and the need for permission to perform extra night shifts for medical residents to avoid worsening health problems in these individuals.

[Analysis of cognitive function and sleep of nursing staff on different shift work]. / Análise das funções cognitivas e sono na equipe de enfermagem nos turnos diurno e noturno.

The aim of this study was to analyze short-term memory, attention and sleep patterns of the nursing staff working night and day shifts. Study participants were 109 subjects in a hospital in Minas Gerais working on the day shift (n = 68) or night shift (n = 41). Data collection was performed using the Sleep Diary and WAIS-III Test Battery. The results showed a significant difference for the quality of sleep of those on night shift work (p < 0.0001; ANOVA). The subjects on the day shifts performed better on the Digit Symbol with a significant difference (p = 0.0008; Mann-Whitney test). In conclusion, the quality of sleep of the group on the night shift showed lower averages compared with those on the day shifts, although they had greater total sleep. The level of attention showed to be best for the group on the day shift work.

Análise das funções cognitivas e sono na equipe de enfermagem nos turnos diurno e noturno / Análisis de la función cognitiva y el sueño en el equipo de enfermería en los turnos de el día y nocturno / Analysis of cognitive function and sleep of nursing staff on different shift work

Este estudo teve como objetivo analisar a memória de curto prazo, a atenção e o padrão do sono na equipe de enfermagem nos turnos diurno e noturno. Participaram 109 sujeitos de uma instituição hospitalar de Minas Gerais, distribuídos nos turnos: diurno (n= 68) e noturno (n=41). Utilizou-se, para coleta de dados: Diário de sono e Testes da Bateria WAIS III. Os resultados para a medida da qualidade do sono dos sujeitos do turno noturno apresentou diferença significativa (p<0,0001) ANOVA. Os sujeitos do turno diurno tiveram melhor desempenho no Subteste de Digit Symbol, com diferença significativa (p=0,0008), pelo teste Mann-Whitney. Concluiu-se que a qualidade do sono do grupo do noturno mostrou médias menores, em comparação ao diurno, embora apresentassem um tempo total de sono maior. Os níveis de atenção mostraram-se melhores para o grupo do turno diurno.

Este estudio tuvo como objetivo analizar los estándares de memoria a corto plazo, la atención y su sueño personal de enfermería en los turnos. Los participantes del estudio fueron 109 pacientes de un hospital, en Minas Gerais, distribuidos en el turno de día (n = 68) y turno de noche (n = 41). La recolección de datos se realizó a través del diario del sueño y de la batería de prueba WAIS III. Los resultados muestran que existe una diferencia significativa en la calidad del sueño del trabajo en turnos de noche (p <0,0001; ANOVA). Los sujetos del turno de día se desempeñaron mejor en el Digit Symbol, una diferencia significativa (p = 0,0008, prueba de Mann-Whitney). En conclusión, la calidad del sueño de la noche, el grupo mostró promedios más bajos en comparación con el día, pero tuvimos un tiempo total de sueño mayor. El nivel de atención que se presta a ser mejor para el conjunto de la obra turno de día.

The aim of this study was to analyze short-term memory, attention and sleep patterns of the nursing staff working night and day shifts. Study participants were 109 subjects in a hospital in Minas Gerais working on the day shift (n = 68) or night shift (n = 41). Data collection was performed using the Sleep Diary and WAIS-III Test Battery. The results showed a significant difference for the quality of sleep of those on night shift work (p <0.0001; ANOVA). The subjects on the day shifts performed better on the Digit Symbol with a significant difference (p = 0.0008; Mann-Whitney test). In conclusion, the quality of sleep of the group on the night shift showed lower averages compared with those on the day shifts, although they had greater total sleep. The level of attention showed to be best for the group on the day shift work.

[Sleep deprivation effects on cognitive, psychomotor skills and its relationship with personal characteristics of resident doctors]. / Efectos de la privación de sueño en las habilidades cognitivas, psicomotoras y su relación con las características personales de los médicos residentes.

BACKGROUND: In countries such as United States and European Nations changes have been proposed regarding to duty and academic structure of specialists in training, this implies adjustments in the norms concerning the number of hours a week that residents work. The main argument which has underpinned such transformations is based on the assumption that excessive working hours (more than 16 hours uninterrupted) cause cognitive and psychomotor disorders in residents. OBJECTIVE: To evaluate the association between sleep deprivation and cognitive and psychomotor skills of a sample of residents of different specialties of Medicine. METHODS: Longitudinal study with measurements pre and post shifts, in 31 residents of Medicine. The measured variables were: cognitive and psychomotor skills, demographic data and conditions of the shift, quality of sleep and psychopathology. RESULTS: 81% residents showed detriment in at least one of the tests, however, in psychomotor skills significant different results were found in CPR maneuvers between pre and post shift with an improvement in scores. CONCLUSIONS: Sleep deprivation causes detriment of cognitive and psychomotor skills. While our results can't be generalized, they may constitute a precedent for possible changes in the working hours of medical residencies.

Antecedentes: en países como Estados Unidos y las naciones europeas se han propuesto cambios a la estructura asistencial y académica de los médicos especialistas en formación que proponen transformaciones a las normas relativas al número de horas que trabajan a la semana los residentes. El argumento principal que sustenta esas transformaciones se basa en el supuesto de que las horas de trabajo excesivas (más de 16 horas ininterrumpidas) provocan alteraciones cognitivas y psicomotrices en los residentes. Objetivo: evaluar la asociación entre la privación de sueño y las habilidades cognitivas y psicomotoras de una muestra de residentes de diferentes especialidades médicas. Material y métodos: estudio longitudinal, con mediciones pre y post guardia, en 31 residentes de Medicina. Se midieron las variables de: habilidades cognitivas y psicomotoras, datos sociodemográficos y de condiciones de guardia, calidad de sueño y psicopatología. resultados: 81% de los residentes tuvo detrimento en, al menos, una de las pruebas realizadas; sin embargo, en los resultados de las habilidades psicomotoras y en la maniobra de reanimación cardiopulmonar básica se encontró una diferencia significativa en los momentos pre y post guardia con mejoría en las puntuaciones. Conclusiones: la privación de sueño disminuye las habilidades cognitivas y psicomotoras. Si bien nuestros resultados no son generalizables, pueden constituir un precedente para fundamentar posibles cambios referentes a las guardias en las residencias médicas.

Circadian preference in bipolar disorder.

PURPOSE: A role for circadian rhythm abnormalities in the pathogenesis of bipolar disorder (BD) has been suggested. The present study assessed circadian preference, a subjective preference for activities in the morning or evening related to chronotype. METHODS: The sample was comprised of 81 outpatients with BD in remission and 79 control subjects. Circadian preference was derived from an interview evaluating biological rhythms and sleep pattern from the Pittsburgh Sleep Quality Index. RESULTS: Patients were significantly more likely to have an evening preference than control subjects. Circadian preference was also associated with sleep latency. CONCLUSIONS: The association of evening preference and longer sleep latency may be related to the frequent clinical observation of a sleep/wake cycle reversal in bipolar disorder.

[Possibilities and limits of sleep recovery for night-nursing workers]. / Possibilidades e limites da recuperaçao do sono de trabalhadores noturnos de enfermagem.

The present study had the objective of investigating the possibilities/limits of sleep recovery in women workers with medium level in nursing that develop their activities in night shifts in a first-aid clinic at a public hospital in Natal, Rio Grande do Norte, Brazil. This was an analytic study, with a qualitative approach which used the technique of thematic oral history Fifteen women workers with medium level in nursing were interviewed. The following empirical categories were defined: night shift work and night sleep and night rest at work environment Physiological and psychological sufferings are evident on their speech as well as what the lack of sleep causes in health and personal life of these women workers, making the overload of work clear and also the sociocultural imperfections of feminine gender

Internal desynchronization in a model of night-work by forced activity in rats.

Individuals engaged in shift- or night-work show disturbed diurnal rhythms, out of phase with temporal signals associated to the light/dark (LD) cycle, resulting in internal desynchronization. The mechanisms underlying internal desynchrony have been mainly investigated in experimental animals with protocols that induce phase shifts of the LD cycle and thus modify the activity of the suprachiasmatic nucleus (SCN). In this study we developed an animal model of night-work in which the light-day cycle remained stable and rats were required to be active in a rotating wheel for 8 h daily during their sleeping phase (W-SP). This group was compared with rats that were working in the wheel during their activity phase (W-AP) and with undisturbed rats (C). We provide evidence that forced activity during the sleeping phase (W-SP group) alters not only activity, but also the temporal pattern of food intake. In consequence W-SP rats showed a loss of glucose rhythmicity and a reversed rhythm of triacylglycerols. In contrast W-AP rats did not show such changes and exhibited metabolic rhythms similar to those of the controls. The three groups exhibited the nocturnal corticosterone increase, in addition the W-SP and W-AP groups showed increase of plasma corticosterone associated with the start of the working session. Forced activity during the sleep phase did not modify SCN activity characterized by the temporal patterns of PER1 and PER2 proteins, which remained in phase with the LD cycle. These observations indicate that a working regimen during the sleeping period elicits internal desynchronization in which activity combined with feeding uncouples metabolic functions from the biological clock which remains fixed to the LD cycle. The present data suggest that in the night worker the combination of work and eating during working hours may be the cause of internal desynchronization.

Present mood states in Brazilian night nurses.

Variations in the state of momentary emotions of Brazilian hospital nurses on day and night shifts were recorded. Ten graduate nurses working on day and night shifts in the clinical ward of hospitals completed the Present Mood States List of Engelmann at the beginning and end of the first and last days of each shift. Analysis indicated (a) nurses had a stable emotional profile, present at the working shift, and (b) variations in present mood states related to specific effects of shift work were observed when comparisons were made between the present mood states at the beginning and end of each shift duty.