Subject(s)
Brain Ischemia/diagnostic imaging , Brain Ischemia/metabolism , Brain Neoplasms/surgery , Postoperative Complications/diagnostic imaging , Postoperative Complications/metabolism , Brain Ischemia/etiology , Brain Neoplasms/diagnostic imaging , Female , Humans , Middle Aged , Postoperative Complications/etiology , Vasospasm, Intracranial/diagnostic imaging , Vasospasm, Intracranial/etiology , Vasospasm, Intracranial/metabolismABSTRACT
PURPOSE: To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH). METHODS: The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S1P phosphatase expression were measured at day 3, 5, 7, 9. RESULTS: The expression of S1P was enhanced in the cerebral vasospasm after subarachnoid hemorrhage in the rabbits. And S1P expression was consistent with the basilar artery cross-sectional area changes at day 3, 5, 7, 9. CONCLUSION: Sphingosine-1-phosphate expression in the cerebral arterial may be a new indicator in the development of cerebral vasospasm after subarachnoid hemorrhage and provide a new therapeutic method for SAH.
Subject(s)
Lysophospholipids/analysis , Sphingosine/analogs & derivatives , Subarachnoid Hemorrhage/pathology , Vasospasm, Intracranial/pathology , Animals , Basilar Artery/pathology , Disease Models, Animal , Flow Cytometry , Rabbits , Random Allocation , Sphingosine/analysis , Subarachnoid Hemorrhage/complications , Subarachnoid Hemorrhage/metabolism , Time Factors , Vasospasm, Intracranial/etiology , Vasospasm, Intracranial/metabolismABSTRACT
PURPOSE:To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH).METHODS:The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S1P phosphatase expression were measured at day 3, 5, 7, 9.RESULTS: The expression of S1P was enhanced in the cerebral vasospasm after subarachnoid hemorrhage in the rabbits. And S1P expression was consistent with the basilar artery cross-sectional area changes at day 3, 5, 7, 9.CONCLUSION: Sphingosine-1-phosphate expression in the cerebral arterial may be a new indicator in the development of cerebral vasospasm after subarachnoid hemorrhage and provide a new therapeutic method for SAH.
Subject(s)
Animals , Rabbits , Lysophospholipids/analysis , Sphingosine/analogs & derivatives , Subarachnoid Hemorrhage/pathology , Vasospasm, Intracranial/pathology , Basilar Artery/pathology , Disease Models, Animal , Flow Cytometry , Random Allocation , Sphingosine/analysis , Subarachnoid Hemorrhage/complications , Subarachnoid Hemorrhage/metabolism , Time Factors , Vasospasm, Intracranial/etiology , Vasospasm, Intracranial/metabolismABSTRACT
Os autores descrevem as alterações hemodinâmicas encefálicas que ocorrem na vigência do vasoespasmo após a hemorragia subaracnoidea por aneurismas. O conhecimento dessas alterações facilita o entendimento das medidas terapêuticas.
The authors describe the hemodynamic encephalic alterations that occur during the vasospasm after aneurysmal subarachnoid hemorrhage. The knowledge of these alterations promotes better understanding of the therapeutic procedures.