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Synaptotagmin-Like Protein 2a Regulates Angiogenic Lumen Formation via Weibel-Palade Body Apical Secretion of Angiopoietin-2.

Francis, Caitlin R; Claflin, Shea; Kushner, Erich J.

Arterioscler Thromb Vasc Biol ; 41(6): 1972-1986, 2021 06.

Article in English | MEDLINE | ID: mdl-33853352

ABSTRACT

[Figure: see text].

Subject(s)

Angiopoietin-2/metabolism , Exocytosis , Human Umbilical Vein Endothelial Cells/metabolism , Membrane Proteins/metabolism , Neovascularization, Physiologic , Weibel-Palade Bodies/metabolism , Zebrafish Proteins/metabolism , Angiopoietin-2/genetics , Animals , Animals, Genetically Modified , Cells, Cultured , Humans , Membrane Proteins/genetics , Receptor, TIE-2/metabolism , Signal Transduction , Weibel-Palade Bodies/genetics , Zebrafish/genetics , Zebrafish Proteins/genetics , rab27 GTP-Binding Proteins/metabolism

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