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1.
J Clin Periodontol ; 2020 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-31955453

RESUMO

AIM: The present systematic review and meta-analysis was performed to investigate if there was a significantly enhanced risk of dental implant failure due to the increased number of cigarettes smoked per day. MATERIALS AND METHODS: Four databases, including PubMed, Embase, Web of Science, and Scopus were searched until January, 2019. The search terms "dental implant, oral implant, smoking, smoker, tobacco, nicotine, and non-smoker" were used in combination to identify the publications providing data for dental implant failures related to the smoking habit. Publications were excluded if the quantity of cigarettes consumed per day was not reported. Fixed- or random-effects meta-analyses were used to pool the estimates of relative risk (RR) with 95% confidence intervals (CI). RESULTS: Having additional information supplied by the authors, 23 articles were selected for final analysis. The meta-analyses based on implant- and patient- related data showed a significant increase in the RR of implant failure in patients who smoked >20 cigarettes per day compared with non-smokers (Implant based: P = 0.001; RR: 2.45; CI: 1.42-4.22 and Patient based: P < 0.001; RR: 4; CI: 2.72-5.89). CONCLUSION: The risk of implant failure was elevated with an increase in the number of cigarettes smoked per day.

2.
FASEB J ; 2020 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-31957079

RESUMO

To date, it is unclear how fluid dynamics stimulate mechanosensory cells to induce an osteoprotective or osteodestructive response. We investigated how murine hematopoietic progenitor cells respond to 2 minutes of dynamic fluid flow stimulation with a precisely controlled sequence of fluid shear stresses. The response was quantified by measuring extracellular adenosine triphosphate (ATP), immunocytochemistry of Piezo1, and sarcoplasmic/endoplasmic Ca2+ reticulum ATPase 2 (SERCA2), and by the ability of soluble factors produced by mechanically stimulated cells to modulate osteoclast differentiation. We rejected our initial hypothesis that peak wall shear stress rate determines the response of hematopoietic progenitor cells to dynamic fluid shear stress, as it had only a minor correlation with the abovementioned parameters. Low stimulus amplitudes corresponded to activation of Piezo1, SERCA2, low concentrations of extracellular ATP, and inhibition of osteoclastogenesis and resorption area, while high amplitudes generally corresponded to osteodestructive responses. At a given amplitude (3 Pa) and waveform (square), the duration of individual stimuli (duty cycle) showed a strong correlation with the release of ATP and osteoclast number and resorption area. Collectively, our data suggest that hematopoietic progenitor cells respond in a viscoelastic manner to loading, since a combination of high shear stress amplitude and prolonged duty cycle is needed to trigger an osteodestructive response. PLAIN LANGUAGE SUMMARY: In case of painful joints or missing teeth, the current intervention is to replace them with an implant to keep a high-quality lifestyle. When exercising or chewing, the cells in the bone around the implant experience mechanical loading. This loading generally supports bone formation to strengthen the bone and prevent breaking, but can also stimulate bone loss when the mechanical loading becomes too high around orthopedic and dental implants. We still do not fully understand how cells in the bone can distinguish between mechanical loading that strengthens or weakens the bone. We cultured cells derived from the bone marrow in the laboratory to test whether the bone loss response depends on (i) how fast a mechanical load is applied (rate), (ii) how intense the mechanical load is (amplitude), or (iii) how long each individual loading stimulus is applied (duration). We mimicked mechanical loading as it occurs in the body, by applying very precisely controlled flow of fluid over the cells. We found that a mechanosensitive receptor Piezo1 was activated by a low amplitude stimulus, which usually strengthens the bone. The potential inhibitor of Piezo1, namely SERCA2, was only activated by a low amplitude stimulus. This happened regardless of the rate of application. At a constant high amplitude, a longer duration of the stimulus enhanced the bone-weakening response. Based on these results we deduce that a high loading amplitude tends to be bone weakening, and the longer this high amplitude persists, the worse it is for the bone.

3.
Artigo em Inglês | MEDLINE | ID: mdl-31958166

RESUMO

OBJECTIVES: A randomized clinical trial was conducted to compare all three known static guided surgery protocols (pilot, partial, full) with each other and with freehand surgery in terms of accuracy, under the same conditions. MATERIAL AND METHODS: 207 implants of the same brand and type were placed in 101 partially edentulous volunteers in need of implantation in the mandible or maxilla or both. All cases were digitally planned, and the comparison of the planned and actual implant positions was performed using a medical image analysis software with dedicated algorithms. The primary outcome variable was angular deviation (AD, degrees). The secondary outcome variables were coronal global deviation (CGD, mm), apical global deviation (AGD, mm) and voxel overlap (VO, %). RESULTS: AD showed stepwise improvement in significant steps as the amount of guidance increased. The highest mean AD (7.03°± 3.44) was obtained by freehand surgery, and the lowest by fully guided surgery (3.04°± 1.51). As for the secondary outcome variables, all guided protocols turned out to be significantly superior to freehand surgery, but they were not always significantly different from each other. CONCLUSIONS: As for the comparison that this study sought to perform, it can be said that the static guided approach significantly improves the accuracy of dental implant surgery as compared to freehand surgery. Furthermore, the results suggest that any degree of guidance yields better results than freehand surgery and that increasing the level of guidance increases accuracy.

4.
J Prosthet Dent ; 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31959397

RESUMO

STATEMENT OF PROBLEM: Replacing maxillary or mandibular anterior teeth with implant-supported prostheses is challenging because of the small mesiodistal and buccolingual dimensions, which can affect the number and position of implants and thus the definitive prosthetic design. PURPOSE: The purpose of this randomized clinical trial was to assess the clinical and radiographic outcomes of patients treated with implant-supported cantilever fixed partial dentures (ICFPDs) compared with implant-supported conventional fixed partial dentures to replace maxillary anterior teeth. MATERIAL AND METHODS: Fourteen participants missing 2 central incisors and 1 lateral incisor (6 men and 8 women) with a mean age of 40 years (range, 30 to 50 years) were divided equally into 2 groups, the IFF group (n=7; implant-supported FPD design) and the ICF group (n=7; ICFPD). Each participant received 2 implants (13×3.75) according to the fixed partial denture design. All participants were evaluated in terms of the implant stability, peri-implant sulcus depth, marginal bone loss, gingival index, and plaque index at the baseline and after 6, 12, 18, and 24 months. RESULTS: The clinical results revealed no significant difference between the 2 groups in the implant stability, gingival index, or plaque index over the follow-up period. However, regarding the average peri-implant sulcus depth, the implant adjacent to the cantilever showed a significant difference compared with the other implants after 24 months, with an average peri-implant sulcus depth of 2 mm, which was still within the typical range. The average marginal bone loss for implants near the cantilever was significantly higher than that for the other implants in the 2 designs, with a value of 1.8 mm at the 2-year follow-up examination, which was also within the typical range of bone loss per year. CONCLUSIONS: Under the conditions of this randomized clinical trial, implant-supported cantilever fixed dental prostheses can be used successfully to replace maxillary anterior teeth.

5.
J Endod ; 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31959483

RESUMO

Peri-implantitis is becoming a frequent complication observed around dental implants. An endodontic infection of a nearby tooth or an immediate implant placement in an inflamed bone socket from failing endodontic therapy has been associated with retrograde peri-implantitis (RPI), a condition that presents with radiographic lucency at the "apex" of an implant. However, current classification schemes do not capture endodontic lesions that may manifest as coronal or intrabony lesions associated with dental implants. As a result, such cases may be mistreated. Here we present for the first time 2 cases in which peri-implant bone loss occurred in the coronal half of the implant adjacent to a tooth with an endodontic-periodontic lesion and was resolved via endodontic therapy or tooth extraction as indicated. This proof of concept report aimed to introduce endodontic peri-implant ("endo-implant") defects and increase vigilance, which may help prevent overtreatment or mistreatment of such cases.

6.
Clin Oral Investig ; 2020 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-31960132

RESUMO

OBJECTIVES: To assess the prevalence of dental implant-related perforations of relevant anatomical structures and inadequate spacing between the implant and the adjacent tooth or implant, and their association with anatomical location, implant dimension, thread exposure, and presence of graft, using cone beam computed tomography (CBCT). MATERIALS AND METHODS: CBCT scans of patients with implants were retrospectively assessed regarding the presence of implant-related perforation of adjacent anatomical structures, and inadequate mesial and distal spacing between the implant and the adjacent tooth/implant (i.e., < 1 mm or < 3 mm, respectively). Implants were classified according to anatomical location, dimensions, thread exposure, and the presence of graft (i.e., bone graft or bone substitutes). Prevalence of perforations and inadequate spacing was compared among the different implant classifications (Chi-squared test). Significance level was set at 5%. RESULTS: A total of 1109 implants were assessed, out of which 369 (33.3%) presented perforation of adjacent structures. Prevalence of perforations in the maxilla (43.5%) was higher than in the mandible (11.3%). Inadequate spacing was found in 18.2% of the mesial and distal measurements, which was more prevalent in the maxilla (p < 0.001). Implants perforating adjacent structures or placed with inadequate spacing presented higher prevalence of thread exposure (p < 0.001). No significant difference was found between the presence of perforations or inadequate spacing and presence of graft (p > 0.05). CONCLUSIONS: Implant-related perforations of relevant anatomical structures and inadequate spacing between the implant and the adjacent tooth/implant are relatively prevalent and more common in the maxilla. Both are associated with threads exposure. CLINICAL RELEVANCE: Information on dental implant-related perforations and inadequate spacing can assist dental surgeons in pre-surgical planning.

7.
Artigo em Inglês | MEDLINE | ID: mdl-31945212

RESUMO

OBJECTIVE: This review evaluated the change in treatment outcomes after conversion from conventional removable partial denture (RPD) to implant-assisted removable partial denture (IARPD). The patient-reported outcome measures (PROMs), objective parameters for evaluation of functional performance, and biological and mechanical complication were evaluated. MATERIALS AND METHODS: This systematic review was based on the Cochrane review methodology and followed the criteria of the preferred reporting items for systematic reviews and meta-analyses (PRISMA). We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science and Scopus up to April 3, 2019. After the initial search, additional electronic and hand searches were performed to identify further studies, ongoing studies and gray literature, without restrictions on language, year of publication or publication type. RESULTS: In total, 6,544 non-duplicate articles were identified, and 31 were eligible for full-text search. Finally, 19 publications based on 13 independent studies were selected. In the meta-analysis, general patient satisfaction was significantly increased (p < .05), and the improved mastication was remarkable oral function. In oral health-related quality of life, the oral health impact profile score was significantly improved, and improvements of physical pain and psychological disability were prominent (p < .05). Masticatory performance was improved in terms of maximum bite force, active occlusal contact area, and mandibular jaw movement (p < .05). The weighted mean survival rate of implants was 96.60%. CONCLUSIONS: After conversion from conventional RPD to IARPD, the PROMs and masticatory performance significantly improved in partially edentulous patients under mandibular Kennedy classification Ⅰ.

8.
Quintessence Int ; 51(2): 118-126, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31942573

RESUMO

OBJECTIVE: Marginal bone loss (MBL), a prognostic parameter for implant success, is associated with implant- and patient-related variables. The purpose of this study was to analyze the effects of the crown-to-implant ratio and independent factors of implant diameter, implant length, implant type, location, and platform switching on distal and mesial MBLs at the 6-, 12-, 24-, and 36-month recall sessions of single crown implant-supported restorations. METHOD AND MATERIALS: Radiographic and clinical data of patients treated with single crown implants were collected. MBL was measured at the baseline and recall sessions on panoramic radiographs. The crown-to-implant ratio was calculated by dividing the length of the crown by that of the dental implant. RESULTS: The crown-to-implant ratio had a moderately positive correlation with distal MBL at the 6-month recall session (P < .05, r = 0.469) and a weakly positive correlation at the 12- (P < .05, r = 0.220), 24- (P < .05, r = 0.214), and 36- (P < .05, r = 0.250) month recall sessions. Distal and mesial MBL did not significantly differ among the four implant types at any recall session (P > .05). The crown-to-implant ratio had no significant correlation with mesial MBL at the 12-, 24-, or 36-month recall session (P > .05), and a moderately positive correlation at the 6-month recall session (P < .001, r = 0.434). CONCLUSIONS: MBL was similar among different implant types in the short and medium terms. There was a positive correlation between distal MBL and the crown-to-implant ratio.


Assuntos
Perda do Osso Alveolar , Implantes Dentários , Coroas , Planejamento de Prótese Dentária , Prótese Dentária Fixada por Implante , Seguimentos , Humanos , Estudos Retrospectivos
9.
Quintessence Int ; 51(2): 128-141, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31942574

RESUMO

OBJECTIVES: The aim of this study was to determine the influence of patient-related systemic factors, local bone and intraoral factors, and implant-related factors on peri-implant marginal bone loss (MBL). METHOD AND MATERIALS: The following data were collected from patients who received dental implants and were recalled for examinations at least 3 years after treatment completion: medical history, age, sex, habits, periodontal health, implant size and surface, surgical procedure, prosthesis type, implant failure, Plaque Index, and oral hygiene. MBL was investigated using both baseline and follow-up panoramic radiographs. RESULTS: The study included 1,126 dental implants placed in 304 patients (185 [60.9%] women and 119 [39.1%] men). The mean age was 54.30 ± 13.52 years (range 22 to 83 years). The mean follow-up period was 58.8 ± 11.2 months. The MBL was observed in 271 (24.1%) implants, of which 160 (14.2%) were ≤ 2 mm and 111 (9.9%) were > 2 mm. Respective mean MBL values on mesial and distal sides were 0.42 ± 1.03 mm and 0.42 ± 1.02 mm. Of the implants, 19 (1.7%) were lost, leading to an implant success rate of 98.3%. Age, history of hysterectomy, history of periodontitis, oral hygiene, abrasions, smoking, implant location, implant surface, implant length, surgical procedure type, and prosthesis type were all found to be statistically significant for MBL (P < .05). Certain combinations of these factors resulted in increased MBL. CONCLUSION: In the present study, local factors had more significant effects on MBL than did systemic factors, and combinations of these factors had greater effects on MBL.


Assuntos
Perda do Osso Alveolar , Doenças Ósseas Metabólicas , Implantes Dentários , Adulto , Idoso , Idoso de 80 Anos ou mais , Planejamento de Prótese Dentária , Prótese Dentária Fixada por Implante , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia Panorâmica , Estudos Retrospectivos , Adulto Jovem
10.
Quintessence Int ; 51(2): 170-177, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31942577

RESUMO

OBJECTIVE: Some patients with Down syndrome experience premature edentulism, which can lead to severe alveolar atrophy. This may cause retention problems with purely mucosa-supported dentures and ill-fitting total dentures. The intellectual disability associated with Down syndrome, with an (implied) inadequate ability for compliance, may pose a further challenge to dental treatment. The aim of this case report was to demonstrate that a combined implant-prosthetic denture with bar constructions can, nevertheless, be implemented in elderly Down syndrome patients with limited cooperation ability. METHOD AND MATERIALS: This report is the first to describe the procedure for an implant-supported total prosthetic restoration with bar joint in a 52-year-old edentulous patient with Down syndrome and limited ability to cooperate. Previous dental solutions had severely curtailed the patient's quality of life. By combining various forms of treatment, including behavior management, the course of therapy could be adapted to the patient's cooperation capability. RESULTS: The implant-supported total prosthetic restoration with bar joint was well accepted by the patient. Moreover, the patient's relatives reported that his life quality had improved distinctly (eg, considerable weight-gain, more positive mood). No impairments of the prostheses were observed during the 24-month follow-up period, and both implants remained clinically inconspicuous. CONCLUSION: The lack, or inadequacy, of dental prostheses can impair the life quality of individuals in need of such restorations. Implant-supported dentures in combination with a bar construction improve the retention of prostheses in atrophied jaws. This form of restoration is also proving to be a successful therapy option for elderly persons with Down syndrome.


Assuntos
Implantes Dentários , Síndrome de Down , Arcada Edêntula , Idoso , Prótese Dentária Fixada por Implante , Falha de Restauração Dentária , Revestimento de Dentadura , Seguimentos , Humanos , Pessoa de Meia-Idade , Qualidade de Vida , Resultado do Tratamento
11.
Anaerobe ; : 102153, 2020 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-31962136

RESUMO

For dental implants the accumulation of anaerobic bacteria is a main reason for peri-implant inflammation, which untreated can lead to implant loss. Oxygen releasing substances may act as antibacterial agents. In this study glucose-1-phosphate (Glc-1P) biofunctionalized zinc peroxide (ZnO2) nanoparticles of four different synthesis ratio (1-10:1) and sizes (4-5 nm) were tested against the anaerobes Fusobacterium nucleatum, Porphyromonas gingivalis, and Prevotella intermedia, as well as against Aggregatibacter actinomycetemcomitans, Enterococcus faecalis, Staphylococcus aureus, Lactobacillus paracasei, and the yeast Candida albicans. Nanoparticles stabilized with o-phosphorylethanolamine, bis[2-(methacryloyloxy)ethyl] phosphate, or dioctyl sulfosuccinate instead of glucose were used as controls. For every combination of test strain and nanoparticle both, the minimal inhibitory (MIC) and minimal microbicidal concentration (MBC or MFC) were determined under different pH conditions in microtiter plates. Furthermore, transmission electron (TEM) and fluorescence microscopy after live-dead-staining was performed on selected combinations of pathogen and nanoparticle in order to visualize the interactions. The ZnO2/Glc-1P nanoparticles had an inhibitory effect on gram-negative anaerobes and on A. actinomycetemcomitans with a pH-dependent MIC ≥25 µg/ml and MBC ≥50 µg/ml, while the gram-positive species tested and C. albicans were not inhibited. In TEM images, attachment of nanoparticle-chains to the bacterial outer membrane and subsequent penetration was found together with an intracellular oxygen release. For nanoparticles with other stabilizers than glucose an invasion was only seen in elongated, dividing cells, possibly because of the more porous cell wall in the parting layer. Decorating ZnO2 by glucose-1-phosphate is a Trojan horse approach to permit their uptake in gram-negative oxygen-sensitive bacterial cells.

12.
Int J Mol Sci ; 21(2)2020 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-31963895

RESUMO

Ultraviolet treatment of titanium implants makes their surfaces hydrophilic and enhances osseointegration. However, the mechanism is not fully understood. This study hypothesizes that the recruitment of fibrinogen, a critical molecule for blood clot formation and wound healing, is influenced by the degrees of hydrophilicity/hydrophobicity of the implant surfaces. Computational fluid dynamics (CFD) implant models were created for fluid flow simulation. The hydrophilicity level was expressed by the contact angle between the implant surface and blood plasma, ranging from 5° (superhydrophilic), 30° (hydrophilic) to 50° and 70° (hydrophobic), and 100° (hydrorepellent). The mass of fibrinogen flowing into the implant interfacial zone (fibrinogen infiltration) increased in a time dependent manner, with a steeper slope for surfaces with greater hydrophilicity. The mass of blood plasma absorbed into the interfacial zone (blood plasma infiltration) was also promoted by the hydrophilic surfaces but it was rapid and non-time-dependent. There was no linear correlation between the fibrinogen infiltration rate and the blood plasma infiltration rate. These results suggest that hydrophilic implant surfaces promote both fibrinogen and blood plasma infiltration to their interface. However, the infiltration of the two components were not proportional, implying a selectively enhanced recruitment of fibrinogen by hydrophilic implant surfaces.

13.
J Mater Sci Mater Med ; 31(2): 19, 2020 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-31965338

RESUMO

Titanium alloys have been widely used as biomaterials, especially for orthopedic prostheses and dental implants, but these materials have Young's modulus almost three times greater than human cortical bones. Because of this, new alloys are being produced for the propose of decreasing Young's modulus to achieve a more balanced mechanical compatibility with the bone. In this paper, it is reported the development of Ti-25Ta alloys as a base material, in which was introduced zirconium, with concentration varying between 0 and 40 wt%, with the aim of biomedical applications. The alloys were prepared in an arc-melting furnace. The microstructural analysis was performed by x-ray diffraction as well as optical and scanning electron microscopy. Selected mechanical properties were analyzed by microhardness and Young's modulus measurements, and cytotoxicity analysis by indirect test. X-ray measurements revealed the presence of α″ phase in the alloy without zirconium; α″ + ß phases for alloys with 10, 20, and 30 wt% of zirconium, and ß phase only for the alloy with 40 wt% of zirconium. These results were corroborated by the microscopy results. The hardness of the alloy was higher than that of cp-Ti due to the actions of zirconium and tantalum as hardening agents. The Young's modulus decreases with high levels of zirconium due to the stabilization of the ß phase. The cytotoxicity test showed that the extracts of studied alloys are not cytotoxic for osteoblast cells in short periods of culture.

14.
Artigo em Inglês | MEDLINE | ID: mdl-31965723

RESUMO

INTRODUCTION: Alveolar ridge augmentation either prior to or during implant placement is a predictable procedure under certain conditions. A major complication during the healing phase is incision line opening and membrane exposure which may result in reduced bone gain and reduced implant survival. This case report describes alveolar bone regeneration around three dental implants despite membrane exposure that developed during healing post-surgically. CASE PRESENTATION: A 72-year-old female presented requesting dental implants to replace missing #s 18, 19 and 20. A cone-beam computed tomography (CBCT) scan showed loss of horizontal and vertical ridge dimensions. All implants were placed with a variable degree of implant thread exposure on their buccal surfaces, ranging from 3-4.5 mm. Simultaneous bone grafting was done using freeze dried bone allograft and deproteinized bovine bone mineral which was covered by a d-PTFE membrane that was secured with tacking screws. Primary closure was obtained, and flaps were sutured. Three weeks post-surgically, membrane exposure occurred. Exposure was monitored and patient was instructed to follow strict oral hygiene instructions around the exposed membrane. Membrane exposure gradually increased without infection and was removed at 16 weeks. Membrane removal revealed dense fibrous tissues covering all implant surfaces. At the second stage surgery, new bone was seen covering all the implants coronal to the cover screws. A trephine core biopsy specimen revealed significant new bone formation and connective tissue around any residual grafted bone. CONCLUSION: d-PTFE membrane exposure does not necessarily lead to adverse healing outcomes for alveolar ridge augmentation if handled properly with close patient follow-up. This article is protected by copyright. All rights reserved.

15.
Arch Oral Biol ; 111: 104650, 2020 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-31931278

RESUMO

OBJECTIVE: The aim of the present study was to review original clinical studies published in indexed databases, which assessed the role of oral yeasts in the etiopathogenesis of peri-implantitis. DESIGN: The focused question was "Do oral yeasts play a role in the etiopathogenesis of peri-implantitis?". Indexed databases were searched up to and including November 2019 using different combinations of the following key indexing terms: alveolar bone loss; candida, dental implant, oral; probing depth, peri-implant mucositis; peri-implantitis; and yeast. Original clinical studies were included. Studies performed on animal models, letters to the Editor, in-vivo/in-vitro/ex-vivo studies, commentaries, case-reports/series and historic reviews were excluded. The pattern of the present review article was customized to summarize the pertinent information. RESULTS: The initial search yielded 69 studies. Sixty-two studies, which did not fit the eligibility criteria were excluded. Seven studies were included and processed for data extraction. In all studies, oral yeasts were identified in conjunction with pathogenic bacteria in the oral biofilm samples collected from patients with peri-implantitis. In 1 study on type-2 diabetic and non-diabetic patients with peri-implantitis, the counts of oral yeasts were significantly higher in type-2 diabetic and systemically healthy patients with peri-implantitis than individuals without peri-implantitis. A prior sample-size estimation was performed in 3 of the 7 included studies. CONCLUSION: There is no direct evidence to confirm that oral yeasts contribute towards the etiopathogenesis of peri-implantitis.

16.
Artigo em Inglês | MEDLINE | ID: mdl-31967984

RESUMO

BACKGROUND: Epidermolysis bullosa (EB) comprises a group of hereditary disorders characterized by mechanical fragility of the skin and mucous membranes, with the development of blisters and vesicles in response to minimum tissue friction. Recessive dystrophic epidermolysis bullosa (RDEB) with generalized involvement is the most common subtype in the oral cavity. The present study was carried out to investigate dental implant survival, peri-implant tissue condition, patient satisfaction, and the impact of treatment upon the quality of life of patients with RDEB rehabilitated with implants and full-arch implant-supported prostheses. MATERIAL AND METHODS: Thirteen patients with RDEB underwent dental implant treatment between September 2005 and December 2016. A retrospective study was made to analyze implant survival, peri-implant tissue health and patient satisfaction. RESULTS: A total of 80 implants were placed (42 in the maxilla and 38 in the mandible) in 13 patients between 20-52 years of age and diagnosed with RDEB. All the implants were rehabilitated on a deferred basis with 20 full-arch prostheses. Fifteen fixed prostheses and 5 implant-supported overdentures were placed. The implant survival rate was 97.5% after a mean follow-up of 7.5 years after prosthetic loading. Fifty percent of the implants showed mucositis at the time of evaluation. Probing depth was maintained at 1-3 mm in 96.2% of the implants, and bleeding upon probing was observed in 67.5% of the implants. There was a high prevalence of bacterial plaque (85%). CONCLUSIONS: The treatment of edentulous patients with RDEB by means of implants and implant-supported prostheses is predictable as evidenced by the high success rate, and improves patient self-esteem and quality of life.

17.
J Nanosci Nanotechnol ; 20(7): 4114-4119, 2020 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-31968428

RESUMO

We have developed a HA nano-coating technology suitable for dental and orthopedic implants using RF magnetron sputtering method which can achieve excellent adhesion to titanium compared with other various PVD coating technologies. As a result, the HA thin film prepared by RF magnetron sputtering has a thickness of about 1.6 [µm] and its adhesion force to base metal is about 11.93 [N] or more and Ca/P ratio is about 1.64, which is suitable for dental and orthopedic implants.

18.
J Nanosci Nanotechnol ; 20(7): 4152-4157, 2020 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-31968433

RESUMO

Highly roughened surfaces on dental implants enhance the bone-bonding ability and in vivo cell adhesion on the implant surface. In this study, zirconia substrates were coated by powder coating using room temperature spray processing to improve their surface properties. Processing factors (particle size of the starting powder, number of repetitions of the deposition cycle, and spraying distance) were controlled to form a dense coating layer with high surface roughness on the zirconia substrate. Starting zirconia powders for coating were heat-treated at high temperature to control the particle size and kinetic energy. The coating layer fabricated from starting powder with a particle size of about 1.52 µm shows a homogeneous and dense microstructure, and it has a maximum surface roughness about 0.37 µm. The surface roughness of the film coatings increased with the number of times that the deposition cycle was repeated. No phase changes between the starting powder and the coating layer were observed, and all of the materials show identical tetragonal phases.

19.
Nutrients ; 12(1)2020 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-31968626

RESUMO

Several factors affect dental implant osseointegration, including surgical issues, bone quality and quantity, and host-related factors, such as patients' nutritional status. Many micronutrients might play a key role in dental implant osseointegration by influencing some alveolar bone parameters, such as healing of the alveolus after tooth extraction. This scoping review aims to summarize the role of dietary supplements in optimizing osseointegration after implant insertion surgery. A technical expert panel (TEP) of 11 medical specialists with expertise in oral surgery, bone metabolism, nutrition, and orthopedic surgery performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP identified micronutrients from the "European Union (EU) Register of nutrition and health claims made on foods" that have a relationship with bone and tooth health, and planned a PubMed search, selecting micronutrients previously identified as MeSH (Medical Subject Headings) terms and adding to each of them the words "dental implants" and "osseointegration". The TEP identified 19 studies concerning vitamin D, magnesium, resveratrol, vitamin C, a mixture of calcium, magnesium, zinc, and vitamin D, and synthetic bone mineral. However, several micronutrients are non-authorized by the "EU Register on nutrition and health claims" for improving bone and/or tooth health. Our scoping review suggests a limited role of nutraceuticals in promoting osseointegration of dental implants, although, in some cases, such as for vitamin D deficiency, there is a clear link among their deficit, reduced osseointegration, and early implant failure, thus requiring an adequate supplementation.

20.
Dent Mater J ; 2020 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-31969548

RESUMO

Since 1970s, a lot of effort has been devoted toward the development of dental implants. Dental implants are nowadays an indispensable part of clinical dentistry. The global dental implant market is expected to reach $13 billion in 2023. Although, the survival rate of dental implants has been reported above 90%, compromised bone conditions promote implant failure and endanger the current high success rates. The main concern is related to the aging population. Diabetes, osteoporosis, obesity and use of drugs are all medical conditions, which can hamper bone healing around dental implants. In view of this, research toward developing better methods of enhancing implant osseointegration have to be continued, especially in the presence of impaired bone condition. In this paper, the current changes and their future perspective are discussed.

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