RESUMO
Malnutrition continues to affect the growth and development of millions of children worldwide, and chronic undernutrition has proven to be largely refractory to interventions. Improved understanding of metabolic development in infancy and how it differs in growth-constrained children may provide insights to inform more timely, targeted, and effective interventions. Here, the metabolome of healthy infants was compared to that of growth-constrained infants from three continents over the first 2 years of life to identify metabolic signatures of aging. Predictive models demonstrated that growth-constrained children lag in their metabolic maturity relative to their healthier peers and that metabolic maturity can predict growth 6 months into the future. Our results provide a metabolic framework from which future nutritional programs may be more precisely constructed and evaluated.
Assuntos
Desenvolvimento Infantil , Metabolismo Energético , Fatores Etários , Biomarcadores , Transtornos da Nutrição Infantil/epidemiologia , Transtornos da Nutrição Infantil/metabolismo , Pré-Escolar , Países em Desenvolvimento , Feminino , Humanos , Lactente , Masculino , Desnutrição/epidemiologia , Desnutrição/etiologia , Desnutrição/metabolismo , Metaboloma , Metabolômica/métodosRESUMO
Nine key forage species (grasses and legumes), together with two types of crop residues, usually fed by farmers to their livestock, were collected from a rainfed area in western Sudan during the dry season (May-April). The grasses investigated were Leptadena pyrotechnia, Cenchrus setigrus, Arista pallida, Eragrotis tremula, Schoenefeldia gracilis, Chloris vergata and Cenchrus biflorus. The crop residues investigated were the grasses, sorghum straw (Sorghum bichlor) and millet straw (Pennisetum typhodium) and the legumes Stylosanthes flavicans and Cajanus cajana. Estimates of organic matter (OM) degradability were done using the nylon bag technique, which was fitted into the model Y = a + b (1 - e(-ct)), in which the asymptote (a + b) represented the total potential degradability. Organic cell wall constituents and hence both metabolizable energy and total digestible energy or nutrients (TDN) were determined. S. flavicans showed the best organic matter degradability, and sorghum straw was better degraded than millet straw. The rest of the grasses showed poor OM degradability. Acid detergent insoluble nitrogen was inversely related to TDN, the latter falling within a narrow range for the different forages. Fermentable metabolizable energy differed only slightly, while the legume S. flavicans had the highest effective rumen digestible protein. Undegraded proteins were high for the straws and the grasses L. pyrotechnia and C. setigerus. Metabolizable protein and microbial protein were highest in the sorghum straw, C. setigerus and S. flavicans.
Assuntos
Ração Animal , Animais Domésticos/fisiologia , Ingestão de Energia , Animais , Cenchrus/metabolismo , Eragrostis/metabolismo , Fabaceae/metabolismo , Poaceae/metabolismo , Estações do Ano , Sudão , Clima TropicalRESUMO
Zinc and copper deficiencies have been reported in heifers of various breeds at four different locations in Sudan. These were Kuku (5 km north of Khartoum), Seleit (20 km northwest of Khartoum), Medani (180 km south of Khartoum) and El Obeid (600 km west of Khartoum). Phosphorus deficiency was only observed in the serum of heifers at El Obeid. The heifers at all locations showed delayed puberty, stunted growth and infertility. The heifers of the local breeds at El Obeid only attained puberty by 1530 days of age compared with 840 days for the pure Friesian heifers at Seleit. The crossbred animals at Kuku and Medani attained puberty at 1440 and 1020 days of age, respectively. The marginal or low zinc and copper contents in pasture, soil or animal feed may have been predisposing factors for the observed deficiencies and might have been responsible for the delayed age of puberty.
Assuntos
Bovinos/fisiologia , Cobre/administração & dosagem , Fosfatos/administração & dosagem , Maturidade Sexual/efeitos dos fármacos , Zinco/administração & dosagem , Ração Animal , Animais , Bovinos/crescimento & desenvolvimento , Doenças dos Bovinos/sangue , Doenças dos Bovinos/fisiopatologia , Cobre/deficiência , Feminino , Fertilidade/efeitos dos fármacos , Distúrbios Nutricionais/sangue , Distúrbios Nutricionais/fisiopatologia , Distúrbios Nutricionais/veterinária , Fosfatos/deficiência , Fósforo/sangue , Fósforo/deficiência , Maturidade Sexual/fisiologia , Sudão , Zinco/deficiênciaRESUMO
Feeding strategies aimed at improving the nutritive value of crop residues through chemical treatment or utilizing other available feed resources as small ruminant feeds were carried out during the hot dry summer season when rangeland pasture deteriorates drastically. The study utilized small-scale farmer animals and crop residues chemically treated as animal feeds. Other feeds were groundnut haulms (GNH) and tree pods (TP) of Faidherbia albida. A total of 30 adult lactating goats with their kids (30) were allocated in completely randomized design to the following treatments: untreated sorghum straw (USS, control), sorghum straw treated with 4.7% urea solution (TSS), TSS+treepods (TSS+TP), USS+groundnuthaulms (USS+GNH) and TSS+GNH. Parameters investigated were: changes in body weight (BW) of the does and their kids as well as milk composition of the does. The results showed that dry matter intake (DMI) was reduced (P<0.05) by urea treatment, but it was increased (P<0.05) by supplementation. In vitro organic matter digestibility (IVOMD) was improved (P<0.05) by urea treatment and supplementation with either GNH or TP. BW of does decreased (P<0.05) in the TSS group, while a significant increase was obtained in the TSS+GNH group. BW of the kids belonging to the does given USS+GNH or TSS+TP was higher (P<0.05) than BW of the kids that belonged to the does fed other rations. However, no losses in BW were detected. It could be concluded that the combination of urea treatment and supplementation with either GNH or TP improved DMI, BW, digestibility and milk yield.
RESUMO
The association between the combination of age and physiological status of dairy Nubian goats, pregnancy or lactation and blood concentration of zinc (Zn) and copper (Cu) was investigated. The animals were divided into (a) young (4-6 months old), (b) adult (9-12 months old), (c) pregnant (within 50 days of their first pregnancy and (e) lactating animals grouped according to parity (up to 50 days after first, second or third kidding). Each group or sub-group consisted of five animals. The data analysis revealed that plasma Zn concentration decreased (3.91-1.12mg/l) significantly with increase in age. There was a significant increase in Zn levels in high yielders compared to low ones (2.00-6.59mg/l). Cu plasma levels increased (5.01-3.17mg/l) significantly in adult compared to young animals but decreased (5.01-4.13mg/l) significantly after first kidding compared to second and third kidding as well as in pregnant animals. It can be shown that the different physiological states would impose certain demands on animal needs for these trace elements and hence adequate amounts in the diet should be accounted for to achieve the best animal performance.