RESUMO
The incidence of dysmetabolic factors in 100 elderly patients with hypertension stage II and the role of melatoninproducing function of epiphysis (pineal gland) in the development of these disorders were studied. It was found that the decrease of melatoninproducing function is one of the factors causing disorders of carbohydrate and lipid metabolism in elderly patients with hypertension. Simultaneous application of Melatonin with lisinopril or amlodipine have the normalizing effect on metabolic parameters affected in patients with arterial hypertension.
Assuntos
Anti-Hipertensivos/uso terapêutico , Hipertensão/tratamento farmacológico , Melatonina/uso terapêutico , Síndrome Metabólica/prevenção & controle , Idoso , Anti-Hipertensivos/administração & dosagem , Glicemia/análise , Índice de Massa Corporal , Metabolismo dos Carboidratos/efeitos dos fármacos , Quimioterapia Combinada , Humanos , Hipertensão/complicações , Hipertensão/metabolismo , Hipertensão/fisiopatologia , Insulina/sangue , Metabolismo dos Lipídeos/efeitos dos fármacos , Lipídeos/sangue , Melatonina/administração & dosagem , Melatonina/análogos & derivados , Melatonina/urina , Síndrome Metabólica/etiologia , Síndrome Metabólica/metabolismo , Síndrome Metabólica/fisiopatologia , Pessoa de Meia-Idade , Glândula Pineal/metabolismo , Glândula Pineal/fisiopatologia , Circunferência da CinturaRESUMO
This work was aimed at study changes of the epiphyseal melatonin-producing function in elderly patients with hypertensive disease, as well as the relationships of those changes with the degree of arterial hypertension and 24-hour arterial pressure profile disorders. Examination of 18 young (20-34 years) and 20 elderly (60-74 years) healthy people has documented the decrease of melatonin-producing function in aging. In the group of 100 hypertensive disease patients, the nocturnal 6-hydro-oxymelatonin-sulafate (6-HMS) excretion was significantly lower (by 26.5%) than in their healthy age-matched individuals, thus evidencing for more pronounced disturbance of the melatonin-producing function in the former. It is noteworthy that lower melatonin-producing function of the epiphysis was revealed in the patients with the higher level of average 24-hour arterial pressure value and in the patients with a disturbed 24-hour arterial pressure profile "non-dippers".
Assuntos
Hipertensão/metabolismo , Melatonina/metabolismo , Glândula Pineal/metabolismo , Adulto , Fatores Etários , Idoso , Envelhecimento , Pressão Sanguínea , Monitorização Ambulatorial da Pressão Arterial , Ritmo Circadiano , Humanos , Hipertensão/diagnóstico , Hipertensão/fisiopatologia , Melatonina/análogos & derivados , Melatonina/urina , Pessoa de Meia-Idade , Índice de Gravidade de DoençaRESUMO
In the course of aging both monkeys and people reveal decreased night and average daily level of melatonin in the blood plasma and reduced hormone circadian rhythm amplitude, which evidence the disorder of the pineal gland melatonin releasing function. Peptide preparations of the pineal gland (Epithalamin--a complex of peptides isolated from the pineal gland and Epitalon--synthetic tetrapeptide) recover night release of endogenous melatonin and lead to the normalization of the hormone circadian rhythm in the blood plasma. In elderly people Epithalamin and Epitalon modulate pineal gland functional state: people with pineal gland functional insufficiency report an increase of night melatonin level. The preparations of the pineal gland, effectively increasing melatonin concentration and having no side effects, can be used in clinical geriatric practice.