Integrating large language models in care, research, and education in multiple sclerosis management.

Use of techniques derived from generative artificial intelligence (AI), specifically large language models (LLMs), offer a transformative potential on the management of multiple sclerosis (MS). Recent LLMs have exhibited remarkable skills in producing and understanding human-like texts. The integration of AI in imaging applications and the deployment of foundation models for the classification and prognosis of disease course, including disability progression and even therapy response, have received considerable attention. However, the use of LLMs within the context of MS remains relatively underexplored. LLMs have the potential to support several activities related to MS management. Clinical decision support systems could help selecting proper disease-modifying therapies; AI-based tools could leverage unstructured real-world data for research or virtual tutors may provide adaptive education materials for neurologists and people with MS in the foreseeable future. In this focused review, we explore practical applications of LLMs across the continuum of MS management as an initial scope for future analyses, reflecting on regulatory hurdles and the indispensable role of human supervision.

From admission to discharge: a systematic review of clinical natural language processing along the patient journey.

BACKGROUND: Medical text, as part of an electronic health record, is an essential information source in healthcare. Although natural language processing (NLP) techniques for medical text are developing fast, successful transfer into clinical practice has been rare. Especially the hospital domain offers great potential while facing several challenges including many documents per patient, multiple departments and complex interrelated processes. METHODS: In this work, we survey relevant literature to identify and classify approaches which exploit NLP in the clinical context. Our contribution involves a systematic mapping of related research onto a prototypical patient journey in the hospital, along which medical documents are created, processed and consumed by hospital staff and patients themselves. Specifically, we reviewed which dataset types, dataset languages, model architectures and tasks are researched in current clinical NLP research. Additionally, we extract and analyze major obstacles during development and implementation. We discuss options to address them and argue for a focus on bias mitigation and model explainability. RESULTS: While a patient's hospital journey produces a significant amount of structured and unstructured documents, certain steps and documents receive more research attention than others. Diagnosis, Admission and Discharge are clinical patient steps that are researched often across the surveyed paper. In contrast, our findings reveal significant under-researched areas such as Treatment, Billing, After Care, and Smart Home. Leveraging NLP in these stages can greatly enhance clinical decision-making and patient outcomes. Additionally, clinical NLP models are mostly based on radiology reports, discharge letters and admission notes, even though we have shown that many other documents are produced throughout the patient journey. There is a significant opportunity in analyzing a wider range of medical documents produced throughout the patient journey to improve the applicability and impact of NLP in healthcare. CONCLUSIONS: Our findings suggest that there is a significant opportunity to leverage NLP approaches to advance clinical decision-making systems, as there remains a considerable understudied potential for the analysis of patient journey data.

Implementation and evaluation of an additional GPT-4-based reviewer in PRISMA-based medical systematic literature reviews.

BACKGROUND: PRISMA-based literature reviews require meticulous scrutiny of extensive textual data by multiple reviewers, which is associated with considerable human effort. OBJECTIVE: To evaluate feasibility and reliability of using GPT-4 API as a complementary reviewer in systematic literature reviews based on the PRISMA framework. METHODOLOGY: A systematic literature review on the role of natural language processing and Large Language Models (LLMs) in automatic patient-trial matching was conducted using human reviewers and an AI-based reviewer (GPT-4 API). A RAG methodology with LangChain integration was used to process full-text articles. Agreement levels between two human reviewers and GPT-4 API for abstract screening and between a single reviewer and GPT-4 API for full-text parameter extraction were evaluated. RESULTS: An almost perfect GPT-human reviewer agreement in the abstract screening process (Cohen's kappa > 0.9) and a lower agreement in the full-text parameter extraction were observed. CONCLUSION: As GPT-4 has performed on a par with human reviewers in abstract screening, we conclude that GPT-4 has an exciting potential of being used as a main screening tool for systematic literature reviews, replacing at least one of the human reviewers.

[Use of AI-based applications by hospital staff: task profiles and qualification requirements]. / Einsatz von KI-basierten Anwendungen durch Krankenhauspersonal: Aufgabenprofile und Qualifizierungsbedarfe.

BACKGROUND: Artificial intelligence (AI) is becoming increasingly important for the future development of hospitals. To unlock the large potential of AI, job profiles of hospital staff members need to be further developed in the direction of AI and digitization skills through targeted qualification measures. This affects both medical and non-medical processes along the entire value chain in hospitals. The aim of this paper is to provide an overview of the skills required to deal with smart technologies in a clinical context and to present measures for training employees. METHODS: As part of the "SmartHospital.NRW" project in 2022, we conducted a literature review as well as interviews and workshops with experts. AI technologies and fields of application were identified. RESULTS: Key findings include adapted and new task profiles, synergies and dependencies between individual task profiles, and the need for a comprehensive interdisciplinary and interprofessional exchange when using AI-based applications in hospitals. DISCUSSION: Our article shows that hospitals need to promote digital health literacy skills for hospital staff members at an early stage and at the same time recruit technology- and AI-savvy staff. Interprofessional exchange formats and accompanying change management are essential for the use of AI in hospitals.

Uncovering chains of infections through spatio-temporal and visual analysis of COVID-19 contact traces.

A major challenge for departments of public health (DPHs) in dealing with the ongoing COVID-19 pandemic is tracing contacts in exponentially growing SARS-CoV-2 infection clusters. Prevention of further disease spread requires a comprehensive registration of the connections between individuals and clusters. Due to the high number of infections with unknown origin, the healthcare analysts need to identify connected cases and clusters through accumulated epidemiological knowledge and the metadata of the infections in their database. Here we contribute a visual analytics dashboard to identify, assess and visualize clusters in COVID-19 contact tracing networks. Additionally, we demonstrate how graph-based machine learning methods can be used to find missing links between infection clusters and thus support the mission to get a comprehensive view on infection events. This work was developed through close collaboration with DPHs in Germany. We argue how our dashboard supports the identification of clusters by public health experts, discuss ongoing developments and possible extensions.