Study of sunless tanning formulas using molted snake skin as an alternative membrane model.

Sunless tanning formulas have become increasingly popular in recent years for their ability to give people convincing tans without the dangers of skin cancer. Most sunless tanners currently on the market contain dihydroxyacetone (DHA), a keto sugar with three carbons. The temporary pigment provided by these formulas is designed to resemble a UV-induced tan. This study evaluated the effectiveness of carbomer gels and cold process self emulsifying bases on skin pigmentation, using different concentrations of a chemical system composed of DHA and N-acetyl tyrosine, which are found in moulted snake skins and their effectiveness was tested by Mexameter(®) MX 18. Eight different sunless tanning formulas were developed, four of which were gels and four of which were emulsions (base, base plus 4.0%, 5.0% and 6.0% (w/w) of a system of DHA and N-acetyl tyrosine). Tests to determine the extent of artificial tanning were done by applying 30 mg cm(-2) of each formula onto standard sizes of moulted snake skin (2.0 cm × 3.0 cm). A Mexameter(®) MX 18 was used to evaluate the extent of coloration in the moulted snake skin at T(0) (before the application) and after 24, 48, 72, 168, 192 and 216 h. The moulted snake skins can be used as an alternative membrane model for in vitro sunless tanning efficacy tests due to their similarity to the human stratum corneum. The DHA concentration was found to influence the initiation of the pigmentation in both sunless tanning systems (emulsion and gel) as well as the time required to increases by a given amount on the tanning index. In the emulsion system, the DHA concentration also influenced the final value on the tanning index. The type of system (emulsion or gel) has no influence on the final value in the tanning index after 216 h for samples with the same DHA concentration.

Novas metodologias analíticas para avaliação da eficácia fotoprotetora (in vitro) - revisão / New analytical methods for photoprotection effectiveness testing (in vitro) - a review

Atualmente, são utilizadas técnicas in vitro e in vivo para a avaliação do Fator de Proteção Solar (FPS) e do Fator de Proteção de UVA (FPA). O presente trabalho propõe a revisão das técnicas para as avaliações desses fatores in vitro preconizadas por FDA (Food and Drug Administration Agency) e COLIPA (European Cosmetic, Toiletry and Perfumery Association). O enfoque maior foi direcionado à análise espectrofotométrica de soluções diluídas e à espectrofotometria de reflectância com esfera integrada.

Currently, both in vitro and in vivo techniques are used to measure Sun Protection Factor (SPF) and UVA Protection Factor (APF). This paper reviews the in vitro techniques to test these factors, recommended by the FDA (USA Food and Drug Administration) and COLIPA (European Cosmetic, Toiletry and Perfumery Association). The main focus is on the spectrophotometric analysis of dilute solutions and the use of reflectance spectrophotometry with an integrating sphere.

Utility of electron beam computed tomography to stratify patients presenting to the emergency room with chest pain.

One hundred thirty-four patients presenting to the emergency room with the chief complaint of chest pain were studied with electron beam computed tomography scan. Electron beam computed tomography scanning had a 98% negative predictive value in this setting.

[Results of conventional detachment surgery. I. Study planning, patients and vision results]. / Ergebnisse nach konventioneller Ablatiochirurgie. I. Studienplanung, Patienten und Visusergebnisse.

A consecutive series of patients with retinal detachment were examined. All patients were treated primarily with buckling procedure. Patients with redetachment, bilateral detachment, vitrectomy or history of strabismus or amblyopia were excluded. Of these 155 patients, 117 could be examined. 97% of patients without macula detachment are able to keep or improve their visual acuity. 85% of those patients with macula detachment showed an improvement of visual acuity. The most important prognostic factor for the visual outcome is the duration of macula detachment. In cases of more than four days duration a visual acuity of 20/40 or more could not be expected.

[Results of conventional retinal detachment surgery. II. Changes in refraction]. / Ergebnisse nach konventioneller Ablatiochirurgie. II. Refraktionsänderungen.

In a comparative study we examined the refractive changes in 117 patients following conventional buckling retinal detachment surgery. Of these, 54 had a segmental scleral buckle, 18, an encircling buckle, and 45, a combination of both methods. Comprising about 2D, the changes in spherical equivalent were most marked in the patients who had combined operations. A correlation exists between buckle height and extent of refractive change (p = 0.0297).

[Results of conventional retinal detachment surgery. III. Orthoptic results]. / Ergebnisse nach konventioneller Ablatiochirurgie. III. Orthoptische Resultate.

In a comparative study we examined orthoptic side effects in 117 patients following conventional retinal detachment surgery. Of these, 54 had had a segmental scleral buckle, 18 a simple encircling band and 45 encircling band combined with a radial buckle. Persistent diplopia was found in 6% of cases following segmental buckles, in 11% following simple encircling procedures and in 20% following combined operations with encircling bands and segmental buckles. The incidence of diplopia was more than 30% in cases with high encircling buckles.

The development and functioning of the sense of shame.

An extensive literature on shame has not yet sufficiently addressed the nature and functioning of this affect from the psychoanalytic, developmental point of view. This paper tries to lay the ground for such a task.