Assuntos
Antineoplásicos/efeitos adversos , Ceratose/induzido quimicamente , Ceratose/genética , Vemurafenib/efeitos adversos , Antineoplásicos/uso terapêutico , Humanos , Masculino , Melanoma/tratamento farmacológico , Pessoa de Meia-Idade , Inibidores de Proteínas Quinases/efeitos adversos , Inibidores de Proteínas Quinases/uso terapêutico , Proteínas Proto-Oncogênicas B-raf/antagonistas & inibidores , Neoplasias Cutâneas/tratamento farmacológico , Vemurafenib/uso terapêuticoRESUMO
Pemphigoid gestationis is a rare, autoimmune blistering dermatosis (Holmes and Black In: Clin Exp Dermatol 7:65-73, 1982). It is unique in that it is diagnosed primarily in association with pregnancy. It has been estimated to occur in 1:50,000 pregnancies [Shornick et al. In: J Am Acad Dermatol 8:214-224, 1983]. Involvement of the infant is exceedingly rare, while the pathogenic trigger initiating disease has remained elusive; the interaction of IgG1 auto-antibodies and the 180 kD BPA2 remains paramount in understanding the immunologic mechanism of disease. We describe a 29 year-old multiparous woman who presented at 29 weeks gestation with skin findings characteristic of pemphigoid gestationis. She later gave birth to a full-term male who was born with extensive bullae and several denuded areas of his head, trunk and limbs. The diagnosis of pemphigoid gestationis in both mother and son was confirmed using direct immunofluorescence. In conclusion, we present a well documented, rare case of pemphigoid gestationis with maternal transfer to the infant. A historical and epidemiological review of this rare blistering disorder is discussed along with current theories on pathogenic and immunologic mechanisms.
Assuntos
Penfigoide Gestacional/diagnóstico , Adulto , Membrana Basal/imunologia , Complemento C3/análise , Feminino , Técnica Direta de Fluorescência para Anticorpo , Idade Gestacional , Humanos , Recém-Nascido , Masculino , Troca Materno-Fetal/imunologia , Penfigoide Gestacional/tratamento farmacológico , Penfigoide Gestacional/imunologia , Prednisona/uso terapêutico , GravidezRESUMO
Polymethylmethacrylate (PMMA) is a synthetic polymer with multiple uses in industry and medicine. In dermatology, it is primarily used as an injectable implant for the correction of rhytides. We report the first case of an adverse event caused by the recreational use of PMMA in the form of an invisible tattoo granuloma.
Assuntos
Granuloma de Corpo Estranho/etiologia , Dermatopatias/etiologia , Tatuagem/efeitos adversos , Adulto , Corantes/administração & dosagem , Corantes/efeitos adversos , Feminino , Humanos , Microesferas , Polimetil Metacrilato/administração & dosagem , Polimetil Metacrilato/efeitos adversosRESUMO
Blue rubber-bleb nevus syndrome (BRBNS) is an uncommon systemic disorder characterized by cutaneous and visceral cavernous hemangiomas. The characteristic rubbery textured and easily compressible lesions usually present in childhood and predominate cutaneously over the trunk and extremities. Gastrointestinal foci appear most commonly in the small bowel, a site that appears to dominate visceral involvement. We review the case of a 23-year-old white woman, whose numerous lesions on her trunk, extremities, and oral mucosa had been present since childhood.