RESUMO
The effects of chronic oral vasodilator therapy were studied in a group of patients with refractory congestive heart failure. Fifteen patients were treated acutely with intravenous sodium nitroprusside and sublingual isosorbide dinitrate. After continuous therapy with nitroprusside and isosorbide dinitrate for up to 72 hours the patients were then placed on isosorbide dinitrate and oral phenoxybenzamine. Hemodynamic responses to nitroprusside, isosorbide dinitrate, and phenoxybenzamine with isosorbide dinitrate were determined. After a mean follow-up of seven months, nine patients who were receiving isosorbide dinitrate and phenoxybenzamine underwent repeat hemodynamic studies. Beneficial effects of acute vasodilator therapy included a significant reduction in pulmonary capillary wedge pressure and systemic vascular resistance, and significant increases in cardiac index and stroke work index. Mean arterial blood pressure and heart rate were unchanged. During the period of chronic vasodilator administration, no other change in basic therapy with isosorbide dinitrate and phenoxybenzamine (3-21 months), the favorable effects observed acutely were maintained. All patients demonstrated symptomatic improvement with minimal side effects. The beneficial hemodynamic responses that are noted with acute vasodilator therapy in patients in advanced congestive heart failure are maintained with oral therapy on a chronic basis.
Assuntos
Insuficiência Cardíaca/tratamento farmacológico , Vasodilatadores/uso terapêutico , Adulto , Idoso , Doença Crônica , Feminino , Insuficiência Cardíaca/fisiopatologia , Hemodinâmica , Humanos , Dinitrato de Isossorbida/administração & dosagem , Dinitrato de Isossorbida/uso terapêutico , Masculino , Pessoa de Meia-Idade , Nitroglicerina/administração & dosagem , Nitroglicerina/uso terapêutico , Nitroprussiato/administração & dosagem , Nitroprussiato/uso terapêuticoAssuntos
Eletrodos , Átrios do Coração , Marca-Passo Artificial/instrumentação , Idoso , Arritmia Sinusal/terapia , Arritmias Cardíacas/terapia , Bradicardia/terapia , Cateterismo Cardíaco , Estudos de Avaliação como Assunto , Feminino , Bloqueio Cardíaco/terapia , Insuficiência Cardíaca/terapia , Ventrículos do Coração , Humanos , Hipotensão/terapia , Masculino , Pessoa de Meia-IdadeAssuntos
Sintomas Afetivos/etiologia , Aldosterona , Angiotensina II , Peso Corporal , Natriurese , Potássio/urina , Síndrome Pré-Menstrual/etiologia , Renina , Equilíbrio Hidroeletrolítico , Adolescente , Adulto , Aldosterona/metabolismo , Angiotensina II/metabolismo , Ansiedade/etiologia , Depressão/etiologia , Estrogênios/metabolismo , Fadiga/etiologia , Feminino , Humanos , Progesterona/metabolismo , Renina/metabolismo , Transmissão SinápticaAssuntos
Colchicina/farmacologia , Glucose/metabolismo , Lítio/farmacologia , Glândula Tireoide/metabolismo , Tireotropina/metabolismo , Animais , Transporte Biológico/efeitos dos fármacos , Dióxido de Carbono/biossíntese , Isótopos de Carbono , Bovinos , Cães , Éteres/metabolismo , Corpos de Inclusão/efeitos dos fármacos , Camundongos , Fosfatos/metabolismo , Fosfolipídeos/biossíntese , Isótopos de Fósforo , Piruvatos/metabolismo , Especificidade da Espécie , Glândula Tireoide/citologia , Glândula Tireoide/efeitos dos fármacos , Hormônios Tireóideos/metabolismo , Tireotropina/farmacologiaAssuntos
Nucleotídeos de Adenina/antagonistas & inibidores , Iodo/metabolismo , Lítio/farmacologia , Glândula Tireoide/metabolismo , Tireotropina/antagonistas & inibidores , Animais , AMP Cíclico/metabolismo , Depressão Química , Técnicas In Vitro , Isótopos de Iodo , Camundongos , Cloreto de Sódio , Tireoglobulina/biossíntese , Glândula Tireoide/efeitos dos fármacosRESUMO
Lithium has been reported to be goitrogenic when used for the treatment of manic-depressive psychosis. To investigate the effects of lithium on iodine metabolism, male Sprague-Dawley rats were placed on a low iodine (LID) or normal iodine diet (NID) containing enough Li(2)CO(3) to give serum lithium levels of 0.23-0.86 mEq/liter (human therapeutic range is 0.6-1.6 mEq/liter). The following effects were noted with lithium treatment: (a) thyroid weight increased concomitant with a slowing of thyroidal iodine release; (b) the ability to concentrate iodide was increased only after goiters were established; (c) on the LID, (131)I uptake was elevated throughout all phases of treatment, even when the release rate was normal; (d) iodine organification was unaffected but the proportion of (131)I present as iodothyronines was decreased; (e) the thyroidal (127)I content was increased; (f) despite these changes, the serum PBI remained normal as did the thyroxine turnover rate; and (g) thyrotropin (TSH) levels in serum were the same as controls except for a slight elevation early in the course of treatment; TSH levels did not correlate with goitrogenesis. When LiCl was injected in large doses into intact rats (giving serum lithium levels of 3.08-3.89 mEq/liter), the iodide concentrating mechanism, (131)I uptake, and (131)I release rates were depressed. Similar experiments in hypophysectomized rats receiving TSH demonstrated these to be local antithyroid effects not mediated through the pituitary. The discrepancy between acute and chronic responses to lithium, and the dissociation between the inhibition of iodine release and stimulatory effects is discussed.