All-Metal Flexible Fiber by Continuously Assembling Nanowires for High Electrical Conductivity.

Fiber electronics booms as a new important field but is currently limited by the challenge of finding both highly flexible and conductive fiber electrodes. Here, all-metal fibers based on nanowires are discovered. Silver nanowires are continuously assembled into robust fibers by salt-induced aggregation and then firmly stabilized by plasmonic welding. The nanowire network structures provide them both high flexibility with moduli at the level of MPa and conductivities up to 106 S m-1. They also show excellent electrochemical properties such as low impedance and high electrochemically active surface area. Their stable chronic single-neuron recording is further demonstrated with good biocompatibility in vivo. These new fiber materials may provide more opportunities for the future development of fiber electronics.

High-performing fiber electrodes based on a gold-shelled silver nanowire framework for bioelectronics.

Flexible fiber electrodes offer new opportunities for bioelectronics and are reliable in vivo applications, high flexibility, high electrical conductivity, and satisfactory biocompatibility are typically required. Herein, we present an all-metal flexible and biocompatible fiber electrode based on a metal nanowire hybrid strategy, i.e., silver nanowires were assembled on a freestanding framework, and further to render them inert, they were plated with a gold nanoshell. Our fiber electrodes exhibited a low modulus of ∼75 MPa and electrical conductivity up to ∼4.8 × 106 S m-1. They can resist chemical erosion with negligible leakage of biotoxic silver ions in the physiological environment, thus ensuring satisfactory biocompatibility. Finally, we demonstrated the hybrid fiber as a neural electrode that stimulated the sciatic nerve of a mouse, proving its potential for applications in bioelectronics.

Association between sarcopenia and cognitive impairment in the older people: a meta-analysis.

PURPOSE: The effects of sarcopenia on the older people are profound, increasing the risk of adverse outcomes for older patients. Although the substantial impact of sarcopenia on maintaining functional independence and adverse health outcomes has been described many times in the past, the link between sarcopenia and cognitive impairment in older adults remains lacking in evidence and controversial. Therefore, we conducted a comprehensive search of available national and international databases and carried out a meta-analysis to examine the association between sarcopenia in older people and cognitive impairment. METHODS: Relevant experiments had been recognized via looking out electronic databases and conference sessions. The present study included case-control, cohort, or cross-sectional studies of the association between sarcopenia and cognitive impairment in the older people. RESULTS: The meta-analysis included 26 articles and 18,788 participants were involved after assessment of eligibility. The results of this meta-analysis showed that the risk of developing cognitive impairment was significantly higher in patients with sarcopenia than in those without sarcopenia [OR = 1.75; 95% CI = 1.57, 1.95; P < 0.00001], MMSE score of sarcopenia group was lower than that of non-sarcopenia group, the difference was statistically significant [OR = - 2.23; 95% CI = - 2.48, - 1.99; P < 0.00001]. CONCLUSION: Overall, this meta-analysis showed an association between sarcopenia and cognitive impairment in the older people, demonstrating a significant association between sarcopenia and cognitive impairment. This suggested that providing comprehensive sarcopenia screening and active prevention for the older people with cognitive decline has certain clinical value for improving the quality of life of the older people.