A Ketogenic Diet Sensitizes Pancreatic Cancer to Inhibition of Glutamine Metabolism.

Pancreatic cancer is the third leading cause of cancer death in the United States, and while conventional chemotherapy remains the standard treatment, responses are poor. Safe and alternative therapeutic strategies are urgently needed 1 . A ketogenic diet has been shown to have anti-tumor effects across diverse cancer types but will unlikely have a significant effect alone. However, the diet shifts metabolism in tumors to create new vulnerabilities that can be targeted (1). Modulators of glutamine metabolism have shown promise in pre-clinical models but have failed to have a marked impact against cancer in the clinic. We show that a ketogenic diet increases TCA and glutamine-associated metabolites in murine pancreatic cancer models and under metabolic conditions that simulate a ketogenic diet in vitro. The metabolic shift leads to increased reliance on glutamine-mediated anaplerosis to compensate for low glucose abundance associated with a ketogenic diet. As a result, glutamine metabolism inhibitors, such as DON and CB839 in combination with a ketogenic diet had robust anti-cancer effects. These findings provide rationale to study the use of a ketogenic diet with glutamine targeted therapies in a clinical context.

Social, Demographic, and Psychological Factors Associated with Middle-Aged Mother's Vocabulary: Findings from the Millennium Cohort Study.

Based on a sample of 8271 mothers, this study explored a set of psychological and sociodemographic factors associated with their vocabulary, drawing on data from a large, nationally representative sample of children born in 2000. The dependent variable was maternal vocabulary assessed when cohort members were at fourteen years of age, and the mothers were in their mid-forties. Data were also collected when cohort members were at birth, 9 months old, and at ages 3, 7, 11 and 14 years. Correlational analysis showed that family income at birth, parent-child relationship quality at age 3, maternal educational qualifications at age 11, and maternal personality trait Openness at age 14 were significantly and positively associated with maternal vocabulary. It also showed maternal malaise at 9 months and children's behavioral adjustment at age 7, and maternal traits Neuroticism and Agreeableness at age 14 were significantly and negatively associated with maternal vocabulary. Maternal age was also significantly and positively associated with vocabulary. Regression analysis showed that maternal age, malaise, parent-child relationship quality, children's behavioral adjustment, maternal educational qualifications, and traits Openness and Agreeableness were significant predictors of maternal vocabulary, accounting for 33% of total variance. The implications and limitations are discussed.

Correlates of Conscientiousness: Findings from the Millennium Cohort Study.

This study explored correlates of the trait Conscientiousness drawing on longitudinal data from the Millennium Cohort Study (MCS), with a sample of 7,436 mothers. Data were collected when participants' children were born and again at ages nine months, 3, 11, and 14 years. Structural equation modeling showed that the family poverty indicator, self-esteem, parent-child relationship, children's behavioral problems, and education all had significant and direct effects on maternal trait Conscientiousness. The strongest predictor was self-esteem (measured over 13 years previously), followed by children's behavioral problems and parent-child relationship quality. The implications for helping mothers and their children are considered and limitations are discussed.

The Big-Five personality factors, cognitive ability, health, and social-demographic indicators as independent predictors of self-efficacy: A longitudinal study.

This study set out to examine to what extent a set of psychological, health and socio-demographic factors are associated with self-efficacy (SE) in a large sample of over 12,000 participants over a two-year period. We were interested in the correlates of self-efficacy (criterion variable) with gender, age, education and occupation, the Big-Five personality factors and cognitive ability, as well as mental and physical health (predictor variables). Regression analyses showed that four of the Big-Five personality factors (extraversion, neuroticism, conscientiousness, and openness), cognitive ability, mental and physical health, gender, education and occupation were all significant and independent predictors of self-efficacy, accounting for 23% of the variance of the outcome variable. Personality variables, particularly Neuroticism and Conscientiousness, were the most powerful predictors of SE two years later. The implications for encouraging SE in individuals are discussed.

Childhood onset of migraine, gender, psychological distress and locus of control as predictors of migraine in adulthood.

This study explored a set of psychological and socio-demographic factors in childhood and adulthood associated with migraines assessed at age 42 years. Data were drawn from a large, nationally representative, prospective longitudinal study: the 1970 British Cohort Study (BCS70). In total, 5628 cohort members with data on parental social class at birth, cognitive ability (intelligence), self-esteem and locus of control at age 10 years, psychological distress and educational qualifications at age 34, and current occupation at age 42 years were examined. We assessed whether or not they regularly experienced migraines at age 42 years. Logistic regression analysis showed that childhood migraine, gender and adult psychological distress, as well as childhood locus of control (for females only), were significant and independent predictors of the prevalence of migraine in adulthood. Childhood migraine seemed to have a long-lasting effect on adult migraine, and psychological distress also appeared to detrimentally affect adult migraine over time.

Childhood heart problems, adulthood emotional stability, and sex associated with self-report heart conditions in adulthood.

The present study investigated biomedical, social, and psychological factors associated with self-reported heart conditions in adulthood in a British cohort. In total, 5697 (50.7% males) participants with data on parental socioeconomic status, childhood cognitive ability, childhood heart problems, educational qualifications, current occupational levels, adulthood personality traits, and the prevalence of self-reported heart conditions in adulthood were included in the study. The prevalence of self-reported heart conditions measured at age 54 years was the outcome variable. Hierarchical logistic regression analysis showed that childhood heart problems identified by physicians (OR = 3.47:1.74-6.92, p < 0.001) and trait emotional stability (OR = 0.83:0.75-0.93, p < 0.001) were the significant and independent predictors of self-reported heart conditions in adulthood. There were also significant sex effects on the prevalence of the outcome variable (OR = 0.53:0.42-0.63, p < 0.001). Both a biomedical and a psychological factor were significantly associated with self-reported heart conditions in adulthood.

Treatment Efficacy of Internet Gaming Disorder With Attention Deficit Hyperactivity Disorder and Emotional Dysregulaton.

BACKGROUND: Recent youth with Attention Deficit Hyperactivity Disorder (ADHD) noticed emotional dysregulation if they had Internet Gaming Disorder (IGD). This study aims to understand the treatment efficacy of IGD with ADHD and emotional dysregulaton. METHOD: A total of 101 ADHD youths were recruited. We used the Chen Internet Addiction Scale and IGD criteria of the diagnotsic statistical manual (DSM)-5 to confirm IGD. The Swanson, Nolan, and Pelham questionnaire Version IV was used for symptoms of ADHD and oppositional defiant disorder. Disruptive mood dysregulation disorder was assessed by psychiatrist. RESULTS: There is a new phenomenon that emotional dysregulation has been frequently noticed in severely gaming-addicted ADHD youth. Treatment efficacy of IGD is good when the underlying symptom of ADHD is controlled. Symptom scores of disruptive mood dysregulation (DMDD) were significantly reduced by 71.9%, 74.8%, and 84.4% at week 2, 3, and 4, respectively (P ≤ .001) after adjusting baseline symptom severity. CONCLUSION: IGD may strongly arouse emotional dysregulation. Future DSM criteria could consider these gaming-addicted youth as a specific subclass of ADHD.

Biomedical, psychological, environmental and behavioural factors associated with adult obesity in a nationally representative sample.

OBJECTIVE: To identify personality, biomedical and behavioural factors associated with adult obesity in a large longitudinal sample. METHOD: In total, 5360 participants with data on personality, neurological functioning, maternal smoking during pregnancy, education and occupation, physical exercise, adult self-reported BMI and obesity were included in the study. Obesity at 55 years was the outcome variable. RESULTS: The rates of obesity increased from 9.5 to 22.8% from age 33 to 55 years. Logistic regression analyses (adjusted estimates) showed that childhood neurological functioning (OR = 1.32: 1.07-1.63, P < 0.01), maternal smoking during pregnancy (OR = 1.42: 1.22-1.65, P < 0.001), educational qualifications (OR = 0.54: 0.37-0.79, P < 0.01), trait conscientiousness (OR = 0.80:0.74-0.86, P < 0.001) and physical exercise (OR = 0.87: 0.82-0.92, P < 0.001) were significant predictors of obesity at age 55 years for both men and women. Trait extraversion for men (OR = 1.16: 1.07-1.26, P < 0.001) and trait emotional stability for women (OR = 0.90: 0.82-0.99, P < 0.05) were also significant predictors of the outcome variable. CONCLUSION: Biomedical, psychological, environmental and behavioural factors were all associated with adult obesity.

Correlates of Adult Vocabulary Task Performance: Findings from a British Cohort.

This study explored a longitudinal data set of 4361 adults (2119 males and 2239 females) to examine factors that influence adult vocabulary task performance. Data were collected at birth, in childhood (age 10 years), during teenage years (age 16 years), and in adulthood (ages 30, 34, and 42 years) to examine the effects of family social status, childhood cognitive ability, teenager locus of control, psychological distress, educational qualifications, and occupational prestige in adulthood on an adult vocabulary task-an index of crystallized intelligence. Structural equation modeling showed that childhood cognitive ability, teenager locus of control, education, and occupation were all significant and direct predictors of adult vocabulary task performance. Parental social status affected the outcome variable mediated through educational qualifications. The strongest predictor of adult vocabulary task performance was childhood cognitive ability, followed by educational qualifications and locus of control. Finally, limitations were acknowledged.

GHQ score changes from teenage to young adulthood.

This study investigated the change in the General Health Questionnaire (GHQ-12) scores from teenage years to young adulthood using a large, nationally representative sample in the UK. It took account of socio-demographic variables, childhood intelligence, behavioural problems and self-esteem at teenage and educational qualifications in early adulthood. In total, 3942 cohort members had the complete data on GHQ at ages 16 and 30 years. T-tests showed that there was statistically significant increase of GHQ mean scores over the 14 years (p < .001), however at the item level there were changes in both directions. The analysis showed that over 14 years the test-retest correlation was r = 0.24, indicating a modest level of stability. The GHQ was significantly and negatively associated with self-esteem, and positively associated with childhood behavioural problems. Regression analysis showed that gender, self-esteem, and behavioural problems measured in the teenage years were all significant predictors of GHQ at both time points, indicating the long-term effects of psychological and behavioural factors on teenagers and young adults' mental health outcome. The implications for early interventions in school and family settings are discussed.

GENDER DIFFERENCES IN INTELLIGENCE OF 5- TO 11-YEAR-OLDS ON THE COLOURED PROGRESSIVE MATRICES IN EGYPT.

This study was based on data for a sample of 1756 Egyptian primary school children (863 boys and 893 girls) aged 5-11 years assessed for intelligence with Raven's Coloured Progressive Matrices (CPM). The results showed that boys obtained a slightly higher IQ than girls and had greater variance.

Childhood locus of control and self-esteem, education, psychological distress and physical exercise as predictors of adult obesity.

OBJECTIVE: To investigate to what extent locus of control, self-esteem, psychological distress, physical exercise, as well as socio-demographic factors are associated with obesity in 42-year-old adults in a longitudinal birth cohort study. METHOD: The sample consisted of 5645 participants born in Great Britain in 1970 and followed up at 10, 34 and 42 years with data on body mass index measured at 34 and 42 years. RESULTS: There was an increase of adult obesity from 15.5% at age 34 to 21.2% at 42 years. Locus of control and self-esteem measured at age 10 years, psychological distress and educational qualifications assessed at age 34, and current occupational levels and physical exercise were all significantly associated with adult obesity at age 42. The associations remained significant after controlling for birth weight and gestation, maternal and paternal BMI, childhood BMI, and intelligence. CONCLUSION: Childhood locus of control and self-esteem, educational qualifications, psychological distress and physical exercise were all significantly and independently associated with adult obesity.

Teenage locus of control, psychological distress, educational qualifications and occupational prestige as well as gender as independent predictors of adult binge drinking.

Our objective was to investigate various psychological and socio-demographic factors in childhood and adulthood that relate to alcohol intake and binge drinking at age 42 years. Data were drawn from the 1970 British Cohort Study (BCS70), a prospective longitudinal study monitoring the development of babies born in 1970, with nine follow-ups. The analytic sample comprised 5190 cohort members with complete data on parental social class at birth, cognitive ability at age 10 years, locus of control at age 16 years, psychological distress at age 30 years, educational qualifications obtained at age 34 years, and current occupation and alcohol consumption at age 42 years. Results showed that sex (male), lower parental social class, adolescent external locus of control, psychological distress, lower scores on childhood intelligence, lower educational qualifications, and less-professional occupations were all significantly and positively associated with binge drinking in adulthood. Hierarchical logistic regression analyses showed that sex (OR = 0.52, CI: 0.44-0.60, p < .001), parental social class (OR = 0.67, CI: 0.50-0.92 to OR = 0.49, CI: 0.31-0.57, p < .05 to p < .01), locus of control beliefs (OR = 0.90, CI: 0.84-0.96, p < .01), adult psychological distress (OR = 1.28, CI: 1.04-1.58, p < .05), educational qualifications (OR = 0.70, CI: 0.53-0.92 to OR = 0.39, CI: 0.25-0.61, p < .05 to p < .001), and occupational prestige (OR = 0.59, CI: 0.38-0.95 to OR = 0.36, CI: 0.20-0.65, p < .05 to p < .01) were all significant and independent predictors of adult binge drinking. Both psychological and socio-demographic factors associated with adult excessive alcohol consumption. Adolescent locus of control beliefs had a significant effect on adult binge drinking 26 years later.

The Biota Project: A Case Study of a Multimedia, Grassroots Approach to Scientific Communication for Engaging Diverse Audiences.

The Biota Project communicates science to populations historically ignored by the scientific community. The Biota Project is comprised of a team of young professionals from a myriad of backgrounds and locations with interests in promoting science accessibility and equity. We do this by highlighting research conducted by scientists from underrepresented groups in relatable yet underrated locations with the intention of increasing the participation of underrepresented populations in science. The Biota Project centers on the scientific definition of symbiosis as a tool for both educating and learning from its followers. We deliver stories on the environments of our own backyards by merging art and science and distributing these publicly available stories widely online through short films, media clips, drawings, paintings, blogs, and e-newsletters. This project demonstrates a fresh, transferable perspective on strengthening science communication in a way that conjoins scientific discovery with social justice through the promotion of critical thinking by its target audience. Likewise, contributors learn how to better support local communities with each new story and environment. The Biota Project thus sets a symbiotic tone for re-calibrating the balance between academics, researchers, and local communities. When science is made relevant through understanding, its quality and significance are enhanced, and public recognition of its value is increased.

Associations between childhood biomedical factors, maternal smoking, personality traits, Body and Mass Index and the prevalence of asthma in adulthood.

OBJECTIVE: The study set out to investigate socio-economic, biomedical, health and behavioural and psychological factors in childhood and adulthood associated with the prevalence of asthma in adulthood, drawing data from The National Child Development Studies (NCDS), a birth cohort in the UK. DESIGN: The National Child Development Study, a nationally representative sample of 17,415 babies born in Great Britain in 1958 and followed up at 7, 11, 33 and 50 years was used. MAIN OUTCOME MEASURE: The prevalence of asthma at age 50 was the outcome measure. The analytic sample consists of 5118 participants with complete data on a set of measures at birth, at ages 7, 11, 33 and 50 years. RESULTS: Using logistic regression analyses, results showed that childhood asthma (OR = 6.77: 4.38-10.48, p < .001) and respiratory symptoms (OR = 1.83: 1.18-2.86, p < .01), maternal smoking during pregnancy (OR = 1.26: 1.00-1.59, p < .05), Body and Mass Index (BMI) (OR = 1.03: 1.02-1.05, p < .001), traits Neuroticism (OR = 1.13: 1.01-1.21, p < .05) and Conscientiousness (OR = 0.76: 0.76-0.96, p < .01), as well as sex (OR = 1.49: 1.15-1.94, p < .001) were all significantly associated with the prevalence of asthma in adulthood. CONCLUSION: The study shows that both childhood and adulthood psychological and sociological factors are significantly associated with the prevalence of asthma in adulthood, though more work need to be done in this area.

How Presentation of Drug Detection Results Changed Reports of Product Adherence in South Africa, Uganda and Zimbabwe.

Accurate estimates of study product use are critical to understanding and addressing adherence challenges in HIV prevention trials. The VOICE trial exposed a significant gap between self-reported adherence and drug detection. The VOICE-D qualitative study was designed to better understand non-adherence during VOICE, and was conducted in 2 stages: before (stage 1) and after (stage 2) drug detection results were provided to participants. Transcripts from 44 women who participated in both stages were analysed to understand the effect of presenting drug detection data on narratives of product use. Thirty-six women reported high adherence in stage 1, yet admitted non-use in stage 2, three reported high adherence in both stages (contrary to their drug detection results) and five had consistent responses across both stages and drug results. Presenting objective measures of use may facilitate more accurate product use reporting and should be evaluated in future prevention trials.

Social-Demographic Indicators, Cognitive Ability, Personality Traits, and Region as Independent Predictors of Income: Findings from the UK Household Longitudinal Study (UKHLS).

This paper reports on a longitudinal study of over 12,000 people based on the UK Household Longitudinal Study data. We were interested in their monthly income (as the criterion variable) as it related to their gender, age, education, occupation, personality, intelligence, and region where they lived (as the predictor variables). Correlations showed that, after occupation and education, gender and cognitive ability (particularly numeric ability) were the strongest correlates of income. Hierarchical regressions showed that age and gender accounted for 9% of the variance, intelligence and personality added another 5%, and education and occupation added a further 15%, while region added a further 1%. All four models were statistically significant (p < 0.001). The study suggests that, in future research of this kind on the personal correlates of income, social-demographic, psychological, and regional factors all need to be considered. Limitations are acknowledged.

A Strengths-Based Case Management Intervention to Reduce HIV Viral Load Among People Who Use Drugs.

Engaging highly marginalized HIV positive people in sustained medical care is vital for optimized health and prevention efforts. Prior studies have found that strengths-based case management helps link people who use drugs to HIV care. We conducted a pilot to assess whether a strengths-based case management intervention may help people who use injection drugs (PWID) or smoke crack cocaine (PWSC) achieve undetectable HIV viral load. PWID and PWSC were recruited in Oakland, California using targeted sampling methods and referral from jails and were tested for HIV. HIV positive participants not receiving HIV care (n = 19) were enrolled in a pilot strengths-based case management intervention and HIV positive participants already in HIV care (n = 29) were followed as comparison participants. The intervention was conducted by a social worker and an HIV physician. Special attention was given to coordinating care as participants cycled through jail and community settings. Surveys and HIV viral load tests were conducted quarterly for up to 11 visits. HIV viral load became undetectable for significantly more participants in the intervention than in the comparison group by their last follow-up (intervention participants: 32% at baseline and 74% at last follow-up; comparison participants: 45% at baseline and 34% at last follow-up; p = 0.008). In repeated measures analysis, PBO intervention participants had higher odds of achieving undetectable viral load over time than comparison participants (p = 0.033). Strengths-based case management may help this highly vulnerable group achieve undetectable HIV viral load over time.

End-Users' Product Preference Across Three Multipurpose Prevention Technology Delivery Forms: Baseline Results from Young Women in Kenya and South Africa.

A multipurpose prevention technology (MPT) that combines HIV and pregnancy prevention is a promising women's health intervention, particularly for young women. However, little is known about the drivers of acceptability and product choice for MPTs in this population. This paper explores approval ratings and stated choice across three different MPT delivery forms among potential end-users. The Trio Study was a mixed-methods study in women ages 18-30 that examined acceptability of three MPT delivery forms: oral tablets, injections, and vaginal ring. Approval ratings and stated choice among the products was collected at baseline. Factors influencing stated product choice were explored using multivariable multinomial logistic regression. The majority (62%) of women in Trio stated they would choose injections, 27% would choose tablets and 11% would choose the ring. Significant predictors of choice included past experience with similar contraceptive delivery forms, age, and citing frequency of use as important. Ring choice was higher for older (25-30) women than for younger (18-24) women (aRR = 3.1; p < 0.05). These results highlight the importance of familiarity in MPT product choice of potential for variations in MPT preference by age.

Personality traits neuroticism and openness as well as early abnormal eye conditions as predictors of the occurrence of eye problems in adulthood.

This study set out to examine the associations between psychological, biomedical and socio-demographic factors in childhood and adulthood associated with the occurrence of self-reported eye conditions in adulthood. In total, 5706 participants with complete data on parental social class at birth, cognitive ability accessed at age 11 years, abnormal eye conditions by the age of 16 years diagnosed by medical professionals, educational qualifications obtained at age 33 years, the Big Five Factor personality traits measured at age 50 years, current occupational levels and self-reported eye conditions at age 54 years were included in the study. Logistic regression analysis showed that among all the factors examined early abnormal eye conditions, traits neuroticism and openness as well as sex were the significant predictors of self-reported eye conditions in adulthood.