[The experimental infection of bats with lyssavirus serotypes 1 and 4]. / Eksperimental'noe zarazhenie letuchikh myshei lissavirusami serotipov 1 i 4.

The results of intramuscular inoculation of 111 bats (Myotis daubentoni, Myotis brandtii) with three strains of Lyssaviruses--Yuli, Stade, and 1150 are presented. Bats were found to have low susceptibility, especially to strains of serotype 4. After infection with serotype 4 viruses, fewer bats died but within shorter periods than after infection with serotype 1. After inoculation with strain 1150, 60% of bats yielded virus, whereas only 9-24% did after inoculation with type 4 strains. The survival time after inoculation was 32.2 and 19.0 days, respectively. Manifestations of the disease, virus distribution in viscera, and the results of examinations of specimens from bats by express methods are described.

[The results of using direct solid-phase immunoenzyme analysis for assessing the specific activity of rabies vaccines]. / Rezul'taty ispol'zovaniia priamogo tverdofaznogo immunofermentnogo analiza dlia otsenki spetsificheskoi aktivnosti antirabicheskikh vaktsin.

The effectiveness of the solid-phase enzyme immunoassay (EIA) in the determination of the specific activity of rabies vaccines is evaluated in comparison with that of the protective test in mice. Inactivated tissue-culture, concentrated tissue-culture and purified cerebral tissue vaccines for human use were studied. The methods for performing two EIA variants and evaluating the results are described. The average level of correlation between the results of EIA and the protective test for vaccines of different groups was revealed (0.546), the highest correlation index being obtained for tissue-culture vaccines: 0.753. On the basis of the data obtained in this study the expediency of using EIA for the determination of the specific activity of rabies vaccines has been substantiated.