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BACKGROUND: Respiratory recurrent papillomatosis (RRP) is a fatal disease with no known cure. In severe RRP cases, systemic bevacizumab (SB) could be used as adjuvant therapy. OBJECTIVE: This study aims to determine the extent and type of evidence in relation to the clinical outcomes of RRP after SB treatment. METHODS: Participants with RRP of all genders are included in this scoping review. There were no exclusion criteria (country, language, or document type). The information sources included experimental, quasi-experimental, and analytical observational studies. Unpublished data will not be covered, but gray literature was covered. Screening, paper selection, and data extraction were all done by two independent reviewers. This procedure was performed blindly. RESULTS: Of the 175 unique records found, 15 were eligible for inclusion. Fourteen studies were included after applying inclusion and exclusion criteria. Thirty-four patients in these studies came from the United States, India, Germany, Colombia, Argentina, Chile, and Spain. In total, 17 and 34 patients were below 18 years old and were adults respectively. The most commonly reported dose was 10 mg/kg, which was received by 25 (73.5%) patients. According to reports, 58.8% of patients completed the questionnaire. Twelve (35%) patients did not require a repeat surgery. The time interval between surgical procedures has increased for patients who require them. CONCLUSION: SB may be a promissory treatment and control option for RRP. More research is needed to evaluate the efficiency and adverse effects in various populations.
RESUMO
Objetivo: Describir las características clínicas y microbiológicas de recién nacidos con sepsis admitidos a UCI neonatal de la Fundación Valle del Lili. Materiales y métodos: estudio retrospectivo descriptivo entre los años 2012 y 2015. Se seleccionaron neonatos con diagnóstico de sepsis con más de tres días de manejo antibiótico. Resultados: Se analizaron datos de las historias de 569 pacientes. El 37.9% (216) de los neonatos tenían peso al nacimiento <1500 g, 29.2% (166) entre 1500-2500 g, y 33.9% (187) >2500 g. Para un total de 396 (69.6%) pacientes con sepsis temprana, 308 (54.1%) con sepsis tardía. Las características clínicas más comunes fueron las respiratorias. El principal diagnóstico de infección en sepsis tardía fue la bacteremia (46.4%), seguido de la infección asociada al catéter (17.8%). El aislamiento más común para sepsis temprana fue Streptococcus agalactiae en el 21.9%, mientras que en sepsis tardía fue Staphylococcus epidermidis en el 22.6%. La mortalidad encontrada en sepsis temprana fue de 8.8% y en tardía de 8.5%. Conclusiones: La sepsis neonatal, a pesar de la mejoría en los controles prenatales, continúa siendo una patología frecuente con un importante porcentaje de morbimortalidad. El Streptococcus agalactiae fue la principal causa de sepsis temprana en nuestros pacientes.
Objective: To describe the clinical and microbiological characteristics of newborns with sepsis admitted to the Neonatal Intensive Care Unit of Fundación Valle del Lili in Cali, Colombia. Methods: Descriptive, observational, retrospective study between 2012 and 2015. We included newborns with diagnosis of sepsis with more than three days of antibiotic management. Results: A total of 569 patients were included, 37.9% (216) of the newborns had a birth weight <1500g, 29.2% (166) between 1500 and 2500g , and 32.9% (187) >2500g. 396 (69.6%) patients with early-onset sepsus, 308 (54.1%) had late-onset sepsis. The most common clinical characteristics were respiratory symptoms. The main diagnosis of infection in late-onset sepsis was bacteremia (46.4%) followed by catheter associated infection (17.8%). The most common blood culture isolation for early-onset sepsis was Streptococcus agalactiae (21.9%) and Staphylococcus epidermidis in late onset sepsis (22.6%). The mortality found in early-onset sepsis was 8.8% and in late-onset sepsis was 8.5%. Conclusions: Neonatal sepsis continue to be a frequent diagnosis with significant morbidity and mortality. Better strategies for the prevention of this entity are required including the prenatal period.