The percentage of CD39+ monocytes is higher in pregnant COVID-19+ patients than in nonpregnant COVID-19+ patients.

Current medical guidelines consider pregnant women with COVID-19 to be a high-risk group. Since physiological gestation downregulates the immunological response to maintain "maternal-fetal tolerance", SARS-CoV-2 infection may constitute a potentially threatening condition to both the mother and the fetus. To establish the immune profile in pregnant COVID-19+ patients, a cross-sectional study was conducted. Pregnant women with COVID-19 (P-COVID-19+; n = 15) were analyzed and compared with nonpregnant women with COVID-19 (NP-COVID-19+; n = 15) or those with physiological pregnancy (P-COVID-19-; n = 13). Serological cytokine and chemokine concentrations, leucocyte immunophenotypes, and mononuclear leucocyte responses to polyclonal stimuli were analyzed in all groups. Higher concentrations of serological TNF-α, IL-6, MIP1b and IL-4 were observed within the P-COVID-19+ group, while cytokines and chemokines secreted by peripheral leucocytes in response to LPS, IL-6 or PMA-ionomicin were similar among the groups. Immunophenotype analysis showed a lower percentage of HLA-DR+ monocytes in P-COVID-19+ than in P-COVID-19- and a higher percentage of CD39+ monocytes in P-COVID-19+ than in NP-COVID-19+. After whole blood polyclonal stimulation, similar percentages of T cells and TNF+ monocytes between groups were observed. Our results suggest that P-COVID-19+ elicits a strong inflammatory response similar to NP-COVID19+ but also displays an anti-inflammatory response that controls the ATP/adenosine balance and prevents hyperinflammatory damage in COVID-19.

Carcinoma nasofaríngeo: presentación de un caso, revisión de la literatura y de la casuística del Instituto Nacional de Pediatría de 1984-1994 / Nasopharynx carcinoma: a case report, review of literature and casuistry at the Instituto Nacional de Pediatría from 1984-1994

Se presenta el caso clínico de un paciente masculino de nueve años de edad con un año de evolución caracterizado por dolor intenso, hemifacila derecho, ataque al estado general, caracterizado por astenia, adinamia e hipodrexia, parálisis facial periférica izquierda y aumento de volumen cervical. La tomografía computada(TC), mostró tumoración que involucra la silla turca, seno cavernoso y fosa infratemporal derecha así como nasofaringe. El estudio histopatológico demostró ser carcinoma de nasofaringe. Se presenta el caso, se revisa la literatura y la casuística del Instituto Nacional de Pediatría de 1984 a 1994