1.
Org Lett
; 11(6): 1417-20, 2009 Mar 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19228042
RESUMO
The first total synthesis of ipomoeassin F was carried out using a convergent approach that relied upon the use of Schmidt glycosidation technology for the coupling of two suitably protected monosaccharide fragments. After two steps, ring-closing metathesis was used to form the macrocyclic ring, and seven more steps then furnished ipomoeassin F. In vitro inhibitory activity against a four-panel cell line showed low nanomolar inhibitory activity.