[Intermediate uveitis]. / Les uvéites intermédiaires.

Intermediate uveitis is a chronic and insidious disease. Children and young adults are preferentially affected. Vision loss and floaters are commonly reported in a quiet eye. The inflammation predominates in the vitreous and some characteristic peripheral exsudates may be observed. Intermediate uveitis is generally idiopathic but may sometimes be associated with a systemic disease that must be researched and treated. The treatment of the idiopathic form is only necessary in case of complications and will consist in corticosteroids eventually combined with immunosuppressive drugs. Surgery (cryotherapy, vitrectomy) will be reserved for complications non responding to medical therapy.

Chorioretinal post-transplant lymphoproliferative disorder induced by the Epstein-Barr virus.

BACKGROUND: The Epstein-Barr virus (EBV) is responsible for the lymphoproliferative disorders observed in transplanted patients. METHODS: The case history is described of a 59 year old man with a chorioretinal lesion who had received a single lung transplant and was on immunosuppressive treatment. Immunoglobulin gene rearrangement and EBV detection by polymerase chain reaction (PCR) with semiquantification were used on the vitreous material. RESULTS: A proliferation of B lymphocytes with a monoclonal subpopulation was found by PCR on the vitreous sample. The large amounts of EBV genomes found in the vitreous suggest that EBV was the cause of the lymphoproliferation. Healing of the lesion was achieved by a decrease in immunosuppressive treatment and the use of nucleotide analogues. CONCLUSION: The diagnosis of ocular post-transplant lymphoproliferative disorder (PTLD) can be made by PCR on vitreous material. Early diagnosis and treatment can lead to regression of limited monoclonal lesions.