RESUMO
Mycobacterium lentiflavum is a nontuberculous, slowly growing mycobacterium usually recognized as a contaminant. Here, we report a case of disseminated M. lentiflavum infection responsible for hemophagocytic lymphohistocytosis in a heart-transplanted man.
Assuntos
Transplante de Coração , Linfo-Histiocitose Hemofagocítica/complicações , Linfo-Histiocitose Hemofagocítica/diagnóstico , Infecções por Mycobacterium não Tuberculosas/diagnóstico , Infecções por Mycobacterium não Tuberculosas/microbiologia , Micobactérias não Tuberculosas/isolamento & purificação , Idoso , Humanos , Masculino , Micobactérias não Tuberculosas/classificaçãoRESUMO
INTRODUCTION: ANCA vasculitis may involve the skin and develop slowly without specific histology, and without autoantibodies. CASE REPORT: We report a 50-year-old woman who experienced bilateral mastectomy because of ulcero-necrotic, non-specific inflammatory cutaneous lesions of the breasts. First considered by others as a malinger patient, she developed oto-neurological lesions leading to the diagnosis of Wegener's granulomatosis. Five years later, specific antibodies of the disease were present. CONCLUSION: Cutaneous involvement by ANCA vasculitis can be isolated for a long time. Physicians must have a high degree of suspicion to avoid diagnostic delay of ANCA vasculitis.
Assuntos
Anticorpos Anticitoplasma de Neutrófilos/sangue , Granulomatose com Poliangiite/diagnóstico , Fatores Imunológicos/sangue , Biomarcadores/sangue , Mama/patologia , Diagnóstico Tardio , Diagnóstico Diferencial , Quimioterapia Combinada , Feminino , Glucocorticoides/uso terapêutico , Granulomatose com Poliangiite/sangue , Granulomatose com Poliangiite/tratamento farmacológico , Granulomatose com Poliangiite/cirurgia , Humanos , Imunossupressores/efeitos adversos , Imunossupressores/uso terapêutico , Simulação de Doença , Mastectomia , Pessoa de Meia-Idade , Falha de Tratamento , Resultado do TratamentoRESUMO
INTRODUCTION: Ischemic cholangitis in intensive care unit is a recently reported liver disease in patients who have had a prolonged mechanical ventilation and vasopressive drug support for multiple organ deficiency. Prognosis is usually poor and the only life-saving therapy is liver transplantation despite ursodesoxycholic acid treatment. CASE REPORT: We report a 63-year-old man who presented with a sclerosis cholangitis after a month in intensive care unit, effectively treated with fenofibrate and ursodesoxycholic acid. Recent reports underline fenofibrate efficacy in the treatment of primary biliary cirrhosis, especially in association with ursodesoxycholic acid. This treatment has prevented liver transplantation for our patient with a correct quality of life. CONCLUSION: The addition of fibrate to ursodesoxycholic acid improves persistent cholestasis in sclerosing cholangitis.
Assuntos
Colangite Esclerosante/tratamento farmacológico , Colangite Esclerosante/etiologia , Cuidados Críticos , Fenofibrato/administração & dosagem , Ácido Ursodesoxicólico/administração & dosagem , Colagogos e Coleréticos/administração & dosagem , Colagogos e Coleréticos/uso terapêutico , Fenofibrato/uso terapêutico , Humanos , Hipolipemiantes/administração & dosagem , Hipolipemiantes/uso terapêutico , Unidades de Terapia Intensiva , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Ácido Ursodesoxicólico/uso terapêuticoAssuntos
Dor nas Costas/etiologia , Diarreia/complicações , Artérias Mesentéricas/patologia , Placa Aterosclerótica/diagnóstico , Redução de Peso , Dor Abdominal/etiologia , Adulto , Angiodisplasia/complicações , Angiodisplasia/etiologia , Caquexia/etiologia , Constrição Patológica/complicações , Constrição Patológica/diagnóstico , Diagnóstico Diferencial , Diarreia/etiologia , Feminino , Infecções por Helicobacter/complicações , Humanos , Nutrição Parenteral/métodos , Placa Aterosclerótica/complicações , Fatores de Risco , Fumar/efeitos adversos , Gastropatias/complicações , Úlcera Gástrica/complicações , Resultado do TratamentoRESUMO
Links between Takayasu's arteritis (TA) and tuberculosis are discussed in the literature. We report the case of a Caucasian woman who was first seen for a regressive fever, associated with a normal clinical and chest and abdominal CT-scan examination. A minor granulomatous hepatitis was documented. She had no symptoms for the following four years. A second episode of persisting fever led to the diagnosis of simultaneous occurrence of diffuse TA and severe disseminated tuberculosis. Both affections were treated and the patient was still in good health after three years of follow-up. Simultaneous occurrence of both diseases in our observation supports evidence for a relationship between those two granulomatous diseases.
Assuntos
Arterite de Takayasu/complicações , Tuberculose Miliar/complicações , Corticosteroides/uso terapêutico , Antituberculosos/uso terapêutico , Quimioterapia Combinada , Feminino , Humanos , Pessoa de Meia-Idade , Mycobacterium tuberculosis/isolamento & purificação , Inibidores da Agregação Plaquetária/uso terapêutico , Índice de Gravidade de Doença , Arterite de Takayasu/diagnóstico , Arterite de Takayasu/tratamento farmacológico , Resultado do Tratamento , Tuberculose Miliar/diagnóstico , Tuberculose Miliar/tratamento farmacológicoRESUMO
We report a case of hypocomplementemic urticarial vasculitis heralding a relapsing polychondritis in a 63-year-old woman. The patient, who had suffered in the past from polymyalgia rheumatica, suddenly experienced a generalized urticarial eruption with a dramatic decrease in C4 complement fraction and the presence of anti-C1q antibodies. Two months later, an ear chondritis occurred and the patient rapidly responded to steroids and dapsone. To our knowledge, this association has never been reported.
Assuntos
Leucemia Mielomonocítica Aguda/diagnóstico , Leucemia Mielomonocítica Aguda/patologia , Infiltração Leucêmica , Pele/patologia , Úlcera/etiologia , Doenças da Vulva/etiologia , Adulto , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Leucemia Mielomonocítica Aguda/complicações , Prognóstico , Fatores de TempoAssuntos
Prótese Vascular/efeitos adversos , Endocardite Bacteriana/diagnóstico , Enterobacter cloacae , Infecções por Enterobacteriaceae/diagnóstico , Infecções Relacionadas à Prótese/diagnóstico , Idoso , Endocardite Bacteriana/etiologia , Infecções por Enterobacteriaceae/etiologia , Humanos , Masculino , Infecções Relacionadas à Prótese/etiologiaRESUMO
INTRODUCTION: Ictero-hemorrhagic leptospirosis is an endemic disease in France. Weil's disease, a form of leptospirosis, is well known. Fort Bragg fever is characterized by a constant pretibial papular lesion. First described in the USA, this non icteric form of leptospirosis is usually benign. We report the first French case of a mixed form of leptospirosis. EXEGESIS: A 52-year-old man living in South East France suffered from fever and myalgias associated with a pretibial papular lesion. A severe icterus appeared and permitted a diagnosis of leptospirosis. CONCLUSION: Our case recalls the clinical presentation of Fort Bragg fever, which is recognized through its inflammatory pretibial lesion associated or not with icterus.
Assuntos
Leptospirose/diagnóstico , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Bilirrubina/sangue , Diagnóstico Diferencial , Humanos , Icterícia/sangue , Icterícia/complicações , Icterícia/diagnóstico , Leptospirose/sangue , Leptospirose/complicações , Leptospirose/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Penicilina G/administração & dosagem , Penicilina G/uso terapêutico , Terminologia como Assunto , Fatores de Tempo , Resultado do TratamentoRESUMO
INTRODUCTION: Palpation of soft tissues constitutes part of the physical examination when faced with a patient with fever of unknown origin. Our case highlights the difficulty of diagnosis when the tumor still remains impalpable ten months after onset of fever and severe biological inflammatory process. EXEGESIS: A 49-year-old woman was admitted for fever of unknown origin associated with important biological inflammatory process. In view of her past medical history of breast carcinoma, a search for a relapse was performed and remained negative. Despite multiple investigations and repeated physical examinations, no diagnosis was obtained. Finally, [18F] fluorodoexyglucose positron emission tomography led to a diagnosis showing a high fixation located in the right thigh, related to a myxoid liposarcoma after surgical resection. CONCLUSION: Dramatic regression of fever and biological inflammatory process after surgical treatment illustrates the concept of "small tumor and fever of unknown origin", an exceptional entity but which physicians should be aware of. The role of new technical imaging with [18F] fluorodoexyglucose positron emission tomography has however to be clarified in the evaluation of fever of unknown origin.
Assuntos
Febre de Causa Desconhecida/etiologia , Lipossarcoma/complicações , Neoplasias de Tecidos Moles/complicações , Neoplasias da Mama , Feminino , Febre de Causa Desconhecida/patologia , Humanos , Inflamação , Lipossarcoma/cirurgia , Anamnese , Pessoa de Meia-Idade , Neoplasias de Tecidos Moles/cirurgia , Tomografia Computadorizada de Emissão , Resultado do TratamentoAssuntos
Corticosteroides/efeitos adversos , Abscesso Encefálico/etiologia , Transplante de Coração , Nocardiose/etiologia , Prednisona/efeitos adversos , Arterite de Células Gigantes/tratamento farmacológico , Humanos , Hospedeiro Imunocomprometido , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
PURPOSE: Prothrombin gene mutation G20210A (factor II) is, in frequency, the second genetic polymorphism involved in venous thrombosis. We report a retrospective studies on 38 patients issued from our medical department, all heterozygous for the factor II mutation and a literature review. METHODS: We have studied 38 patients, all heterozygous for the factor II mutation, selected through a population of 516 tested patients issued from our medical department from 1997 to 2002. The research was performed face with history of thrombotic or obstetrical events, angiopathy or familial screening. RESULTS: Twenty out of thirty-eight patients have at least one episode of venous thrombosis: superficial thromboses, deep thromboses and/or pulmonary embolism. One case of cerebral thrombophlebitis is observed. Venous thrombotic risk factors are associated in 12 cases (60%). Four out of thirty-eight patients have one episode of arterial thrombosis: cardiovascular, peripheral or cerebral. Arterial thrombotic risk factors are associated in all cases. Median age of the first venous thrombosis is earlier than the one of arterial thrombosis (39.11 versus 49.25 years). CONCLUSION: Our studies confirms the interest to search the prothrombin gene mutation when faced with a venous thrombotic event (deep vein thrombosis and/or pulmonary embolism) with or without acquired risk factors. Its involvement in thrombotic arterial disease is still a matter of debate. Data concerning its involvement in systemic diseases and angiopathies (thromboangeitis obliterans, Raynaud's phenomenon and migraine) are still needed. Mechanisms of thromboses could be an increase of prothrombin plasma level with high thrombin synthesis.
Assuntos
Heterozigoto , Mutação/genética , Protrombina/genética , Embolia Pulmonar/genética , Trombose/genética , Adulto , Idoso , Artérias , Feminino , França/epidemiologia , Triagem de Portadores Genéticos , Testes Genéticos/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Polimorfismo Genético/genética , Protrombina/metabolismo , Embolia Pulmonar/sangue , Embolia Pulmonar/epidemiologia , Estudos Retrospectivos , Fatores de Risco , Trombose/sangue , Trombose/epidemiologia , VeiasRESUMO
The Muckle-Wells syndrome is a rare autosomal dominant disorder belonging to the group of hereditary fever syndromes. The chronic infantile neurological cutaneous and articular (CINCA) syndrome is a systemic inflammatory disorder of unknown etiology with neonatal onset. They are considered as two different entities. We report the case of a 36-year-old man suffering since birth from a nonpruritic generalized urticaria, with inflammatory flares, joint manifestations and progressive deafness requiring a bilateral hearing aid. An initial diagnosis of Muckle-Wells syndrome was made. However, the patient had an unusual clinical presentation with slightly dysmorphic facial appearance, clubbing of the fingers, mild mental retardation and papilledema. After a genetic advice, a diagnosis of CINCA syndrome was made. Search for mutations in the CIAS1 gene revealed a new mutation in a heterozygous state. This case report really raises the question of a link between these two inflammatory diseases. Further studies are needed to confirm the involvement of mutations of the CIAS1 gene in CINCA syndrome.