Epicardial fat thickness correlates with coronary in-stent restenosis in patients with acute myocardial infarction / La grasa epicárdica se relaciona con la reestenosis del stent en pacientes con infarto agudo de miocardio

Objective: To determine the relation between epicardial fat thickness and coronary in-stent restenosis in patients with acute myocardial infarction and percutaneous coronary intervention. Methods: A prospective study was conducted, which included 129 patients (67.3% male, mean age 62.9 ± 10 years) with ST segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention with bare metal stent. Patients were divided in two groups according to the presence (n = 21) or not (n = 108) of in-stent restenosis during one year follow-up. Results: Epicardial fat was significantly thicker in patients with coronary in-stent restenosis (5.51 ± 1.6 vs 4.14 ± 2.0 mm, p = 0.006). A proportionally and significantly thicker epicardial fat was found according to the increase in coronary disease severity (3.3 ± 0.9 mm vs 4.3 ± 1.8 mm vs 4.7 ± 2.3 mm vs 6.7 ± 2.2mm, for type A, B1, B2 and C lesions, respectively, p=0.001) and number of vessels (3.07 ± 1.2 mm vs 4.92 ± 1.8 mm vs 5.43 ± 2.2 mm, for one, two and three vessels disease, respectively, p < 0.0001). Epicardial fat thickness ≥ 4.7 mm had 75.0% sensibility and 69.0% specificity for predicting restenosis (AUC = 0.737). Conclusions: Echocardiographic evaluation of epicardial fat thickness could identify those patients with acute myocardial infarction with greater probabilities of in-stent restenosis after percutaneous coronary intervention

Objetivos: Determinar la relación entre el grosor de la grasa epicárdica y la reestenosis del stent en pacientes con infarto agudo de miocardio e intervención coronaria percutánea. Métodos: Se realizó un estudio prospectivo en 129 pacientes (67,3% del sexo masculino, edad media: 62,9 ± 10 años) con diagnóstico de infarto agudo de miocardio con elevación del ST e intervención coronaria percutánea primaria con stent metálico convencional, divididos en 2 grupos según presencia (n = 21) o no (n = 108) de reestenosis durante un año de seguimiento posterior a la intervención. Resultados: La grasa epicárdica fue significativamente mayor en los pacientes con reestenosis del stent (5,51 ± 1,6 vs. 4,14 ± 2,0 mm; p = 0,006), aumento en la severidad de la lesión angiográfica (3,3 ± 0,9 vs. 4, 3± 1,8 vs. 4,7 ± 2,3 vs. 6,7 ± 2,2 mm, para lesiones tipo A, B1, B2 y C, respectivamente; p = 0,001) y el número de vasos enfermos (3,07 ± 1,2vs. 4,92 ± 1,8 vs. 5.43 ± 2.2 mm, para uno, 2 y 3 vasos, respectivamente; p < 0,0001). La grasa epicárdica ≥ 4,7 mm mostró una sensibilidad del 75,0% y una especificidad del 69,0% en la predicción de reestenosis (área bajo la curva de 0,737). Conclusiones: La evaluación ecocardiográfica de la grasa epicárdica puede identificar pacientes con infarto agudo de miocardio con mayores probabilidades de reestenosis del stent después de una intervención coronaria percutánea

Epicardial fat thickness correlates with coronary in-stent restenosis in patients with acute myocardial infarction.

OBJECTIVE: To determine the relation between epicardial fat thickness and coronary in-stent restenosis in patients with acute myocardial infarction and percutaneous coronary intervention. METHODS: A prospective study was conducted, which included 129 patients (67.3% male, mean age 62.9±10 years) with ST segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention with bare metal stent. Patients were divided in two groups according to the presence (n=21) or not (n=108) of in-stent restenosis during one year follow-up. RESULTS: Epicardial fat was significantly thicker in patients with coronary in-stent restenosis (5.51±1.6 vs 4.14±2.0mm, p=0.006). A proportionally and significantly thicker epicardial fat was found according to the increase in coronary disease severity (3.3±0.9mm vs 4.3±1.8mm vs 4.7±2.3mm vs 6.7±2.2mm, for type A, B1, B2 and C lesions, respectively, p=0.001) and number of vessels (3.07±1.2mm vs 4.92±1.8mm vs 5.43±2.2mm, for one, two and three vessels disease, respectively, p<0.0001). Epicardial fat thickness ≥4.7mm had 75.0% sensibility and 69.0% specificity for predicting restenosis (AUC=0.737). CONCLUSIONS: Echocardiographic evaluation of epicardial fat thickness could identify those patients with acute myocardial infarction with greater probabilities of in-stent restenosis after percutaneous coronary intervention.