RESUMO
El objetivo del estudio es realizar una estimación de la prevalencia de los niños y niñas con trastornos del espectro autista (TEA) atendidos en ocho Centros de Desarrollo Infantil y de Atención Precoz (CDIAP) en Cataluña y cuantificar los menores de 31 meses que incluimos en el grupo de riesgo de TEA, así como crear una herramienta (APTEA.cat) útil para la recogida de datos de los centros comprendidos en el estudio. La prevalencia obtenida se acerca a los 1:160 según la OMS (2018b). Identificar a la población de riesgo por presencia de signos de alerta pone de manifiesto la necesidad de incrementar los programas de sensibilización y formación de los profesionales que atienden al niño o niña para potenciar la detección lo más pronto posible
The study aims at estimating the prevalence of children with autism spectrum disorders (ASD) in eight of the Catalan Child Development and Early Care Centres (CDIAP) and to quantify the children under 31 months included in the ASD risk group, as well as to create a tool (APTEA.cat) to collect data from the centres that took part in the study. The prevalence obtained is close to 1:160 according to the WHO (2018). Identifying the population at risk due to the warning signs highlights the need to increase the number of awareness and training programmes for professionals who assist children; so that early detection is enhanced
L'objectiu de l'estudi és realitzar una estimació de la prevalença dels nens I nenes amb trastorns de l'espectre autista (TEA) atesos a vuit centres de desenvolupament infantil I d'atenció precoç (CDIAP) a Catalunya I quantificar els menors de 31 mesos que vam incloure en el grup de risc de TEA, així com crear una eina (APTEA.cat) útil per a la recollida de dades dels centres compresos a l'estudi. La prevalença obtinguda s'apropa als 1:160 segons l'OMS (2018). Identificar la població de risc per la presència de signes d'alerta posa de manifest la necessitat d'incrementar els programes de sensibilització I formació dels professionals que atenen el nen o nena per potenciar la detecció el més aviat posible
Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Transtorno do Espectro Autista/epidemiologia , Deficiências do Desenvolvimento/epidemiologia , Prevalência , Diagnóstico Precoce , Transtorno do Espectro Autista/diagnóstico , Deficiências do Desenvolvimento/diagnóstico , Fatores Etários , Fatores de Risco , Distribuição por Sexo , Espanha/epidemiologiaRESUMO
BACKGROUND: Hypoxia plays an important role in many biological/pathological processes. In particular, hypoxia is associated with cardiac ischemia. which, although initially inducing a protective response, will ultimately lead to the death of cardiomyocytes and loss of tissue, severely affecting cardiac functionality. Although myocardial damage/loss remains an insurmountable problem for adult mammals, the same is not true for adult zebrafish, which are able to completely regenerate their heart after extensive injury. Myocardial regeneration in zebrafish involves the dedifferentiation and proliferation of cardiomyocytes to replace the damaged/missing tissue; at present, however, little is known about what factors regulate this process. METHODS AND RESULTS: We surmised that ventricular amputation would lead to hypoxia induction in the myocardium of zebrafish and that this may play a role in regulating the regeneration of the missing cardiac tissue. Using a combination of O(2) perturbation, conditional transgenics, in vitro cell culture, and microarray analysis, we found that hypoxia induces cardiomyocytes to dedifferentiate and proliferate during heart regeneration in zebrafish and have identified a number of genes that could play a role in this process. CONCLUSION: These results indicate that hypoxia plays a positive role during heart regeneration, which should be taken into account in future strategies aimed at inducing heart regeneration in humans.