1.
Bull Exp Biol Med
; 134(4): 400-2, 2002 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12533771
RESUMO
Effects of acute and chronic caffeine intake on the level and pattern of morphine self-administration behavior in WAG/G and Fisher-344 rats were studied. Both acute and chronic caffeine intake decreased morphine self-administration only in WAG/G rats, which attested to increased sensitivity of these rats to reinforcing effects of morphine. Possible relationship between the observed changes and increased anxiety in rats receiving caffeine is discussed.